Nondigestible Functional Oligosaccharides: Enzymatic Production and Food Applications for Intestinal Health

Biochemical characterization and cleavage pattern analysis of a novel chitosanase with cellulase activity

(2022) Haipeng Su et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Optimized production of xylooligosaccharides from poplar: A biorefinery strategy with sequential acetic acid/sodium acetate hydrolysis followed by xylanase hydrolysis

(2022) Hong Liao et al.   BIORESOURCE TECHNOLOGY

Enhancing heterologous expression of a key enzyme for the biosynthesis of 2′‐fucosyllactose

(2022) Wenxian Liu et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

In vitro fermentation of human milk oligosaccharides by individual Bifidobacterium longum-dominant infant fecal inocula

(2022) Hongye Li et al.   CARBOHYDRATE POLYMERS

Selective Utilization of the Human Milk Oligosaccharides 2′-Fucosyllactose, 3-Fucosyllactose, and Difucosyllactose by Various Probiotic and Pathogenic Bacteria

(2021) Krista Salli et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Feruloylated Arabinoxylan and Oligosaccharides: Chemistry, Nutritional Functions, and Options for Enzymatic Modification

(2021) Shang Lin et al.   Annual Review of Food Science and Technology

A Comparison of the In Vitro Effects of 2’Fucosyllactose and Lactose on the Composition and Activity of Gut Microbiota from Infants and Toddlers

(2021) Pieter Van den Abbeele et al.   Nutrients

Biotechnological Production of 2′-Fucosyllactose: A Prevalent Fucosylated Human Milk Oligosaccharide

(2021) Wenting Zhou et al.   ACS Synthetic Biology

A Novel β-1,4-Galactosyltransferase from Histophilus somni Enables Efficient Biosynthesis of Lacto-N-Neotetraose via Both Enzymatic and Cell Factory Approaches

(2021) Guocong Luo et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Effects of mannan-oligosaccharide and Bacillus subtilis supplementation to preweaning Holstein dairy heifers on body weight gain, diarrhea, and shedding of fecal pathogens

(2021) P.M. Lucey et al.   JOURNAL OF DAIRY SCIENCE

Exploring Effects of Chitosan Oligosaccharides on the DSS-Induced Intestinal Barrier Impairment In Vitro and In Vivo

(2021) Yujie Wang et al.   MOLECULES

Current status of xylooligosaccharides: Production, characterization, health benefits and food application

(2021) Ayyappan Palaniappan et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Paludibacter propionicigenes GH10 xylanase as a tool for enzymatic xylooligosaccharides production from heteroxylans

(2021) Milena Moreira Vacilotto et al.   CARBOHYDRATE POLYMERS

Effect of squid pen chitooligosaccharide and epigallocatechin gallate on discoloration and shelf-life of yellowfin tuna slices during refrigerated storage

(2021) Avtar Singh et al.   FOOD CHEMISTRY

Human Milk Oligosaccharides Modulate Fecal Microbiota and Are Safe for Use in Children With Overweight: A Randomized Controlled Trial

(2021) Cilius Esmann Fonvig et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

A randomized trial to evaluate the impact of copra meal hydrolysate on gastrointestinal symptoms and gut microbiome

(2021) Witida Sathitkowitchai et al.   PeerJ

2′FL and LNnT Exert Antipathogenic Effects against C. difficile ATCC 9689 In Vitro, Coinciding with Increased Levels of Bifidobacteriaceae and/or Secondary Bile Acids

(2021) Louise Kristine Vigsnaes et al.   Pathogens

Composition analysis and oral administered effects on dextran sulfate sodium-induced colitis of galactooligosaccharides bioconverted by Bacillus circulans

(2021) Hye-Ryung Park et al.   CARBOHYDRATE POLYMERS

Efficient biosynthesis of lacto-N-neotetraose by a novel β-1,4-galactosyltransferase from Aggregatibacter actinomycetemcomitans NUM4039

(2021) Yingying Zhu et al.   ENZYME AND MICROBIAL TECHNOLOGY

Site-directed mutation of β-galactosidase from Streptococcus thermophilus for galactooligosaccharide-enriched yogurt making

(2021) J.C. Zhao et al.   JOURNAL OF DAIRY SCIENCE

β-Mannanase BoMan26B from Bacteroides ovatus produces mannan-oligosaccharides with prebiotic potential from galactomannan and softwood β-mannans

(2021) Abhishek Bhattacharya et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

CRISPRi-Guided Multiplexed Fine-Tuning of Metabolic Flux for Enhanced Lacto-N-neotetraose Production in Bacillus subtilis

(2020) Xiaomin Dong et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Effects of Nondigestible Oligosaccharides on Obesity

(2020) Qixing Nie et al.   Annual Review of Food Science and Technology

Biochemical characterization of a novel α-L-fucosidase from Pedobacter sp. and its application in synthesis of 3′-fucosyllactose and 2′-fucosyllactose

(2020) Ran Shi et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Influence of 2′-fucosyllactose and galacto-oligosaccharides on the growth and adhesion of Streptococcus mutans

(2020) K. Salli et al.   BRITISH JOURNAL OF NUTRITION

Enzymatic transfucosylation for synthesis of human milk oligosaccharides

(2020) Birgitte Zeuner et al.   CARBOHYDRATE RESEARCH

Human milk oligosaccharide supplementation in irritable bowel syndrome patients: A parallel, randomized, double‐blind, placebo‐controlled study

(2020) Cristina Iribarren et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Chitosan Oligosaccharides attenuate loperamide-induced constipation through regulation of gut microbiota in mice

(2020) Xiaoyu Zhang et al.   CARBOHYDRATE POLYMERS

Efficient Biosynthesis of 2′-Fucosyllactose Using an In Vitro Multienzyme Cascade

(2020) Chao Li et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Fermentation Kinetics of Selected Dietary Fibers by Human Small Intestinal Microbiota Depend on the Type of Fiber and Subject

(2020) Mara P. H. Trijp et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Blends of Human Milk Oligosaccharides Confer Intestinal Epithelial Barrier Protection In Vitro

(2020) Jane M. Natividad et al.   Nutrients

Production of Lacto-N-triose II and Lacto-N-neotetraose from Chitin by a Novel β-N-Acetylhexosaminidase Expressed in Pichia pastoris

(2020) Yihao Liu et al.   ACS Sustainable Chemistry & Engineering

Effect of xylo‐oligosaccharides (XOS) addition on technological and sensory attributes of cookies

(2020) Réka Juhász et al.   Food Science & Nutrition

Nonspecific enzymatic hydrolysis of a highly ordered chitopolysaccharide substrate

(2020) Daria N. Poshina et al.   CARBOHYDRATE RESEARCH

Efficient sequential synthesis of lacto-N-triose II and lacto-N-neotetraose by a novel β-N-acetylhexosaminidase from Tyzzerella nexilis

(2020) Yi-Hao Liu et al.   FOOD CHEMISTRY

Technological benefits of using inulin and xylooligosaccharide in dulce de leche

(2020) Ludmila S. Leddomado et al.   FOOD HYDROCOLLOIDS

Efficient production of acetylated xylooligosaccharides from Hawthorn kernels by a xylanase from Paecilomyces aerugineus

(2020) Xueqiang Liu et al.   INDUSTRIAL CROPS AND PRODUCTS

High-level expression of a glycoside hydrolase family 26 β-mannanase from Aspergillus niger in Pichia pastoris for production of partially hydrolysed fenugreek gum

(2020) Nan-Nan Wang et al.   PROCESS BIOCHEMISTRY

Phenotypic and genetic characterization of differential galacto-oligosaccharide utilization in Lactobacillus plantarum

(2020) Jori Fuhren et al.   Scientific Reports

Antifungal activity of well-defined chito-oligosaccharide preparations against medically relevant yeasts

(2019) Monica Ganan et al.   PLoS One

Enzymatic and cell factory approaches to the production of human milk oligosaccharides

(2019) Magda Faijes et al.   BIOTECHNOLOGY ADVANCES

In Vitro Digestibility of Galactooligosaccharides: Effect of the Structural Features on Their Intestinal Degradation

(2019) Alvaro Ferreira-Lazarte et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

L. acidophilus La-5, fructo-oligosaccharides and inulin may improve sensory acceptance and texture profile of a synbiotic diet mousse

(2019) Douglas Xavier-Santos et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

Prospecting prebiotics, innovative evaluation methods, and their health applications: a review

(2019) Ishu Khangwal et al.   3 Biotech

A sustainable process for procuring biologically active fractions of high-purity xylooligosaccharides and water-soluble lignin from Moso bamboo prehydrolyzate

(2019) Caoxing Huang et al.   Biotechnology for Biofuels

Characterization of an acetyl xylan esterase from the marine bacterium Ochrovirga pacifica and its synergism with xylanase on beechwood xylan

(2019) Sachithra Amarin Hettiarachchi et al.   Microbial Cell Factories

Effect of Konjac mannan oligosaccharides on diphenoxylate-induced constipation in mice

(2019) Xiaoyan Liu et al.   Journal of Functional Foods

Can functional oligosaccharides reduce the risk of diabetes mellitus?

(2019) Di Zhu et al.   FASEB JOURNAL

Prebiotics Fructo-, Galacto-, and Mannan-Oligosaccharide Do Not Protect against 5-Fluorouracil–Induced Intestinal Mucositis in Rats

(2019) Roger Yazbeck et al.   JOURNAL OF NUTRITION

β-Galactosidases: A great tool for synthesizing galactose-containing carbohydrates

(2019) Lili Lu et al.   BIOTECHNOLOGY ADVANCES

Prebiotics: Trends in food, health and technological applications

(2019) David de Paulo Farias et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

2′-Fucosyllactose alters the composition and activity of gut microbiota from formula-fed infants receiving complementary feeding in a validated intestinal model

(2019) P. Van den Abbeele et al.   Journal of Functional Foods

A Bacterial β1–3-Galactosyltransferase Enables Multigram-Scale Synthesis of Human Milk Lacto-N-tetraose (LNT) and Its Fucosides

(2019) John B. McArthur et al.   ACS Catalysis

Preparation, characterization, and prebiotic activity of manno-oligosaccharides produced from cassia gum by a glycoside hydrolase family 134 β-mannanase

(2019) Yan-xiao Li et al.   FOOD CHEMISTRY

Molecular characterization of a novel chitinase CmChi1 from Chitinolyticbacter meiyuanensis SYBC-H1 and its use in N-acetyl-d-glucosamine production

(2018) Alei Zhang et al.   Biotechnology for Biofuels

Chitooligosaccharides and their biological activities: A comprehensive review

(2018) Fakhra Liaqat et al.   CARBOHYDRATE POLYMERS

Cloning, characterization and substrate degradation mode of a novel chitinase from Streptomyces albolongus ATCC 27414

(2018) Li Gao et al.   FOOD CHEMISTRY

Arabinoxylanase from glycoside hydrolase family 5 is a selective enzyme for production of specific arabinoxylooligosaccharides

(2018) Peter Falck et al.   FOOD CHEMISTRY

The xylooligosaccharide addition and sodium reduction in requeijão cremoso processed cheese

(2018) Luana L. Ferrão et al.   FOOD RESEARCH INTERNATIONAL

Substrate specificity and transfucosylation activity of GH29 α- l -fucosidases for enzymatic production of human milk oligosaccharides

(2018) Birgitte Zeuner et al.   New Biotechnology

Endo-xylanases as tools for production of substituted xylooligosaccharides with prebiotic properties

(2018) Eva Nordberg Karlsson et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Secretory expression of β-mannanase in Saccharomyces cerevisiae and its high efficiency for hydrolysis of mannans to mannooligosaccharides

(2018) Junquan Liu et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Production optimization and characterization of mannooligosaccharide generating β-mannanase from Aspergillus oryzae

(2018) Uttam Kumar Jana et al.   BIORESOURCE TECHNOLOGY

Human Milk Oligosaccharides: 2′-Fucosyllactose (2′-FL) and Lacto-N-Neotetraose (LNnT) in Infant Formula

(2018) Yvan Vandenplas et al.   Nutrients

One-step process for producing prebiotic arabino-xylooligosaccharides from brewer's spent grain employing Trichoderma species

(2018) Cláudia Amorim et al.   FOOD CHEMISTRY

Supplementation With 2′-FL and scGOS/lcFOS Ameliorates Rotavirus-Induced Diarrhea in Suckling Rats

(2018) Ignasi Azagra-Boronat et al.   Frontiers in Cellular and Infection Microbiology

Production of HMOs using microbial hosts — from cell engineering to large scale production

(2018) Katrine Bych et al.   CURRENT OPINION IN BIOTECHNOLOGY

Structural characterization and evaluation of prebiotic activity of oil palm kernel cake mannanoligosaccharides

(2017) Naveena Reddy Kalidas et al.   FOOD CHEMISTRY

The effect of room temperature ionic liquids on the selective biocatalytic hydrolysis of chitin via sequential or simultaneous strategies

(2017) E. Husson et al.   GREEN CHEMISTRY

Structural Characterization and in Vitro Fermentation of β-Mannooligosaccharides Produced from Locust Bean Gum by GH-26 endo-β-1,4-Mannanase (ManB-1601)

(2017) Praveen Kumar Srivastava et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics

(2017) Glenn R. Gibson et al.   Nature Reviews Gastroenterology & Hepatology

Systematic review of the concentrations of oligosaccharides in human milk

(2017) Stephan Thurl et al.   NUTRITION REVIEWS

Chitosan oligosaccharide: Biological activities and potential therapeutic applications

(2017) Chatchai Muanprasat et al.   PHARMACOLOGY & THERAPEUTICS

Impact of exogenous strains on in vitro fermentation and anti-colon cancer activities of maize resistant starch and xylo-oligosaccharides

(2017) Dan-Ting Yin et al.   STARCH-STARKE

A GH115 α-glucuronidase from Schizophyllum commune contributes to the synergistic enzymatic deconstruction of softwood glucuronoarabinoxylan

(2016) Lauren S. McKee et al.   Biotechnology for Biofuels

Revisiting the structural features of arabinoxylans from brewers’ spent grain

(2016) Elisabete Coelho et al.   CARBOHYDRATE POLYMERS

Chitosan oligosaccharide suppresses tumor progression in a mouse model of colitis-associated colorectal cancer through AMPK activation and suppression of NF-κB and mTOR signaling

(2016) Tharinee Mattaveewong et al.   CARBOHYDRATE POLYMERS

Advances in characterisation and biological activities of chitosan and chitosan oligosaccharides

(2016) Pan Zou et al.   FOOD CHEMISTRY

The effects of konjac oligosaccharide on TNBS-induced colitis in rats

(2016) Ruixue Liu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The Mechanism by Which Arabinoxylanases Can Recognize Highly Decorated Xylans

(2016) Aurore Labourel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thermostable β-galactosidases for the synthesis of human milk oligosaccharides

(2016) Birgitte Zeuner et al.   New Biotechnology

Low Dosage of Chitosan Supplementation Improves Intestinal Permeability and Impairs Barrier Function in Mice

(2016) Guiping Guan et al.   Biomed Research International

Novel α-L-Fucosidases from a Soil Metagenome for Production of Fucosylated Human Milk Oligosaccharides

(2016) Mateusz Lezyk et al.   PLoS One

Oligomannan Prebiotic Attenuates Immunological, Clinical and Behavioral Symptoms in Mouse Model of Inflammatory Bowel Disease

(2016) Szilamér Ferenczi et al.   Scientific Reports

The use of chitooligosaccharide in beer brewing for protection against beer-spoilage bacteria and its influence on beer performance

(2015) Xue Zhao et al.   BIOTECHNOLOGY LETTERS

Oligosaccharides in infant formula: more evidence to validate the role of prebiotics

(2015) Yvan Vandenplas et al.   BRITISH JOURNAL OF NUTRITION

A systematic review and meta-analysis of the prebiotics and synbiotics effects on glycaemia, insulin concentrations and lipid parameters in adult patients with overweight or obesity

(2015) Bruna T.S. Beserra et al.   CLINICAL NUTRITION

Mannan biotechnology: from biofuels to health

(2015) Montarop Yamabhai et al.   CRITICAL REVIEWS IN BIOTECHNOLOGY

Chitosanases from Family 46 of Glycoside Hydrolases: From Proteins to Phenotypes

(2015) Pascal Viens et al.   Marine Drugs

Genetic Mechanisms of Prebiotic Oligosaccharide Metabolism in Probiotic Microbes

(2015) Yong Jun Goh et al.   Annual Review of Food Science and Technology

An acidic, thermostable exochitinase with β-N-acetylglucosaminidase activity from Paenibacillus barengoltzii converting chitin to N-acetyl glucosamine

(2014) Xing Fu et al.   Biotechnology for Biofuels

Antifungal effect of chito-oligosaccharides with different degrees of polymerization

(2014) Md. Hafizur Rahman et al.   EUROPEAN JOURNAL OF PLANT PATHOLOGY

The human milk oligosaccharide 2′-fucosyllactose modulates CD14 expression in human enterocytes, thereby attenuating LPS-induced inflammation

(2014) YingYing He et al.   GUT

Human milk oligosaccharides shorten rotavirus-induced diarrhea and modulate piglet mucosal immunity and colonic microbiota

(2014) Min Li et al.   ISME Journal

Production of β-galactosidase from streptococcus thermophilus for galactooligosaccharides synthesis

(2014) Vikas Sangwan et al.   JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE

Recovery and Purification of Oligosaccharides from Copra Meal by Recombinant Endo-β-mannanase and Deciphering Molecular Mechanism Involved and Its Role as Potent Therapeutic Agent

(2014) Arabinda Ghosh et al.   MOLECULAR BIOTECHNOLOGY

Xylooligosaccharide increases bifidobacteria but not lactobacilli in human gut microbiota

(2014) Sydney M. Finegold et al.   Food & Function

Evidence for xylooligosaccharide utilization inWeissellastrains isolated from Indian fermented foods and vegetables

(2013) Ami Patel et al.   FEMS MICROBIOLOGY LETTERS

Galactooligosaccharides formation during enzymatic hydrolysis of lactose: Towards a prebiotic-enriched milk

(2013) Barbara Rodriguez-Colinas et al.   FOOD CHEMISTRY

Stachyose-Enriched α-Galacto-oligosaccharides Regulate Gut Microbiota and Relieve Constipation in Mice

(2013) Ting Li et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Prebiotics as functional foods: A review

(2013) Sadeq Hasan Al-Sheraji et al.   Journal of Functional Foods

Galacto-Oligosaccharides Have Prebiotic Activity in a Dynamic In Vitro Colon Model Using a 13C-Labeling Technique

(2012) Annet J. H. Maathuis et al.   JOURNAL OF NUTRITION

Chitosan oligosaccharide as potential therapy of inflammatory bowel disease: Therapeutic efficacy and possible mechanisms of action

(2012) Mohammad Yousef et al.   PHARMACOLOGICAL RESEARCH

A randomised crossover study investigating the effects of galacto-oligosaccharides on the faecal microbiota in men and women over 50 years of age

(2011) Gemma E. Walton et al.   BRITISH JOURNAL OF NUTRITION

Synthesis of galacto-oligosaccharides by β-galactosidase from Aspergillus oryzae using partially dissolved and supersaturated solution of lactose

(2011) Carlos Vera et al.   ENZYME AND MICROBIAL TECHNOLOGY

Short chain xylooligosaccharides: a potential prebiotic used to improve batter fermentation and its effect on the quality attributes of idli, a cereal-legume-based Indian traditional food

(2011) Ayyappan Appukuttan Aachary et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY

Structure and Function of an Arabinoxylan-specific Xylanase

(2011) Márcia A. S. Correia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Influence ofBifidobacterium bifidumon Release of Minerals from Bread with Differing Bran Content

(2011) Beata Nalepa et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Carbohydrate catabolic flexibility in the mammalian intestinal commensal Lactobacillus ruminis revealed by fermentation studies aligned to genome annotations

(2011) Michelle M O’ Donnell et al.   Microbial Cell Factories

Synthesis of β-Galactooligosaccharides from Lactose Using Microbial β-Galactosidases

(2010) Daniel Obed Otieno   COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY

Cooperation of β-galactosidase and β-N-acetylhexosaminidase from bifidobacteria in assimilation of human milk oligosaccharides with type 2 structure

(2010) Mika Miwa et al.   GLYCOBIOLOGY

Production of Chitooligosaccharides and Their Potential Applications in Medicine

(2010) Berit B. Aam et al.   Marine Drugs

Structual Analysis of Neutral and Acidic Xylooligosaccharides from Hardwood Kraft Pulp, and Their Utilization by Intestinal Bacteriain Vitro

(2009) Takayuki OHBUCHI et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Synergistic effect of chitooligosaccharides and lysozyme for meat preservation

(2008) M.S. Rao et al.   LWT-FOOD SCIENCE AND TECHNOLOGY