Gasdermin D Deficiency Limits the Transition of Atherosclerotic Plaques to an Inflammatory Phenotype in ApoE Knock-Out Mice

Impact of myeloid RIPK1 gene deletion on atherogenesis in ApoE-deficient mice

(2021) Isabelle Coornaert et al.   ATHEROSCLEROSIS

MicroRNA‐302c‐3p inhibits endothelial cell pyroptosis via directly targeting NOD‐, LRR‐ and pyrin domain‐containing protein 3 in atherosclerosis

(2021) Baochen Bai et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Caspase-11-Gasdermin D-Mediated Pyroptosis Is Involved in the Pathogenesis of Atherosclerosis

(2021) Mengqing Jiang et al.   Frontiers in Pharmacology

Gasdermin D Mediates Inflammation-Induced Defects in Reverse Cholesterol Transport and Promotes Atherosclerosis

(2021) Emmanuel Opoku et al.   Frontiers in Cell and Developmental Biology

The selective NLRP3 inhibitor MCC950 hinders atherosclerosis development by attenuating inflammation and pyroptosis in macrophages

(2021) Wenyun Zeng et al.   Scientific Reports

VX-765 attenuates atherosclerosis in ApoE deficient mice by modulating VSMCs pyroptosis

(2020) Yiyi Li et al.   EXPERIMENTAL CELL RESEARCH

Salidroside Decreases Atherosclerosis Plaque Formation via Inhibiting Endothelial Cell Pyroptosis

(2020) Sha-Sha Xing et al.   INFLAMMATION

FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation

(2020) Jun Jacob Hu et al.   NATURE IMMUNOLOGY

Gasdermin family: a promising therapeutic target for cancers and inflammation-driven diseases

(2020) Danbin Wu et al.   Journal of Cell Communication and Signaling

Cathepsin B Is Required for NLRP3 Inflammasome Activation in Macrophages, Through NLRP3 Interaction

(2020) Angélique Chevriaux et al.   Frontiers in Cell and Developmental Biology

Succination inactivates gasdermin D and blocks pyroptosis

(2020) Fiachra Humphries et al.   SCIENCE

Caspase-11, a specific sensor for intracellular lipopolysaccharide recognition, mediates the non-canonical inflammatory pathway of pyroptosis

(2019) Xiaoli Huang et al.   Cell and Bioscience

Macrophage Death as a Pharmacological Target in Atherosclerosis

(2019) Wim Martinet et al.   Frontiers in Pharmacology

Caspase-1 initiates apoptosis in the absence of gasdermin D

(2019) Kohsuke Tsuchiya et al.   Nature Communications

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Pyroptosis and its relationship to atherosclerosis

(2018) Yuan-Jun Xu et al.   CLINICA CHIMICA ACTA

The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages

(2018) Charles L. Evavold et al.   IMMUNITY

Nicotine promotes atherosclerosis via ROS-NLRP3-mediated endothelial cell pyroptosis

(2018) Xianxian Wu et al.   Cell Death & Disease

OxLDL induces vascular endothelial cell pyroptosis through miR‐125a‐5p/TET2 pathway

(2018) Zeng Zhaolin et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Everolimus depletes plaque macrophages, abolishes intraplaque neovascularization and improves survival in mice with advanced atherosclerosis

(2018) Ammar Kurdi et al.   VASCULAR PHARMACOLOGY

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

p38δ MAPKHighlights

(2016) Kristiina Rajamäki et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

NLRP3 Inflammasome Expression and Activation in Human Atherosclerosis

(2016) Geena Paramel Varghese et al.   Journal of the American Heart Association

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

Inhibition of Caspase-1 Activation in Endothelial Cells Improves Angiogenesis

(2015) Jahaira Lopez-Pastrana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of the NLRP3 Inflammasome in Carotid Atherosclerosis

(2015) Xin Shi et al.   Journal of Stroke & Cerebrovascular Diseases

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Expression of the NLRP3 Inflammasome in Carotid Atherosclerosis

(2015) Xin Shi et al.   Journal of Stroke & Cerebrovascular Diseases

Silence of NLRP3 Suppresses Atherosclerosis and Stabilizes Plaques in Apolipoprotein E-Deficient Mice

(2014) Fei Zheng et al.   MEDIATORS OF INFLAMMATION

Inflammation-related induction of absent in melanoma 2 (AIM2) in vascular cells and atherosclerotic lesions suggests a role in vascular pathogenesis

(2013) Maani Hakimi et al.   JOURNAL OF VASCULAR SURGERY

Oxidized Low Density Lipoprotein Induced Caspase-1 Mediated Pyroptotic Cell Death in Macrophages: Implication in Lesion Instability?

(2013) Jing Lin et al.   PLoS One

Caspase-1 Deficiency Decreases Atherosclerosis in Apolipoprotein E-Null Mice

(2012) Jessica Gage et al.   CANADIAN JOURNAL OF CARDIOLOGY

Computational Stress Analysis of Atherosclerotic Plaques in ApoE Knockout Mice

(2010) Yuliya Vengrenyuk et al.   ANNALS OF BIOMEDICAL ENGINEERING

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Cholesterol Crystals Activate the NLRP3 Inflammasome in Human Macrophages: A Novel Link between Cholesterol Metabolism and Inflammation

(2010) Kristiina Rajamäki et al.   PLoS One