Article
Pharmacology & Pharmacy
Hanan S. Althagafy, Fares E. M. Ali, Emad H. M. Hassanein, Zuhair M. Mohammedsaleh, Mohamed I. Kotb El-Sayed, Ahmed M. Atwa, Ahmed M. Sayed, Ayman A. Soubh
Summary: This study demonstrates that canagliflozin can effectively attenuate ulcerative colitis by regulating multiple pathways and targets, reducing inflammation, alleviating oxidative stress, and restoring colonic function.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Congcong Guo, Yue Zhang, Tao Ling, Chongjie Zhao, Yanru Li, Meng Geng, Sailun Gai, Wei Qi, Xuegang Luo, Liehuan Chen, Tongcun Zhang, Nan Wang
Summary: Chitosan oligosaccharides (COS) can improve colitis by regulating intestinal microbiota and the PPAR gamma/SIRT1-mediated NF-kappa B pathway.
Article
Immunology
Yifan Qu, Xinyi Li, Fengying Xu, Shimin Zhao, Xuemei Wu, Yuzhen Wang, Jiming Xie
Summary: The study demonstrates that kaempferol has significant anti-inflammatory and antioxidant effects in DSS-induced colitis mice, alleviating UC symptoms by modulating the gut microbiota and TLR4-related signaling pathways.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Environmental Sciences
Basel A. Abdel-Wahab, Saad A. Alkahtani, Abdulsalam A. Alqahtani, Emad H. M. Hassanein
Summary: This study demonstrates the therapeutic potential of umbelliferone (UMB) in a rat model of ulcerative colitis (UC), showing its ability to improve pathological injury and exert anti-inflammatory and antioxidant effects.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Ping Zhou, Jia Lai, Yueyue Li, Junzhu Deng, Chunling Zhao, Qianqian Huang, Fei Yang, Shuo Yang, Yuesong Wu, Xiaoqin Tang, Feihong Huang, Long Wang, Xinwu Huang, Wenjun Zou, Jianming Wu
Summary: This study investigated the effects of methyl gallate (MG) on ulcerative colitis (UC) and found that MG can regulate macrophage polarization, alleviate inflammation, and inhibit the TLR4/NF-kappa B signaling pathway in UC treatment. Additionally, MG can alter the diversity and composition of the gut microbiota, contributing to the therapeutic effects on UC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Yuxin Dai, Qiulu Lu, Peiyi Li, Junyu Zhu, Jiaxin Jiang, Tong Zhao, Yue Hu, Kang Ding, Min Zhao
Summary: This study aimed to investigate the mechanism of Xianglian Pill (XLP) in treating ulcerative colitis (UC) induced by dextran sulfate sodium (DSS). The results showed that XLP treated UC by regulating the TLR4/MyD88/NF-kappa B signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Bayan Y. Ghanim, Nidal A. Qinna
Summary: This review highlights the important role of the Nrf2-ARE transcriptional pathway in regulating cellular defence systems and discusses different modes of hepatocyte cell death. Research suggests that Nrf2 plays a critical and complex regulatory role in cell death.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Nutrition & Dietetics
Xuejiao Zhang, Bowei Zhang, Bo Peng, Jin Wang, Yaozhong Hu, Ruican Wang, Shuo Wang
Summary: The study demonstrates that sucrose has differential effects on colitis at different doses. Low-dose sucrose intervention alleviates colitis by reducing inflammation and repairing mucosal damages while high-dose sucrose intervention exacerbates colitis. Additionally, the three doses of sucrose administration significantly alter gut microbiota composition, with low-dose sucrose restoring microbial dysfunction and enhancing the production of short chain fatty acids.
Article
Agriculture, Multidisciplinary
Zecai Zhang, Yueqi Cui, Siyu Liu, Jiang Huang, Yu Liu, Yulong Zhou, Zhanbo Zhu
Summary: This study investigated the protective effects and potential mechanisms of zingerone (ZO) extracted from ginger on dextran sulfate sodium (DSS)-induced mouse ulcerative colitis (UC). The results showed that ZO alleviated weight loss, reduced disease activity index scores, and improved pathological changes in colon tissue. Mechanism analysis revealed that ZO inhibited the activation of the nuclear factor-kappa B pathway and regulated peroxisome proliferator-activated receptor gamma (PPAR gamma) expression. The findings suggest that ZO supplementation may be a new dietary strategy for UC treatment.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Medicine, Research & Experimental
Mohamed A. Morsy, Seham A. Abdel-Gaber, Rehab A. Rifaai, Mostafa M. Mohammed, Anroop B. Nair, Walaa Yehia Abdelzaher
Summary: Telmisartan demonstrates protective effects against hepatic I/R injury in rats by modulating oxidative stress parameters, myeloperoxidase levels, PPARγ and TLR4 mRNA expression, as well as NF-κB and caspase-3 immunoexpression.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Oncology
Sheng Yu, Haihua Qian
Summary: The study demonstrated that deoxyschizandrin (DSD) can alleviate symptoms of mice with DSS-induced ulcerative colitis by inhibiting body inflammation, improving oxidative stress, and reducing the apoptosis of colonic epithelial cells, possibly through inhibition of the TLR4/NF-kappa B signaling pathway.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Neurosciences
Yingnan Zhao, Zengkun Li, Enrong Lu, Qi Sheng, Yu Zhao
Summary: The study found that berberine protects rats from cerebral I/R injury by up-regulating PPAR-gamma to inhibit NF-kappa B-mediated pyroptosis.
BRAIN RESEARCH BULLETIN
(2021)
Article
Medicine, Research & Experimental
Jingyi Hu, Yiheng Tong, Zhaofeng Shen, Yanan Li, Cheng Cheng, Ryan Au, Feng Xu, Yajun Liu, Lei Zhu, Hong Shen
Summary: Ulcerative colitis (UC) is a chronic inflammatory disease of the intestine, and dysbiosis of gut microbiota is one of its main pathogenic mechanisms. This study found that Gegen Qinlian decoction (GD) could inhibit the expansion of pathogenic Escherichia coli (E. coli) by activating PPAR-gamma signaling pathway, which contributes to the improvement of UC symptoms.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Xiaoqin Xu, Juan Zhang, Liang Chen, Yu Sun, Degang Qing, Xuelei Xin, Chunyan Yan
Summary: The study demonstrates that Alhagi pseudalhagi Desv. Extract (APE) exerts protective effects against intestinal inflammation in ulcerative colitis (UC) mice by repairing colon mucosa injury, reducing weight loss, and lowering inflammatory markers levels, possibly through affecting the TLR4-dependent NF-kappa B signaling pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Miao Liu, Gang Mao, Xuelei Zhou, Xuemei Wan, Fan Zhang, Li Dai, Ya Chen, Ning Dai, Yan Zhang, Qiang Du
Summary: Carvacrol can ameliorate colitis symptoms in UC rats, improve pathological symptoms, inhibit the activation of the TLR4/NF-kappa B signaling pathway, and reduce inflammation-induced injury in rats.
NATURAL PRODUCT COMMUNICATIONS
(2022)
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)