Caspase-4/11–Mediated Pulmonary Artery Endothelial Cell Pyroptosis Contributes to Pulmonary Arterial Hypertension

Sex Differences in Pulmonary Hypertension

(2021) Hannah Morris et al.   CLINICS IN CHEST MEDICINE

PhospholipaseCγ1/calcium-dependent membranous localization of Gsdmd-N drives endothelial pyroptosis, contributing to lipopolysaccharide-induced fatal outcome.

(2020) Hong Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Caspase-1 induces smooth muscle cell growth in hypoxia-induced pulmonary hypertension

(2019) Camilla Udjus et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

GLI1-mediated pulmonary artery smooth muscle cell pyroptosis contributes to hypoxia-induced pulmonary hypertension

(2019) Siyu He et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Programmed death-ligand 1 triggers PASMCs pyroptosis and pulmonary vascular fibrosis in pulmonary hypertension

(2019) Min Zhang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

CCL5 deficiency rescues pulmonary vascular dysfunction, and reverses pulmonary hypertension via caveolin-1-dependent BMPR2 activation

(2018) Xiaowei Nie et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Caspase-11-dependent pyroptosis of lung epithelial cells protects from melioidosis while caspase-1 mediates macrophage pyroptosis and production of IL-18

(2018) Jinyong Wang et al.   PLoS Pathogens

Caspase-11 promotes renal fibrosis by stimulating IL-1β maturation via activating caspase-1

(2018) Nai-jun Miao et al.   ACTA PHARMACOLOGICA SINICA

Haemodynamic definitions and updated clinical classification of pulmonary hypertension

(2018) Gérald Simonneau et al.   EUROPEAN RESPIRATORY JOURNAL

Risk assessment, prognosis and guideline implementation in pulmonary arterial hypertension

(2017) Athénaïs Boucly et al.   EUROPEAN RESPIRATORY JOURNAL

Caspase-11 non-canonical inflammasome: a critical sensor of intracellular lipopolysaccharide in macrophage-mediated inflammatory responses

(2017) Young-Su Yi   IMMUNOLOGY

Caspase-11–mediated endothelial pyroptosis underlies endotoxemia-induced lung injury

(2017) Kwong Tai Cheng et al.   JOURNAL OF CLINICAL INVESTIGATION

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

cGAS drives noncanonical-inflammasome activation in age-related macular degeneration

(2017) Nagaraj Kerur et al.   NATURE MEDICINE

Epidemiology and treatment of pulmonary arterial hypertension

(2017) Edmund M. T. Lau et al.   Nature Reviews Cardiology

Gasdermins: Effectors of Pyroptosis

(2017) Stephen B. Kovacs et al.   TRENDS IN CELL BIOLOGY

Egr-1 identifies neointimal remodeling and relates to progression in human pulmonary arterial hypertension

(2016) Diederik E. van der Feen et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes

(2016) Robin A. Aglietti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hemorrhagic shock primes for lung vascular endothelial cell pyroptosis: role in pulmonary inflammation following LPS

(2016) Jie Yang et al.   Cell Death & Disease

Absence of the inflammasome adaptor ASC reduces hypoxia-induced pulmonary hypertension in mice

(2015) Fadila Telarevic Cero et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Five-Year Outcomes of Patients Enrolled in the REVEAL Registry

(2015) Harrison W. Farber et al.   CHEST

Ellagic acid prevents monocrotaline-induced pulmonary artery hypertension via inhibiting NLRP3 inflammasome activation in rats

(2015) Bing Tang et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension

(2015) Lu Long et al.   NATURE MEDICINE

Absence of the calcium-binding protein, S100A1, confers pulmonary hypertension in mice associated with endothelial dysfunction and apoptosis

(2014) Krystyna Teichert-Kuliszewska et al.   CARDIOVASCULAR RESEARCH

Inflammation and Immunity in the Pathogenesis of Pulmonary Arterial Hypertension

(2014) Marlene Rabinovitch et al.   CIRCULATION RESEARCH

EETs and CYP2J2 inhibit TNF-α-induced apoptosis in pulmonary artery endothelial cells and TGF-β1-induced migration in pulmonary artery smooth muscle cells

(2013) WENJING FENG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Definitions and Diagnosis of Pulmonary Hypertension

(2013) Marius M. Hoeper et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Relevant Issues in the Pathology and Pathobiology of Pulmonary Hypertension

(2013) Rubin M. Tuder et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

A brief overview of mouse models of pulmonary arterial hypertension: problems and prospects

(2012) Jose Gomez-Arroyo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Modern Age Pathology of Pulmonary Arterial Hypertension

(2012) Elvira Stacher et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Monocrotaline-induced pulmonary arterial hypertension is attenuated by TNF-α antagonists via the suppression of TNF-α expression and NF-κB pathway in rats

(2012) Qiang Wang et al.   VASCULAR PHARMACOLOGY

The monocrotaline model of pulmonary hypertension in perspective

(2011) Jose G. Gomez-Arroyo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

ASPIRE registry: Assessing the Spectrum of Pulmonary hypertension Identified at a REferral centre

(2011) J. Hurdman et al.   EUROPEAN RESPIRATORY JOURNAL

Bone morphogenetic protein receptor II regulates pulmonary artery endothelial cell barrier function

(2010) V. J. Burton et al.   BLOOD