Polyunsaturated Fatty Acids: Conversion to Lipid Mediators, Roles in Inflammatory Diseases and Dietary Sources

Role of Specialized Pro-resolving Mediators in Reducing Neuroinflammation in Neurodegenerative Disorders

(2022) Jana Ponce et al.   Frontiers in Aging Neuroscience

Overexpression of phospholipid: diacylglycerol acyltransferase in Brassica napus results in changes in lipid metabolism and oil accumulation

(2022) Stepan Fenyk et al.   BIOCHEMICAL JOURNAL

The Biased Activities of Prostanoids and Their Receptors: Review and Beyond

(2022) Hiromichi Fujino   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Specialized Proresolving Lipid Mediators: A Potential Therapeutic Target for Atherosclerosis

(2022) Juan Salazar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Climate change and n-3 LC-PUFA availability

(2022) Karsoon Tan et al.   PROGRESS IN LIPID RESEARCH

Polyunsaturated fatty acids and fatty acid-derived lipid mediators: Recent advances in the understanding of their biosynthesis, structures, and functions

(2022) Simon C. Dyall et al.   PROGRESS IN LIPID RESEARCH

Desaturases and elongases involved in long-chain polyunsaturated fatty acid biosynthesis in aquatic animals: From genes to functions

(2022) Ó. Monroig et al.   PROGRESS IN LIPID RESEARCH

Formation, Signaling and Occurrence of Specialized Pro-Resolving Lipid Mediators—What is the Evidence so far?

(2022) Nils Helge Schebb et al.   Frontiers in Pharmacology

Lipoxin alleviates oxidative stress: a state-of-the-art review

(2022) You Zhou et al.   INFLAMMATION RESEARCH

Enhancing the accumulation of eicosapentaenoic acid and docosahexaenoic acid in transgenic Camelina through the CRISPR‐Cas9 inactivation of the competing FAE1 pathway

(2022) Lihua Han et al.   PLANT BIOTECHNOLOGY JOURNAL

Eicosanoid-Activated PPARα Inhibits NFκB-Dependent Bacterial Clearance During Post-Influenza Superinfection

(2022) Ronald Lucarelli et al.   Frontiers in Cellular and Infection Microbiology

Protectins: Their biosynthesis, metabolism and structure-functions

(2022) Trond Vidar Hansen et al.   BIOCHEMICAL PHARMACOLOGY

Human CYP2B6 produces oxylipins from polyunsaturated fatty acids and reduces diet-induced obesity

(2022) Melissa M. Heintz et al.   PLoS One

Arachidonate 15-lipoxygenase type B: Regulation, function, and its role in pathophysiology

(2022) Yvonne Benatzy et al.   Frontiers in Pharmacology

Detoxification Cytochrome P450s (CYPs) in Families 1–3 Produce Functional Oxylipins from Polyunsaturated Fatty Acids

(2022) Jazmine A. Eccles et al.   Cells

A New E-Series Resolvin: RvE4 Stereochemistry and Function in Efferocytosis of Inflammation-Resolution

(2021) Stephania Libreros et al.   Frontiers in Immunology

Regulation of long-chain polyunsaturated fatty acid biosynthesis in teleost fish

(2021) Dizhi Xie et al.   PROGRESS IN LIPID RESEARCH

Specialized Pro-resolving Lipid Mediators and Glial Cells: Emerging Candidates for Brain Homeostasis and Repair

(2021) Marta Tiberi et al.   Frontiers in Cellular Neuroscience

Specialized Proresolving Mediators for Therapeutic Interventions Targeting Metabolic and Inflammatory Disorders

(2021) Yong-Hyun Han et al.   Biomolecules & Therapeutics

Molecular insights into lipoxygenases for biocatalytic synthesis of diverse lipid mediators

(2021) Jung-Ung An et al.   PROGRESS IN LIPID RESEARCH

The Functions of Cytochrome P450 ω-hydroxylases and the Associated Eicosanoids in Inflammation-Related Diseases

(2021) Kai-Di Ni et al.   Frontiers in Pharmacology

Untangling the web of 5-lipoxygenase-derived products from a molecular and structural perspective: The battle between pro- and anti-inflammatory lipid mediators

(2021) Nathaniel C. Gilbert et al.   BIOCHEMICAL PHARMACOLOGY

Specialized pro‐resolving mediators: biosynthesis and biological role in bacterial infections

(2021) Paul M. Jordan et al.   FEBS Journal

MCTR1 alleviates lipopolysaccharide‐induced acute lung injury by protecting lung endothelial glycocalyx

(2020) Hui Li et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Inflammation resolution: a dual-pronged approach to averting cytokine storms in COVID-19?

(2020) Dipak Panigrahy et al.   CANCER AND METASTASIS REVIEWS

Resolvin D1 and D2 inhibit tumour growth and inflammation via modulating macrophage polarization

(2020) Kai Shan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Maresin 1 Promotes Wound Healing and Socket Bone Regeneration for Alveolar Ridge Preservation

(2020) C.W. Wang et al.   JOURNAL OF DENTAL RESEARCH

The enzymology of the human prostanoid pathway

(2020) Roger Gregory Biringer   MOLECULAR BIOLOGY REPORTS

15-Epi-LXA4and 17-epi-RvD1 restore TLR9-mediated impaired neutrophil phagocytosis and accelerate resolution of lung inflammation

(2020) Meriem Sekheri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resolvin D1 Reduces Lung Infection and Inflammation Activating Resolution in Cystic Fibrosis

(2020) Elisa Isopi et al.   Frontiers in Immunology

Resolvin D1 protects against sepsis‐induced cardiac injury in mice

(2020) Menglong Wang et al.   BIOFACTORS

Oxidation of polyunsaturated fatty acids to produce lipid mediators

(2020) William W. Christie et al.   Essays in Biochemistry

Moving forward with isoprostanes, neuroprostanes and phytoprostanes: where are we now?

(2020) Omar S. Ahmed et al.   Essays in Biochemistry

PCTR1 improves pulmonary edema fluid clearance through activating the sodium channel and lymphatic drainage in lipopolysaccharide‐induced ARDS

(2020) Pu‐hong Zhang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Molecular mechanisms for biosynthesis and assembly of nutritionally important very long chain polyunsaturated fatty acids in microorganisms

(2020) Xiao Qiu et al.   PROGRESS IN LIPID RESEARCH

Towards model-driven characterization and manipulation of plant lipid metabolism

(2020) Sandra M. Correa et al.   PROGRESS IN LIPID RESEARCH

Understanding FAHFAs: From structure to metabolic regulation

(2020) Kristyna Brejchova et al.   PROGRESS IN LIPID RESEARCH

Specialized pro-resolving mediator network: an update on production and actions

(2020) Nan Chiang et al.   Essays in Biochemistry

Eicosanoids

(2020) Philip C. Calder   Essays in Biochemistry

Protectin DX promotes epithelial injury repair and inhibits fibroproliferation partly via ALX/PI3K signalling pathway

(2020) Jing‐Xiang Yang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

A Review of Prostanoid Receptors: Expression, Characterization, Regulation, and Mechanism of Action

(2020) Roger G. Biringer   Journal of Cell Communication and Signaling

The Biosynthesis of Enzymatically Oxidized Lipids

(2020) Ali A. Hajeyah et al.   Frontiers in Endocrinology

Co-delivery of resolvin D1 and antibiotics with nanovesicles to lungs resolves inflammation and clears bacteria in mice

(2020) Jin Gao et al.   Communications Biology

Maresin1 Alleviates Metabolic Dysfunction in Septic Mice: A 1H NMR-Based Metabolomics Analysis

(2019) Yu Hao et al.   MEDIATORS OF INFLAMMATION

Omega-3 Long-Chain Polyunsaturated Fatty Acids, EPA and DHA: Bridging the Gap between Supply and Demand

(2019) Douglas Tocher et al.   Nutrients

Beyond leukotriene formation – the noncanonical functions of 5-lipoxygenase

(2019) Ann-Kathrin Häfner et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Targeting biosynthetic networks of the proinflammatory and proresolving lipid metabolome

(2019) Markus Werner et al.   FASEB JOURNAL

Cyp2b-null male mice are susceptible to diet-induced obesity and perturbations in lipid homeostasis

(2019) Melissa M Heintz et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

The lipid biochemistry of eukaryotic algae

(2019) Yonghua Li-Beisson et al.   PROGRESS IN LIPID RESEARCH

Protective effects of GPR37 via regulation of inflammation and multiple cell death pathways after ischemic stroke in mice

(2019) Myles R. McCrary et al.   FASEB JOURNAL

The Role of Leukotrienes as Potential Therapeutic Targets in Allergic Disorders

(2019) Airi Jo-Watanabe et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Resolvin D5 Inhibits Neuropathic and Inflammatory Pain in Male But Not Female Mice: Distinct Actions of D-Series Resolvins in Chemotherapy-Induced Peripheral Neuropathy

(2019) Xin Luo et al.   Frontiers in Pharmacology

Projected declines in global DHA availability for human consumption as a result of global warming

(2019) Stefanie M. Colombo et al.   AMBIO

PAHSAs attenuate immune responses and promote β cell survival in autoimmune diabetic mice

(2019) Ismail Syed et al.   JOURNAL OF CLINICAL INVESTIGATION

Increase in lysophosphatidate acyltransferase activity in oilseed rape ( Brassica napus ) increases seed triacylglycerol content despite its low intrinsic flux control coefficient

(2019) Helen K. Woodfield et al.   NEW PHYTOLOGIST

Should formula for infants provide arachidonic acid along with DHA? A position paper of the European Academy of Paediatrics and the Child Health Foundation

(2019) Berthold Koletzko et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Maresin 1 activates LGR6 receptor promoting phagocyte immunoresolvent functions

(2019) Nan Chiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Rapid Metabolization of Protectin D1 by β-Oxidation of Its Polar Head Chain

(2019) Laurence Balas et al.   JOURNAL OF MEDICINAL CHEMISTRY

Updates to the n-3 polyunsaturated fatty acid biosynthesis pathway: DHA synthesis rates, tetracosahexaenoic acid and (minimal) retroconversion

(2019) Adam H. Metherel et al.   PROGRESS IN LIPID RESEARCH

Resolution of neuroinflammation: mechanisms and potential therapeutic option

(2019) Nikolaos Dokalis et al.   Seminars in Immunopathology

Algae: Critical Sources of Very Long-Chain Polyunsaturated Fatty Acids

(2019) John L. Harwood   Biomolecules

GPR101 mediates the pro-resolving actions of RvD5n-3 DPA in arthritis and infections

(2019) Magdalena B. Flak et al.   JOURNAL OF CLINICAL INVESTIGATION

Regiospecificity of a novel bacterial lipoxygenase from Myxococcus xanthus for polyunsaturated fatty acids

(2018) Jung-Ung An et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Resolvin E1 attenuates injury-induced vascular neointimal formation by inhibition of inflammatory responses and vascular smooth muscle cell migration

(2018) Guizhu Liu et al.   FASEB JOURNAL

T cell–intrinsic prostaglandin E 2 -EP2/EP4 signaling is critical in pathogenic T H 17 cell–driven inflammation

(2018) Jinju Lee et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Role of lipid mediators and control of lymphocyte responses in type 2 immunopathology

(2018) Sachin K. Samuchiwal et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Cytochromecis an oxidative stress–activated plasmalogenase that cleaves plasmenylcholine and plasmenylethanolamine at thesn-1 vinyl ether linkage

(2018) Christopher M. Jenkins et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GPR37 regulates macrophage phagocytosis and resolution of inflammatory pain

(2018) Sangsu Bang et al.   JOURNAL OF CLINICAL INVESTIGATION

Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators

(2018) Charles N. Serhan et al.   JOURNAL OF CLINICAL INVESTIGATION

15-epi-Lipoxin A4, Resolvin D2, and Resolvin D3 Induce NF-κB Regulators in Bacterial Pneumonia

(2018) Ho Pan Sham et al.   JOURNAL OF IMMUNOLOGY

Biological activities of non-enzymatic oxygenated metabolites of polyunsaturated fatty acids (NEO-PUFAs) derived from EPA and DHA: New anti-arrhythmic compounds?

(2018) Jean-Marie Galano et al.   MOLECULAR ASPECTS OF MEDICINE

Bioactive Lipids and Chronic Inflammation: Managing the Fire Within

(2018) Valerio Chiurchiù et al.   Frontiers in Immunology

Discovery of a benzenesulfonamide-based dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase that favorably modulates lipid mediator biosynthesis in inflammation

(2018) Sun-Yee Cheung et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The Arachidonic Acid Monooxygenase. From Biochemical Curiosity to Physiological/Pathophysiological Significance

(2018) Jorge H. Capdevila et al.   JOURNAL OF LIPID RESEARCH

15d-PGJ2-loaded nanocapsules ameliorate experimental gout arthritis by reducing pain and inflammation in a PPAR-gamma-sensitive manner in mice

(2018) Kenji W. Ruiz-Miyazawa et al.   Scientific Reports

Galectin-3 deficiency protects lipopolysaccharide-induced chondrocytes injury via regulation of TLR4 and PPAR-γ-mediated NF-κB signaling pathway

(2018) Jian-sheng Wang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Proresolving Lipid Mediators Resolvin D1 and Protectin D1 Isomer Attenuate Neointimal Hyperplasia in the Rat Carotid Artery Balloon Injury Model

(2018) Yoshihisa Makino et al.   JOURNAL OF SURGICAL RESEARCH

Docosanoids and elovanoids from omega-3 fatty acids are pro-homeostatic modulators of inflammatory responses, cell damage and neuroprotection

(2018) Nicolas G. Bazan   MOLECULAR ASPECTS OF MEDICINE

Update on GM canola crops as novel sources of omega‐3 fish oils

(2018) Johnathan A. Napier et al.   PLANT BIOTECHNOLOGY JOURNAL

Emerging role of 12/15-Lipoxygenase (ALOX15) in human pathologies

(2018) Nikhlesh K. Singh et al.   PROGRESS IN LIPID RESEARCH

Pro-resolving lipid mediators: Agents of anti-ageing?

(2018) Ross Doyle et al.   SEMINARS IN IMMUNOLOGY

Mechanisms of Cytochrome P450-Catalyzed Oxidations

(2018) F. Peter Guengerich   ACS Catalysis

Identification of specialized pro-resolving mediator clusters from healthy adults after intravenous low-dose endotoxin and omega-3 supplementation: a methodological validation

(2018) Paul C. Norris et al.   Scientific Reports

Lipoxin and Resolvin Receptors Transducing the Resolution of Inflammation in Cardiovascular Disease

(2018) John Pirault et al.   Frontiers in Pharmacology

13-Series resolvins mediate the leukocyte-platelet actions of atorvastatin and pravastatin in inflammatory arthritis

(2017) Mary E. Walker et al.   FASEB JOURNAL

Resolvins suppress tumor growth and enhance cancer therapy

(2017) Megan L. Sulciner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Effect of Cytochrome P450 Metabolites of Arachidonic Acid in Nephrology

(2017) Fan Fan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Step changes in leaf oil accumulation via iterative metabolic engineering

(2017) Thomas Vanhercke et al.   METABOLIC ENGINEERING

Structural elucidation and physiologic functions of specialized pro-resolving mediators and their receptors

(2017) Nan Chiang et al.   MOLECULAR ASPECTS OF MEDICINE

New pro-resolving n-3 mediators bridge resolution of infectious inflammation to tissue regeneration

(2017) Charles N. Serhan et al.   MOLECULAR ASPECTS OF MEDICINE

Resolvin D1 enhances the resolution of lung inflammation caused by long-term Pseudomonas aeruginosa infection

(2017) M Codagnone et al.   Mucosal Immunology

Immune resolution mechanisms in inflammatory arthritis

(2017) Mauro Perretti et al.   Nature Reviews Rheumatology

14,15-EET Suppresses Neuronal Apoptosis in Ischemia–Reperfusion Through the Mitochondrial Pathway

(2017) Hui-Xia Geng et al.   NEUROCHEMICAL RESEARCH

Modulation of lipid biosynthesis by stress in diatoms

(2017) Olga Sayanova et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Isoprostanes, neuroprostanes and phytoprostanes: An overview of 25 years of research in chemistry and biology

(2017) Jean-Marie Galano et al.   PROGRESS IN LIPID RESEARCH

Too much of a good thing: How modulating LTB 4 actions restore host defense in homeostasis or disease

(2017) Stephanie L. Brandt et al.   SEMINARS IN IMMUNOLOGY

Resolvin D1 via prevention of ROS-mediated SHP2 inactivation protects endothelial adherens junction integrity and barrier function

(2017) Rima Chattopadhyay et al.   Redox Biology

Clinical Implications of 20-Hydroxyeicosatetraenoic Acid in the Kidney, Liver, Lung and Brain: An Emerging Therapeutic Target

(2017) Osama Elshenawy et al.   Pharmaceutics

The effects of different frequency treadmill exercise on lipoxin A4 and articular cartilage degeneration in an experimental model of monosodium iodoacetate-induced osteoarthritis in rats

(2017) Yue Yang et al.   PLoS One

Feasibility and physiological relevance of designing highly potent aminopeptidase-sparing leukotriene A4 hydrolase inhibitors

(2017) Shin Numao et al.   Scientific Reports

Omega-6 and omega-3 oxylipins are implicated in soybean oil-induced obesity in mice

(2017) Poonamjot Deol et al.   Scientific Reports

Thraustochytrids as production organisms for docosahexaenoic acid (DHA), squalene, and carotenoids

(2016) Inga Marie Aasen et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Resolvin E1 attenuates atherosclerosis in absence of cholesterol-lowering effects and on top of atorvastatin

(2016) Kanita Salic et al.   ATHEROSCLEROSIS

Resolving Lipid Mediators Maresin 1 and Resolvin D2 Prevent Atheroprogression in Mice

(2016) Joana Viola et al.   CIRCULATION RESEARCH

Hydroxyoctadecadienoic acids: Oxidised derivatives of linoleic acid and their role in inflammation associated with metabolic syndrome and cancer

(2016) Venkat N. Vangaveti et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Fatty acids, eicosanoids and PPAR gamma

(2016) Rachel Marion-Letellier et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Specialized proresolving lipid mediators in patients with coronary artery disease and their potential for clot remodeling

(2016) Tarec K. Elajami et al.   FASEB JOURNAL

Membrane-dependent Activities of Human 15-LOX-2 and Its Murine Counterpart

(2016) Gunes Bender et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Branched Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) Protect against Colitis by Regulating Gut Innate and Adaptive Immune Responses

(2016) Jennifer Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel Resolvin D2 Receptor Axis in Infectious Inflammation

(2016) Nan Chiang et al.   JOURNAL OF IMMUNOLOGY

Resolvin D3 Is Dysregulated in Arthritis and Reduces Arthritic Inflammation

(2016) Hildur H. Arnardottir et al.   JOURNAL OF IMMUNOLOGY

Maresin 1 Mitigates Inflammatory Response and Protects Mice from Sepsis

(2016) Ruidong Li et al.   MEDIATORS OF INFLAMMATION

Canola engineered with a microalgal polyketide synthase-like system produces oil enriched in docosahexaenoic acid

(2016) Terence A Walsh et al.   NATURE BIOTECHNOLOGY

Synthetic redesign of plant lipid metabolism

(2016) Richard P. Haslam et al.   PLANT JOURNAL

Evolutionary alteration of ALOX15 specificity optimizes the biosynthesis of antiinflammatory and proresolving lipoxins

(2016) Susan Adel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long-chain polyunsaturated fatty acid biosynthesis in chordates: Insights into the evolution of Fads and Elovl gene repertoire

(2016) L. Filipe C. Castro et al.   PROGRESS IN LIPID RESEARCH

The role of neutrophils in inflammation resolution

(2016) Hefin R. Jones et al.   SEMINARS IN IMMUNOLOGY

The Anti-Inflammatory Effects of Prostaglandins

(2016) Jose U. Scher et al.   JOURNAL OF INVESTIGATIVE MEDICINE

15-Lipoxygenase metabolites of α-linolenic acid, [13-(S)-HPOTrE and 13-(S)-HOTrE], mediate anti-inflammatory effects by inactivating NLRP3 inflammasome

(2016) Naresh Kumar et al.   Scientific Reports

Proresolving actions of a new resolvin D1 analog mimetic qualifies as an immunoresolvent

(2015) Sarah K. Orr et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Resolvin E1 (RvE1) Attenuates Atherosclerotic Plaque Formation in Diet and Inflammation-Induced Atherogenesis

(2015) H. Hasturk et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

5-Lipoxygenase is a direct p53 target gene in humans

(2015) Bianca Gilbert et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Role of omega-3 PUFA-derived mediators, the protectins, in influenza virus infection

(2015) Yumiko Imai   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Pathophysiology of the hepoxilins

(2015) Cecil R. Pace-Asciak   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Protectins and maresins: New pro-resolving families of mediators in acute inflammation and resolution bioactive metabolome

(2015) Charles N. Serhan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Transcellular biosynthesis of eicosanoid lipid mediators

(2015) Valérie Capra et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Cytochrome P450 epoxygenase pathway of polyunsaturated fatty acid metabolism

(2015) Arthur A. Spector et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Prostaglandin E2-induced inflammation: Relevance of prostaglandin E receptors

(2015) Kohichi Kawahara et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Prostaglandin E2-EP4 signaling persistently amplifies CD40-mediated induction of IL-23 p19 expression through canonical and non-canonical NF-κB pathways

(2015) Xiaojun Ma et al.   Cellular & Molecular Immunology

Transgenic plants as a sustainable, terrestrial source of fish oils

(2015) Johnathan A. Napier et al.   EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY

Enhanced seed oil content by overexpressing genes related to triacylglyceride synthesis

(2015) Fang Liu et al.   GENE

Identification of resolvin D2 receptor mediating resolution of infections and organ protection

(2015) Nan Chiang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

12/15-Lipoxygenase metabolites of arachidonic acid activate PPARγ: a possible neuroprotective effect in ischemic brain

(2015) Li Sun et al.   JOURNAL OF LIPID RESEARCH

Aspirin-triggered resolvin D1 is produced during self-resolving gram-negative bacterial pneumonia and regulates host immune responses for the resolution of lung inflammation

(2015) R E Abdulnour et al.   Mucosal Immunology

Elucidation of novel 13-series resolvins that increase with atorvastatin and clear infections

(2015) Jesmond Dalli et al.   NATURE MEDICINE

Resolvin Infectious Inflammation by Targeting the Host Response

(2015) Craig R. Lee et al.   NEW ENGLAND JOURNAL OF MEDICINE

Evolutionary aspects of lipoxygenases and genetic diversity of human leukotriene signaling

(2015) Thomas Horn et al.   PROGRESS IN LIPID RESEARCH

MARESIN 1 PREVENTS LIPOPOLYSACCHARIDE-INDUCED NEUTROPHIL SURVIVAL AND ACCELERATES RESOLUTION OF ACUTE LUNG INJURY

(2015) Jie Gong et al.   SHOCK

19-Hydroxyeicosatetraenoic acid and isoniazid protect against angiotensin II-induced cardiac hypertrophy

(2015) Samya Elkhatali et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Advances in Our Understanding of Oxylipins Derived from Dietary PUFAs

(2015) Melissa Gabbs et al.   Advances in Nutrition

Long-chain omega-3 fatty acids and the brain: a review of the independent and shared effects of EPA, DPA and DHA

(2015) Simon C. Dyall   Frontiers in Aging Neuroscience

Maresin 1 mitigates LPS-induced acute lung injury in mice

(2014) Jie Gong et al.   BRITISH JOURNAL OF PHARMACOLOGY

Discovery of a Class of Endogenous Mammalian Lipids with Anti-Diabetic and Anti-inflammatory Effects

(2014) Mark M. Yore et al.   CELL

Roles of prostaglandin receptors in female reproduction

(2014) Y. Sugimoto et al.   JOURNAL OF BIOCHEMISTRY

Discovery of essential fatty acids

(2014) Arthur A. Spector et al.   JOURNAL OF LIPID RESEARCH

Comparison of Thraustochytrids Aurantiochytrium sp., Schizochytrium sp., Thraustochytrium sp., and Ulkenia sp. for Production of Biodiesel, Long-Chain Omega-3 Oils, and Exopolysaccharide

(2014) Kim Jye Lee Chang et al.   MARINE BIOTECHNOLOGY

Metabolic Engineering Camelina sativa with Fish Oil-Like Levels of DHA

(2014) James R. Petrie et al.   PLoS One

Maresin Biosynthesis and Identification of Maresin 2, a New Anti-Inflammatory and Pro-Resolving Mediator from Human Macrophages

(2014) Bin Deng et al.   PLoS One

The Pro-Resolving Lipid Mediator Maresin 1 (MaR1) Attenuates Inflammatory Signaling Pathways in Vascular Smooth Muscle and Endothelial Cells

(2014) Anuran Chatterjee et al.   PLoS One

Resolvin D1 limits 5-lipoxygenase nuclear localization and leukotriene B4synthesis by inhibiting a calcium-activated kinase pathway

(2014) Gabrielle Fredman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phospholipase A2 regulates eicosanoid class switching during inflammasome activation

(2014) P. C. Norris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid Mediators in the Resolution of Inflammation

(2014) Charles N. Serhan et al.   Cold Spring Harbor Perspectives in Biology

Transcript abundance on its own cannot be used to infer fluxes in central metabolism

(2014) Jörg Schwender et al.   Frontiers in Plant Science

Cysteinyl Leukotriene Receptor-1 Antagonists as Modulators of Innate Immune Cell Function

(2014) A. J. Theron et al.   Journal of Immunology Research

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

Integrative pathway dissection of molecular mechanisms of moxLDL-induced vascular smooth muscle phenotype transformation

(2013) George S Karagiannis et al.   BMC Cardiovascular Disorders

Resolvin D1 improves survival in experimental sepsis through reducing bacterial load and preventing excessive activation of inflammatory response

(2013) F. Chen et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Regulation and enhancement of lipid accumulation in oil crops: The use of metabolic control analysis for informed genetic manipulation

(2013) John L. Harwood et al.   EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY

D-series resolvin attenuates vascular smooth muscle cell activation and neointimal hyperplasia following vascular injury

(2013) Takuya Miyahara et al.   FASEB JOURNAL

The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A4 hydrolase (LTA4H), and shifts macrophage phenotype

(2013) Jesmond Dalli et al.   FASEB JOURNAL

Synergistic effect of WRI1 and DGAT1 coexpression on triacylglycerol biosynthesis in plants

(2013) Thomas Vanhercke et al.   FEBS LETTERS

Prostaglandin E2-EP3 Signaling Induces Inflammatory Swelling by Mast Cell Activation

(2013) K. Morimoto et al.   JOURNAL OF IMMUNOLOGY

Human cytochromes P450 in health and disease

(2013) D. W. Nebert et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Successful high-level accumulation of fish oil omega-3 long-chain polyunsaturated fatty acids in a transgenic oilseed crop

(2013) Noemi Ruiz-Lopez et al.   PLANT JOURNAL

Arachidonic acid and lipoxin A4 as possible endogenous anti-diabetic molecules

(2013) Undurti N. Das   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Resolvin D1 Receptor Stereoselectivity and Regulation of Inflammation and Proresolving MicroRNAs

(2012) Sriram Krishnamoorthy et al.   AMERICAN JOURNAL OF PATHOLOGY

Recommended dietary reference intakes, nutritional goals and dietary guidelines for fat and fatty acids: a systematic review

(2012) Javier Aranceta et al.   BRITISH JOURNAL OF NUTRITION

Cysteinyl leukotriene receptors, old and new; implications for asthma

(2012) T. M. Laidlaw et al.   CLINICAL AND EXPERIMENTAL ALLERGY

12/15-Lipoxygenase Orchestrates the Clearance of Apoptotic Cells and Maintains Immunologic Tolerance

(2012) Stefan Uderhardt et al.   IMMUNITY

PGD Synthase and PGD2in Immune Resposne

(2012) Myungsoo Joo et al.   MEDIATORS OF INFLAMMATION

Metabolic Engineering Plant Seeds with Fish Oil-Like Levels of DHA

(2012) James R. Petrie et al.   PLoS One

Caprylic Triglyceride as a Novel Therapeutic Approach to Effectively Improve the Performance and Attenuate the Symptoms Due to the Motor Neuron Loss in ALS Disease

(2012) Wei Zhao et al.   PLoS One

Vascular effects of prostacyclin: does activation of PPARδ play a role?

(2012) Zvonimir S. Katusic et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

LC-PUFA from photosynthetic microalgae: occurrence, biosynthesis, and prospects in biotechnology

(2011) Inna Khozin-Goldberg et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Identification of putative residues involved in the accessibility of the substrate-binding site of lipoxygenase by site-directed mutagenesis studies

(2011) Cynthia Palmieri-Thiers et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

The N-terminal β-barrel domain of mammalian lipoxygenases including mouse 5-lipoxygenase is not essential for catalytic activity and membrane binding but exhibits regulatory functions

(2011) Matthias Walther et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Chiral lipidomics of E-series resolvins: Aspirin and the biosynthesis of novel mediators

(2011) Sungwhan F. Oh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Dimerization of human 5-lipoxygenase

(2011) Ann-Kathrin Häfner et al.   BIOLOGICAL CHEMISTRY

Enzymes of the Cyclooxygenase Pathways of Prostanoid Biosynthesis

(2011) William L. Smith et al.   CHEMICAL REVIEWS

Phospholipase A2Enzymes: Physical Structure, Biological Function, Disease Implication, Chemical Inhibition, and Therapeutic Intervention

(2011) Edward A. Dennis et al.   CHEMICAL REVIEWS

Prostanoid Receptors

(2011) Takako Hirata et al.   CHEMICAL REVIEWS

Aspirin-triggered lipoxin A4 attenuates LPS-induced pro-inflammatory responses by inhibiting activation of NF-κB and MAPKs in BV-2 microglial cells

(2011) Yan-Ping Wang et al.   Journal of Neuroinflammation

The Structure of Human 5-Lipoxygenase

(2011) N. C. Gilbert et al.   SCIENCE

Thromboxane and the thromboxane receptor in cardiovascular disease

(2010) Emer M Smyth   Clinical Lipidology

Saturated-efferocytosis generates pro-resolving CD11blow macrophages: Modulation by resolvins and glucocorticoids

(2010) Sagie Schif-Zuck et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Clearance of apoptotic cells: implications in health and disease

(2010) Michael R. Elliott et al.   JOURNAL OF CELL BIOLOGY

Lipoxin A4 inhibits IL-1β-induced IL-8 and ICAM-1 expression in 1321N1 human astrocytoma cells

(2009) Yann Decker et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Molecular modification of triacylglycerol accumulation by over-expression of DGAT1 to produce canola with increased seed oil content under field conditionsThis paper is one of a selection of papers published in a Special Issue from the National Research Council of Canada – Plant Biotechnology Institute.

(2009) David C. Taylor et al.   Botany

Cardiac 12/15 lipoxygenase–induced inflammation is involved in heart failure

(2009) Yosuke Kayama et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Effects of Low-Dose Aspirin on Acute Inflammatory Responses in Humans

(2009) T. Morris et al.   JOURNAL OF IMMUNOLOGY

12/15-Lipoxygenase Counteracts Inflammation and Tissue Damage in Arthritis

(2009) G. Kronke et al.   JOURNAL OF IMMUNOLOGY

Quantitative analysis of phospholipids containing arachidonate and docosahexaenoate chains in microdissected regions of mouse brain

(2009) Paul H. Axelsen et al.   JOURNAL OF LIPID RESEARCH

International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the Formyl Peptide Receptor (FPR) Family

(2009) R. D. Ye et al.   PHARMACOLOGICAL REVIEWS

Alpha-linolenic acid and its conversion to longer chain n−3 fatty acids: Benefits for human health and a role in maintaining tissue n−3 fatty acid levels

(2009) Gwendolyn Barceló-Coblijn et al.   PROGRESS IN LIPID RESEARCH

The versatility of algae and their lipid metabolism

(2008) John L. Harwood et al.   BIOCHIMIE

Peroxisome proliferator-activated receptor-  reduces inflammation and vascular leakage in a murine model of acute lung injury

(2008) M. B. Schaefer et al.   EUROPEAN RESPIRATORY JOURNAL

Metabolic control analysis is helpful for informed genetic manipulation of oilseed rape (Brassica napus) to increase seed oil content

(2008) Randall J. Weselake et al.   JOURNAL OF EXPERIMENTAL BOTANY

Cyclooxygenases: structural and functional insights

(2008) Carol A. Rouzer et al.   JOURNAL OF LIPID RESEARCH

Eoxins are proinflammatory arachidonic acid metabolites produced via the 15-lipoxygenase-1 pathway in human eosinophils and mast cells

(2008) S. Feltenmark et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Platelet 12-Lipoxygenase, New Findings about Its Activity, Membrane Binding and Low-resolution Structure

(2007) Ansari M. Aleem et al.   JOURNAL OF MOLECULAR BIOLOGY