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Title
TRAP1 Chaperones the Metabolic Switch in Cancer
Authors
Keywords
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Journal
Biomolecules
Volume 12, Issue 6, Pages 786
Publisher
MDPI AG
Online
2022-06-04
DOI
10.3390/biom12060786
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Note: Only part of the references are listed.- Enhanced Expression of TRAP1 Protects Mitochondrial Function in Motor Neurons under Conditions of Oxidative Stress
- (2022) Benjamin E. Clarke et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Mitoquinone Helps Combat the Neurological, Cognitive, and Molecular Consequences of Open Head Traumatic Brain Injury at Chronic Time Point
- (2022) Muhammad Ali Haidar et al. Biomedicines
- Antitumor Activity of a Mitochondrial-Targeted HSP90 Inhibitor in Gliomas
- (2022) Shiyou Wei et al. CLINICAL CANCER RESEARCH
- Advances towards Understanding the Mechanism of Action of the Hsp90 Complex
- (2022) Chrisostomos Prodromou et al. Biomolecules
- Plasma Hsp90 levels in patients with systemic sclerosis and relation to lung and skin involvement: a cross-sectional and longitudinal study
- (2021) Hana Štorkánová et al. Scientific Reports
- The Mitochondrial Chaperone TRAP1 as a Candidate Target of Oncotherapy
- (2021) Shulan Xie et al. Frontiers in Oncology
- Targeting the mitochondrial chaperone TRAP1: strategies and therapeutic perspectives
- (2021) Stefano A. Serapian et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- The extensive and functionally uncharacterized mitochondrial phosphoproteome
- (2021) Natalie M. Niemi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The tumor suppressor folliculin inhibits lactate dehydrogenase A and regulates the Warburg effect
- (2021) Mark R. Woodford et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- The molecular chaperone TRAP1 in cancer: From the basics of biology to pharmacological targeting
- (2021) Ionica Masgras et al. SEMINARS IN CANCER BIOLOGY
- Cell cycle on the crossroad of tumorigenesis and cancer therapy
- (2021) Jing Liu et al. TRENDS IN CELL BIOLOGY
- Suppressing TRAP1 sensitizes glioblastoma multiforme cells to temozolomide
- (2021) Nan Wang et al. Experimental and Therapeutic Medicine
- Defining the molecular mechanisms of the mitochondrial permeability transition through genetic manipulation of F-ATP synthase
- (2021) Andrea Carrer et al. Nature Communications
- Atomistic Simulations of the Mechanisms of the Poorly Catalytic Mitochondrial Chaperone Trap1: Insights into the Effects of Structural Asymmetry on Reactivity
- (2021) Stefano A. Serapian et al. ACS Catalysis
- Mitoquinone Inactivates Mitochondrial Chaperone TRAP1 by Blocking the Client Binding Site
- (2021) Nam Gu Yoon et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Targeting cancer metabolism in the era of precision oncology
- (2021) Zachary E. Stine et al. NATURE REVIEWS DRUG DISCOVERY
- TRAP1 in Oxidative Stress and Neurodegeneration
- (2021) Inês Ramos Rego et al. Antioxidants
- Mutations in Hsp90 Cochaperones Result in a Wide Variety of Human Disorders
- (2021) Jill L. Johnson Frontiers in Molecular Biosciences
- TRAP1 inhibits MIC60 ubiquitination to mitigate the injury of cardiomyocytes and protect mitochondria in extracellular acidosis
- (2021) Lingxiao Zhang et al. Cell Death Discovery
- S-nitrosylation affects TRAP1 structure and ATPase activity and modulates cell response to apoptotic stimuli
- (2020) Fiorella Faienza et al. BIOCHEMICAL PHARMACOLOGY
- The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in mitochondrial metabolic homeostasis
- (2020) Abhinav Joshi et al. BMC BIOLOGY
- Dual Binding to Orthosteric and Allosteric Sites Enhances the Anticancer Activity of a TRAP1-Targeting Drug
- (2020) Sung Hu et al. JOURNAL OF MEDICINAL CHEMISTRY
- Mitochondrial TCA cycle metabolites control physiology and disease
- (2020) Inmaculada Martínez-Reyes et al. Nature Communications
- Honokiol bis-dichloroacetate is a selective allosteric inhibitor of the mitochondrial chaperone TRAP1
- (2020) Carlos Sanchez-Martin et al. ANTIOXIDANTS & REDOX SIGNALING
- Rational Design of Allosteric and Selective Inhibitors of the Molecular Chaperone TRAP1
- (2020) Carlos Sanchez-Martin et al. Cell Reports
- Post-translational modifications of Hsp90 and translating the chaperone code
- (2020) Sarah J. Backe et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Inhibition of HDAC1/2 Along with TRAP1 Causes Synthetic Lethality in Glioblastoma Model Systems
- (2020) Trang T. T. Nguyen et al. Cells
- The mitochondrial permeability transition pore: Is it formed by the ATP synthase, adenine nucleotide translocators or both?
- (2020) Christopher P. Baines et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
- Alzheimer Cells on Their Way to Derailment Show Selective Changes in Protein Quality Control Network
- (2020) Margreet B. Koopman et al. Frontiers in Molecular Biosciences
- Analysis of serum Hsp90 as a potential biomarker of β cell autoimmunity in type 1 diabetes
- (2019) Gail J. Ocaña et al. PLoS One
- Interplay between TRAP1 and sirtuin-3 modulates mitochondrial respiration and oxidative stress to maintain stemness of glioma stem cells
- (2019) Hye-Kyung Park et al. CANCER RESEARCH
- Myc-mediated transcriptional regulation of the mitochondrial chaperone TRAP1 controls primary and metastatic tumor growth
- (2019) Ekta Agarwal et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Metabolic Basis of Kidney Cancer
- (2019) W. Marston Linehan et al. Cancer Discovery
- Activation of LXR Receptors and Inhibition of TRAP1 Causes Synthetic Lethality in Solid Tumors
- (2019) Trang Thi Thu Nguyen et al. Cancers
- The interplay between redox signalling and proteostasis in neurodegeneration: In vivo effects of a mitochondria-targeted antioxidant in Huntington's disease mice
- (2019) Brígida R. Pinho et al. FREE RADICAL BIOLOGY AND MEDICINE
- Mitochondrial chaperone, TRAP1 as a potential pharmacological target to combat cancer metabolism
- (2019) Balaji Ramkumar et al. MITOCHONDRION
- Protein S-Nitrosylation: Determinants of Specificity and Enzymatic Regulation of S-Nitrosothiol-Based Signaling
- (2018) Colin T. Stomberski et al. ANTIOXIDANTS & REDOX SIGNALING
- Structure of the intact 14-subunit human cytochrome c oxidase
- (2018) Shuai Zong et al. CELL RESEARCH
- Calcium binding to a remote site can replace magnesium as cofactor for mitochondrial Hsp90 (TRAP1) ATPase activity
- (2018) Daniel Elnatan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Structural Asymmetry of Mitochondrial Hsp90 (Trap1) Determines Fine Tuning of Functional Dynamics
- (2018) Elisabetta Moroni et al. Journal of Chemical Theory and Computation
- Different approaches to modeling analysis of mitochondrial swelling
- (2018) Sabzali Javadov et al. MITOCHONDRION
- Metabolic Plasticity of Tumor Cell Mitochondria
- (2018) Giuseppe Cannino et al. Frontiers in Oncology
- TRAP1 controls cell cycle G2-M transition through the regulation of CDK1 and MAD2 expression/ubiquitination
- (2017) Lorenza Sisinni et al. JOURNAL OF PATHOLOGY
- The Plasticity of the Hsp90 Co-chaperone System
- (2017) Priyanka Sahasrabudhe et al. MOLECULAR CELL
- The HSP90 chaperone machinery
- (2017) Florian H. Schopf et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Mitochondrial Complex II: At the Crossroads
- (2017) Ayenachew Bezawork-Geleta et al. TRENDS IN BIOCHEMICAL SCIENCES
- An Hsp90 co-chaperone protein in yeast is functionally replaced by site-specific posttranslational modification in humans
- (2017) Abbey D. Zuehlke et al. Nature Communications
- Mitochondrial targeted HSP90 inhibitor Gamitrinib-TPP (G-TPP) induces PINK1/Parkin-dependent mitophagy
- (2017) Fabienne C. Fiesel et al. Oncotarget
- A Mitochondrial-targeted purine-based HSP90 antagonist for leukemia therapy
- (2017) Kelly G. Bryant et al. Oncotarget
- Cytosolic Hsp90α and its mitochondrial isoform Trap1 are differentially required in a breast cancer model
- (2017) Evangelia Vartholomaiou et al. Oncotarget
- Absence of Neurofibromin Induces an Oncogenic Metabolic Switch via Mitochondrial ERK-Mediated Phosphorylation of the Chaperone TRAP1
- (2017) Ionica Masgras et al. Cell Reports
- Symmetry broken and rebroken during the ATP hydrolysis cycle of the mitochondrial Hsp90 TRAP1
- (2017) Daniel Elnatan et al. eLife
- Plasma Heat Shock Protein 90alpha as a Biomarker for the Diagnosis of Liver Cancer: An Official, Large-scale, and Multicenter Clinical Trial
- (2017) Yan Fu et al. EBioMedicine
- The Chaperone TRAP1 As a Modulator of the Mitochondrial Adaptations in Cancer Cells
- (2017) Ionica Masgras et al. Frontiers in Oncology
- Activation of apoptosis signalling pathways by reactive oxygen species
- (2016) Maureen Redza-Dutordoir et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- S -nitrosylation of the Mitochondrial Chaperone TRAP1 Sensitizes Hepatocellular Carcinoma Cells to Inhibitors of Succinate Dehydrogenase
- (2016) Salvatore Rizza et al. CANCER RESEARCH
- Mitochondrial Sirtuins in Cancer: Emerging Roles and Therapeutic Potential
- (2016) J. George et al. CANCER RESEARCH
- Role of mitochondrial dysfunction in cancer progression
- (2016) Chia-Chi Hsu et al. EXPERIMENTAL BIOLOGY AND MEDICINE
- Tumor necrosis factor receptor-associated protein 1 improves hypoxia-impaired energy production in cardiomyocytes through increasing activity of cytochrome c oxidase subunit II
- (2016) Fei Xiang et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Transgenic Expression of the Mitochondrial Chaperone TNFR-associated Protein 1 (TRAP1) Accelerates Prostate Cancer Development
- (2016) Sofia Lisanti et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A Novel In Vitro CypD-Mediated p53 Aggregation Assay Suggests a Model for Mitochondrial Permeability Transition by Chaperone Systems
- (2016) Ivan Lebedev et al. JOURNAL OF MOLECULAR BIOLOGY
- Metabolic reprogramming identifies the most aggressive lesions at early phases of hepatic carcinogenesis
- (2016) Marta Anna Kowalik et al. Oncotarget
- Calcium and mitochondria in the regulation of cell death
- (2015) Sten Orrenius et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Tumor Necrosis Factor Receptor-associated Protein 1 (TRAP1) Mutation and TRAP1 Inhibitor Gamitrinib-triphenylphosphonium (G-TPP) Induce a Forkhead Box O (FOXO)-dependent Cell Protective Signal from Mitochondria
- (2015) Hyunjin Kim et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Development of a Mitochondria-Targeted Hsp90 Inhibitor Based on the Crystal Structures of Human TRAP1
- (2015) Changwook Lee et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Hsp90: Breaking the Symmetry
- (2015) Matthias P. Mayer et al. MOLECULAR CELL
- The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in Signal Transduction, and Role in Pathophysiology
- (2015) Paolo Bernardi et al. PHYSIOLOGICAL REVIEWS
- Aberrantly upregulated TRAP1 is required for tumorigenesis of breast cancer
- (2015) Bo Zhang et al. Oncotarget
- Targeting TRAP1 as a downstream effector of BRAF cytoprotective pathway: a novel strategy for human BRAF-driven colorectal carcinoma
- (2015) Valentina Condelli et al. Oncotarget
- A Hyperactive Signalosome in Acute Myeloid Leukemia Drives Addiction to a Tumor-Specific Hsp90 Species
- (2015) Hongliang Zong et al. Cell Reports
- MICOS coordinates with respiratory complexes and lipids to establish mitochondrial inner membrane architecture
- (2015) Jonathan R Friedman et al. eLife
- Inhibition of succinate dehydrogenase by the mitochondrial chaperone TRAP1 has anti-oxidant and anti-apoptotic effects on tumor cells
- (2015) Giulia Guzzo et al. Oncotarget
- Citrate – new functions for an old metabolite
- (2014) Vito Iacobazzi et al. BIOLOGICAL CHEMISTRY
- Combination treatment with doxorubicin and gamitrinib synergistically augments anticancer activity through enhanced activation of Bim
- (2014) Hye-Kyung Park et al. BMC CANCER
- Neuroprotective effects of the mitochondria-targeted antioxidant MitoQ in a model of inherited amyotrophic lateral sclerosis
- (2014) Ernesto Miquel et al. FREE RADICAL BIOLOGY AND MEDICINE
- Asymmetric Hsp90 N Domain SUMOylation Recruits Aha1 and ATP-Competitive Inhibitors
- (2014) Mehdi Mollapour et al. MOLECULAR CELL
- Structural Asymmetry in the Closed State of Mitochondrial Hsp90 (TRAP1) Supports a Two-Step ATP Hydrolysis Mechanism
- (2014) Laura A. Lavery et al. MOLECULAR CELL
- PhosphoSitePlus, 2014: mutations, PTMs and recalibrations
- (2014) Peter V. Hornbeck et al. NUCLEIC ACIDS RESEARCH
- Mitochondrial oxidative phosphorylation TRAP(1)ped in tumor cells
- (2014) Andrea Rasola et al. TRENDS IN CELL BIOLOGY
- Chaperoning mitochondrial permeability transition: regulation of transition pore complex by a J-protein, DnaJC15
- (2014) D Sinha et al. Cell Death & Disease
- Deletion of the Mitochondrial Chaperone TRAP-1 Uncovers Global Reprogramming of Metabolic Networks
- (2014) Sofia Lisanti et al. Cell Reports
- A novel N-terminal extension in mitochondrial TRAP1 serves as a thermal regulator of chaperone activity
- (2014) James R Partridge et al. eLife
- Regulation of molecular chaperones through post-translational modifications: Decrypting the chaperone code
- (2013) Philippe Cloutier et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- PINK1 protects against cell death induced by mitochondrial depolarization, by phosphorylating Bcl-xL and impairing its pro-apoptotic cleavage
- (2013) G Arena et al. CELL DEATH AND DIFFERENTIATION
- The Mitochondrial Chaperone TRAP1 Promotes Neoplastic Growth by Inhibiting Succinate Dehydrogenase
- (2013) Marco Sciacovelli et al. Cell Metabolism
- TRAP1 rescues PINK1 loss-of-function phenotypes
- (2013) Li Zhang et al. HUMAN MOLECULAR GENETICS
- Metabolic stress regulates cytoskeletal dynamics and metastasis of cancer cells
- (2013) M. Cecilia Caino et al. JOURNAL OF CLINICAL INVESTIGATION
- Whole-exome resequencing reveals recessive mutations in TRAP1 in individuals with CAKUT and VACTERL association
- (2013) Pawaree Saisawat et al. KIDNEY INTERNATIONAL
- Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis
- (2013) S. Yoshida et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Dimers of mitochondrial ATP synthase form the permeability transition pore
- (2013) V. Giorgio et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Drosophila Trap1 protects against mitochondrial dysfunction in a PINK1/parkin model of Parkinson’s disease
- (2013) A C Costa et al. Cell Death & Disease
- Landscape of the mitochondrial Hsp90 metabolome in tumours
- (2013) Young Chan Chae et al. Nature Communications
- Sorcin modulates mitochondrial Ca2+ handling and reduces apoptosis in neonatal rat cardiac myocytes
- (2012) Jorge Suarez et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Mitochondrial c-Src regulates cell survival through phosphorylation of respiratory chain components
- (2012) Masato Ogura et al. BIOCHEMICAL JOURNAL
- Control of Tumor Bioenergetics and Survival Stress Signaling by Mitochondrial HSP90s
- (2012) Young Chan Chae et al. CANCER CELL
- The Therapeutic Target Hsp90 and Cancer Hallmarks
- (2012) Yoshihiko Miyata et al. CURRENT PHARMACEUTICAL DESIGN
- TRAP1 Controls Mitochondrial Fusion/Fission Balance through Drp1 and Mff Expression
- (2012) Hironori Takamura et al. PLoS One
- TRAP-1, the mitochondrial Hsp90
- (2011) Dario C. Altieri et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Targeted inhibition of mitochondrial Hsp90 suppresses localised and metastatic prostate cancer growth in a genetic mouse model of disease
- (2011) B H Kang et al. BRITISH JOURNAL OF CANCER
- Targeted deletion of GSNOR in hepatocytes of mice causes nitrosative inactivation of O6-alkylguanine-DNA alkyltransferase and increased sensitivity to genotoxic diethylnitrosamine
- (2011) Wei Wei et al. CARCINOGENESIS
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- TRAP1 and the proteasome regulatory particle TBP7/Rpt3 interact in the endoplasmic reticulum and control cellular ubiquitination of specific mitochondrial proteins
- (2011) M R Amoroso et al. CELL DEATH AND DIFFERENTIATION
- HSP75 protects against cardiac hypertrophy and fibrosis
- (2011) Yan Zhang et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- The Mitochondria-Targeted Antioxidant MitoQ Prevents Loss of Spatial Memory Retention and Early Neuropathology in a Transgenic Mouse Model of Alzheimer's Disease
- (2011) M. J. McManus et al. JOURNAL OF NEUROSCIENCE
- Mitochondrial Chaperone Trap1 and the Calcium Binding Protein Sorcin Interact and Protect Cells against Apoptosis Induced by Antiblastic Agents
- (2010) M. Landriscina et al. CANCER RESEARCH
- Heat Shock Protein 60 Regulation of the Mitochondrial Permeability Transition Pore in Tumor Cells
- (2010) J. C. Ghosh et al. CANCER RESEARCH
- Combined in Silico and Experimental Approach for Drug Design: The Binding Mode of Peptidic and Non-Peptidic Inhibitors to Hsp90 N-Terminal Domain
- (2010) Simona Tomaselli et al. Chemical Biology & Drug Design
- Preclinical Characterization of Mitochondria-Targeted Small Molecule Hsp90 Inhibitors, Gamitrinibs, in Advanced Prostate Cancer
- (2010) B. H. Kang et al. CLINICAL CANCER RESEARCH
- Asymmetric Activation of the Hsp90 Dimer by Its Cochaperone Aha1
- (2010) Marco Retzlaff et al. MOLECULAR CELL
- Cytoprotective Mitochondrial Chaperone TRAP-1 As a Novel Molecular Target in Localized and Metastatic Prostate Cancer
- (2009) Irwin Leav et al. AMERICAN JOURNAL OF PATHOLOGY
- TRAP1, a novel mitochondrial chaperone responsible for multi-drug resistance and protection from apoptotis in human colorectal carcinoma cells
- (2009) Eleonora Costantino et al. CANCER LETTERS
- HIF-1: upstream and downstream of cancer metabolism
- (2009) Gregg L Semenza CURRENT OPINION IN GENETICS & DEVELOPMENT
- Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90
- (2009) Byoung Heon Kang et al. JOURNAL OF CLINICAL INVESTIGATION
- Proteomic analysis of S-nitrosylation and denitrosylation by resin-assisted capture
- (2009) Michael T Forrester et al. NATURE BIOTECHNOLOGY
- Activation of mitochondrial ERK protects cancer cells from death through inhibition of the permeability transition
- (2009) A. Rasola et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
- (2009) M. G. Vander Heiden et al. SCIENCE
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