Immunopathogenesis of IBD: current state of the art

The Epithelial Danger Signal IL-1α Is a Potent Activator of Fibroblasts and Reactivator of Intestinal Inflammation

(2015) Melania Scarpa et al.   AMERICAN JOURNAL OF PATHOLOGY

Disease-Specific Alterations in the Enteric Virome in Inflammatory Bowel Disease

(2015) Jason M. Norman et al.   CELL

Homeostasis, Inflammation, and Disease Susceptibility

(2015) Maya E. Kotas et al.   CELL

Role of Inflammasomes in Intestinal Inflammation and Crohnʼs Disease

(2015) Anthony Opipari et al.   INFLAMMATORY BOWEL DISEASES

Emerging roles of gut microbiota and the immune system in the development of the enteric nervous system

(2015) Panagiotis S. Kabouridis et al.   JOURNAL OF CLINICAL INVESTIGATION

The gut connectome: making sense of what you eat

(2015) Diego V. Bohórquez et al.   JOURNAL OF CLINICAL INVESTIGATION

Gut/brain axis and the microbiota

(2015) Emeran A. Mayer et al.   JOURNAL OF CLINICAL INVESTIGATION

New developments in goblet cell mucus secretion and function

(2015) G M H Birchenough et al.   Mucosal Immunology

The unusual suspects—innate lymphoid cells as novel therapeutic targets in IBD

(2015) Rimma Goldberg et al.   Nature Reviews Gastroenterology & Hepatology

Mongersen, an Oral SMAD7 Antisense Oligonucleotide, and Crohn’s Disease

(2015) Giovanni Monteleone et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inflammation-induced lymphangiogenesis and lymphatic dysfunction

(2014) Shan Liao et al.   ANGIOGENESIS

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

The Treatment-Naive Microbiome in New-Onset Crohn’s Disease

(2014) Dirk Gevers et al.   Cell Host & Microbe

The composition of the gut microbiota shapes the colon mucus barrier

(2014) H. E. Jakobsson et al.   EMBO REPORTS

MicroRNAs: new players in IBD

(2014) R Kalla et al.   GUT

IL-13Rα2-bearing, type II NKT cells reactive to sulfatide self-antigen populate the mucosa of ulcerative colitis

(2014) Ivan J Fuss et al.   GUT

Mode of Delivery and Risk of Inflammatory Bowel Disease in the Offspring

(2014) Alanna Bruce et al.   INFLAMMATORY BOWEL DISEASES

Impact of Abdominal Visceral Adipose Tissue on Disease Outcome in Pediatric Crohnʼs Disease

(2014) Victor Uko et al.   INFLAMMATORY BOWEL DISEASES

Cross-talk Between RORγt+ Innate Lymphoid Cells and Intestinal Macrophages Induces Mucosal IL-22 Production in Crohnʼs Disease

(2014) Shinta Mizuno et al.   INFLAMMATORY BOWEL DISEASES

Overexpression of ATP-activated P2X7 Receptors in the Intestinal Mucosa Is Implicated in the Pathogenesis of Crohnʼs Disease

(2014) Adriane R. Neves et al.   INFLAMMATORY BOWEL DISEASES

Fibrosis in Ulcerative Colitis

(2014) Ilyssa O. Gordon et al.   INFLAMMATORY BOWEL DISEASES

Role of HMGB1 as a Suitable Biomarker of Subclinical Intestinal Inflammation and Mucosal Healing in Patients with Inflammatory Bowel Disease

(2014) Francesca Palone et al.   INFLAMMATORY BOWEL DISEASES

VEGF-C–dependent stimulation of lymphatic function ameliorates experimental inflammatory bowel disease

(2014) Silvia D’Alessio et al.   JOURNAL OF CLINICAL INVESTIGATION

The alarmin IL-33 promotes regulatory T-cell function in the intestine

(2014) Chris Schiering et al.   NATURE

The multilayered complexity of ceRNA crosstalk and competition

(2014) Yvonne Tay et al.   NATURE

TH9 cells that express the transcription factor PU.1 drive T cell–mediated colitis via IL-9 receptor signaling in intestinal epithelial cells

(2014) Katharina Gerlach et al.   NATURE IMMUNOLOGY

Mycobiota in gastrointestinal diseases

(2014) Pranab K. Mukherjee et al.   Nature Reviews Gastroenterology & Hepatology

Genetic association and functional role of Crohn disease risk alleles involved in microbial sensing, autophagy, and endoplasmic reticulum (ER) stress

(2013) Eveline Hoefkens et al.   Autophagy

MicroRNA-124 Regulates STAT3 Expression and Is Down-regulated in Colon Tissues of Pediatric Patients With Ulcerative Colitis

(2013) Georgios Koukos et al.   GASTROENTEROLOGY

Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis

(2013) Malin E V Johansson et al.   GUT

Crohn's disease complicated by strictures: a systematic review

(2013) Florian Rieder et al.   GUT

Geographical variability and environmental risk factors in inflammatory bowel disease

(2013) Siew C Ng et al.   GUT

The Role of Polymorphonuclear Leukocyte Trafficking in the Perpetuation of Inflammation During Inflammatory Bowel Disease

(2013) Jennifer C. Brazil et al.   INFLAMMATORY BOWEL DISEASES

Induced and Natural Regulatory T Cells in the Development of Inflammatory Bowel Disease

(2013) Christopher G. Mayne et al.   INFLAMMATORY BOWEL DISEASES

MicroRNAs: Essential players in the regulation of inflammation

(2013) Ana Rebane et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IL-22-producing CD4+ cells are depleted in actively inflamed colitis tissue

(2013) J M Leung et al.   Mucosal Immunology

New targets for mucosal healing and therapy in inflammatory bowel diseases

(2013) M F Neurath   Mucosal Immunology

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

The Gut Microbiome in Intestinal Fibrosis: Environmental Protector or Provocateur?

(2013) F. Rieder   Science Translational Medicine

Regulatory T Cells and Immune Tolerance in the Intestine

(2013) O. J. Harrison et al.   Cold Spring Harbor Perspectives in Biology

Microbiota of De-Novo Pediatric IBD: Increased Faecalibacterium Prausnitzii and Reduced Bacterial Diversity in Crohn's But Not in Ulcerative Colitis

(2012) Richard Hansen et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Innate Lymphoid Cells: Balancing Immunity, Inflammation, and Tissue Repair in the Intestine

(2012) Elia D. Tait Wojno et al.   Cell Host & Microbe

Increased Levels of Survivin, via Association With Heat Shock Protein 90, in Mucosal T Cells From Patients With Crohn's Disease

(2012) Heitor S.P. de Souza et al.   GASTROENTEROLOGY

Pro-Angiogenic Activity of TLRs and NLRs: A Novel Link Between Gut Microbiota and Intestinal Angiogenesis

(2012) Anja Schirbel et al.   GASTROENTEROLOGY

Pattern recognition receptor and autophagy gene variants are associated with development of antimicrobial antibodies in Crohnʼs disease

(2012) Travis B. Murdoch et al.   INFLAMMATORY BOWEL DISEASES

Adipose Tissue and Inflammatory Bowel Disease Pathogenesis

(2012) Christopher Fink et al.   INFLAMMATORY BOWEL DISEASES

Unraveling the mystery of the hygiene hypothesis through Helicobacter pylori infection

(2012) Kouji Matsushima et al.   JOURNAL OF CLINICAL INVESTIGATION

RORγt-dependent IL-17A-producing cells in the pathogenesis of intestinal inflammation

(2012) T Kanai et al.   Mucosal Immunology

Integrative inflammasome activity in the regulation of intestinal mucosal immune responses

(2012) E Elinav et al.   Mucosal Immunology

MUC1 and MUC13 differentially regulate epithelial inflammation in response to inflammatory and infectious stimuli

(2012) Y H Sheng et al.   Mucosal Immunology

Inflammasomes in health and disease

(2012) Till Strowig et al.   NATURE

Reciprocal interactions of the intestinal microbiota and immune system

(2012) Craig L. Maynard et al.   NATURE

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

Inflammasomes: far beyond inflammation

(2012) Jorge Henao-Mejia et al.   NATURE IMMUNOLOGY

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

(2012) Thomas A Wynn et al.   NATURE MEDICINE

Crohn's Disease-Associated Adherent-Invasive Escherichia coli Adhesion Is Enhanced by Exposure to the Ubiquitous Dietary Polysaccharide Maltodextrin

(2012) Kourtney P. Nickerson et al.   PLoS One

Interactions Between the Microbiota and the Immune System

(2012) L. V. Hooper et al.   SCIENCE

MicroRNAs in inflammatory bowel disease - pathogenesis, diagnostics and therapeutics

(2012) Mehmet Coskun   WORLD JOURNAL OF GASTROENTEROLOGY

Cellular and molecular mechanisms of intestinal fibrosis

(2012) Silvia Speca   WORLD JOURNAL OF GASTROENTEROLOGY

Low exposure to sunlight is a risk factor for Crohn’s disease

(2011) V. Nerich et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Crohn disease: A current perspective on genetics, autophagy and immunity

(2011) Thaddeus S. Stappenbeck et al.   Autophagy

Hygiene Hypothesis and Autoimmune Diseases

(2011) Graham A. W. Rook   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Activation of the Receptor NKG2D Leads to Production of Th17 Cytokines in CD4+ T Cells of Patients With Crohn's Disease

(2011) Benjamin Pariente et al.   GASTROENTEROLOGY

Development of the Human Gastrointestinal Microbiota and Insights From High-Throughput Sequencing

(2011) Maria Gloria Dominguez-Bello et al.   GASTROENTEROLOGY

The Commensal Microbiota and Enteropathogens in the Pathogenesis of Inflammatory Bowel Diseases

(2011) Benoit Chassaing et al.   GASTROENTEROLOGY

Crohn's disease: NOD2, autophagy and ER stress converge

(2011) T. Fritz et al.   GUT

Apoptosis of regulatory T lymphocytes is increased in chronic inflammatory bowel disease and reversed by anti-TNF  treatment

(2011) C. Veltkamp et al.   GUT

Mesenteric fat as a source of C reactive protein and as a target for bacterial translocation in Crohn's disease

(2011) Laurent Peyrin-Biroulet et al.   GUT

Visceral adipocytes: old actors in obesity and new protagonists in Crohn's disease?

(2011) Alessandra Zulian et al.   GUT

Smokers with active Crohnʼs disease have a clinically relevant dysbiosis of the gastrointestinal microbiota*

(2011) Jane L. Benjamin et al.   INFLAMMATORY BOWEL DISEASES

miR-143 and miR-145 are downregulated in ulcerative colitis: Putative regulators of inflammation and protooncogenes

(2011) Joel R. Pekow et al.   INFLAMMATORY BOWEL DISEASES

The JAK2 variant rs10758669 in Crohn’s disease: altering the intestinal barrier as one mechanism of action

(2011) Matthias Prager et al.   INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

Endotoxin levels in house dust samples and juvenile inflammatory bowel disease — a case–control study

(2011) Anja Boneberger et al.   Journal of Crohns & Colitis

IL-23–responsive innate lymphoid cells are increased in inflammatory bowel disease

(2011) Alessandra Geremia et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Comparison of the fecal microbiota profiles between ulcerative colitis and Crohn’s disease using terminal restriction fragment length polymorphism analysis

(2011) Akira Andoh et al.   JOURNAL OF GASTROENTEROLOGY

Peripheral education of the immune system by colonic commensal microbiota

(2011) Stephanie K. Lathrop et al.   NATURE

Autophagy in immunity and inflammation

(2011) Beth Levine et al.   NATURE

Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease

(2011) Manuel A Rivas et al.   NATURE GENETICS

The role of bacteria and pattern-recognition receptors in Crohn's disease

(2011) Si Ming Man et al.   Nature Reviews Gastroenterology & Hepatology

Colonic mucosa-associated microbiota is influenced by an interaction of Crohn disease and FUT2 (Secretor) genotype

(2011) P. Rausch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ever-expanding function of NOD2: autophagy, viral recognition, and T cell activation

(2011) Michael H. Shaw et al.   TRENDS IN IMMUNOLOGY

The Sterile Inflammatory Response

(2010) Kenneth L. Rock et al.   Annual Review of Immunology

Nonresolving Inflammation

(2010) Carl Nathan et al.   CELL

Role of gut microbiota in the control of energy and carbohydrate metabolism

(2010) Koen Venema   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

The complex interplay of NOD-like receptors and the autophagy machinery in the pathophysiology of Crohn disease

(2010) Susanne Billmann-Born et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Imbalance of NKp44+NKp46− and NKp44−NKp46+ Natural Killer Cells in the Intestinal Mucosa of Patients With Crohn's Disease

(2010) Tetsuro Takayama et al.   GASTROENTEROLOGY

ATG16L1 and NOD2 Interact in an Autophagy-Dependent Antibacterial Pathway Implicated in Crohn's Disease Pathogenesis

(2010) Craig R. Homer et al.   GASTROENTEROLOGY

Antibiotic use and inflammatory bowel diseases in childhood

(2010) A. Hviid et al.   GUT

Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome

(2010) C. Bauer et al.   GUT

The NLRP3 Inflammasome Protects against Loss of Epithelial Integrity and Mortality during Experimental Colitis

(2010) Md. Hasan Zaki et al.   IMMUNITY

Identification of microRNAs associated with ileal and colonic Crohnʼs disease†

(2010) Feng Wu et al.   INFLAMMATORY BOWEL DISEASES

DAMPening Inflammation by Modulating TLR Signalling

(2010) A. M. Piccinini et al.   MEDIATORS OF INFLAMMATION

Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology

(2010) Sofia Buonocore et al.   NATURE

Genome-wide association identifies multiple ulcerative colitis susceptibility loci

(2010) Dermot P B McGovern et al.   NATURE GENETICS

The dual nature of TH17 cells: shifting the focus to function

(2010) William O'Connor et al.   NATURE IMMUNOLOGY

Effector T cell plasticity: flexibility in the face of changing circumstances

(2010) Kenneth M Murphy et al.   NATURE IMMUNOLOGY

Tight Junctions, Intestinal Permeability, and Autoimmunity

(2009) Jeroen Visser et al.   Annals of the New York Academy of Sciences

Crohn's disease-associated adherent-invasiveE. coliare selectively favoured by impaired autophagy to replicate intracellularly

(2009) Pierre Lapaquette et al.   CELLULAR MICROBIOLOGY

The immunopathogenesis of Crohn's disease: a three-stage model

(2009) Gavin W Sewell et al.   CURRENT OPINION IN IMMUNOLOGY

Monitoring disease activity by stool analyses: from occult blood to molecular markers of intestinal inflammation and damage

(2009) D Foell et al.   GUT

Dendritic cells in intestinal homeostasis and disease

(2009) Maria Rescigno et al.   JOURNAL OF CLINICAL INVESTIGATION

Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease

(2009) Andrew M. Smith et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ethyl pyruvate decreases HMGB1 release and ameliorates murine colitis

(2009) Shaival H. Davé et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Endoplasmic reticulum stress and intestinal inflammation

(2009) A Kaser et al.   Mucosal Immunology

A Crohn's disease–associated NOD2 mutation suppresses transcription of human IL10 by inhibiting activity of the nuclear ribonucleoprotein hnRNP-A1

(2009) Eiichiro Noguchi et al.   NATURE IMMUNOLOGY

Intestinal fibrosis in IBD—a dynamic, multifactorial process

(2009) Florian Rieder et al.   Nature Reviews Gastroenterology & Hepatology

TGF-β: A Master of All T Cell Trades

(2008) Ming O. Li et al.   CELL

XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease

(2008) Arthur Kaser et al.   CELL

MicroRNAs Are Differentially Expressed in Ulcerative Colitis and Alter Expression of Macrophage Inflammatory Peptide-2α

(2008) Feng Wu et al.   GASTROENTEROLOGY

Regulation of Gut Inflammation and Th17 Cell Response by Interleukin-21

(2008) Daniele Fina et al.   GASTROENTEROLOGY

VEGF-A Links Angiogenesis and Inflammation in Inflammatory Bowel Disease Pathogenesis

(2008) Franco Scaldaferri et al.   GASTROENTEROLOGY

Disorders of a modern lifestyle: reconciling the epidemiology of inflammatory bowel diseases

(2008) C. N Bernstein et al.   GUT

Anti tumour necrosis-α therapy increases the number of FOXP3+regulatory T cells in children affected by Crohn’s disease

(2008) Ida Ricciardelli et al.   IMMUNOLOGY

Helicobacter pyloriColonization Is Inversely Associated with Childhood Asthma

(2008) Yu Chen et al.   JOURNAL OF INFECTIOUS DISEASES

A microbial symbiosis factor prevents intestinal inflammatory disease

(2008) Sarkis K. Mazmanian et al.   NATURE

Common variants in the NLRP3 region contribute to Crohn's disease susceptibility

(2008) Alexandra-Chloé Villani et al.   NATURE GENETICS

Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients

(2008) H. Sokol et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA