Review
Biochemistry & Molecular Biology
Lee M. Booty, Clare E. Bryant
Summary: The discovery of pyroptosis and its implications in infection and immunity has provided new insights into host defense against pathogens. However, the regulation of pyroptosis is complex and varies between cell types, stimulation conditions, pathogens, and animal species. Excessive inflammation caused by pyroptosis contributes to the development of sepsis. Understanding the regulation of pyroptotic pathways is crucial for identifying potential therapeutic targets for sepsis.
JOURNAL OF MOLECULAR BIOLOGY
(2022)
Review
Immunology
Claudine S. S. Greenwood, Meghan A. A. Wynosky-Dolfi, Allison M. M. Beal, Lee M. M. Booty
Summary: The discovery of gasdermin D (GSDMD) as the terminal executioner of pyroptosis fills an important gap in our understanding of cell death and highlights the significance of the gasdermin family. GSDMD connects the innate alarm systems to an explosive, inflammatory form of cell death, triggering immunological responses in the local environment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Julia Nowowiejska, Anna Baran, Justyna Magdalena Hermanowicz, Anna Pryczynicz, Beata Sieklucka, Dariusz Pawlak, Iwona Flisiak
Summary: Psoriasis is an important issue in dermatological practice, causing both aesthetic and quality of life concerns. The pathogenesis of psoriasis remains uncertain, but GSDMD, a protein involved in cell inflammation, proliferation, and death, may play a role. The study found increased expression of GSDMD in psoriatic skin, but no significant differences in serum and urinary GSDMD concentrations between psoriasis patients and controls.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Ruixuan You, Xinglan He, Zhuotong Zeng, Yi Zhan, Yangfan Xiao, Rong Xiao
Summary: Autoimmune diseases are a group of heterogeneous diseases caused by the destruction of immune tolerance and the production of autoantibodies. Excessive exacerbation of pyroptosis, a form of programmed cell death, plays a crucial role in the development of autoimmune diseases. Inflammasomes act as switches for pyroptosis, and various pyroptosis pathways disrupt immune system homeostasis and promote autoimmunity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Dhruv Chauhan, Dieter Demon, Lieselotte Vande Walle, Oonagh Paerewijck, Annalisa Zecchin, Leslie Bosseler, Karin Santoni, Remi Planes, Silvia Ribo, Amelie Fossoul, Amanda Goncalves, Hanne Van Gorp, Nina Van Opdenbosch, Filip Van Hauwermeiren, Etienne Meunier, Andy Wullaert, Mohamed Lamkanfi
Summary: This study confirms the presence of multiple canonical inflammasomes in neutrophils and identifies their differential roles in neutrophil immune responses. It provides new insights into the immune mechanisms of neutrophils.
Review
Cardiac & Cardiovascular Systems
Xinzhe Chen, Peng-Chao Tian, Kai Wang, Man Wang, Kun Wang
Summary: Cardiovascular disease (CVD) is a common and serious health threat. Different forms of cardiomyocyte death, including apoptosis, necrosis, and pyroptosis, play important roles in the pathogenesis of CVD. Controlling cardiomyocyte pyroptosis holds promise for the treatment of cardiovascular disease.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Endocrinology & Metabolism
Yu Liu, Da-Wei Wang, Dan Wang, Bin-Hong Duan, Hong-Yu Kuang
Summary: Exenatide attenuated NASH by inhibiting the pyroptosis signaling pathway, indicating its potential as a novel therapeutic target.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sebastian A. Hughes, Meng Lin, Ashley Weir, Bing Huang, Liya Xiong, Ngee Kiat Chua, Jiyi Pang, Jascinta P. Santavanond, Rochelle Tixeira, Marcel Doerflinger, Yexuan Deng, Chien-Hsiung Yu, Natasha Silke, Stephanie A. Conos, Daniel Frank, Daniel S. Simpson, James M. Murphy, Kate E. Lawlor, Jaclyn S. Pearson, John Silke, Marc Pellegrini, Marco Herold, Ivan K. H. Poon, Seth L. Masters, Mingsong Li, Qin Tang, Yuxia Zhang, Maryam Rashidi, Lanlan Geng, James E. Vince
Summary: This study reveals that genetic mutations in X-linked inhibitor of apoptosis (XIAP) can lead to cell death-associated inflammatory diseases. The findings show that patients with XIAP deficiency-associated inflammatory bowel disease have increased inflammatory IL-1 beta maturation and cell death-associated caspase-8 and Gasdermin D (GSDMD) processing, which can be reduced by patient treatment.
Article
Immunology
Shuiliang Ruan, Chenyang Han, Yongjia Sheng, Jin Wang, Xiaohong Zhou, Qiaobing Guan, Wenyan Li, Caiqun Zhang, Yi Yang
Summary: The study demonstrated that Antcin A could inhibit pyroptosis in Kupffer cells and alleviate the inflammatory response in liver tissue of NAFLD mice by targeting the NLRP3 inflammasome. This mechanism contributes to the protective effects of Antcin A on liver health.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Immunology
Marta Slaufova, Tugay Karakaya, Michela Di Filippo, Paulina Hennig, Hans-Dietmar Beer
Summary: Gasdermins are a family of pore-forming proteins that are involved in (auto)inflammatory diseases and cancer. They can form pores, leading to cell death and inflammation, and are closely associated with the functions of keratinocytes and the skin.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Lin Gao, Xiaowu Dong, Weijuan Gong, Wei Huang, Jing Xue, Qingtian Zhu, Nan Ma, Weiwei Chen, Xianghui Fu, Xiang Gao, Zhaoyu Lin, Yanbing Ding, Juanjuan Shi, Zhihui Tong, Tingting Liu, Rajarshi Mukherjee, Robert Sutton, Guotao Lu, Weiqin Li
Summary: This study reveals the critical role of NLRP3 inflammasome and GSDMD activation-mediated pyroptosis in acinar cells, linking pancreatic necrosis and systemic inflammation in acute pancreatitis. Targeting pyroptosis signaling pathways holds promise for specific therapy for acute pancreatitis.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Review
Oncology
Xiuxia Lu, Tianhui Guo, Xing Zhang
Summary: Pyroptosis, a new form of programmed cell death, has garnered attention in cancer research. Various stimuli can trigger pyroptosis, but its role in cancer remains unclear with conflicting findings. Despite the uncertainties, pyroptosis may hold potential as a promising anti-cancer therapy.
Review
Biochemistry & Molecular Biology
Hongyong Huang, Yanmin Weng, Wen Tian, Xian Lin, Jian Chen, Lianxiang Luo
Summary: This review provides an overview of the mechanisms of pyroptosis, the relationship between the gasdermin family and pyroptosis, and the interplay between pyroptosis and anti-tumor immunity. Additionally, the potential implications of pyroptosis in cancer immunotherapy are discussed, along with future research possibilities and a novel approach to tumor treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Review
Immunology
Subhashini Brahadeeswaran, Tiasha Dasgupta, Venkatraman Manickam, Viswanathan Saraswathi, Ramasamy Tamizhselvi
Summary: The liver is responsible for important physiological processes and its role in activating the innate immune system and causing inflammation is crucial. Chronic ethanol exposure disrupts the liver's inflammatory mechanism and releases proinflammatory mediators. Activation of the NLRP3 inflammasome is involved in liver fibrosis/cirrhosis, leading to hepatocyte destruction and metabolic dysregulation. Alcohol intake also affects liver epigenetics, promoting the development of alcoholic liver disease (ALD). Understanding the role of NLRP3 inflammasome and epigenetic modifications could lead to potential therapeutic targets for ALD.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Remi Planes, Miriam Pinilla, Karin Santoni, Audrey Hessel, Charlotte Passemar, Kenneth Lay, Perrine Paillette, Ana-Luiza Chaves Valadao, Kim Samirah Robinson, Paul Bastard, Nathaniel Lam, Ricardo Fadrique, Ida Rossi, David Pericat, Salimata Bagayoko, Stephen Adonai Leon-Icaza, Yoann Rombouts, Eric Perouzel, Michele Tiraby, Qian Zhang, Pietro Cicuta, Emmanuelle Jouanguy, Olivier Neyrolles, Clare E. Bryant, Andres R. Floto, Caroline Goujon, Franklin Zhong Lei, Guillaume Martin-Blondel, Stein Silva, Jean-Laurent Casanova, Celine Cougoule, Bruno Reversade, Julien Marcoux, Emmanuel Ravet, Etienne Meunier
Summary: The activation of inflammasomes plays a crucial role in regulating the infection of SARS-CoV-2. Lung epithelial cells serve as the primary entry site of the virus and express the inflammasome-forming sensor NLRP1. The cleavage of NLRP1 by coronavirus 3CL proteases leads to inflammasome assembly, cell death, and reduced production of viral particles. Additionally, these proteases also inactivate the executioner protein Gasdermin D, promoting an alternative form of cell death called pyroptosis. Analysis of pyroptosis markers in COVID-19 patients suggests that GSDME/caspase-3 could potentially serve as markers of disease severity.
Article
Gastroenterology & Hepatology
Eva Juarez-Hernandez, Norberto C. Chavez-Tapia, Diana C. Brizuela-Alcantara, Misael Uribe, Martha H. Ramos-Ostos, Natalia Nuno-Lambarri
ANNALS OF HEPATOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Alejandra Altamirano-Barrera, Misael Uribe, Norberto C. Chavez-Tapia, Natalia Nuno-Lambarri
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2018)
Article
Cell Biology
Mayra Dominguez-Perez, Arturo Simoni-Nieves, Patricia Rosales, Natalia Nuno-Lambarri, Monica Rosas-Lemus, Veronica Souza, Roxana U. Miranda, Leticia Bucio, Salvador Uribe Carvajal, Jens U. Marquardt, Daekwan Seo, Luis E. Gomez-Quiroz, Maria Concepcion Gutierrez-Ruiz
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Estel Solsona-Vilarrasa, Raquel Fucho, Sandra Torres, Susana Nunez, Natalia Nuno-Lambarri, Carlos Enrich, Carmen Garcia-Ruiz, Jose C. Fernandez-Checa
Review
Biochemistry & Molecular Biology
Nicolas Salva-Pastor, Norberto C. Chavez-Tapia, Misael Uribe, Natalia Nuno-Lambarri
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2019)
Article
Gastroenterology & Hepatology
Nicolas Salva-Pastor, Guillermo Nahum Lopez-Sanchez, Norberto Carlos Chavez-Tapia, Jorge Roman Audifred-Salomon, Danniela Niebla-Cardenas, Rafael Topete-Estrada, Helga Pereznunez-Zamora, Rafael Vidaltamayo-Ramirez, Margarita Elodia Baez-Arellano, Misael Uribe, Natalia Nuno-Lambarri
ANNALS OF HEPATOLOGY
(2020)
Review
Gastroenterology & Hepatology
Guillermo Nahum Lopez-Sanchez, Mayra Dominguez-Perez, Misael Uribe, Norberto Carlos Chavez-Tapia, Natalia Nuno-Lambarri
Summary: The global obesity pandemic is leading to increasing rates of non-alcoholic fatty liver diseases, prompting international efforts to develop reliable biomarkers for hepatic steatosis and steatohepatitis. MicroRNAs have been proposed as diagnostic and prognostic biomarkers to improve clinical intervention strategies for patients with hepatic steatosis.
ANNALS OF HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
David Vidal-Gonzalez, Guillermo Nahum Lopez-Sanchez, Luis Arturo Concha-Rebollar, Andrea Rodriguez-Herrera, Fernando Morales-Ramirez, Norberto Chavez-Tapia, Misael Uribe, Juan Alberto Nader-Kawachi, Natalia Nuno-Lambarri
ANNALS OF HEPATOLOGY
(2020)
Review
Gastroenterology & Hepatology
Itzayana Rodriguez-Antonio, Guillermo N. Lopez-Sanchez, Victor Y. Garrido-Camacho, Misael Uribe, Norberto C. Chavez-Tapia, Natalia Nuno-Lambarri
Review
Gastroenterology & Hepatology
Alan Eduardo Botello-Manilla, Norberto Carlos Chavez-Tapia, Misael Uribe, Natalia Nuno-Lambarri
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2020)
Article
Endocrinology & Metabolism
Nestor Martinez-Zavala, Guillermo Nahum Lopez-Sanchez, Alma Vergara-Lopez, Norberto Carlos Chavez-Tapia, Misael Uribe, Natalia Nuno-Lambarri
ARCHIVES OF OSTEOPOROSIS
(2020)
Review
Gastroenterology & Hepatology
Alan Eduardo Botello-Manilla, Guillermo Nahum Lopez-Sanchez, Norberto Carlos Chavez-Tapia, Misael Uribe, Natalia Nuno-Lambarri
Summary: Non-alcoholic fatty liver disease is a liver condition with fat accumulation, ranging from benign steatosis to liver cancer. It is associated with multiple disorders like diabetes and polycystic ovary syndrome. Research indicates it is also a risk factor for developing certain respiratory diseases.
ANNALS OF HEPATOLOGY
(2021)
Review
Chemistry, Medicinal
Jesus Rivera-Aguirre, Guillermo Nahum Lopez-Sanchez, Norberto Carlos Chavez-Tapia, Misael Uribe, Natalia Nuno-Lambarri
Summary: Metabolically associated fatty liver disease, previously known as nonalcoholic fatty liver disease, is a common liver disease worldwide and a major cause of liver transplantation. It is characterized by the presence of more than 5% lipid droplets in hepatocytes without concurrent liver diseases. Various factors, such as inflammatory cytokine secretion, mitochondrial and endoplasmic reticulum dysfunction, alteration of the intestine-liver axis, bacterial dysbiosis, and genetic and epigenetic factors, can contribute to the progression of metabolically associated fatty liver disease to fibrosis, cirrhosis, and hepatocellular carcinoma.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2023)
Review
Gastroenterology & Hepatology
Guillermo Nahum Lopez-Sanchez, Mayra Dominguez-Perez, Misael Uribe, Natalia Nuno-Lambarri
CLINICAL AND MOLECULAR HEPATOLOGY
(2020)