Cancer Cells Tune the Signaling Pathways to Empower de Novo Synthesis of Nucleotides
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Cancer Cells Tune the Signaling Pathways to Empower de Novo Synthesis of Nucleotides
Authors
Keywords
-
Journal
Cancers
Volume 11, Issue 5, Pages 688
Publisher
MDPI AG
Online
2019-05-17
DOI
10.3390/cancers11050688
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Direct stimulation of NADP+ synthesis through Akt-mediated phosphorylation of NAD kinase
- (2019) Gerta Hoxhaj et al. SCIENCE
- Macrophage-Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer
- (2019) Christopher J. Halbrook et al. Cell Metabolism
- Increased Serine and One-Carbon Pathway Metabolism by PKCλ/ι Deficiency Promotes Neuroendocrine Prostate Cancer
- (2019) Miguel Reina-Campos et al. CANCER CELL
- Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers
- (2018) Fang Huang et al. Cell Metabolism
- NUFIP1 is a ribosome receptor for starvation-induced ribophagy
- (2018) Gregory A. Wyant et al. SCIENCE
- Small-Molecule Screen Identifies De Novo Nucleotide Synthesis as a Vulnerability of Cells Lacking SIRT3
- (2018) Karina N. Gonzalez Herrera et al. Cell Reports
- Urea Cycle Dysregulation Generates Clinically Relevant Genomic and Biochemical Signatures
- (2018) Joo Sang Lee et al. CELL
- Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells
- (2018) Martina Bajzikova et al. Cell Metabolism
- Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth
- (2018) Andrew G Cox et al. EMBO JOURNAL
- Revisiting the role of dihydroorotate dehydrogenase as a therapeutic target for cancer
- (2018) Joseph T. Madak et al. PHARMACOLOGY & THERAPEUTICS
- Oncogenic KRAS supports pancreatic cancer through regulation of nucleotide synthesis
- (2018) Naiara Santana-Codina et al. Nature Communications
- CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells
- (2017) Jiyeon Kim et al. NATURE
- Purine synthesis promotes maintenance of brain tumor initiating cells in glioma
- (2017) Xiuxing Wang et al. NATURE NEUROSCIENCE
- Global metabolic reprogramming of colorectal cancer occurs at adenoma stage and is induced by MYC
- (2017) Kiyotoshi Satoh et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Twenty-five years of mTOR: Uncovering the link from nutrients to growth
- (2017) David M. Sabatini PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Lysosomal cholesterol activates mTORC1 via an SLC38A9–Niemann-Pick C1 signaling complex
- (2017) Brian M. Castellano et al. SCIENCE
- A New View into the Regulation of Purine Metabolism: The Purinosome
- (2017) Anthony M. Pedley et al. TRENDS IN BIOCHEMICAL SCIENCES
- Conversion of PRPS Hexamer to Monomer by AMPK-Mediated Phosphorylation Inhibits Nucleotide Synthesis in Response to Energy Stress
- (2017) Xu Qian et al. Cancer Discovery
- PTEN Regulates Glutamine Flux to Pyrimidine Synthesis and Sensitivity to Dihydroorotate Dehydrogenase Inhibition
- (2017) Deepti Mathur et al. Cancer Discovery
- Adaptive Reprogramming of De Novo Pyrimidine Synthesis Is a Metabolic Vulnerability in Triple-Negative Breast Cancer
- (2017) Kristin K. Brown et al. Cancer Discovery
- The mTORC1 Signaling Network Senses Changes in Cellular Purine Nucleotide Levels
- (2017) Gerta Hoxhaj et al. Cell Reports
- Sequestration-Mediated Downregulation of de Novo Purine Biosynthesis by AMPK
- (2016) Danielle L. Schmitt et al. ACS Chemical Biology
- Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia
- (2016) David B. Sykes et al. CELL
- Drug target molecules to guide immunosuppression
- (2016) Stein Bergan et al. CLINICAL BIOCHEMISTRY
- NAD+ Kinase as a Therapeutic Target in Cancer
- (2016) P. M. Tedeschi et al. CLINICAL CANCER RESEARCH
- Phosphoribosyl Diphosphate (PRPP): Biosynthesis, Enzymology, Utilization, and Metabolic Significance
- (2016) Bjarne Hove-Jensen et al. MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
- LKB1 loss links serine metabolism to DNA methylation and tumorigenesis
- (2016) Filippos Kottakis et al. NATURE
- Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth
- (2016) Andrew G. Cox et al. NATURE CELL BIOLOGY
- Spatial colocalization and functional link of purinosomes with mitochondria
- (2016) J. B. French et al. SCIENCE
- mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle
- (2016) I. Ben-Sahra et al. SCIENCE
- The Ras/Raf/MEK/ERK signaling pathway and its role in the occurrence and development of HCC
- (2016) Lei Li et al. Oncology Letters
- Lysosomal recruitment of TSC2 is a universal response to cellular stress
- (2016) Constantinos Demetriades et al. Nature Communications
- Fundamentals of cancer metabolism
- (2016) R. J. DeBerardinis et al. Science Advances
- Tumor suppressor p53 and its mutants in cancer metabolism
- (2015) Juan Liu et al. CANCER LETTERS
- Pyruvate Kinase Isoform Expression Alters Nucleotide Synthesis to Impact Cell Proliferation
- (2015) Sophia Y. Lunt et al. MOLECULAR CELL
- Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis
- (2015) Shiran Rabinovich et al. NATURE
- Regulation of mammalian nucleotide metabolism and biosynthesis
- (2015) Andrew N. Lane et al. NUCLEIC ACIDS RESEARCH
- Regulation of mTORC1 by PI3K signaling
- (2015) Christian C. Dibble et al. TRENDS IN CELL BIOLOGY
- YAP and TAZ: a nexus for Hippo signaling and beyond
- (2015) Carsten Gram Hansen et al. TRENDS IN CELL BIOLOGY
- Regulation of nucleotide metabolism by mutant p53 contributes to its gain-of-function activities
- (2015) Madhusudhan Kollareddy et al. Nature Communications
- ATM Couples Replication Stress and Metabolic Reprogramming during Cellular Senescence
- (2015) Katherine M. Aird et al. Cell Reports
- Protein and Nucleotide Biosynthesis Are Coupled by a Single Rate-Limiting Enzyme, PRPS2, to Drive Cancer
- (2014) John T. Cunningham et al. CELL
- Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome
- (2014) Suchithra Menon et al. CELL
- Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells
- (2014) Sudha Mannava et al. CELL CYCLE
- Ribose-5-phosphate isomerase A regulates hepatocarcinogenesisviaPP2A and ERK signaling
- (2014) Shih-Ci Ciou et al. INTERNATIONAL JOURNAL OF CANCER
- Rheb Protein Binds CAD (Carbamoyl-phosphate Synthetase 2, Aspartate Transcarbamoylase, and Dihydroorotase) Protein in a GTP- and Effector Domain-dependent Manner and Influences Its Cellular Localization and Carbamoyl-phosphate Synthetase (CPSase) Activity
- (2014) Tatsuhiro Sato et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Akt Phosphorylation and Regulation of Transketolase Is a Nodal Point for Amino Acid Control of Purine Synthesis
- (2014) Arindam Saha et al. MOLECULAR CELL
- SAICAR Induces Protein Kinase Activity of PKM2 that Is Necessary for Sustained Proliferative Signaling of Cancer Cells
- (2014) Kirstie E. Keller et al. MOLECULAR CELL
- The Biology of YAP/TAZ: Hippo Signaling and Beyond
- (2014) Stefano Piccolo et al. PHYSIOLOGICAL REVIEWS
- p90RSKs mediate the activation of ribosomal RNA synthesis by the hypertrophic agonist phenylephrine in adult cardiomyocytes
- (2013) Ze Zhang et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Stimulation of de Novo Pyrimidine Synthesis by Growth Signaling Through mTOR and S6K1
- (2013) I. Ben-Sahra et al. SCIENCE
- Quantitative Phosphoproteomics Reveal mTORC1 Activates de Novo Pyrimidine Synthesis
- (2013) A. M. Robitaille et al. SCIENCE
- DCK is frequently inactivated in acquired gemcitabine-resistant human cancer cells
- (2012) Yuriko Saiki et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- MYC on the Path to Cancer
- (2012) Chi V. Dang CELL
- Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism
- (2012) Haoqiang Ying et al. CELL
- Targeting the PI3K pathway for cancer therapy
- (2012) Navid Sadeghi et al. Future Medicinal Chemistry
- TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1
- (2012) Christian C. Dibble et al. MOLECULAR CELL
- Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation
- (2012) J. Ye et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation
- (2011) Sophia Y. Lunt et al. Annual Review of Cell and Developmental Biology
- GTP depletion synergizes the anti-proliferative activity of chemotherapeutic agents in a cell type-dependent manner
- (2011) Tao Lin et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth
- (2011) D. Gaglio et al. Molecular Systems Biology
- DHODH modulates transcriptional elongation in the neural crest and melanoma
- (2011) Richard Mark White et al. NATURE
- A Gene Expression Signature Associated with “K-Ras Addiction” Reveals Regulators of EMT and Tumor Cell Survival
- (2009) Anurag Singh et al. CANCER CELL
- Enzymology of Purine and Pyrimidine Antimetabolites Used in the Treatment of Cancer
- (2009) William B. Parker CHEMICAL REVIEWS
- Mizoribine: A New Approach in the Treatment of Renal Disease
- (2009) Yukihiko Kawasaki Clinical & Developmental Immunology
- The molecular determinants of de novo nucleotide biosynthesis in cancer cells
- (2009) Xuemei Tong et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
- Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
- (2009) M. G. Vander Heiden et al. SCIENCE
- Is cancer a disease of abnormal cellular metabolism? New angles on an old idea
- (2008) Ralph J Deberardinis GENETICS IN MEDICINE
- The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
- (2008) Heather R. Christofk et al. NATURE
- Global Regulation of Nucleotide Biosynthetic Genes by c-Myc
- (2008) Yen-Chun Liu et al. PLoS One
- Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
- (2008) D. R. Wise et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search