Human cytochromes P450 in health and disease

The cytochrome P450 genesis locus: the origin and evolution of animal cytochrome P450s

(2013) D. R. Nelson et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Craniosynostosis and Multiple Skeletal Anomalies in Humans and Zebrafish Result from a Defect in the Localized Degradation of Retinoic Acid

(2011) Kathrin Laue et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Rare variants in the CYP27B1 gene are associated with multiple sclerosis

(2011) Sreeram V. Ramagopalan et al.   ANNALS OF NEUROLOGY

The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders

(2011) Walter L. Miller et al.   ENDOCRINE REVIEWS

Bimodal targeting of cytochrome P450s to endoplasmic reticulum and mitochondria: the concept of chimeric signals

(2011) Narayan G. Avadhani et al.   FEBS Journal

Cytochrome P450 1B1 Contributes to Renal Dysfunction and Damage Caused by Angiotensin II in Mice

(2011) Brett L. Jennings et al.   HYPERTENSION

Conformational Changes of NADPH-Cytochrome P450 Oxidoreductase Are Essential for Catalysis and Cofactor Binding

(2011) Chuanwu Xia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mouse Knockout of the Cholesterogenic Cytochrome P450 Lanosterol 14α-Demethylase (Cyp51) Resembles Antley-Bixler Syndrome

(2011) Rok Keber et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Entity of Clinically Isolated Adrenal Insufficiency Caused by a Partially Inactivating Mutation of the Gene Encoding for P450 Side Chain Cleavage Enzyme (CYP11A1)

(2011) Silvia Parajes et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Genetic Defect inCYP24A1, the Vitamin D 24-Hydroxylase Gene, in a Patient with Severe Infantile Hypercalcemia

(2011) Andrew Dauber et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Early steps in steroidogenesis: intracellular cholesterol trafficking

(2011) Walter L. Miller et al.   JOURNAL OF LIPID RESEARCH

Cytochrome P450 mediates dopamine formation in the brain in vivo

(2011) Ewa Bromek et al.   JOURNAL OF NEUROCHEMISTRY

Quantitative Prediction of Human Pregnane X Receptor and Cytochrome P450 3A4 Mediated Drug-Drug Interaction in a Novel Multiple Humanized Mouse Line

(2011) M. Hasegawa et al.   MOLECULAR PHARMACOLOGY

Effects on DHEA levels by estrogen in rat astrocytes and CNS co-cultures via the regulation of CYP7B1-mediated metabolism

(2011) Åsa Fex Svenningsen et al.   NEUROCHEMISTRY INTERNATIONAL

Mutations inCYP24A1and Idiopathic Infantile Hypercalcemia

(2011) Karl P. Schlingmann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Orphans in the Human Cytochrome P450 Superfamily: Approaches to Discovering Functions and Relevance in Pharmacology

(2011) F. P. Guengerich et al.   PHARMACOLOGICAL REVIEWS

Structural basis for human NADPH-cytochrome P450 oxidoreductase deficiency

(2011) C. Xia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of CYP26 enzymes in defining appropriate retinoic acid exposure during embryogenesis

(2010) Tracie Pennimpede et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Impaired hepatic drug and steroid metabolism in congenital adrenal hyperplasia due to P450 oxidoreductase deficiency

(2010) Dorota Tomalik-Scharte et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Phenotype-Genotype Correlations of 13 Rare CYP21A2 Mutations Detected in 46 Patients Affected with 21-Hydroxylase Deficiency and in One Carrier

(2010) V. Tardy et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Isolated 17,20-Lyase Deficiency due to the Cytochrome b5Mutation W27X

(2010) Renée C. Kok et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Congenital Adrenal Hyperplasia Due to Steroid 21-Hydroxylase Deficiency: An Endocrine Society Clinical Practice Guideline

(2010) Phyllis W. Speiser et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Short- and Long-Term Outcome of Patients with Pseudo-Vitamin D Deficiency Rickets Treated with Calcitriol

(2010) T. Edouard et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Partial Defect in the Cholesterol Side-Chain Cleavage Enzyme P450scc (CYP11A1) Resembling Nonclassic Congenital Lipoid Adrenal Hyperplasia

(2010) Taninee Sahakitrungruang et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

An appetite for exercise

(2010) Leonie Welberg   NATURE REVIEWS NEUROSCIENCE

Removal of maternal retinoic acid by embryonic CYP26 is required for correct Nodal expression during early embryonic patterning

(2009) M. Uehara et al.   GENES & DEVELOPMENT

Bile acids: regulation of synthesis

(2009) John Y. L. Chiang   JOURNAL OF LIPID RESEARCH

Neonatal Cholestatic Liver Disease in an Asian Patient With a Homozygous Mutation in the Oxysterol 7α-hydroxylase Gene

(2009) Isao Ueki et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Sequence Alterations within CYP7B1 Implicate Defective Cholesterol Homeostasis in Motor-Neuron Degeneration

(2008) Maria K. Tsaousidou et al.   AMERICAN JOURNAL OF HUMAN GENETICS

mRNA Distribution and Heterologous Expression of Orphan Cytochrome P450 20A1

(2008) K. Stark et al.   DRUG METABOLISM AND DISPOSITION

Expression and purification of orphan cytochrome P450 4X1 and oxidation of anandamide

(2008) Katarina Stark et al.   FEBS Journal

Endogenous Functions of the Aryl Hydrocarbon Receptor (AHR): Intersection of Cytochrome P450 1 (CYP1)-metabolized Eicosanoids and AHR Biology

(2008) Daniel W. Nebert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Severe Combined Adrenal and Gonadal Deficiency Caused by Novel Mutations in the Cholesterol Side Chain Cleavage Enzyme, P450scc

(2008) Chan Jong Kim et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Extraadrenal 21-Hydroxylation by CYP2C19 and CYP3A4: Effect on 21-Hydroxylase Deficiency

(2008) Larissa G. Gomes et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

A Novel Homozygous Mutation inCYP11A1Gene Is Associated with Late-Onset Adrenal Insufficiency and Hypospadias in a 46,XY Patient

(2008) Petr Rubtsov et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Role of genetic variant A-204C of cholesterol 7α-hydroxylase (CYP7A1) in susceptibility to gallbladder cancer

(2008) Anvesha Srivastava et al.   MOLECULAR GENETICS AND METABOLISM

Knock-In Mouse Lines Expressing either Mitochondrial or Microsomal CYP1A1: Differing Responses to Dietary Benzo[a]pyrene as Proof of Principle

(2008) H. Dong et al.   MOLECULAR PHARMACOLOGY

Phenotype of the Cyp1a1/1a2/1b1(-/-) Triple-Knockout Mouse

(2008) N. Dragin et al.   MOLECULAR PHARMACOLOGY

4??-Hydroxycholesterol is a new endogenous CYP3A marker: relationship to CYP3A5 genotype, quinine 3-hydroxylation and sex in Koreans, Swedes and Tanzanians

(2008) Ulf Diczfalusy et al.   Pharmacogenetics and Genomics

Interference of endocrine disrupting chemicals with aromatase CYP19 expression or activity, and consequences for reproduction of teleost fish

(2007) Ksenia Cheshenko et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY