Design and Synthesis of TRAP1 Selective Inhibitors: H-Bonding with Asn171 Residue in TRAP1 Increases Paralog Selectivity

The Mitochondrial Chaperone TRAP1 as a Candidate Target of Oncotherapy

(2021) Shulan Xie et al.   Frontiers in Oncology

Chemical Perturbation of Oncogenic Protein Folding: from the Prediction of Locally Unstable Structures to the Design of Disruptors of Hsp90‐Client Interactions

(2020) Giorgio Colombo et al.   CHEMISTRY-A EUROPEAN JOURNAL

Rational Design of Allosteric and Selective Inhibitors of the Molecular Chaperone TRAP1

(2020) Carlos Sanchez-Martin et al.   Cell Reports

Development of pyrazolo[3,4-d]pyrimidine-6-amine-based TRAP1 inhibitors that demonstrate in vivo anticancer activity in mouse xenograft models

(2020) Darong Kim et al.   BIOORGANIC CHEMISTRY

Machine Learning of Allosteric Effects: The Analysis of Ligand-Induced Dynamics to Predict Functional Effects in TRAP1

(2020) Mariarosaria Ferraro et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Interplay between TRAP1 and sirtuin-3 modulates mitochondrial respiration and oxidative stress to maintain stemness of glioma stem cells

(2019) Hye-Kyung Park et al.   CANCER RESEARCH

The HSP90 Family: Structure, Regulation, Function, and Implications in Health and Disease

(2018) Abdullah Hoter et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Paralog Specificity Determines Subcellular Distribution, Action Mechanism, and Anticancer Activity of TRAP1 Inhibitors

(2017) Hye-Kyung Park et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Chaperone TRAP1 As a Modulator of the Mitochondrial Adaptations in Cancer Cells

(2017) Ionica Masgras et al.   Frontiers in Oncology

Development of a Mitochondria-Targeted Hsp90 Inhibitor Based on the Crystal Structures of Human TRAP1

(2015) Changwook Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

TRAP1 revisited: Novel localizations and functions of a ‘next-generation’ biomarker (Review)

(2014) MARIA ROSARIA AMOROSO et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Identification of Novel HSP90α/β Isoform Selective Inhibitors Using Structure-Based Drug Design. Demonstration of Potential Utility in Treating CNS Disorders such as Huntington’s Disease

(2014) Justin T. Ernst et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mitochondrial Hsp90s suppress calcium-mediated stress signals propagating from mitochondria to the ER in cancer cells

(2014) Hye-Kyung Park et al.   Molecular Cancer

Correlation between chemotype-dependent binding conformations of HSP90α/β and isoform selectivity—Implications for the structure-based design of HSP90α/β selective inhibitors for treating neurodegenerative diseases

(2013) Justin T. Ernst et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Experimental and Structural Testing Module to Analyze Paralogue-Specificity and Affinity in the Hsp90 Inhibitors Series

(2013) Tony Taldone et al.   JOURNAL OF MEDICINAL CHEMISTRY

Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2

(2013) Pallav D Patel et al.   Nature Chemical Biology

TRAP1 regulation of mitochondrial life or death decision in cancer cells and mitochondria-targeted TRAP1 inhibitors

(2012) Byoung-Heon Kang   BMB Reports

TRAP-1, the mitochondrial Hsp90

(2011) Dario C. Altieri et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Advances in the clinical development of heat shock protein 90 (Hsp90) inhibitors in cancers

(2011) Komal Jhaveri et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Conformational dynamics of the molecular chaperone Hsp90

(2011) Kristin A. Krukenberg et al.   QUARTERLY REVIEWS OF BIOPHYSICS

Mitochondrial Chaperone Trap1 and the Calcium Binding Protein Sorcin Interact and Protect Cells against Apoptosis Induced by Antiblastic Agents

(2010) M. Landriscina et al.   CANCER RESEARCH

BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90

(2009) K. Lundgren et al.   MOLECULAR CANCER THERAPEUTICS

Understanding ligand-based modulation of the Hsp90 molecular chaperone dynamics at atomic resolution

(2008) G. Colombo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA