Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains

The landscape of molecular chaperones across human tissues reveals a layered architecture of core and variable chaperones

(2021) Netta Shemesh et al.   Nature Communications

A reference map of the human binary protein interactome

(2020) Katja Luck et al.   NATURE

Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions

(2020) Paul M. Müller et al.   NATURE CELL BIOLOGY

A Genetic Map of the Response to DNA Damage in Human Cells

(2020) Michele Olivieri et al.   CELL

Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases

(2020) Marija Buljan et al.   MOLECULAR CELL

Expanded encyclopaedias of DNA elements in the human and mouse genomes

(2020) Jill E. Moore et al.   NATURE

Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells

(2020) Seung W. Ryu et al.   PLOS BIOLOGY

A High-Density Human Mitochondrial Proximity Interaction Network

(2020) Hana Antonicka et al.   Cell Metabolism

Zika Virus Dependence on Host Hsp70 Provides a Protective Strategy against Infection and Disease

(2019) Shuhei Taguwa et al.   Cell Reports

g:Profiler: a web server for functional enrichment analysis and conversions of gene lists (2019 update)

(2019) Uku Raudvere et al.   NUCLEIC ACIDS RESEARCH

An acquired scaffolding function of the DNAJ-PKAc fusion contributes to oncogenic signaling in fibrolamellar carcinoma

(2019) Rigney E Turnham et al.   eLife

Spatial and proteomic profiling reveals centrosome‐independent features of centriolar satellites

(2019) Ladan Gheiratmand et al.   EMBO JOURNAL

The Hsp70 chaperone network

(2019) Rina Rosenzweig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Peak calling by Sparse Enrichment Analysis for CUT&RUN chromatin profiling

(2019) Michael P. Meers et al.   Epigenetics & Chromatin

Hsp70 at the membrane: driving protein translocation

(2018) Elizabeth A. Craig   BMC BIOLOGY

Exploration of Benzothiazole Rhodacyanines as Allosteric Inhibitors of Protein–Protein Interactions with Heat Shock Protein 70 (Hsp70)

(2018) Hao Shao et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Screen for Epstein-Barr Virus Proteins That Inhibit the DNA Damage Response Reveals a Novel Histone Binding Protein

(2018) Ting-Hin Ho et al.   JOURNAL OF VIROLOGY

Molecular Mechanism of J-Domain-Triggered ATP Hydrolysis by Hsp70 Chaperones

(2018) Roman Kityk et al.   MOLECULAR CELL

High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies

(2018) Ji-Young Youn et al.   MOLECULAR CELL

DNAJC17 is localized in nuclear speckles and interacts with splicing machinery components

(2018) A. Pascarella et al.   Scientific Reports

Interrogation of Mammalian Protein Complex Structure, Function, and Membership Using Genome-Scale Fitness Screens

(2018) Joshua Pan et al.   Cell Systems

H3–H4 Histone Chaperone Pathways

(2018) Prerna Grover et al.   Annual Review of Genetics

Co-evolution of spliceosomal disassembly interologs: crowning J-protein component with moonlighting RNA-binding activity

(2018) S. Raut et al.   CURRENT GENETICS

ChIP‐Atlas: a data‐mining suite powered by full integration of public ChIP‐seq data

(2018) Shinya Oki et al.   EMBO REPORTS

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains

(2018) Jean-Philippe Lambert et al.   MOLECULAR CELL

IID 2018 update: context-specific physical protein–protein interactions in human, model organisms and domesticated species

(2018) Max Kotlyar et al.   NUCLEIC ACIDS RESEARCH

The BioGRID interaction database: 2019 update

(2018) Rose Oughtred et al.   NUCLEIC ACIDS RESEARCH

Computational correction of copy number effect improves specificity of CRISPR–Cas9 essentiality screens in cancer cells

(2017) Robin M Meyers et al.   NATURE GENETICS

Genes and molecular pathways underpinning ciliopathies

(2017) Jeremy F. Reiter et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Two chaperones locked in an embrace: structure and function of the ribosome-associated complex RAC

(2017) Ying Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

How Do J-Proteins Get Hsp70 to Do So Many Different Things?

(2017) Elizabeth A. Craig et al.   TRENDS IN BIOCHEMICAL SCIENCES

Two chaperones locked in an embrace: structure and function of the ribosome-associated complex RAC

(2017) Ying Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Features of the Chaperone Cellular Network Revealed through Systematic Interaction Mapping

(2017) Kamran Rizzolo et al.   Cell Reports

Evolution of an intricate J-protein network driving protein disaggregation in eukaryotes

(2017) Nadinath B Nillegoda et al.   eLife

An efficient targeted nuclease strategy for high-resolution mapping of DNA binding sites

(2017) Peter J Skene et al.   eLife

Mutations in DNAJB13 , Encoding an HSP40 Family Member, Cause Primary Ciliary Dyskinesia and Male Infertility

(2016) Elma El Khouri et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Regulation of centriolar satellite integrity and its physiology

(2016) Akiko Hori et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Data Independent Acquisition analysis in ProHits 4.0

(2016) Guomin Liu et al.   Journal of Proteomics

deepTools2: a next generation web server for deep-sequencing data analysis

(2016) Fidel Ramírez et al.   NUCLEIC ACIDS RESEARCH

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators

(2016) Nicole St-Denis et al.   Cell Reports

The Biology of Proteostasis in Aging and Disease

(2015) Johnathan Labbadia et al.   Annual Review of Biochemistry

Targeting Cullin–RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation

(2015) Emil Bulatov et al.   BIOCHEMICAL JOURNAL

RBBP4 Regulates Histone Deacetylation and Bipolar Spindle Assembly During Oocyte Maturation in the Mouse1

(2015) Ahmed Z. Balboula et al.   BIOLOGY OF REPRODUCTION

A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface

(2015) Gagan D. Gupta et al.   CELL

Defining Hsp70 Subnetworks in Dengue Virus Replication Reveals Key Vulnerability in Flavivirus Infection

(2015) Shuhei Taguwa et al.   CELL

Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes

(2015) Jean-Philippe Lambert et al.   Journal of Proteomics

Crucial HSP70 co-chaperone complex unlocks metazoan protein disaggregation

(2015) Nadinath B. Nillegoda et al.   NATURE

Systematic proteomics of the VCP–UBXD adaptor network identifies a role for UBXN10 in regulating ciliogenesis

(2015) Malavika Raman et al.   NATURE CELL BIOLOGY

MSPLIT-DIA: sensitive peptide identification for data-independent acquisition

(2015) Jian Wang et al.   NATURE METHODS

Small GTPase RBJ Mediates Nuclear Entrapment of MEK1/MEK2 in Tumor Progression

(2014) Taoyong Chen et al.   CANCER CELL

Expansion of Biological Pathways Based on Evolutionary Inference

(2014) Yang Li et al.   CELL

A Quantitative Chaperone Interaction Network Reveals the Architecture of Cellular Protein Homeostasis Pathways

(2014) Mikko Taipale et al.   CELL

DNAJC19, a Mitochondrial Cochaperone Associated with Cardiomyopathy, Forms a Complex with Prohibitins to Regulate Cardiolipin Remodeling

(2014) Ricarda Richter-Dennerlein et al.   Cell Metabolism

An atlas of active enhancers across human cell types and tissues

(2014) Robin Andersson et al.   NATURE

Nucleosomal regulation of chromatin composition and nuclear assembly revealed by histone depletion

(2014) Christian Zierhut et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Splicing Mutation in the Novel Mitochondrial Protein DNAJC11 Causes Motor Neuron Pathology Associated with Cristae Disorganization, and Lymphoid Abnormalities in Mice

(2014) Fotis Ioakeimidis et al.   PLoS One

Molecular Structure, Function, and Dynamics of Clathrin-Mediated Membrane Traffic

(2014) T. Kirchhausen et al.   Cold Spring Harbor Perspectives in Biology

Tousled-like kinases phosphorylate Asf1 to promote histone supply during DNA replication

(2014) Ilnaz M. Klimovskaia et al.   Nature Communications

CrossMap: a versatile tool for coordinate conversion between genome assemblies

(2013) Hao Zhao et al.   BIOINFORMATICS

The Cotranslational Function of Ribosome-Associated Hsp70 in Eukaryotic Protein Homeostasis

(2013) Felix Willmund et al.   CELL

Histone variant H3.3 maintains a decondensed chromatin state essential for mouse preimplantation development

(2013) C.-J. Lin et al.   DEVELOPMENT

SAINTexpress: Improvements and additional features in Significance Analysis of INTeractome software

(2013) Guoci Teo et al.   Journal of Proteomics

The CRAPome: a contaminant repository for affinity purification–mass spectrometry data

(2013) Dattatreya Mellacheruvu et al.   NATURE METHODS

Diversity in the origins of proteostasis networks — a driver for protein function in evolution

(2013) Evan T. Powers et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Protein Interaction Network of the Mammalian Hippo Pathway Reveals Mechanisms of Kinase-Phosphatase Interactions

(2013) A. L. Couzens et al.   Science Signaling

Placing the HIRA Histone Chaperone Complex in the Chromatin Landscape

(2013) Nikolay A. Pchelintsev et al.   Cell Reports

Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition

(2012) Mikko Taipale et al.   CELL

Codanin-1, mutated in the anaemic disease CDAI, regulates Asf1 function in S-phase histone supply

(2012) Katrine Ask et al.   EMBO JOURNAL

A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells

(2012) Kyle J. Roux et al.   JOURNAL OF CELL BIOLOGY

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

Rbg1–Tma46 dimer structure reveals new functional domains and their role in polysome recruitment

(2012) Sandrea M. Francis et al.   NUCLEIC ACIDS RESEARCH

Comet: An open-source MS/MS sequence database search tool

(2012) Jimmy K. Eng et al.   PROTEOMICS

Sequential Establishment of Marks on Soluble Histones H3 and H4

(2011) Francisca Alvarez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

iProphet: Multi-level Integrative Analysis of Shotgun Proteomic Data Improves Peptide and Protein Identification Rates and Error Estimates

(2011) David Shteynberg et al.   MOLECULAR & CELLULAR PROTEOMICS

Human CABIN1 Is a Functional Member of the Human HIRA/UBN1/ASF1a Histone H3.3 Chaperone Complex

(2011) T. S. Rai et al.   MOLECULAR AND CELLULAR BIOLOGY

A Specific Function for the Histone Chaperone NASP to Fine-Tune a Reservoir of Soluble H3-H4 in the Histone Supply Chain

(2011) Adam J.L. Cook et al.   MOLECULAR CELL

Defining human ERAD networks through an integrative mapping strategy

(2011) John C. Christianson et al.   NATURE CELL BIOLOGY

The Generating Function of CID, ETD, and CID/ETD Pairs of Tandem Mass Spectra: Applications to Database Search

(2010) Sangtae Kim et al.   MOLECULAR & CELLULAR PROTEOMICS

A DNAJB Chaperone Subfamily with HDAC-Dependent Activities Suppresses Toxic Protein Aggregation

(2010) Jurre Hageman et al.   MOLECULAR CELL

HSP90 at the hub of protein homeostasis: emerging mechanistic insights

(2010) Mikko Taipale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The HSP70 chaperone machinery: J proteins as drivers of functional specificity

(2010) Harm H. Kampinga et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The program for processing newly synthesized histones H3.1 and H4

(2010) Eric I Campos et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The highly conserved eukaryotic DRG factors are required for efficient translation in a manner redundant with the putative RNA helicase Slh1

(2010) Marie-Claire Daugeron et al.   NUCLEIC ACIDS RESEARCH

A Global Protein Kinase and Phosphatase Interaction Network in Yeast

(2010) A. Breitkreutz et al.   SCIENCE

Defining the Human Deubiquitinating Enzyme Interaction Landscape

(2009) Mathew E. Sowa et al.   CELL

Saccharomyces cerevisiaeRbg1 Protein and Its Binding Partner Gir2 Interact on Polyribosomes with Gcn1

(2009) P. K. Wout et al.   EUKARYOTIC CELL

The RJL family of small GTPases is an ancient eukaryotic invention probably functionally associated with the flagellar apparatus

(2009) Marek Elias et al.   GENE

Novel Adenosine-Derived Inhibitors of 70 kDa Heat Shock Protein, Discovered Through Structure-Based Design†

(2009) Douglas S. Williamson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cwc23, an Essential J Protein Critical for Pre-mRNA Splicing with a Dispensable J Domain

(2009) C. Sahi et al.   MOLECULAR AND CELLULAR BIOLOGY

Dimeric heat shock protein 40 binds radial spokes for generating coupled power strokes and recovery strokes of 9 + 2 flagella

(2008) Chun Yang et al.   JOURNAL OF CELL BIOLOGY

Diphthamide modification of eEF2 requires a J-domain protein and is essential for normal development

(2008) T. R. Webb et al.   JOURNAL OF CELL SCIENCE

Defining the TRiC/CCT interactome links chaperonin function to stabilization of newly made proteins with complex topologies

(2008) Alice Y Yam et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY