Specialized pro‐resolving mediators: biosynthesis and biological role in bacterial infections

PCTR1 enhances repair and bacterial clearance in skin wounds.

(2021) Brian E. Sansbury et al.   AMERICAN JOURNAL OF PATHOLOGY

MAR1 suppresses inflammatory response in LPS-induced RAW 264.7 macrophages and human primary peripheral blood mononuclear cells via the SIRT1/PGC-1α/PPAR-γ pathway

(2021) Wei Wang et al.   Journal of Inflammation-London

Inhibition of the Lipoxin A4 and Resolvin D1 Receptor Impairs Host Response to Acute Lung Injury Caused by Pneumococcal Pneumonia in Mice

(2021) Emily R. Siegel et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

15-Lipoxygenase-1 biosynthesis of 7S,14S-diHDHA implicates 15-Lipoxygenase-2 in biosynthesis of resolvin D5

(2020) Steven C Perry et al.   JOURNAL OF LIPID RESEARCH

Resolvin E1 is a pro-repair molecule that promotes intestinal epithelial wound healing

(2020) Miguel Quiros et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

15-Epi-LXA4and 17-epi-RvD1 restore TLR9-mediated impaired neutrophil phagocytosis and accelerate resolution of lung inflammation

(2020) Meriem Sekheri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resolvin D1 Reduces Lung Infection and Inflammation Activating Resolution in Cystic Fibrosis

(2020) Elisa Isopi et al.   Frontiers in Immunology

Resolvin D1 protects against sepsis‐induced cardiac injury in mice

(2020) Menglong Wang et al.   BIOFACTORS

Lipoxin A 4 impairs effective bacterial control and potentiates joint inflammation and damage caused by Staphylococcus aureus infection

(2020) Daiane Boff et al.   FASEB JOURNAL

Role of Human 15-Lipoxygenase-2 in the Biosynthesis of the Lipoxin Intermediate, 5S,15S-diHpETE, Implicated with the Altered Positional Specificity of Human 15-Lipoxygenase-1

(2020) Steven C. Perry et al.   BIOCHEMISTRY

Specialized pro-resolving mediator network: an update on production and actions

(2020) Nan Chiang et al.   Essays in Biochemistry

Staphylococcus aureus-Derived α-Hemolysin Evokes Generation of Specialized Pro-resolving Mediators Promoting Inflammation Resolution

(2020) Paul M. Jordan et al.   Cell Reports

Maresin-1 and Resolvin E1 Promote Regenerative Properties of Periodontal Ligament Stem Cells Under Inflammatory Conditions

(2020) Emmanuel Albuquerque-Souza et al.   Frontiers in Immunology

Co-delivery of resolvin D1 and antibiotics with nanovesicles to lungs resolves inflammation and clears bacteria in mice

(2020) Jin Gao et al.   Communications Biology

Lipoxin A4 promotes reduction and antibiotic efficacy against Pseudomonas aeruginosa biofilm

(2020) J.M. Thornton et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Maresin1 Alleviates Metabolic Dysfunction in Septic Mice: A 1H NMR-Based Metabolomics Analysis

(2019) Yu Hao et al.   MEDIATORS OF INFLAMMATION

Targeting biosynthetic networks of the proinflammatory and proresolving lipid metabolome

(2019) Markus Werner et al.   FASEB JOURNAL

Vacuolar (H+)-ATPase Critically Regulates Specialized Proresolving Mediator Pathways in Human M2-like Monocyte-Derived Macrophages and Has a Crucial Role in Resolution of Inflammation

(2019) Zhigang Rao et al.   JOURNAL OF IMMUNOLOGY

Resolvin D1 (RvD1) and maresin 1 (Mar1) contribute to human macrophage control of M. tuberculosis infection while resolving inflammation

(2019) Andy Ruiz et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Lipoxin A4 ameliorates alveolar fluid clearance disturbance in lipopolysaccharide-induced lung injury via aquaporin 5 and MAPK signaling pathway

(2019) Fang Ba et al.   Journal of Thoracic Disease

Exotoxins from Staphylococcus aureus activate 5-lipoxygenase and induce leukotriene biosynthesis

(2019) Erik Romp et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Biosynthetic metabolomes of cysteinyl-containing immunoresolvents

(2019) Charlotte C. Jouvene et al.   FASEB JOURNAL

GPR101 mediates the pro-resolving actions of RvD5n-3 DPA in arthritis and infections

(2019) Magdalena B. Flak et al.   JOURNAL OF CLINICAL INVESTIGATION

Lipoxin suppresses inflammation via the TLR4/MyD88/NF‐κB pathway in periodontal ligament cells

(2019) Muhanad Ali et al.   ORAL DISEASES

Lipid mediators of inflammation and Resolution in individuals with tuberculosis and tuberculosis-Diabetes

(2019) Rupak Shivakoti et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Identification and Complete Stereochemical Assignments of the New Resolvin Conjugates in Tissue Regeneration in Human Tissues that Stimulate Proresolving Phagocyte Functions and Tissue Regeneration

(2018) Xavier de la Rosa et al.   AMERICAN JOURNAL OF PATHOLOGY

Selectivity of phospholipid hydrolysis by phospholipase A 2 enzymes in activated cells leading to polyunsaturated fatty acid mobilization

(2018) Alma M. Astudillo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Identification and structure elucidation of the pro-resolving mediators provides novel leads for resolution pharmacology

(2018) Jesmond Dalli et al.   BRITISH JOURNAL OF PHARMACOLOGY

Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators

(2018) Charles N. Serhan et al.   JOURNAL OF CLINICAL INVESTIGATION

15-epi-Lipoxin A4, Resolvin D2, and Resolvin D3 Induce NF-κB Regulators in Bacterial Pneumonia

(2018) Ho Pan Sham et al.   JOURNAL OF IMMUNOLOGY

Human macrophages differentially produce specific resolvin or leukotriene signals that depend on bacterial pathogenicity

(2018) Oliver Werz et al.   Nature Communications

The evolutionary hypothesis of reaction specificity of mammalian ALOX15 orthologs

(2018) Hartmut Kuhn et al.   PROGRESS IN LIPID RESEARCH

Novel mediators and mechanisms in the resolution of infectious inflammation: evidence for vagus regulation

(2018) C. N. Serhan et al.   JOURNAL OF INTERNAL MEDICINE

Treating inflammation and infection in the 21st century: new hints from decoding resolution mediators and mechanisms

(2017) Charles N. Serhan   FASEB JOURNAL

New pro-resolving n-3 mediators bridge resolution of infectious inflammation to tissue regeneration

(2017) Charles N. Serhan et al.   MOLECULAR ASPECTS OF MEDICINE

Resolvin D1 enhances the resolution of lung inflammation caused by long-term Pseudomonas aeruginosa infection

(2017) M Codagnone et al.   Mucosal Immunology

A cluster of immunoresolvents links coagulation to innate host defense in human blood

(2017) Paul C. Norris et al.   Science Signaling

A cluster of immunoresolvents links coagulation to innate host defense in human blood

(2017) Paul C. Norris et al.   Science Signaling

Protectin DX increases survival in a mouse model of sepsis by ameliorating inflammation and modulating macrophage phenotype

(2017) Haifa Xia et al.   Scientific Reports

The Protectin PCTR1 Is Produced by Human M2 Macrophages and Enhances Resolution of Infectious Inflammation

(2016) Sesquile Ramon et al.   AMERICAN JOURNAL OF PATHOLOGY

Lipoxin A4 prevents tight junction disruption and delays the colonization of cystic fibrosis bronchial epithelial cells by Pseudomonas aeruginosa

(2016) Gerard Higgins et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Lipoxin A4 augments host defense in sepsis and reduces Pseudomonas aeruginosa virulence through quorum sensing inhibition

(2016) Benedict Wu et al.   FASEB JOURNAL

Resolvin D2 decreases TLR4 expression to mediate resolution in human monocytes

(2016) Amanda Croasdell et al.   FASEB JOURNAL

Group X Secreted Phospholipase A2Releases ω3 Polyunsaturated Fatty Acids, Suppresses Colitis, and Promotes Sperm Fertility

(2016) Remi Murase et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel Resolvin D2 Receptor Axis in Infectious Inflammation

(2016) Nan Chiang et al.   JOURNAL OF IMMUNOLOGY

Resolvin E1 Reverses Experimental Periodontitis and Dysbiosis

(2016) Chun-Teh Lee et al.   JOURNAL OF IMMUNOLOGY

Identification and Actions of the Maresin 1 Metabolome in Infectious Inflammation

(2016) Romain A. Colas et al.   JOURNAL OF IMMUNOLOGY

Resolvin D1 Dampens Pulmonary Inflammation and Promotes Clearance of NontypeableHaemophilus influenzae

(2016) Amanda Croasdell et al.   JOURNAL OF IMMUNOLOGY

Maresin 1 Mitigates Inflammatory Response and Protects Mice from Sepsis

(2016) Ruidong Li et al.   MEDIATORS OF INFLAMMATION

Correction for Adel et al., Evolutionary alteration of ALOX15 specificity optimizes the biosynthesis of antiinflammatory and proresolving lipoxins

(2016)   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pseudomonas aeruginosasabotages the generation of host proresolving lipid mediators

(2016) Becca A. Flitter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resolvin D3 multi-level proresolving actions are host protective during infection

(2016) Paul C. Norris et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Resolvin D4 stereoassignment and its novel actions in host protection and bacterial clearance

(2016) Jeremy W. Winkler et al.   Scientific Reports

Identification and Actions of a Novel Third Maresin Conjugate in Tissue Regeneration: MCTR3

(2016) Jesmond Dalli et al.   PLoS One

The Regulation of Proresolving Lipid Mediator Profiles in Baboon Pneumonia by Inhaled Carbon Monoxide

(2015) Jesmond Dalli et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Novel proresolving and tissue-regenerative resolvin and protectin sulfido-conjugated pathways

(2015) Jesmond Dalli et al.   FASEB JOURNAL

Structural and functional biology of arachidonic acid 15-lipoxygenase-1 (ALOX15)

(2015) Igor Ivanov et al.   GENE

Identification of resolvin D2 receptor mediating resolution of infections and organ protection

(2015) Nan Chiang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Aspirin-triggered resolvin D1 is produced during self-resolving gram-negative bacterial pneumonia and regulates host immune responses for the resolution of lung inflammation

(2015) R E Abdulnour et al.   Mucosal Immunology

Elucidation of novel 13-series resolvins that increase with atorvastatin and clear infections

(2015) Jesmond Dalli et al.   NATURE MEDICINE

Effects of Lipoxin A4 on antimicrobial actions of neutrophils in sepsis

(2015) B. Wu et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

MARESIN 1 PREVENTS LIPOPOLYSACCHARIDE-INDUCED NEUTROPHIL SURVIVAL AND ACCELERATES RESOLUTION OF ACUTE LUNG INJURY

(2015) Jie Gong et al.   SHOCK

Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease

(2014) Mark D. Turner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Maresin 1 mitigates LPS-induced acute lung injury in mice

(2014) Jie Gong et al.   BRITISH JOURNAL OF PHARMACOLOGY

Combination Therapy of 15-Epi-Lipoxin A4 With Antibiotics Protects Mice From Escherichia coli–Induced Sepsis*

(2014) Tomomi Ueda et al.   CRITICAL CARE MEDICINE

Pro-resolving lipid mediators are leads for resolution physiology

(2014) Charles N. Serhan   NATURE

Plasma Metabolomics in Human Pulmonary Tuberculosis Disease: A Pilot Study

(2014) Jennifer K. Frediani et al.   PLoS One

Resolvin D1 limits 5-lipoxygenase nuclear localization and leukotriene B4synthesis by inhibiting a calcium-activated kinase pathway

(2014) Gabrielle Fredman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of 14-series sulfido-conjugated mediators that promote resolution of infection and organ protection

(2014) J. Dalli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aspirin-triggered resolvin D1 down-regulates inflammatory responses and protects against endotoxin-induced acute kidney injury

(2014) Jiao Chen et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Lipid Mediators in the Resolution of Inflammation

(2014) Charles N. Serhan et al.   Cold Spring Harbor Perspectives in Biology

Resolvin D1 improves survival in experimental sepsis through reducing bacterial load and preventing excessive activation of inflammatory response

(2013) F. Chen et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Specific lipid mediator signatures of human phagocytes: microparticles stimulate macrophage efferocytosis and pro-resolving mediators

(2012) J. Dalli et al.   BLOOD

Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain

(2012) Charles N. Serhan et al.   FASEB JOURNAL

Infection regulates pro-resolving mediators that lower antibiotic requirements

(2012) Nan Chiang et al.   NATURE

Resolvin E1 promotes phagocytosis-induced neutrophil apoptosis and accelerates resolution of pulmonary inflammation

(2012) D. El Kebir et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aspirin-triggered lipoxin enhances macrophage phagocytosis of bacteria while inhibiting inflammatory cytokine production

(2011) David Prescott et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Lipoxygenase and Leukotriene Pathways: Biochemistry, Biology, and Roles in Disease

(2011) Jesper Z. Haeggström et al.   CHEMICAL REVIEWS

17(R)-Resolvin D1 differentially regulates TLR4-mediated responses of primary human macrophages to purified LPS and live E. coli

(2011) Christine D. Palmer et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Modulation of NF-κB signalling by microbial pathogens

(2011) Masmudur M. Rahman et al.   NATURE REVIEWS MICROBIOLOGY

Lipoxin A4 Increases Survival by Decreasing Systemic Inflammation and Bacterial Load in Sepsis

(2011) Jean Walker et al.   SHOCK

Specialized pro-resolving lipid mediators in the inflammatory response: An update

(2010) Gerard Bannenberg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Suppressive action of resolvin D1 on the production and release of septic mediators in D-galactosamine-sensitized endotoxin shock mice

(2010) TAISUKE MURAKAMI et al.   Experimental and Therapeutic Medicine

15-Epi-lipoxin A4Inhibits Myeloperoxidase Signaling and Enhances Resolution of Acute Lung Injury

(2009) Driss El Kebir et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Lipoxins: resolutionary road

(2009) Paola Maderna et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Anti-Inflammatory and Proresolving Mediator Resolvin E1 Protects Mice from Bacterial Pneumonia and Acute Lung Injury

(2009) H. Seki et al.   JOURNAL OF IMMUNOLOGY

Effects of Low-Dose Aspirin on Acute Inflammatory Responses in Humans

(2009) T. Morris et al.   JOURNAL OF IMMUNOLOGY

Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis

(2009) Matthew Spite et al.   NATURE

Shared Principles in NF-κB Signaling

(2008) Matthew S. Hayden et al.   CELL

Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE