The roles of molecular chaperones in regulating cell metabolism

The hallmarks of cancer metabolism: Still emerging

(2022) Natalya N. Pavlova et al.   Cell Metabolism

The long noncoding RNA glycoLINC assembles a lower glycolytic metabolon to promote glycolysis

(2022) Youming Zhu et al.   MOLECULAR CELL

Metabolic signatures of regulation by phosphorylation and acetylation

(2022) Kirk Smith et al.   iScience

The Purinosome: A Case Study for a Mammalian Metabolon

(2022) Anthony M. Pedley et al.   Annual Review of Biochemistry

The mitochondrial chaperone TRAP1 regulates F-ATP synthase channel formation

(2022) Giuseppe Cannino et al.   CELL DEATH AND DIFFERENTIATION

Purine biosynthetic enzymes assemble into liquid-like condensates dependent on the activity of chaperone protein HSP90

(2022) Anthony M. Pedley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting allosteric regulation of cancer metabolism

(2022) Daniel M. Kremer et al.   Nature Chemical Biology

Learning the chemical grammar of biomolecular condensates

(2022) Henry R. Kilgore et al.   Nature Chemical Biology

TRAP1 Chaperones the Metabolic Switch in Cancer

(2022) Laura A. Wengert et al.   Biomolecules

Interaction of client—the scaffold on which FeS clusters are build—with J-domain protein Hsc20 and its evolving Hsp70 partners

(2022) Jaroslaw Marszalek et al.   Frontiers in Molecular Biosciences

Native Size-Exclusion Chromatography–Based Mass Spectrometry Reveals New Components of the Early Heat Shock Protein 90 Inhibition Response Among Limited Global Changes

(2022) Rahul S. Samant et al.   MOLECULAR & CELLULAR PROTEOMICS

Quantitative proteomic analysis of temporal lysosomal proteome and the impact of the KFERQ-like motif and LAMP2A in lysosomal targeting

(2021) Merve Kacal et al.   Autophagy

The Mitochondrial Chaperone TRAP1 as a Candidate Target of Oncotherapy

(2021) Shulan Xie et al.   Frontiers in Oncology

The functions and regulation of heat shock proteins; key orchestrators of proteostasis and the heat shock response

(2021) Benjamin J. Lang et al.   ARCHIVES OF TOXICOLOGY

The role of liquid–liquid phase separation in regulating enzyme activity

(2021) Brian G. O'Flynn et al.   CURRENT OPINION IN CELL BIOLOGY

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains

(2021) Benjamin L. Piette et al.   MOLECULAR CELL

Molecular Chaperone GRP94/GP96 in Cancers: Oncogenesis and Therapeutic Target

(2021) Xiaofeng Duan et al.   Frontiers in Oncology

Metabolon: a novel cellular structure that regulates specific metabolic pathways

(2021) Tian Tian et al.   Cancer Communications

Oncogenic HSP90 facilitates metabolic alterations in aggressive B-cell lymphomas

(2021) M. Nieves Calvo-Vidal et al.   CANCER RESEARCH

Metabolic channeling: predictions, deductions, and evidence

(2021) Vidhi Pareek et al.   MOLECULAR CELL

Design and Synthesis of TRAP1 Selective Inhibitors: H-Bonding with Asn171 Residue in TRAP1 Increases Paralog Selectivity

(2021) Sujae Yang et al.   ACS Medicinal Chemistry Letters

Liquid–liquid phase separation: a principal organizer of the cell’s biochemical activity architecture

(2021) Jason Z. Zhang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Mitochondrial iron–sulfur clusters: Structure, function, and an emerging role in vascular biology

(2021) Austin D. Read et al.   Redox Biology

Biogenesis of Iron–Sulfur Clusters and Their Role in DNA Metabolism

(2021) Ruifeng Shi et al.   Frontiers in Cell and Developmental Biology

Recent advances in understanding catalysis of protein folding by molecular chaperones

(2020) David Balchin et al.   FEBS LETTERS

Biochemical Convergence of Mitochondrial Hsp70 System Specialized in Iron–Sulfur Cluster Biogenesis

(2020) Malgorzata Kleczewska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hypoxia Drives the Assembly of the Multi-Enzyme Purinosome Complex

(2020) Cyrielle Doigneaux et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolomics and mass spectrometry imaging reveal channeled de novo purine synthesis in cells

(2020) Vidhi Pareek et al.   SCIENCE

Rational Design of Allosteric and Selective Inhibitors of the Molecular Chaperone TRAP1

(2020) Carlos Sanchez-Martin et al.   Cell Reports

Post-translational modifications of Hsp90 and translating the chaperone code

(2020) Sarah J. Backe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ERK2 Phosphorylates PFAS to Mediate Posttranslational Control of De Novo Purine Synthesis

(2020) Eunus S. Ali et al.   MOLECULAR CELL

Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells

(2020) Seung W. Ryu et al.   PLOS BIOLOGY

Dynamically Shaping Chaperones. Allosteric Modulators of HSP90 Family as Regulatory Tools of Cell Metabolism in Neoplastic Progression

(2020) Carlos Sanchez-Martin et al.   Frontiers in Oncology

Regulation of glycolysis by the hypoxia‐inducible factor (HIF): implications for cellular physiology

(2020) S. J. Kierans et al.   JOURNAL OF PHYSIOLOGY-LONDON

Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates

(2019) Simon Alberti et al.   CELL

Interplay between TRAP1 and sirtuin-3 modulates mitochondrial respiration and oxidative stress to maintain stemness of glioma stem cells

(2019) Hye-Kyung Park et al.   CANCER RESEARCH

Targetome analysis of chaperone-mediated autophagy in cancer cells

(2019) Yuqing Hao et al.   Autophagy

Mapping Post-Translational Modifications of de Novo Purine Biosynthetic Enzymes: Implications for Pathway Regulation

(2019) Chunliang Liu et al.   JOURNAL OF PROTEOME RESEARCH

Cancer Cells Tune the Signaling Pathways to Empower de Novo Synthesis of Nucleotides

(2019) Elodie Villa et al.   Cancers

The Hsp70 chaperone network

(2019) Rina Rosenzweig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Functional cross-talk between allosteric effects of activating and inhibiting ligands underlies PKM2 regulation

(2019) Jamie A Macpherson et al.   eLife

HSP90 Molecular Chaperones, Metabolic Rewiring, and Epigenetics: Impact on Tumor Progression and Perspective for Anticancer Therapy

(2019) Valentina Condelli et al.   Cells

Probing and engineering liquid-phase organelles

(2019) Dan Bracha et al.   NATURE BIOTECHNOLOGY

Role of HSP90 in the Regulation of de Novo Purine Biosynthesis

(2018) Anthony M. Pedley et al.   BIOCHEMISTRY

Tom70 enhances mitochondrial preprotein import efficiency by binding to internal targeting sequences

(2018) Sandra Backes et al.   JOURNAL OF CELL BIOLOGY

Molecular Mechanism of J-Domain-Triggered ATP Hydrolysis by Hsp70 Chaperones

(2018) Roman Kityk et al.   MOLECULAR CELL

The coming of age of chaperone-mediated autophagy

(2018) Susmita Kaushik et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

CHIP E3 ligase mediates proteasomal degradation of the proliferation regulatory protein ALDH1L1 during the transition of NIH3T3 fibroblasts from G0/G1 to S-phase

(2018) Qasim A. Khan et al.   PLoS One

The role of dynamic enzyme assemblies and substrate channelling in metabolic regulation

(2018) Lee J. Sweetlove et al.   Nature Communications

Conserved conformational selection mechanism of Hsp70 chaperone-substrate interactions

(2018) Ashok Sekhar et al.   eLife

The role of chaperones in iron sulfur cluster biogenesis

(2018) Rita Puglisi et al.   FEBS LETTERS

The HSP90 Family: Structure, Regulation, Function, and Implications in Health and Disease

(2018) Abdullah Hoter et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Multiple functionalities of molecular chaperones revealed through systematic mapping of their interaction networks

(2018) Kamran Rizzolo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Study of purinosome assembly in cell-based model systems with de novo purine synthesis and salvage pathway deficiencies

(2018) Veronika Baresova et al.   PLoS One

Enzymatic complexes across scales

(2018) Panagiotis L. Kastritis et al.   Essays in Biochemistry

Hsp90 and Hsp70 chaperones: Collaborators in protein remodeling

(2018) Olivier Genest et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microtubule-directed transport of purine metabolons drives their cytosolic transit to mitochondria

(2018) Chung Yu Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteomic interrogation of HSP90 and insights for medical research

(2017) Lorenz Weidenauer et al.   Expert Review of Proteomics

Hsp70 - a master regulator in protein degradation

(2017) María Rosario Fernández-Fernández et al.   FEBS LETTERS

Identification of a multienzyme complex for glucose metabolism in living cells

(2017) Casey L. Kohnhorst et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Higher order structures in purine and pyrimidine metabolism

(2017) Iva Chitrakar et al.   JOURNAL OF STRUCTURAL BIOLOGY

HSP90 promotes cell glycolysis, proliferation and inhibits apoptosis by regulating PKM2 abundance via Thr-328 phosphorylation in hepatocellular carcinoma

(2017) Qiuran Xu et al.   Molecular Cancer

The HSP90 chaperone machinery

(2017) Florian H. Schopf et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Biomolecular condensates: organizers of cellular biochemistry

(2017) Salman F. Banani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Clarifying the supercomplex: the higher-order organization of the mitochondrial electron transport chain

(2017) James A Letts et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Brownian dynamic study of an enzyme metabolon in the TCA cycle: Substrate kinetics and channeling

(2017) Yu-ming M. Huang et al.   PROTEIN SCIENCE

A New View into the Regulation of Purine Metabolism: The Purinosome

(2017) Anthony M. Pedley et al.   TRENDS IN BIOCHEMICAL SCIENCES

Clarifying the supercomplex: the higher-order organization of the mitochondrial electron transport chain

(2017) James A Letts et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Chaperone-mediated autophagy substrate proteins in cancer

(2017) Ying Tang et al.   Oncotarget

Absence of Neurofibromin Induces an Oncogenic Metabolic Switch via Mitochondrial ERK-Mediated Phosphorylation of the Chaperone TRAP1

(2017) Ionica Masgras et al.   Cell Reports

The Chaperone TRAP1 As a Modulator of the Mitochondrial Adaptations in Cancer Cells

(2017) Ionica Masgras et al.   Frontiers in Oncology

Direct Evidence for Metabolon Formation and Substrate Channeling in Recombinant TCA Cycle Enzymes

(2016) Beyza Bulutoglu et al.   ACS Chemical Biology

Mitochondria and Cancer

(2016) Sejal Vyas et al.   CELL

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

The human HSP70 family of chaperones: where do we stand?

(2016) Jürgen Radons   CELL STRESS & CHAPERONES

Role of chaperone-mediated autophagy in metabolism

(2016) Inmaculada Tasset et al.   FEBS Journal

Mitochondria and Cancer

(2016) Wei-Xing Zong et al.   MOLECULAR CELL

The epichaperome is an integrated chaperome network that facilitates tumour survival

(2016) Anna Rodina et al.   NATURE

Spatial colocalization and functional link of purinosomes with mitochondria

(2016) J. B. French et al.   SCIENCE

HK2/hexokinase-II integrates glycolysis and autophagy to confer cellular protection

(2015) Valerie P Tan et al.   Autophagy

Dynamic Architecture of the Purinosome Involved in Human De Novo Purine Biosynthesis

(2015) Minjoung Kyoung et al.   BIOCHEMISTRY

Krebs cycle metabolon formation: metabolite concentration gradient enhanced compartmentation of sequential enzymes

(2015) Fei Wu et al.   CHEMICAL COMMUNICATIONS

Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death

(2015) Hong-guang Xia et al.   JOURNAL OF CELL BIOLOGY

Development of a Mitochondria-Targeted Hsp90 Inhibitor Based on the Crystal Structures of Human TRAP1

(2015) Changwook Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Clinical severity in Lesch–Nyhan disease: The role of residual enzyme and compensatory pathways

(2015) Rong Fu et al.   MOLECULAR GENETICS AND METABOLISM

Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis

(2015) Susmita Kaushik et al.   NATURE CELL BIOLOGY

Regulation of mammalian nucleotide metabolism and biosynthesis

(2015) Andrew N. Lane et al.   NUCLEIC ACIDS RESEARCH

Purinosome formation as a function of the cell cycle

(2015) Chung Yu Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural insight into mechanisms for dynamic regulation of PKM2

(2015) Ping Wang et al.   Protein & Cell

Krebs Cycle Metabolon: Structural Evidence of Substrate Channeling Revealed by Cross-Linking and Mass Spectrometry

(2014) Fei Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Quantitative Chaperone Interaction Network Reveals the Architecture of Cellular Protein Homeostasis Pathways

(2014) Mikko Taipale et al.   CELL

Deficient Chaperone-Mediated Autophagy in Liver Leads to Metabolic Dysregulation

(2014) Jaime L. Schneider et al.   Cell Metabolism

Structure of Transmembrane Domain of Lysosome-associated Membrane Protein Type 2a (LAMP-2A) Reveals Key Features for Substrate Specificity in Chaperone-mediated Autophagy

(2014) Ashok K. Rout et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Perilous journey: a tour of the ubiquitin–proteasome system

(2014) Gary Kleiger et al.   TRENDS IN CELL BIOLOGY

STUB1/CHIP is required for HIF1A degradation by chaperone-mediated autophagy

(2013) João Vasco Ferreira et al.   Autophagy

Cell cycle regulation of purine synthesis by phosphoribosyl pyrophosphate and inorganic phosphate

(2013) Alla Fridman et al.   BIOCHEMICAL JOURNAL

G-protein-coupled receptor regulation ofde novopurine biosynthesis: a novel druggable mechanism

(2013) Ye Fang et al.   Biotechnology & Genetic Engineering Reviews

Hexokinase 2 Is Required for Tumor Initiation and Maintenance and Its Systemic Deletion Is Therapeutic in Mouse Models of Cancer

(2013) Krushna C. Patra et al.   CANCER CELL

The Mitochondrial Chaperone TRAP1 Promotes Neoplastic Growth by Inhibiting Succinate Dehydrogenase

(2013) Marco Sciacovelli et al.   Cell Metabolism

The machinery of macroautophagy

(2013) Yuchen Feng et al.   CELL RESEARCH

Chaperone-mediated autophagy degrades mutant p53

(2013) H. Vakifahmetoglu-Norberg et al.   GENES & DEVELOPMENT

Chaperone-mediated Autophagy Targets Hypoxia-inducible Factor-1α (HIF-1α) for Lysosomal Degradation

(2013) Maimon E. Hubbi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hsp70/Hsp90 chaperone machinery is involved in the assembly of the purinosome

(2013) J. B. French et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis

(2013) S. Yoshida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Landscape of the mitochondrial Hsp90 metabolome in tumours

(2013) Young Chan Chae et al.   Nature Communications

LAMP2A overexpression in breast tumors promotes cancer cell survival via chaperone-mediated autophagy

(2012) Tapas Saha   Autophagy

Mitochondrial c-Src regulates cell survival through phosphorylation of respiratory chain components

(2012) Masato Ogura et al.   BIOCHEMICAL JOURNAL

Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition

(2012) Mikko Taipale et al.   CELL

Small Molecule Activation of PKM2 in Cancer Cells Induces Serine Auxotrophy

(2012) Charles Kung et al.   CHEMISTRY & BIOLOGY

Identification of the Components of a Glycolytic Enzyme Metabolon on the Human Red Blood Cell Membrane

(2012) Estela Puchulu-Campanella et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mapping Protein-Protein Proximity in the Purinosome

(2012) Yijun Deng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure and Dynamics of the ATP-Bound Open Conformation of Hsp70 Chaperones

(2012) Roman Kityk et al.   MOLECULAR CELL

Serine is a natural ligand and allosteric activator of pyruvate kinase M2

(2012) Barbara Chaneton et al.   NATURE

Hypoxic stress activates chaperone-mediated autophagy and modulates neuronal cell survival

(2012) Eisuke Dohi et al.   NEUROCHEMISTRY INTERNATIONAL

Inhibitory effect of dietary lipids on chaperone-mediated autophagy

(2012) J. A. Rodriguez-Navarro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Hsp90 chaperone machinery: Conformational dynamics and regulation by co-chaperones

(2011) Jing Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Microautophagy of Cytosolic Proteins by Late Endosomes

(2011) Ranjit Sahu et al.   DEVELOPMENTAL CELL

Acetylation Targets the M2 Isoform of Pyruvate Kinase for Degradation through Chaperone-Mediated Autophagy and Promotes Tumor Growth

(2011) Lei Lv et al.   MOLECULAR CELL

GPCRs regulate the assembly of a multienzyme complex for purine biosynthesis

(2011) Florence Verrier et al.   Nature Chemical Biology

An Interaction Network Predicted from Public Data as a Discovery Tool: Application to the Hsp90 Molecular Chaperone Machine

(2011) Pablo C. Echeverría et al.   PLoS One

Conformational dynamics of the molecular chaperone Hsp90

(2011) Kristin A. Krukenberg et al.   QUARTERLY REVIEWS OF BIOPHYSICS

Chaperone-Mediated Autophagy Is Required for Tumor Growth

(2011) M. Kon et al.   Science Translational Medicine

A photoconvertible fluorescent reporter to track chaperone-mediated autophagy

(2011) Hiroshi Koga et al.   Nature Communications

Chaperone-assisted degradation: multiple paths to destruction

(2010) Nadja Kettern et al.   BIOLOGICAL CHEMISTRY

Structural Analysis of the Interactions Between Hsp70 Chaperones and the Yeast DNA Replication Protein Orc4p

(2010) María Moreno-del Álamo et al.   JOURNAL OF MOLECULAR BIOLOGY

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

Mitochondrial protein import: from proteomics to functional mechanisms

(2010) Oliver Schmidt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

HSP90 at the hub of protein homeostasis: emerging mechanistic insights

(2010) Mikko Taipale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The HSP70 chaperone machinery: J proteins as drivers of functional specificity

(2010) Harm H. Kampinga et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Microtubule-assisted mechanism for functional metabolic macromolecular complex formation

(2010) S. An et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

Mitochondrial carrier protein biogenesis: role of the chaperones Hsc70 and Hsp90

(2009) Vincenzo Zara et al.   BIOCHEMICAL JOURNAL

Importing Mitochondrial Proteins: Machineries and Mechanisms

(2009) Agnieszka Chacinska et al.   CELL

Novel Hsp90 partners discovered using complementary proteomic approaches

(2009) Pavel A. Tsaytler et al.   CELL STRESS & CHAPERONES

The molecular determinants of de novo nucleotide biosynthesis in cancer cells

(2009) Xuemei Tong et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Solution conformation of wild-type E. coli Hsp70 (DnaK) chaperone complexed with ADP and substrate

(2009) E. B. Bertelsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

hsp70 genes in the human genome: Conservation and differentiation patterns predict a wide array of overlapping and specialized functions

(2008) Luciano Brocchieri et al.   BMC EVOLUTIONARY BIOLOGY

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

(2008) Ralph J. DeBerardinis et al.   Cell Metabolism

Guidelines for the nomenclature of the human heat shock proteins

(2008) Harm H. Kampinga et al.   CELL STRESS & CHAPERONES

The BAG proteins: a ubiquitous family of chaperone regulators

(2008) M. Kabbage et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

Reversible Compartmentalization of de Novo Purine Biosynthetic Complexes in Living Cells

(2008) S. An et al.   SCIENCE