Untangling the web of 5-lipoxygenase-derived products from a molecular and structural perspective: The battle between pro- and anti-inflammatory lipid mediators

Anti-inflammatory celastrol promotes a switch from leukotriene biosynthesis to formation of specialized pro-resolving lipid mediators

(2021) Simona Pace et al.   PHARMACOLOGICAL RESEARCH

A Boxed Warning for Montelukast: The FDA Perspective

(2021) Katherine Clarridge et al.   Journal of Allergy and Clinical Immunology-In Practice

Structural insights on ligand recognition at the human leukotriene B4 receptor 1

(2021) Nairie Michaelian et al.   Nature Communications

Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products

(2020) Nathaniel C. Gilbert et al.   Nature Chemical Biology

Fatty Acid Allosteric Regulation of C-H Activation in Plant and Animal Lipoxygenases

(2020) Adam R. Offenbacher et al.   MOLECULES

Arachidonic acid promotes the binding of 5-lipoxygenase on nanodiscs containing 5-lipoxygenase activating protein in the absence of calcium-ions

(2020) Ramakrishnan B. Kumar et al.   PLoS One

Specialized pro-resolving mediator network: an update on production and actions

(2020) Nan Chiang et al.   Essays in Biochemistry

Staphylococcus aureus-Derived α-Hemolysin Evokes Generation of Specialized Pro-resolving Mediators Promoting Inflammation Resolution

(2020) Paul M. Jordan et al.   Cell Reports

Structure-based, multi-targeted drug discovery approach to eicosanoid inhibition: Dual inhibitors of mPGES-1 and 5-lipoxygenase activating protein (FLAP)

(2020) Joseph D. Ho et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Targeting biosynthetic networks of the proinflammatory and proresolving lipid metabolome

(2019) Markus Werner et al.   FASEB JOURNAL

Novel benzoxanthene lignans that favorably modulate lipid mediator biosynthesis: A promising pharmacological strategy for anti-inflammatory therapy

(2019) Jana Gerstmeier et al.   BIOCHEMICAL PHARMACOLOGY

Structural basis of ligand recognition at the human MT1 melatonin receptor

(2019) Benjamin Stauch et al.   NATURE

An Alternative Pathway to Leukotriene B4 Enantiomers Involving a 1,8-Diol-Forming Reaction of an Algal Oxylipin

(2019) Hans Jagusch et al.   ORGANIC LETTERS

Ginkgolic Acid is a Multi-Target Inhibitor of Key Enzymes in Pro-Inflammatory Lipid Mediator Biosynthesis

(2019) Jana Gerstmeier et al.   Frontiers in Pharmacology

Discovery of the Oral Leukotriene C4 Synthase Inhibitor (1S,2S)-2-({5-[(5-Chloro-2,4-difluorophenyl)(2-fluoro-2-methylpropyl)amino]-3-methoxypyrazin-2-yl}carbonyl)cyclopropanecarboxylic Acid (AZD9898) as a New Treatment for Asthma

(2019) Magnus Munck af Rosenschöld et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure-based mechanism of cysteinyl leukotriene receptor inhibition by antiasthmatic drugs

(2019) Aleksandra Luginina et al.   Science Advances

Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors

(2019) Anastasiia Gusach et al.   Nature Communications

Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators

(2018) Charles N. Serhan et al.   JOURNAL OF CLINICAL INVESTIGATION

Na+-mimicking ligands stabilize the inactive state of leukotriene B4 receptor BLT1

(2018) Tetsuya Hori et al.   Nature Chemical Biology

Human macrophages differentially produce specific resolvin or leukotriene signals that depend on bacterial pathogenicity

(2018) Oliver Werz et al.   Nature Communications

Discovery of a benzenesulfonamide-based dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase that favorably modulates lipid mediator biosynthesis in inflammation

(2018) Sun-Yee Cheung et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Emerging Structural Biology of Lipid G-Protein Coupled Receptors

(2018) Martin Audet et al.   PROTEIN SCIENCE

The MemProtMD database: a resource for membrane-embedded protein structures and their lipid interactions

(2018) Thomas D Newport et al.   NUCLEIC ACIDS RESEARCH

Recent advances in clinical development of leukotriene B4 pathway drugs

(2017) L. Bhatt et al.   SEMINARS IN IMMUNOLOGY

The direct role of 5-lipoxygenase on tau pathology, synaptic integrity and cognition in a mouse model of tauopathy

(2017) Alana N. Vagnozzi et al.   Translational Psychiatry

Feasibility and physiological relevance of designing highly potent aminopeptidase-sparing leukotriene A4 hydrolase inhibitors

(2017) Shin Numao et al.   Scientific Reports

5-Lipoxygenase-activating protein rescues activity of 5-lipoxygenase mutations that delay nuclear membrane association and disrupt product formation

(2016) Jana Gerstmeier et al.   FASEB JOURNAL

A comprehensive map of molecular drug targets

(2016) Rita Santos et al.   NATURE REVIEWS DRUG DISCOVERY

Identification of the Substrate Access Portal of 5-Lipoxygenase

(2015) Sunayana Mitra et al.   BIOCHEMISTRY

Lipoxin and resolvin biosynthesis is dependent on 5-lipoxygenase activating protein

(2015) Christoph Lehmann et al.   FASEB JOURNAL

The structural basis for specificity in lipoxygenase catalysis

(2015) Marcia E. Newcomer et al.   PROTEIN SCIENCE

The Intracellular Localisation and Phosphorylation Profile of the Human 5-Lipoxygenase Δ13 Isoform Differs from That of Its Full Length Counterpart

(2015) Eric P. Allain et al.   PLoS One

Identification and signature profiles for pro-resolving and inflammatory lipid mediators in human tissue

(2014) Romain A. Colas et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Inhibition of 5-Lipoxygenase Selectively Triggers Disruption of c-Myc Signaling in Prostate Cancer Cells

(2014) Sivalokanathan Sarveswaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Structure of Human 15-Lipoxygenase-2 with a Substrate Mimic

(2014) Matthew J. Kobe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of a Lipoxygenase in Complex with Substrate

(2014) David B. Neau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pro-resolving lipid mediators are leads for resolution physiology

(2014) Charles N. Serhan   NATURE

Roles of coactosin-like protein (CLP) and 5-lipoxygenase-activating protein (FLAP) in cellular leukotriene biosynthesis

(2014) D. Basavarajappa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resolvin D1 limits 5-lipoxygenase nuclear localization and leukotriene B4synthesis by inhibiting a calcium-activated kinase pathway

(2014) Gabrielle Fredman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Allosteric sodium in class A GPCR signaling

(2014) Vsevolod Katritch et al.   TRENDS IN BIOCHEMICAL SCIENCES

5-Lipoxygenase Activating Protein Reduction Ameliorates Cognitive Deficit, Synaptic Dysfunction, and Neuropathology in a Mouse Model of Alzheimer’s Disease

(2013) Phillip F. Giannopoulos et al.   BIOLOGICAL PSYCHIATRY

Structure and interaction with phospholipids of a prokaryotic lipoxygenase from Pseudomonas aeruginosa

(2013) Albert Garreta et al.   FASEB JOURNAL

Modulation of 5-Lipoxygenase in Proteotoxicity and Alzheimer's Disease

(2013) E. Valera et al.   JOURNAL OF NEUROSCIENCE

Lipid metabolism enzyme 5-LOX and its metabolite LTB4 are capable of activating transcription factor NF-κB in hepatoma cells

(2012) Yu Zhao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The nuclear membrane leukotriene synthetic complex is a signal integrator and transducer

(2012) Angela M. Bair et al.   MOLECULAR BIOLOGY OF THE CELL

Crystal Structure of 12-Lipoxygenase Catalytic-Domain-Inhibitor Complex Identifies a Substrate-Binding Channel for Catalysis

(2012) Shu Xu et al.   STRUCTURE

OPM database and PPM web server: resources for positioning of proteins in membranes

(2011) Mikhail A. Lomize et al.   NUCLEIC ACIDS RESEARCH

The Structure of Human 5-Lipoxygenase

(2011) N. C. Gilbert et al.   SCIENCE

Leukotriene Inflammatory Mediators Meet Their Match

(2011) C. D. Funk   Science Translational Medicine

The 5-lipoxygenase/leukotriene pathway in preclinical models of cardiovascular disease

(2010) D. Poeckel et al.   CARDIOVASCULAR RESEARCH

Common structural features of mapeg-a widespread superfamily of membrane associated proteins with highly divergent functions in eicosanoid and glutathione metabolism

(2010) Per-Johan Jakobsson et al.   PROTEIN SCIENCE

Coactosin-like protein functions as a stabilizing chaperone for 5-lipoxygenase: role of tryptophan 102

(2009) Julia Esser et al.   BIOCHEMICAL JOURNAL

Oxymetazoline Inhibits and Resolves Inflammatory Reactions in Human Neutrophils

(2009) Ingrid Beck-Speier et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Expression of 5-lipoxygenase and 15-lipoxygenase in rheumatoid arthritis synovium and effects of intraarticular glucocorticoids

(2009) Karina Roxana Gheorghe et al.   ARTHRITIS RESEARCH & THERAPY

12(S)-hydroxyheptadeca-5Z, 8E, 10E–trienoic acid is a natural ligand for leukotriene B4receptor 2

(2008) Toshiaki Okuno et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The nuclear membrane organization of leukotriene synthesis

(2008) A. K. Mandal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin® for treatment of osteoarthritis of the knee

(2008) Krishanu Sengupta et al.   ARTHRITIS RESEARCH & THERAPY