Inflammasomes, Autophagy, and Cell Death: The Trinity of Innate Host Defense against Intracellular Bacteria

Macrophage Uptake of Necrotic Cell DNA Activates the AIM2 Inflammasome to Regulate a Proinflammatory Phenotype in CKD

(2018) Takanori Komada et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Constitutive Interferon Maintains GBP Expression Required for Release of Bacterial Components Upstream of Pyroptosis and Anti-DNA Responses

(2018) Beiyun C. Liu et al.   Cell Reports

Lipid A Remodeling Is a Pathoadaptive Mechanism That Impacts Lipopolysaccharide Recognition and Intracellular Survival of Burkholderia pseudomallei

(2018) Michael H. Norris et al.   INFECTION AND IMMUNITY

Living dangerously: Burkholderia pseudomallei modulates phagocyte cell death to survive

(2018) Teresa Krakauer   MEDICAL HYPOTHESES

Structural diversity of Burkholderia pseudomallei lipopolysaccharides affects innate immune signaling

(2017) Michael H. Norris et al.   PLoS Neglected Tropical Diseases

Macrophage Autophagy and Bacterial Infections

(2017) Aïcha Bah et al.   Frontiers in Immunology

Inflammasome Complexes: Emerging Mechanisms and Effector Functions

(2016) Vijay A.K. Rathinam et al.   CELL

An outline of necrosome triggers

(2016) Tom Vanden Berghe et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Phagocytosis: An Immunobiologic Process

(2016) Siamon Gordon   IMMUNITY

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

Interferon-induced guanylate-binding proteins in inflammasome activation and host defense

(2016) Bae-Hoon Kim et al.   NATURE IMMUNOLOGY

The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy

(2015) Robert O. Watson et al.   Cell Host & Microbe

The NAIP/NLRC4 inflammasomes

(2015) Russell E Vance   CURRENT OPINION IN IMMUNOLOGY

Caspase-4 mediates non-canonical activation of the NLRP3 inflammasome in human myeloid cells

(2015) Jonathan L. Schmid-Burgk et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5

(2015) Paul J. Baker et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The NAIP-NLRC4 inflammasome in innate immune detection of bacterial flagellin and type III secretion apparatus

(2015) Yue Zhao et al.   IMMUNOLOGICAL REVIEWS

The NLRP1 inflammasomes

(2015) Joseph Chavarría-Smith et al.   IMMUNOLOGICAL REVIEWS

Interfering with Immunity: Detrimental Role of Type I IFNs during Infection

(2015) Sebastian A. Stifter et al.   JOURNAL OF IMMUNOLOGY

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Human caspase-4 mediates noncanonical inflammasome activation against gram-negative bacterial pathogens

(2015) Cierra N. Casson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes

(2015) Elena Viganò et al.   Nature Communications

Melioidosis: molecular aspects of pathogenesis

(2014) Joshua K Stone et al.   Expert Review of Anti-Infective Therapy

The Macrophage Paradox

(2014) Jordan V. Price et al.   IMMUNITY

Treatment and prophylaxis of melioidosis

(2014) David Dance   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Molecular Basis for Specific Recognition of Bacterial Ligands by NAIP/NLRC4 Inflammasomes

(2014) Jeannette L. Tenthorey et al.   MOLECULAR CELL

Inflammatory caspases are innate immune receptors for intracellular LPS

(2014) Jianjin Shi et al.   NATURE

Bacteria–autophagy interplay: a battle for survival

(2014) Ju Huang et al.   NATURE REVIEWS MICROBIOLOGY

The Neutrophil NLRC4 Inflammasome Selectively Promotes IL-1β Maturation without Pyroptosis during Acute Salmonella Challenge

(2014) Kaiwen W. Chen et al.   Cell Reports

NLRC4 and TLR5 Each Contribute to Host Defense in Respiratory Melioidosis

(2014) T. Eoin West et al.   PLoS Neglected Tropical Diseases

Caspase-1-Dependent and -Independent Cell Death Pathways in Burkholderia pseudomallei Infection of Macrophages

(2014) Antje Bast et al.   PLoS Pathogens

RIPK3 contributes to TNFR1-mediated RIPK1 kinase-dependent apoptosis in conditions of cIAP1/2 depletion or TAK1 kinase inhibition

(2013) Y Dondelinger et al.   CELL DEATH AND DIFFERENTIATION

The impact of Toll-like receptors on bacterial virulence strategies

(2013) Nicholas Arpaia et al.   CURRENT OPINION IN MICROBIOLOGY

Macrophages clean up: efferocytosis and microbial control

(2013) Constance J Martin et al.   CURRENT OPINION IN MICROBIOLOGY

Maintenance of vacuole integrity by bacterial pathogens

(2013) Elizabeth A. Creasey et al.   CURRENT OPINION IN MICROBIOLOGY

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

Impaired TLR5 Functionality Is Associated with Survival in Melioidosis

(2013) T. E. West et al.   JOURNAL OF IMMUNOLOGY

The cGAS-STING Pathway for DNA Sensing

(2013) T. Sam Xiao et al.   MOLECULAR CELL

Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock

(2013) J. A. Hagar et al.   SCIENCE

Caspase-11 Protects Against Bacteria That Escape the Vacuole

(2013) Y. Aachoui et al.   SCIENCE

Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

(2013) N. Kayagaki et al.   SCIENCE

Inflammasome Components Coordinate Autophagy and Pyroptosis as Macrophage Responses to Infection

(2013) B. G. Byrne et al.   mBio

Mycobacterium Tuberculosis Activates the DNA-Dependent Cytosolic Surveillance Pathway within Macrophages

(2012) Paolo S. Manzanillo et al.   Cell Host & Microbe

Interactions of Pathogenic Bacteria with Autophagy Systems

(2012) Marija Cemma et al.   CURRENT BIOLOGY

Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

(2012) Chong-Shan Shi et al.   NATURE IMMUNOLOGY

Melioidosis

(2012) W. Joost Wiersinga et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structural mechanism of ubiquitin and NEDD8 deamidation catalyzed by bacterial effectors that induce macrophage-specific apoptosis

(2012) Q. Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LPS remodeling is an evolved survival strategy for bacteria

(2012) Y. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Legionella Effector RavZ Inhibits Host Autophagy Through Irreversible Atg8 Deconjugation

(2012) A. Choy et al.   SCIENCE

Phagosomal Rupture by Mycobacterium tuberculosis Results in Toxicity and Host Cell Death

(2012) Roxane Simeone et al.   PLoS Pathogens

Dissection of a type I interferon pathway in controlling bacterial intracellular infection in mice

(2011) Juliane Lippmann et al.   CELLULAR MICROBIOLOGY

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

(2011) Taro Kawai et al.   IMMUNITY

Caspase-1-induced pyroptotic cell death

(2011) Edward A. Miao et al.   IMMUNOLOGICAL REVIEWS

Mycobacterium tuberculosis Triggers Host Type I IFN Signaling To Regulate IL-1  Production in Human Macrophages

(2011) A. Novikov et al.   JOURNAL OF IMMUNOLOGY

Phagosome dynamics during phagocytosis by neutrophils

(2011) Pontus Nordenfelt et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus

(2011) Yue Zhao et al.   NATURE

The Burkholderia pseudomallei Type III Secretion System and BopA Are Required for Evasion of LC3-Associated Phagocytosis

(2011) Lan Gong et al.   PLoS One

Manipulation of Host Cell Death Pathways during Microbial Infections

(2010) Mohamed Lamkanfi et al.   Cell Host & Microbe

Mycobacterium tuberculosis protein ESAT-6 is a potent activator of the NLRP3/ASC inflammasome

(2010) Bibhuti B. Mishra et al.   CELLULAR MICROBIOLOGY

Intracellular Toll-like Receptors

(2010) Amanda L. Blasius et al.   IMMUNITY

Suppression of Host Innate Immune Response by Burkholderia pseudomallei through the Virulence Factor TssM

(2010) K. S. Tan et al.   JOURNAL OF IMMUNOLOGY

Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome

(2010) E. A. Miao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

Autophagy, Immunity, and Microbial Adaptations

(2009) Vojo Deretic et al.   Cell Host & Microbe

Immunomodulatory Effects of Yersinia pestis Lipopolysaccharides on Human Macrophages

(2009) M. Matsuura et al.   Clinical and Vaccine Immunology

Caspase-1 Mediates Resistance in Murine Melioidosis

(2009) K. Breitbach et al.   INFECTION AND IMMUNITY

When two is better than one: macrophages and neutrophils work in concert in innate immunity as complementary and cooperative partners of a myeloid phagocyte system

(2009) Manuel T. Silva   JOURNAL OF LEUKOCYTE BIOLOGY

The Francisella tularensis pathogenicity island encodes a secretion system that is required for phagosome escape and virulence

(2009) Jeffrey R. Barker et al.   MOLECULAR MICROBIOLOGY

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE

Activation of antibacterial autophagy by NADPH oxidases

(2009) J. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NOD2, RIP2 and IRF5 Play a Critical Role in the Type I Interferon Response to Mycobacterium tuberculosis

(2009) Amit K. Pandey et al.   PLoS Pathogens

Inactivation of Burkholderia pseudomallei bsaQ results in decreased invasion efficiency and delayed escape of bacteria from endocytic vesicles

(2008) Veerachat Muangsombut et al.   ARCHIVES OF MICROBIOLOGY

NOD-like receptors (NLRs): bona fide intracellular microbial sensors

(2008) Michael H Shaw et al.   CURRENT OPINION IN IMMUNOLOGY

The NLR Gene Family: A Standard Nomenclature

(2008) Jenny P.-Y. Ting et al.   IMMUNITY

Burkholderia pseudomallei Type III Secretion System Mutants Exhibit Delayed Vacuolar Escape Phenotypes in RAW 264.7 Murine Macrophages

(2008) M. N. Burtnick et al.   INFECTION AND IMMUNITY

Listeriolysin O allows Listeria monocytogenes replication in macrophage vacuoles

(2008) Cheryl L. Birmingham et al.   NATURE