The Role of Gasdermin-D-Mediated Pyroptosis in Organ Injury and Its Therapeutic Implications

GSDMB is increased in IBD and regulates epithelial restitution/repair independent of pyroptosis

(2022) Nitish Rana et al.   CELL

Umbelliferone ameliorates ulcerative colitis induced by acetic acid via modulation of TLR4/NF-κB-p65/iNOS and SIRT1/PPARγ signaling pathways in rats

(2022) Basel A. Abdel-Wahab et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Direct Inhibition of GSDMD by PEITC Reduces Hepatocyte Pyroptosis and Alleviates Acute Liver Injury in Mice

(2022) Jie Wang et al.   Frontiers in Immunology

Caspase-4/11–Mediated Pulmonary Artery Endothelial Cell Pyroptosis Contributes to Pulmonary Arterial Hypertension

(2022) Yusi Wu et al.   HYPERTENSION

Live or let die: Translational insights and clinical perspectives of gasdermin B‐dependent intestinal epithelial cell fate

(2022) Giuseppe Privitera et al.   Clinical and Translational Medicine

Gasdermin D Deficiency Limits the Transition of Atherosclerotic Plaques to an Inflammatory Phenotype in ApoE Knock-Out Mice

(2022) Pauline Puylaert et al.   Biomedicines

Liver to lung microembolic NETs promote Gasdermin-D-dependent inflammatory lung injury in Sickle Cell Disease

(2022) Ravi Vats et al.   BLOOD

The enigmatic roles of epithelial gasdermin B: Recent discoveries and controversies

(2022) Andrei I. Ivanov et al.   TRENDS IN CELL BIOLOGY

Gasdermin D–mediated release of IL-33 from senescent hepatic stellate cells promotes obesity-associated hepatocellular carcinoma

(2022) Ryota Yamagishi et al.   Science Immunology

Multi-Omics Analysis Reveals the Protection of Gasdermin D in Concanavalin A-Induced Autoimmune Hepatitis

(2022) Kaicen Wang et al.   Microbiology Spectrum

Honokiol alleviates ulcerative colitis by targeting PPAR-γ–TLR4–NF-κB signaling and suppressing gasdermin-D-mediated pyroptosis in vivo and in vitro

(2022) Nan Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The metabolite α-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8

(2021) Jia-yuan Zhang et al.   CELL RESEARCH

Gasdermin E permits interleukin-1 beta release in distinct sublytic and pyroptotic phases

(2021) Bowen Zhou et al.   Cell Reports

Gasdermin D inhibition prevents multiple organ dysfunction during sepsis by blocking NET formation

(2021) Camila Meirelles Silva et al.   BLOOD

GSDMD-Mediated Cardiomyocyte Pyroptosis Promotes Myocardial I/R Injury

(2021) Huairui Shi et al.   CIRCULATION RESEARCH

Role of the inflammasome, gasdermin D, and pyroptosis in non‐alcoholic fatty liver disease

(2021) Itzayana Rodríguez‐Antonio et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Up-regulation of gasdermin C in mouse small intestine is associated with lytic cell death in enterocytes in worm-induced type 2 immunity

(2021) Ranhui Xi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DL-3-n-Butylphthalide Attenuates Myocardial Hypertrophy by Targeting Gasdermin D and Inhibiting Gasdermin D Mediated Inflammation

(2021) Bingjiang Han et al.   Frontiers in Pharmacology

Geranylgeranyl diphosphate synthase 1 knockdown suppresses NLRP3 inflammasome activity via promoting autophagy in sepsis-induced acute lung injury

(2021) Dahuan Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Circulating extracellular vesicles activate the pyroptosis pathway in the brain following ventilation-induced lung injury

(2021) Laura Chavez et al.   Journal of Neuroinflammation

Retinol‐Binding Protein 4 Promotes Cardiac Injury After Myocardial Infarction Via Inducing Cardiomyocyte Pyroptosis Through an Interaction With NLRP3

(2021) Kang‐Zhen Zhang et al.   Journal of the American Heart Association

Dysregulated Microbiota-Driven Gasdermin D Activation Promotes Colitis Development by Mediating IL-18 Release

(2021) Hanchao Gao et al.   Frontiers in Immunology

The Versatile Gasdermin Family: Their Function and Roles in Diseases

(2021) Ju Zou et al.   Frontiers in Immunology

Treatment of Severe Acute Pancreatitis and Related Lung Injury by Targeting Gasdermin D-Mediated Pyroptosis

(2021) Jinxiang Wu et al.   Frontiers in Cell and Developmental Biology

GSDMD Mediates LPS-Induced Septic Myocardial Dysfunction by Regulating ROS-dependent NLRP3 Inflammasome Activation

(2021) Shanshan Dai et al.   Frontiers in Cell and Developmental Biology

Acetylbritannilactone attenuates contrast-induced acute kidney injury through its anti-pyroptosis effects

(2020) Fei Chen et al.   BIOSCIENCE REPORTS

Ghrelin alleviates traumatic brain injury-induced acute lung injury through pyroptosis/NF-κB pathway

(2020) Xue-Fei Shao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Inhibition of AIM2 inflammasome activation alleviates GSDMD-induced pyroptosis in early brain injury after subarachnoid haemorrhage

(2020) Bin Yuan et al.   Cell Death & Disease

Caspase‐1 inhibition prevents neuronal death by targeting the canonical inflammasome pathway of pyroptosis in a murine model of cerebral ischemia

(2020) Jia Li et al.   CNS Neuroscience & Therapeutics

Gasdermin E suppresses tumour growth by activating anti-tumour immunity

(2020) Zhibin Zhang et al.   NATURE

FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation

(2020) Jun Jacob Hu et al.   NATURE IMMUNOLOGY

Blocking GSDMD processing in innate immune cells but not in hepatocytes protects hepatic ischemia–reperfusion injury

(2020) Jichang Li et al.   Cell Death & Disease

Gasdermin D in macrophages restrains colitis by controlling cGAS-mediated inflammation

(2020) Chunmei Ma et al.   Science Advances

Hepatocyte pyroptosis and release of inflammasome particles induce stellate cell activation and liver fibrosis

(2020) Susanne Gaul et al.   JOURNAL OF HEPATOLOGY

Gasdermin D modulates murine lupus and its associated organ damage.

(2020) Xinghao Wang et al.   Arthritis & Rheumatology

Tisp40 Induces Tubular Epithelial Cell GSDMD-Mediated Pyroptosis in Renal Ischemia-Reperfusion Injury via NF-κB Signaling

(2020) Chengcheng Xiao et al.   Frontiers in Physiology

Inflammasome activation and regulation: toward a better understanding of complex mechanisms

(2020) Danping Zheng et al.   Cell Discovery

TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling

(2020) Anna Ciesielska et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Corticosteroids alleviate lipopolysaccharide‐induced inflammation and lung injury via inhibiting NLRP3‐inflammasome activation

(2020) Jia‐Wei Yang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Role of pyroptosis in spinal cord injury and its therapeutic implications

(2020) Abdullah Al Mamun et al.   Journal of Advanced Research

Ablation of GSDMD Improves Outcome of Ischemic Stroke Through Blocking Canonical and Non-canonical Inflammasomes Dependent Pyroptosis in Microglia

(2020) Kankai Wang et al.   Frontiers in Neurology

CD73 alleviates GSDMD‐mediated microglia pyroptosis in spinal cord injury through PI3K/AKT/Foxo1 signaling

(2020) Shun Xu et al.   Clinical and Translational Medicine

NLRP3 inflammasome-mediated endothelial cells pyroptosis is involved in decabromodiphenyl ethane-induced vascular endothelial injury

(2020) Dan Zheng et al.   CHEMOSPHERE

Vitamin D/VDR attenuate cisplatin-induced AKI by down-regulating NLRP3/Caspase-1/GSDMD pyroptosis pathway

(2020) Siqing Jiang et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Inhibition of GGPPS1 attenuated LPS-induced acute lung injury and was associated with NLRP3 inflammasome suppression

(2019) wujian xu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Gasdermin D serves as a key executioner of pyroptosis in experimental cerebral ischemia and reperfusion model both in vivo and in vitro

(2019) Dongping Zhang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Inflammasomes, Autophagy, and Cell Death: The Trinity of Innate Host Defense against Intracellular Bacteria

(2019) Teresa Krakauer   MEDIATORS OF INFLAMMATION

Carbon monoxide releasing molecule-3 inhibits inflammasome activation: A potential therapy for spinal cord injury

(2019) Juan Pablo de Rivero Vaccari   EBioMedicine

Emodin alleviates myocardial ischemia/reperfusion injury by inhibiting gasdermin D-mediated pyroptosis in cardiomyocytes

(2019) Bozhi Ye et al.   Drug Design Development and Therapy

Dihydromyricetin Alleviates Sepsis-Induced Acute Lung Injury through Inhibiting NLRP3 Inflammasome-Dependent Pyroptosis in Mice Model

(2019) Yu-chang Wang et al.   INFLAMMATION

The cleavage of gasdermin D by caspase-11 promotes tubular epithelial cell pyroptosis and urinary IL-18 excretion in acute kidney injury

(2019) Naijun Miao et al.   KIDNEY INTERNATIONAL

Gasdermin D protects against noninfectious liver injury by regulating apoptosis and necroptosis

(2019) Chenxuan Yang et al.   Cell Death & Disease

Endothelial cell pyroptosis plays an important role in Kawasaki disease via HMGB1/RAGE/cathespin B signaling pathway and NLRP3 inflammasome activation

(2019) Chang Jia et al.   Cell Death & Disease

Bacterial Endotoxin Activates the Coagulation Cascade through Gasdermin D-Dependent Phosphatidylserine Exposure

(2019) Xinyu Yang et al.   IMMUNITY

Microparticulate Caspase 1 Regulates Gasdermin D and Pulmonary Vascular Endothelial Cell Injury

(2018) Srabani Mitra et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Downregulation of gasdermin D promotes gastric cancer proliferation by regulating cell cycle-related proteins

(2018) Wei Jie Wang et al.   Journal of Digestive Diseases

Pyroptosis: An inflammatory link between NAFLD and NASH with potential therapeutic implications

(2018) Juliane I. Beier et al.   JOURNAL OF HEPATOLOGY

Gasdermin D plays a key role as a pyroptosis executor of non-alcoholic steatohepatitis in humans and mice

(2018) Bing Xu et al.   JOURNAL OF HEPATOLOGY

Silencing long non-coding RNA Kcnq1ot1 alleviates pyroptosis and fibrosis in diabetic cardiomyopathy

(2018) Fan Yang et al.   Cell Death & Disease

NF-κB-Gasdermin D (GSDMD) Axis Couples Oxidative Stress and NACHT, LRR and PYD Domains-Containing Protein 3 (NLRP3) Inflammasome-Mediated Cardiomyocyte Pyroptosis Following Myocardial Infarction

(2018) Qian Lei et al.   MEDICAL SCIENCE MONITOR

Targeting NLRP3 Inflammasome in the Treatment of CNS Diseases

(2018) Bo-Zong Shao et al.   Frontiers in Molecular Neuroscience

Celastrol inhibits microglial pyroptosis and attenuates inflammatory reaction in acute spinal cord injury rats

(2018) Wangying Dai et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Inflammasome and Autophagy Regulation: A Two-way Street

(2017) Qian Sun et al.   MOLECULAR MEDICINE

NLRP3 Inflammasome in Neurological Diseases, from Functions to Therapies

(2017) Limin Song et al.   Frontiers in Cellular Neuroscience

Inflammatory responses and inflammation-associated diseases in organs

(2017) Linlin Chen et al.   Oncotarget

GSDMB induces an asthma phenotype characterized by increased airway responsiveness and remodeling without lung inflammation

(2016) Sudipta Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interferon Regulatory Factor-1 Mediates Alveolar Macrophage Pyroptosis During LPS-Induced Acute Lung Injury in Mice

(2016) Dongdong Wu et al.   SHOCK

Hemorrhagic shock primes for lung vascular endothelial cell pyroptosis: role in pulmonary inflammation following LPS

(2016) Jie Yang et al.   Cell Death & Disease

TLR4-Upregulated IL-1β and IL-1RI Promote Alveolar Macrophage Pyroptosis and Lung Inflammation through an Autocrine Mechanism

(2016) Xingying He et al.   Scientific Reports

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

Inhibition of Alveolar Macrophage Pyroptosis Reduces Lipopolysaccharide-induced Acute Lung Injury in Mice

(2015) Pin-Hua Pan et al.   CHINESE MEDICAL JOURNAL

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

Hemin inhibits NLRP3 inflammasome activation in sepsis-induced acute lung injury, involving heme oxygenase-1

(2014) Yun-peng Luo et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Inflammasomes in the CNS

(2014) John G. Walsh et al.   NATURE REVIEWS NEUROSCIENCE

Management of Liver Trauma

(2009) S. A. Badger et al.   WORLD JOURNAL OF SURGERY