Geranylgeranyl diphosphate synthase 1 knockdown suppresses NLRP3 inflammasome activity via promoting autophagy in sepsis-induced acute lung injury

S100A12 promotes inflammation and cell apoptosis in sepsis-induced ARDS via activation of NLRP3 inflammasome signaling

(2020) Zhenen zhang et al.   MOLECULAR IMMUNOLOGY

NLRP3 inflammasome inhibition attenuates sepsis-induced platelet activation and prevents multi-organ injury in cecal-ligation puncture

(2020) Denise C. Cornelius et al.   PLoS One

Sepsis Induces Deregulation of IL-13 Production and PD-1 Expression in Lung Group 2 Innate Lymphoid Cells

(2020) Yuichi Akama et al.   SHOCK

Inhibition of GGPPS1 attenuated LPS-induced acute lung injury and was associated with NLRP3 inflammasome suppression

(2019) wujian xu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Beclin1‐driven autophagy modulates the inflammatory response of microglia via NLRP3

(2019) Judith Houtman et al.   EMBO JOURNAL

Autophagy Activation Improves Lung Injury and Inflammation in Sepsis

(2019) Hongying Zhao et al.   INFLAMMATION

Sepsis: evolving concepts and challenges

(2019) R. Salomão et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation

(2019) Nathan Kelley et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The alteration of RhoA geranylgeranylation and Ras farnesylation breaks the integrity of the blood–testis barrier and results in hypospermatogenesis

(2019) Ruilou Zhu et al.   Cell Death & Disease

Geranylgeranyl diphosphate synthase 1 knockout ameliorates ventilator-induced lung injury via regulation of TLR2/4-AP-1 signaling

(2019) Bing Wan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hydrogen alleviated organ injury and dysfunction in sepsis: The role of cross-talk between autophagy and endoplasmic reticulum stress: Experimental research

(2019) Hong-guang Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Autophagy in health and disease: A comprehensive review

(2018) Sarbari Saha et al.   BIOMEDICINE & PHARMACOTHERAPY

Isoprenoids and protein prenylation: implications in the pathogenesis and therapeutic intervention of Alzheimer’s disease

(2018) Angela Jeong et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Sepsis and septic shock

(2018) Maurizio Cecconi et al.   LANCET

PICK1 Deficiency Induces Autophagy Dysfunction via Lysosomal Impairment and Amplifies Sepsis-Induced Acute Lung Injury

(2018) Yunchang Mo et al.   MEDIATORS OF INFLAMMATION

Antidepressants induce autophagy dependent-NLRP3-inflammasome inhibition in Major depressive disorder

(2017) Elísabet Alcocer-Gómez et al.   PHARMACOLOGICAL RESEARCH

Sepsis and Septic Shock Strategies

(2017) Bracken A. Armstrong et al.   SURGICAL CLINICS OF NORTH AMERICA

Geranylgeranyl Diphosphate Synthase Modulates Fetal Lung Branching Morphogenesis Possibly through Controlling K-Ras Prenylation

(2016) Wen-Jun Jia et al.   AMERICAN JOURNAL OF PATHOLOGY

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Protein prenylation: unique fats make their mark on biology

(2016) Mei Wang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Initiation and perpetuation of NLRP3 inflammasome activation and assembly

(2015) Eric I. Elliott et al.   IMMUNOLOGICAL REVIEWS

GGPPS-mediated Rab27A geranylgeranylation regulates β cell dysfunction during type 2 diabetes development by affecting insulin granule docked pool formation

(2015) Shan Jiang et al.   JOURNAL OF PATHOLOGY

Protein prenylation and human diseases: a balance of protein farnesylation and geranylgeranylation

(2015) Na Xu et al.   Science China-Life Sciences

Protein Prenylation: Enzymes, Therapeutics, and Biotechnology Applications

(2014) Charuta C. Palsuledesai et al.   ACS Chemical Biology

In vitro and in vivo anticancer effects of mevalonate pathway modulation on human cancer cells

(2014) P Jiang et al.   BRITISH JOURNAL OF CANCER

Enhancing autophagy with activated protein C and rapamycin protects against sepsis-induced acute lung injury

(2013) Yu-Ting Yen et al.   SURGERY