Article
Microbiology
Zhenhua Wu, Shimeng Huang, Tiantian Li, Na Li, Dandan Han, Bing Zhang, Zhenjiang Zech Xu, Shiyi Zhang, Jiaman Pang, Shilan Wang, Guolong Zhang, Jiangchao Zhao, Junjun Wang
Summary: The study found that oral EGCG helps alleviate colonic inflammation by increasing the abundance of Akkermansia, a short-chain fatty acids-producing bacteria, and promoting SCFAs production. Prophylactic supplementation of EGCG also showed beneficial outcomes. FMT experiments confirmed the role of EGCG in attenuating colitis.
Article
Medicine, Research & Experimental
Danni Yu, Quanhui Dai, Zixiang Wang, Steven X. Hou, Ling V. Sun
Summary: This study aimed to explore the role of ARF1 in intestinal epithelial cells (IECs) and reveal the possible mechanism. The results showed that ARF1 is essential for ISC proliferation and differentiation. Loss of ARF1 increased susceptibility to DSS-induced colitis and gut microbial dysbiosis. Additionally, RNA-seq analysis revealed alterations in multiple metabolic pathways.
Article
Immunology
Yonggang Huang, Miaomiao Wu, Hao Xiao, Hongnan Liu, Guan Yang
Summary: This study suggests that MES treatment can alleviate DSS-induced ulcerative colitis in piglets by reducing symptoms, improving intestinal microbiota, and regulating immune cell function.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Kaline Arnauts, Padhmanand Sudhakar, Sare Verstockt, Cynthia Lapierre, Selina Potche, Clara Caenepeel, Bram Verstockt, Jeroen Raes, Severine Vermeire, Joao Sabino, Catherine Verfaillie, Marc Ferrante
Summary: Microbial dysbiosis is a known phenomenon in patients with inflammatory bowel disease, but the exact mechanism behind host-microbial interactions remains unclear. This study found that the transcriptional response of epithelial cells was not different between patients with ulcerative colitis (UC) and non-IBD controls following exposure to microbiota. However, UC microbiota exposure led to a significant decrease in epithelial barrier integrity, regardless of the origin of the epithelial cells. Furthermore, UC microbiota induced stress responses in all epithelial cells, while responses to healthy volunteer (HV) microbiota were milder.
Article
Multidisciplinary Sciences
Hung-Yu Chiang, Hsueh-Han Lu, Janaki N. Sudhakar, Yu-Wen Chen, Nien-Shin Shih, Yi-Ting Weng, Jr-Wen Shui
Summary: IL-22 induces IL-18 expression by intestinal epithelial cells, and IL-18 plays an important role in host defense against intestinal infection and inflammation.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Xiuyu Ji, Le Su, Ping Zhang, Qiulin Yue, Chen Zhao, Xin Sun, Kunlun Li, Xinli Liu, Song Zhang, Lin Zhao
Summary: Gut microbiota dysbiosis is a global problem caused by antibiotic overuse. This study found that lentinan, a compound found in mushrooms, has therapeutic effects on antibiotic-driven gut microbial dysbiosis in mice. Lentinan improved the diversity and abundance of the gut microbiota and increased the levels of beneficial bacteria while decreasing harmful bacteria. It also increased the concentrations of short-chain fatty acids and improved colon tissue morphology, reducing inflammation. This study provides a theoretical basis for improving the clinical treatment of broad-spectrum antibiotic side effects.
SCIENTIFIC REPORTS
(2022)
Article
Food Science & Technology
Wanzhong Liao, Huafeng Wu, Liangcheng Pang, Bizuan He, Jianjun Tong, Jiuyun Qin, Liang Li, Wei Liu, Xianqiang Zhou, Sihua Huang, Weizhe Jiang, Shujie Fu
Summary: The Hylocereus undatus flower (HUF) has significant anti-inflammatory and immunomodulatory activity. It alleviates colitis by restoring the integrity of the intestinal barrier, reducing the inflammatory response, and regulating gut and lung microbiota.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Biochemistry & Molecular Biology
Zewen Mei, Xingxi Huang, Heng Zhang, Danyi Cheng, Xin Xu, Mingyue Fang, Jutuan Hu, Yangyang Liu, Yunxiang Liang, Yuxia Mei
Summary: Chitin derivatives have a therapeutic effect in ulcerative colitis mice model by relieving inflammation symptoms, protecting the colon, and increasing the abundance of gut microbiota and concentrations of short-chain fatty acids.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Applied
Si-Yuan Lu, Yang Liu, Shijie Tang, Wancong Zhang, Qiuyong Yu, Changqi Shi, Kit-Leong Cheong
Summary: The study found that Gracilaria lemaneiformis polysaccharide (GLP) has therapeutic effects on ulcerative colitis (UC). GLP reduces colon damage, increases short-chain fatty acids in the intestines, and alleviates histopathological inflammation caused by UC. Moreover, GLP improves biodiversity and restores beneficial bacterial abundance.
Article
Plant Sciences
Mu-xia Li, Min-yao Li, Jun-xuan Lei, Yu-zhu Wu, Ze-hao Li, Lin-ming Chen, Chang-lin Zhou, Ji-yan Su, Guo-xin Huang, Xiao-qi Huang, Xue-bao Zheng
Summary: Huangqin decoction (HQD) exhibits anti-inflammatory effects on DSS-induced colitis in mice by regulating gut microbiota and amino acid metabolism, activating the mTOR signaling pathway, and protecting intestinal mucosal barrier integrity.
Article
Food Science & Technology
Jiao Yu, Junwei Zhao, Huiqun Xie, Ming Cai, Liang Yao, Jinmiao Li, Lan Han, Weidong Chen, Nianjun Yu, Daiyin Peng
Summary: The therapeutic effect of Dendrobium huoshanense polysaccharides (DHP) on ulcerative colitis (UC) is confirmed in this study. Through metabolomics and gut flora analysis, it was found that DHP alleviates UC symptoms by improving colonic mucosal barrier function, reducing inflammation, and modulating the composition of gut microbiota.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Plant Sciences
Xiaojing Wang, Shaowei Huang, Meiling Zhang, Yulin Su, Zengfeng Pan, Junjie Liang, Xueqian Xie, Qing Wang, Jinyan Chen, Lian Zhou, Xia Luo
Summary: In this study, the protective effects of Gegen Qinlian decoction (GQD) on intestinal barrier damage in acute ulcerative colitis (UC) were investigated. The results showed that GQD treatment significantly alleviated the pathological symptoms and reduced bacterial infiltration in MLNs and colon tissues. GQD also repaired the structure of epithelial tight junctions, increased the expression of tight junction proteins, and regulated the diversity of gut microbiota and tryptophan metabolism.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Immunology
Shaosong Xi, Yunguang Wang, Chenghao Wu, Weihua Peng, Ying Zhu, Wei Hu
Summary: The study shows that disturbance of intestinal flora leads to the release of exosomes from intestinal epithelial cells. These exosomes cause M1 polarization in the mesenteric lymph nodes and the accumulation of circulating IL-1β. Circulating IL-1β promotes neuronal damage and apoptosis in an autophagy-dependent manner. Targeting intestinal flora or IEC-derived exosomes may contribute to the treatment of SAE.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Hussein Hamade, Jasmine T. Stamps, Dalton T. Stamps, Shyam K. More, Lisa S. Thomas, Anna Y. Blackwood, Nawele L. Lahcene, Sofi L. Castanon, Brenda C. Salumbides, Yosuke Shimodaira, Helen S. Goodridge, Stephan R. Targan, Kathrin S. Michelsen
Summary: Intestinal dendritic cells play an important role in metabolic syndrome by preserving beneficial microbiota and maintaining intestinal epithelial barrier function.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Chia-Hao Lin, Mei-Chi Chen, Ling-Li Lin, David A. Christian, Booki Min, Christopher A. Hunter, Li-Fan Lu
Summary: IL-27 produced by intestinal epithelial cells plays a crucial role in promoting a specific subset of intraepithelial lymphocytes, contributing to barrier immunity in the gut. Loss of IL-27 in IECs leads to a selective defect in certain IEL populations, resulting in elevated pathogen burden during parasitic infection. This suggests that IL-27 from different cell types plays distinct roles in maintaining intestinal homeostasis.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Mengtao Cao, Zhengxi Wu, Qi Lou, Wenli Lu, Jie Zhang, Qi Li, Yifan Zhang, Yikun Yao, Qun Zhao, Ming Li, Haibing Zhang, Youcun Qian
CELL DEATH AND DIFFERENTIATION
(2019)
Article
Medical Laboratory Technology
Jia Tang, Wei Ma, Yangran Chen, Runze Jiang, Qinlong Zeng, Jieliang Tan, Hongqing Jiang, Qing Li, Victor W. Zhang, Jing Wang, Hui Tang, Liangping Luo
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2020)
Article
Medicine, Research & Experimental
Jia Tang, Wei Ma, Liangping Luo
MEDICAL SCIENCE MONITOR
(2019)
Article
Biotechnology & Applied Microbiology
Jia Tang, Wei Ma, Qinlong Zeng, Jieliang Tan, Keshen Cao, Liangping Luo
Article
Medical Laboratory Technology
Jia Tang, Chenglong Zhou, Haihong Shi, Yuying Mo, Weilan Tan, Tielan Sun, Jinling Zhu, Qing Li, Hui Li, Yuping Li, Songbai Wang, Yan Hong, Ning Li, Qinlong Zeng, Jieliang Tan, Wei Ma, Liangping Luo
CLINICA CHIMICA ACTA
(2020)
Review
Biotechnology & Applied Microbiology
Jia Tang, Haihong Shi, Guanyu Ma, Liangping Luo, Zhenghua Tang
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2020)
Article
Immunology
Mengtao Cao, Yuanzheng Peng, Ying Lu, Zhicheng Zou, Jiao Chen, Rita Bottino, Michael Knoll, Hanchen Zhang, Shan Lin, Zuhui Pu, Liang Sun, Zhoubin Fang, Chuanghua Qiu, Yifan Dai, Zhiming Cai, Lisha Mou
Summary: The study found that patients with type 1 diabetes and mice in specific diabetic models show changes in their intestinal microbiota, and treatment with islet Tx or insulin can partially correct the dysregulated bacterial composition.
Article
Chemistry, Analytical
Qin Yang, Bing-Hao Shi, Guo-Li Tian, Qian-Qian Niu, Jia Tang, Dan-Dan Linghu, Hong-Qin He, Ben-Qing Wu, Jiang-Tao Yang, Lu Xu, Ru-Qin Yu
Summary: Gas chromatography-mass spectrometry (GC-MS) was used in this study for urinary metabolomics analysis of inherited metabolic diseases (IMDs), and a chemometric method was proposed to effectively screen stable metabolic biomarkers. The chemometric method demonstrated advantages in identifying candidate metabolic biomarkers more biologically correlated to the metabolic mechanisms and showed good classification performance in discriminating between disease and healthy control groups.
MICROCHEMICAL JOURNAL
(2021)
Article
Cell Biology
Jia Tang, Meihua Tan, Yihui Deng, Hui Tang, Haihong Shi, Mingzhen Li, Wei Ma, Jia Li, Hongzheng Dai, Jianli Li, Shengmei Zhou, Xu Li, Fengxiang Wei, Xiaofen Ma, Liangping Luo
Summary: Progressive familial intrahepatic cholestasis (PFIC) is a rare genetic disease that can be caused by mutations in the TJP2 gene. Two newly discovered TJP2 variants may contribute to cholestasis, with potential involvement of cytoskeleton-related functions and pathways in the pathogenesis of PFIC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Meixing Yu, Jia Tang, Yanqing Huang, Chenbing Guo, Peng Du, Ning Li, Qingli Quan
Summary: This study reveals that HOXA10 regulates cholesterol synthesis in endometrial stromal cells by controlling key genes such as HMGCR, MSMO1, ACAT2, HMGCS1, EBP, and SQLE. This finding provides new insights into the metabolic mechanism of cholesterol in cells and suggests a potential treatment strategy for cholesterol synthesis in patients with ovarian endometriosis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pathology
Yuhua Ye, Guoying Sun, Zhe Ren, Yidan Liang, Hualei Luo, Peng Lin, Xingmin Wang, Zejun Dong, Li Huang, Lang Qin, Wenfang Yu, Ge Wang, Yuqiu Zhou, Jia Tang, Jiwu Lou, Yanhui Liu, Xianqi Zen, Yajun Chen, Yihong Li, Qianqian Zhang, Jin Huang, Ping Zhu, Liang Lin, Xinhua Zhang, Xiangmin Xu
Summary: This study successfully quantified the expression of zeta-globin in alpha-thalassaemia carriers and investigated its expression patterns. The results demonstrated a high diversity of zeta-globin expression and the sensitivity of the quantification methods.
JOURNAL OF CLINICAL PATHOLOGY
(2022)
Article
Endocrinology & Metabolism
Qingli Quan, Jiabao Wu, Meixing Yu, Jia Tang
Summary: EMT was found to be promoted by stroma cell infiltration and inhibited by immune cell infiltration in peritoneal endometriosis. The EMT classification showed potential in precise diagnosis and treatment of peritoneal endometriosis, with drug candidates targeting specific pathways for different clusters.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Immunology
Xiaoli Zhu, Mengxuan Du, Heng Gu, Ruishan Wu, Mengge Gao, Hang Xu, Jia Tang, Mingzhen Li, Xiaohua Liu, Xingming Zhong
Summary: In this study, RNA sequencing was used to analyze the expression profiles of mRNA and lncRNA in the peripheral blood of URSA patients. A lncRNA-mRNA interaction network was constructed, and seven key genes were identified. It was suggested that IGF1 plays a crucial role in regulating maternal immune response and influencing NK and T cells' function in URSA.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)