Inflammatory bowel disease and immunonutrition: novel therapeutic approaches through modulation of diet and the gut microbiome

Vitamin D deficiency and the pathogenesis of Crohn’s disease

(2018) John H. White   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Genome-Wide Association Study Identifies African-Specific Susceptibility Loci in African Americans With Inflammatory Bowel Disease

(2017) Steven R. Brant et al.   GASTROENTEROLOGY

Prolonged fasting suppresses mitochondrial NLRP3 inflammasome assembly and activation via SIRT3-mediated activation of superoxide dismutase 2

(2017) Javier Traba et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Immunologic impact of the intestine in metabolic disease

(2017) Daniel A. Winer et al.   JOURNAL OF CLINICAL INVESTIGATION

Pharmacokinetic and Pharmacodynamic Modeling of Serum Etrolizumab and Circulating β7 Receptor Occupancy in Patients With Ulcerative Colitis

(2017) Xiaohui Wei et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Diversity and functions of intestinal mononuclear phagocytes

(2017) T Joeris et al.   Mucosal Immunology

Adapting to obesity with adipose tissue inflammation

(2017) Shannon M. Reilly et al.   Nature Reviews Endocrinology

Immunoregulation of Inflammatory and Inhibitory Cytokines by Vitamin D3 in Patients with Inflammatory Bowel Diseases

(2017) H. Alhassan Mohammed et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages

(2017) W. K. Eddie Ip et al.   SCIENCE

Microbiota-activated PPAR-γ signaling inhibits dysbiotic Enterobacteriaceae expansion

(2017) Mariana X. Byndloss et al.   SCIENCE

Role of autophagy in the pathogenesis of inflammatory bowel disease

(2017) Tomoya Iida et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Oral administration of yeast β-glucan ameliorates inflammation and intestinal barrier in dextran sodium sulfate-induced acute colitis

(2017) Feifei Han et al.   Journal of Functional Foods

The Impact of Western Diet and Nutrients on the Microbiota and Immune Response at Mucosal Interfaces

(2017) Donjete Statovci et al.   Frontiers in Immunology

Stable Engraftment of Bifidobacterium longum AH1206 in the Human Gut Depends on Individualized Features of the Resident Microbiome

(2016) María X. Maldonado-Gómez et al.   Cell Host & Microbe

Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan

(2016) Valter D. Longo et al.   Cell Metabolism

The Intestinal Immune System in Obesity and Insulin Resistance

(2016) Daniel A. Winer et al.   Cell Metabolism

β-Hydroxybutyrate: A signaling metabolite in starvation response?

(2016) Pedro Rojas-Morales et al.   CELLULAR SIGNALLING

The Relevance of Vitamin D and Antinuclear Antibodies in Patients with Inflammatory Bowel Disease Under Anti-TNF Treatment

(2016) João Santos-Antunes et al.   INFLAMMATORY BOWEL DISEASES

NOD1 and NOD2 signalling links ER stress with inflammation

(2016) A. Marijke Keestra-Gounder et al.   NATURE

Ustekinumab as Induction and Maintenance Therapy for Crohn’s Disease

(2016) Brian G. Feagan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Transkingdom control of viral infection and immunity in the mammalian intestine

(2016) J. K. Pfeiffer et al.   SCIENCE

Protective effects of Lactobacillus plantarum on epithelial barrier disruption caused by enterotoxigenic Escherichia coli in intestinal porcine epithelial cells

(2016) Yunpeng Wu et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Diet and nutritional factors in inflammatory bowel diseases

(2016) Danuta Owczarek   WORLD JOURNAL OF GASTROENTEROLOGY

Metabolic Inflammation-Differential Modulation by Dietary Constituents

(2016) Claire Lyons et al.   Nutrients

A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms

(2016) In Young Choi et al.   Cell Reports

Loss of Response to Anti-TNFs: Definition, Epidemiology and Management

(2016) Giulia Roda et al.   Clinical and Translational Gastroenterology

Mucosal Interactions between Genetics, Diet, and Microbiome in Inflammatory Bowel Disease

(2016) Abigail Basson et al.   Frontiers in Immunology

mTOR Inhibition Attenuates Dextran Sulfate Sodium-Induced Colitis by Suppressing T Cell Proliferation and Balancing TH1/TH17/Treg Profile

(2016) Shurong Hu et al.   PLoS One

Microbiota-Mediated Inflammation and Antimicrobial Defense in the Intestine

(2015) Silvia Caballero et al.   Annual Review of Immunology

Optimizing biologic treatment in IBD: objective measures, but when, how and how often?

(2015) Shomron Ben-Horin et al.   BMC GASTROENTEROLOGY

Effect of caloric restriction on the SIRT1/mTOR signaling pathways in senile mice

(2015) Lina Ma et al.   BRAIN RESEARCH BULLETIN

Lack of Vitamin D Receptor Causes Dysbiosis and Changes the Functions of the Murine Intestinal Microbiome

(2015) Dapeng Jin et al.   CLINICAL THERAPEUTICS

Immune Interactions with Pathogenic and Commensal Fungi: A Two-Way Street

(2015) David M. Underhill et al.   IMMUNITY

Inhibition of Chronic Ulcerative Colitis-associated Adenocarcinoma Development in Mice by VSL#3

(2015) Elena Talero et al.   INFLAMMATORY BOWEL DISEASES

In Vitro Effects of Dietary Inulin on Human Fecal Microbiota and Butyrate Production

(2015) Tae-Hwan Jung et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Soluble Dextrin Fibers Alter the Intestinal Microbiota and Reduce Proinflammatory Cytokine Secretion in Male IL-10–Deficient Mice

(2015) Rosica Valcheva et al.   JOURNAL OF NUTRITION

A potential role for regulatory T-cells in the amelioration of DSS induced colitis by dietary non-digestible polysaccharides

(2015) Anita Hartog et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease

(2015) Yun-Hee Youm et al.   NATURE MEDICINE

Orally delivered β-glucans aggravate dextran sulfate sodium (DSS)-induced intestinal inflammation

(2015) Sigrid E.M. Heinsbroek et al.   NUTRITION RESEARCH

Increased gut microbiota diversity and abundance of Faecalibacterium prausnitzii and Akkermansia after fasting: a pilot study

(2015) Marlene Remely et al.   WIENER KLINISCHE WOCHENSCHRIFT

Oat β-glucan ameliorates dextran sulfate sodium (DSS)-induced ulcerative colitis in mice

(2015) Bo Liu et al.   Food & Function

Vitamin D3 Induces Tolerance in Human Dendritic Cells by Activation of Intracellular Metabolic Pathways

(2015) Gabriela Bomfim Ferreira et al.   Cell Reports

Obesity, inflammation, and the gut microbiota

(2015) Amanda J Cox et al.   Lancet Diabetes & Endocrinology

Rapidly expanding knowledge on the role of the gut microbiome in health and disease

(2014) M.C. Cénit et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Role of the Microbiota in Immunity and Inflammation

(2014) Yasmine Belkaid et al.   CELL

Fasting: Molecular Mechanisms and Clinical Applications

(2014) Valter D. Longo et al.   Cell Metabolism

Meta-analyses of human gut microbes associated with obesity and IBD

(2014) William A. Walters et al.   FEBS LETTERS

Human Gut Dendritic Cells Drive Aberrant Gut-specific T-cell Responses in Ulcerative Colitis, Characterized by Increased IL-4 Production and Loss of IL-22 and IFNγ

(2014) Elizabeth R. Mann et al.   INFLAMMATORY BOWEL DISEASES

The use of sirolimus (rapamycin) in the management of refractory inflammatory bowel disease in children

(2014) Mohamed Mutalib et al.   Journal of Crohns & Colitis

The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic

(2014) Colin Hill et al.   Nature Reviews Gastroenterology & Hepatology

Optimization of the treatment with immunosuppressants and biologics in inflammatory bowel disease

(2014) Sara Renna   WORLD JOURNAL OF GASTROENTEROLOGY

Metabolite and transcriptome analysis during fasting suggest a role for the p53-Ddit4 axis in major metabolic tissues

(2013) Michael Schupp et al.   BMC GENOMICS

Saccharomyces boulardii Does Not Prevent Relapse of Crohn's Disease

(2013) Arnaud Bourreille et al.   Clinical Gastroenterology and Hepatology

Nutritional deficiencies in inflammatory bowel disease: Therapeutic approaches

(2013) Sara Massironi et al.   CLINICAL NUTRITION

Role of “Western Diet” in Inflammatory Autoimmune Diseases

(2013) Arndt Manzel et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Probiotics in the management of irritable bowel syndrome and inflammatory bowel disease

(2013) Kevin Whelan et al.   CURRENT OPINION IN GASTROENTEROLOGY

Changes of the Intestinal Microbiota, Short Chain Fatty Acids, and Fecal pH in Patients with Colorectal Cancer

(2013) Seiji Ohigashi et al.   DIGESTIVE DISEASES AND SCIENCES

Adalimumab for Crohn’s disease after infliximab treatment failure

(2013) Wei Da et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Short-Chain Fatty Acids Activate GPR41 and GPR43 on Intestinal Epithelial Cells to Promote Inflammatory Responses in Mice

(2013) Myung H. Kim et al.   GASTROENTEROLOGY

Advances in inflammatory bowel disease pathogenesis: linking host genetics and the microbiome

(2013) Dan Knights et al.   GUT

1,25-Dihydroxyvitamin D Promotes Negative Feedback Regulation of TLR Signaling via Targeting MicroRNA-155-SOCS1 in Macrophages

(2013) Y. Chen et al.   JOURNAL OF IMMUNOLOGY

Vitamin D Regulates the Gut Microbiome and Protects Mice from Dextran Sodium Sulfate–Induced Colitis

(2013) Jot Hui Ooi et al.   JOURNAL OF NUTRITION

Dysregulated Circulating Dendritic Cell Function in Ulcerative Colitis Is Partially Restored by Probiotic StrainLactobacillus caseiShirota

(2013) Elizabeth R. Mann et al.   MEDIATORS OF INFLAMMATION

Nondigestible oligosaccharides exert nonprebiotic effects on intestinal epithelial cells enhancing the immune response via activation of TLR4-NFκB

(2013) Mercedes Ortega-González et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Vedolizumab as Induction and Maintenance Therapy for Ulcerative Colitis

(2013) Brian G. Feagan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Vedolizumab as Induction and Maintenance Therapy for Crohn's Disease

(2013) William J. Sandborn et al.   NEW ENGLAND JOURNAL OF MEDICINE

VSL#3 probiotics provide protection against acute intestinal ischaemia/reperfusion injury

(2013) S.Y. Salim et al.   Beneficial Microbes

Inulin and fructo-oligosaccharides have divergent effects on colitis and commensal microbiota in HLA-B27 transgenic rats

(2012) Petya T. Koleva et al.   BRITISH JOURNAL OF NUTRITION

Cellular Metabolism and Disease: What Do Metabolic Outliers Teach Us?

(2012) Ralph J. DeBerardinis et al.   CELL

Dietary and commensal derived nutrients: shaping mucosal and systemic immunity

(2012) Sean P Spencer et al.   CURRENT OPINION IN IMMUNOLOGY

Adverse events associated with mTOR inhibitors

(2012) Nicolas Pallet et al.   Expert Opinion On Drug Safety

Adalimumab Induces and Maintains Mucosal Healing in Patients With Crohn's Disease: Data From the EXTEND Trial

(2012) Paul Rutgeerts et al.   GASTROENTEROLOGY

Insight into the prebiotic concept: lessons from an exploratory, double blind intervention study with inulin-type fructans in obese women

(2012) Evelyne M Dewulf et al.   GUT

Micronutrient deficiencies in inflammatory bowel disease: From A to zinc

(2012) Caroline Hwang et al.   INFLAMMATORY BOWEL DISEASES

Multicenter analysis of fecal microbiota profiles in Japanese patients with Crohn’s disease

(2012) Akira Andoh et al.   JOURNAL OF GASTROENTEROLOGY

VSL#3 probiotics exerts the anti-inflammatory activity via PI3k/Akt and NF-κB pathway in rat model of DSS-induced colitis

(2012) Cong Dai et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The cellular and signaling networks linking the immune system and metabolism in disease

(2012) Olivia Osborn et al.   NATURE MEDICINE

Suppression of Oxidative Stress by  -Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor

(2012) T. Shimazu et al.   SCIENCE

Leaky gut and the liver: A role for bacterial translocation in nonalcoholic steatohepatitis

(2012) Yaron Ilan   WORLD JOURNAL OF GASTROENTEROLOGY

Metformin, Independent of AMPK, Induces mTOR Inhibition and Cell-Cycle Arrest through REDD1

(2011) I. Ben Sahra et al.   CANCER RESEARCH

Beneficial Effects of Probiotic Bifidobacterium and Galacto-Oligosaccharide in Patients with Ulcerative Colitis: A Randomized Controlled Study

(2011) Hideki Ishikawa et al.   DIGESTION

Glycan recognition at the interface of the intestinal immune system: Target for immune modulation via dietary components

(2011) Sander de Kivit et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Early Mucosal Healing With Infliximab Is Associated With Improved Long-term Clinical Outcomes in Ulcerative Colitis

(2011) Jean Frédéric Colombel et al.   GASTROENTEROLOGY

Adalimumab Induces and Maintains Clinical Remission in Patients With Moderate-to-Severe Ulcerative Colitis

(2011) William J. Sandborn et al.   GASTROENTEROLOGY

Effect of oligofructose-enriched inulin (OF-IN) on bacterial composition and disease activity of patients with Crohn's disease: results from a double-blinded randomised controlled trial: Table 1

(2011) Marie Joossens et al.   GUT

Dysbiosis of the faecal microbiota in patients with Crohn's disease and their unaffected relatives

(2011) M. Joossens et al.   GUT

Randomised, double-blind, placebo-controlled trial of fructo-oligosaccharides in active Crohn's disease

(2011) J. L. Benjamin et al.   GUT

Immunomodulatory mechanisms of lactobacilli

(2011) Jerry M Wells   Microbial Cell Factories

Clinical trial: the microbiological and immunological effects of synbiotic consumption - a randomized double-blind placebo-controlled study in active Crohn’s disease

(2010) H. Steed et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Vitamin D Receptor Negatively Regulates Bacterial-Stimulated NF-κB Activity in Intestine

(2010) Shaoping Wu et al.   AMERICAN JOURNAL OF PATHOLOGY

Inflammatory Bowel Disease

(2010) Arthur Kaser et al.   Annual Review of Immunology

The fermentable fibre inulin increases postprandial serum short-chain fatty acids and reduces free-fatty acids and ghrelin in healthy subjects

(2010) Joshua Tarini et al.   Applied Physiology Nutrition and Metabolism

Adverse effects of biologics used for treating IBD

(2010) Andreas Stallmach et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

A double-blind, placebo-controlled, cross-over study to establish the bifidogenic effect of a very-long-chain inulin extracted from globe artichoke ( Cynara scolymus) in healthy human subjects

(2010) Adele Costabile et al.   BRITISH JOURNAL OF NUTRITION

Molecular Characterisation of the Faecal Microbiota in Patients with Type II Diabetes

(2010) Xiaokang Wu et al.   CURRENT MICROBIOLOGY

Butyrate and other short-chain fatty acids as modulators of immunity: what relevance for health?

(2010) Kees Meijer et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Immunosuppressive effects via human intestinal dendritic cells of probiotic bacteria and steroids in the treatment of acute ulcerative colitis

(2010) Siew C. Ng et al.   INFLAMMATORY BOWEL DISEASES

Monitoring and surveillance of chronic non-communicable diseases: progress and capacity in high-burden countries

(2010) Ala Alwan et al.   LANCET

Infliximab, Azathioprine, or Combination Therapy for Crohn's Disease

(2010) Jean Frédéric Colombel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns

(2010) M. G. Dominguez-Bello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early life: gut microbiota and immune development in infancy

(2010) R. Martin et al.   Beneficial Microbes

Prevention of TNBS-induced colitis by different Lactobacillus and Bifidobacterium strains is associated with an expansion of γδT and regulatory T cells of intestinal intraepithelial lymphocytes

(2009) Marianna Roselli et al.   INFLAMMATORY BOWEL DISEASES

Pain and inflammatory bowel disease

(2009) Klaus Bielefeldt et al.   INFLAMMATORY BOWEL DISEASES

Low counts of Faecalibacterium prausnitzii in colitis microbiota

(2009) H. Sokol et al.   INFLAMMATORY BOWEL DISEASES

Foxp3+ Regulatory T Cells, Th17 Effector Cells, and Cytokine Environment in Inflammatory Bowel Disease

(2009) Nicola Eastaff-Leung et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Probiotics and immunity

(2009) Andrea T. Borchers et al.   JOURNAL OF GASTROENTEROLOGY

CD4+ T Cells and Lactobacillus casei Control Relapsing Colitis Mediated by CD8+ T Cells

(2009) F. Hacini-Rachinel et al.   JOURNAL OF IMMUNOLOGY

Short-Chain Inulin-Like Fructans Reduce Endotoxin and Bacterial Translocations and Attenuate Development of TNBS-Induced Colitis in Rats

(2008) Hiroyuki Ito et al.   DIGESTIVE DISEASES AND SCIENCES

Adipose Inflammation, Insulin Resistance, and Cardiovascular Disease

(2008) Arti Shah et al.   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

Genes and Molecules of Lactobacilli Supporting Probiotic Action

(2008) S. Lebeer et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS