Metabolomics and mass spectrometry imaging reveal channeled de novo purine synthesis in cells

Cancer Cells Tune the Signaling Pathways to Empower de Novo Synthesis of Nucleotides

(2019) Elodie Villa et al.   Cancers

Gas Cluster Ion Beams for Secondary Ion Mass Spectrometry

(2018) Nicholas Winograd   Annual Review of Analytical Chemistry

The role of dynamic enzyme assemblies and substrate channelling in metabolic regulation

(2018) Lee J. Sweetlove et al.   Nature Communications

Microtubule-directed transport of purine metabolons drives their cytosolic transit to mitochondria

(2018) Chung Yu Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism

(2018) Nora Kory et al.   SCIENCE

A New View into the Regulation of Purine Metabolism: The Purinosome

(2017) Anthony M. Pedley et al.   TRENDS IN BIOCHEMICAL SCIENCES

AGC1/2, the mitochondrial aspartate-glutamate carriers

(2016) N.D. Amoedo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

CRISPR-Cas9 induced mutations along de novo purine synthesis in HeLa cells result in accumulation of individual enzyme substrates and affect purinosome formation

(2016) Veronika Baresova et al.   MOLECULAR GENETICS AND METABOLISM

Spatial colocalization and functional link of purinosomes with mitochondria

(2016) J. B. French et al.   SCIENCE

Dynamic Architecture of the Purinosome Involved in Human De Novo Purine Biosynthesis

(2015) Minjoung Kyoung et al.   BIOCHEMISTRY

Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells

(2015) Lucas B. Sullivan et al.   CELL

High energy gas cluster ions for organic and biological analysis by time-of-flight secondary ion mass spectrometry

(2015) Tina B. Angerer et al.   INTERNATIONAL JOURNAL OF MASS SPECTROMETRY

Quantitative Analysis of Purine Nucleotides Indicates That Purinosomes Increasede NovoPurine Biosynthesis

(2015) Hong Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Purinosome formation as a function of the cell cycle

(2015) Chung Yu Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterisation of biological material with ToF-SIMS: a review

(2014) S. Fearn   MATERIALS SCIENCE AND TECHNOLOGY

Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer

(2014) Roland Nilsson et al.   Nature Communications

Serine, but Not Glycine, Supports One-Carbon Metabolism and Proliferation of Cancer Cells

(2014) Christiaan F. Labuschagne et al.   Cell Reports

Single-cell imaging mass spectrometry

(2013) Melissa K Passarelli et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Mitochondrial chloride channels: electrophysiological characterization and pH induction of channel pore dilation

(2013) Anton Misak et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Mapping Protein-Protein Proximity in the Purinosome

(2012) Yijun Deng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TOF-SIMS with Argon Gas Cluster Ion Beams: A Comparison with C60+

(2011) Sadia Rabbani et al.   ANALYTICAL CHEMISTRY

Label free biochemical 2D and 3D imaging using secondary ion mass spectrometry

(2011) John S Fletcher et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Metabolomic Analysis via Reversed-Phase Ion-Pairing Liquid Chromatography Coupled to a Stand Alone Orbitrap Mass Spectrometer

(2010) Wenyun Lu et al.   ANALYTICAL CHEMISTRY

Compartmentalization of Mammalian Folate-Mediated One-Carbon Metabolism

(2010) Anne S. Tibbetts et al.   Annual Review of Nutrition

Microtubule-assisted mechanism for functional metabolic macromolecular complex formation

(2010) S. An et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IMP Dehydrogenase: Structure, Mechanism, and Inhibition

(2009) Lizbeth Hedstrom   CHEMICAL REVIEWS

A New Dynamic in Mass Spectral Imaging of Single Biological Cells

(2008) John S. Fletcher et al.   ANALYTICAL CHEMISTRY

Advances in Imaging Secondary Ion Mass Spectrometry for Biological Samples

(2008) Steven G. Boxer et al.   Annual Review of Biophysics

Reversible Compartmentalization of de Novo Purine Biosynthetic Complexes in Living Cells

(2008) S. An et al.   SCIENCE