Inhibition of AIM2 inflammasome activation alleviates GSDMD-induced pyroptosis in early brain injury after subarachnoid haemorrhage

Gasdermin D serves as a key executioner of pyroptosis in experimental cerebral ischemia and reperfusion model both in vivo and in vitro

(2019) Dongping Zhang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

MCC950 attenuated early brain injury by suppressing NLRP3 inflammasome after experimental SAH in rats

(2019) Yujie Luo et al.   BRAIN RESEARCH BULLETIN

Rapamycin improves the neuroprotection effect of inhibition of NLRP3 inflammasome activation after TBI

(2019) Yuhua Chen et al.   BRAIN RESEARCH

Intravenous Stem cell Therapy for High Grade Aneurysmal Subarachnoid Haemorrhage: Case Report and Literature Review

(2019) Marie Christine Brunet et al.   World Neurosurgery

Caspase-1 initiates apoptosis in the absence of gasdermin D

(2019) Kohsuke Tsuchiya et al.   Nature Communications

Caspase-1 Is an Apical Caspase Leading to Caspase-3 Cleavage in the AIM2 Inflammasome Response, Independent of Caspase-8

(2018) Vitaliya Sagulenko et al.   JOURNAL OF MOLECULAR BIOLOGY

Aggf1 attenuates neuroinflammation and BBB disruption via PI3K/Akt/NF-κB pathway after subarachnoid hemorrhage in rats

(2018) Qiquan Zhu et al.   Journal of Neuroinflammation

Ablation of caspase-1 protects against TBI-induced pyroptosis in vitro and in vivo

(2018) Wei Liu et al.   Journal of Neuroinflammation

Gasdermin D Exerts Anti-inflammatory Effects by Promoting Neutrophil Death

(2018) Hiroto Kambara et al.   Cell Reports

Peroxiredoxin 1/2 protects brain against H2O2-induced apoptosis after subarachnoid hemorrhage

(2018) Yue Lu et al.   FASEB JOURNAL

The AIM2 inflammasome: Sensor of pathogens and cellular perturbations

(2017) Jérôme Lugrin et al.   IMMUNOLOGICAL REVIEWS

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Recent Insights into the Molecular Mechanisms Underlying Pyroptosis and Gasdermin Family Functions

(2017) Robin A. Aglietti et al.   TRENDS IN IMMUNOLOGY

Resveratrol Attenuates Early Brain Injury after Experimental Subarachnoid Hemorrhage via Inhibition of NLRP3 Inflammasome Activation

(2017) Xiangsheng Zhang et al.   Frontiers in Neuroscience

Pore formation by GSDMD is the effector mechanism of pyroptosis

(2016) Moritz M Gaidt et al.   EMBO JOURNAL

Aneurysmal Subarachnoid Hemorrhage and Neuroinflammation: A Comprehensive Review

(2016) Brandon Lucke-Wold et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Intranasal Delivery of a Caspase-1 Inhibitor in the Treatment of Global Cerebral Ischemia

(2016) Ningjun Zhao et al.   MOLECULAR NEUROBIOLOGY

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes

(2016) Robin A. Aglietti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transient receptor potential channel 1/4 reduces subarachnoid hemorrhage-induced early brain injury in rats via calcineurin-mediated NMDAR and NFAT dephosphorylation

(2016) Zhong Wang et al.   Scientific Reports

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

Microglia regulate blood clearance in subarachnoid hemorrhage by heme oxygenase-1

(2015) Nils Schallner et al.   JOURNAL OF CLINICAL INVESTIGATION

Minocycline Protects Against NLRP3 Inflammasome-Induced Inflammation and P53-Associated Apoptosis in Early Brain Injury After Subarachnoid Hemorrhage

(2015) Jianru Li et al.   MOLECULAR NEUROBIOLOGY

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Activation and Regulation of Cellular Inflammasomes: Gaps in Our Knowledge for Central Nervous System Injury

(2014) Juan Pablo de Rivero Vaccari et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Pyroptotic Neuronal Cell Death Mediated by the AIM2 Inflammasome

(2014) Stephanie E Adamczak et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Amelioration of oxidative stress and protection against early brain injury by astaxanthin after experimental subarachnoid hemorrhage

(2014) Xiang-Sheng Zhang et al.   JOURNAL OF NEUROSURGERY

Caspase-1 activity affects AIM2 speck formation/stability through a negative feedback loop

(2013) C. Juruj et al.   Frontiers in Cellular and Infection Microbiology

The value of serial plasma and cerebrospinal fluid nuclear and mitochondrial deoxyribonucleic acid levels in aneurysmal subarachnoid hemorrhage

(2012) Hung-Chen Wang et al.   JOURNAL OF NEUROSURGERY

Caspase-7 Activation by the Nlrc4/Ipaf Inflammasome Restricts Legionella pneumophila Infection

(2009) Anwari Akhter et al.   PLoS Pathogens