Clarifying the supercomplex: the higher-order organization of the mitochondrial electron transport chain

Supramolecular Organization of Respiratory Complexes

(2016) José Antonio Enríquez   Annual Review of Physiology

Complex I function in mitochondrial supercomplexes

(2016) Giorgio Lenaz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Structure of Mammalian Respiratory Supercomplex I 1 III 2 IV 1

(2016) Meng Wu et al.   CELL

Purification of Ovine Respiratory Complex I Results in a Highly Active and Stable Preparation

(2016) James A. Letts et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Mg2+-containing Water Cluster of Mammalian CytochromecOxidase Collects Four Pumping Proton Equivalents in Each Catalytic Cycle

(2016) Naomine Yano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of a Complete ATP Synthase Dimer Reveals the Molecular Basis of Inner Mitochondrial Membrane Morphology

(2016) Alexander Hahn et al.   MOLECULAR CELL

The architecture of respiratory supercomplexes

(2016) James A. Letts et al.   NATURE

The architecture of the mammalian respirasome

(2016) Jinke Gu et al.   NATURE

Mechanism of super-assembly of respiratory complexes III and IV

(2016) Sara Cogliati et al.   NATURE

Structure of mammalian respiratory complex I

(2016) Jiapeng Zhu et al.   NATURE

Atomic structure of the entire mammalian mitochondrial complex I

(2016) Karol Fiedorczuk et al.   NATURE

Accessory subunits are integral for assembly and function of human mitochondrial complex I

(2016) David A. Stroud et al.   NATURE

Complex I assembly into supercomplexes determines differential mitochondrial ROS production in neurons and astrocytes

(2016) Irene Lopez-Fabuel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systems proteomics of liver mitochondria function

(2016) E. G. Williams et al.   SCIENCE

The CoQH2/CoQ Ratio Serves as a Sensor of Respiratory Chain Efficiency

(2016) Adela Guarás et al.   Cell Reports

COX7A2L Is a Mitochondrial Complex III Binding Protein that Stabilizes the III2+IV Supercomplex without Affecting Respirasome Formation

(2016) Rafael Pérez-Pérez et al.   Cell Reports

Functional asymmetry and electron flow in the bovine respirasome

(2016) Joana S Sousa et al.   eLife

COX7A2L/SCAFI and Pre-Complex III Modify Respiratory Chain Supercomplex Formation in Different Mouse Strains with a Bcs1l Mutation

(2016) Mina Davoudi et al.   PLoS One

Purification of Active Respiratory Supercomplex from Bovine Heart Mitochondria Enables Functional Studies

(2015) Kyoko Shinzawa-Itoh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Horizontal membrane-intrinsic α-helices in the stator a-subunit of an F-type ATP synthase

(2015) Matteo Allegretti et al.   NATURE

Architecture of the mammalian mechanosensitive Piezo1 channel

(2015) Jingpeng Ge et al.   NATURE

A giant molecular proton pump: structure and mechanism of respiratory complex I

(2015) Leonid A. Sazanov   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Electronic Connection Between the Quinone and Cytochrome c Redox Pools and Its Role in Regulation of Mitochondrial Electron Transport and Redox Signaling

(2015) Marcin Sarewicz et al.   PHYSIOLOGICAL REVIEWS

Mechanistic insight from the crystal structure of mitochondrial complex I

(2015) V. Zickermann et al.   SCIENCE

ND3, ND1 and 39kDa subunits are more exposed in the de-active form of bovine mitochondrial complex I

(2014) Marion Babot et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The Respiratory Chain Supercomplex Organization Is Independent of COX7a2l Isoforms

(2014) Arnaud Mourier et al.   Cell Metabolism

Kinetic evidence against partitioning of the ubiquinone pool and the catalytic relevance of respiratory-chain supercomplexes

(2014) J. N. Blaza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Respiratory Supercomplex Association Limits Production of Reactive Oxygen Species from Complex I

(2013) Evelina Maranzana et al.   ANTIOXIDANTS & REDOX SIGNALING

Functional role of mitochondrial respiratory supercomplexes

(2013) Maria Luisa Genova et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

I Function, Therefore I Am: Overcoming Skepticism about Mitochondrial Supercomplexes

(2013) Antoni Barrientos et al.   Cell Metabolism

Cardiolipin-dependent formation of mitochondrial respiratory supercomplexes

(2013) Eugenia Mileykovskaya et al.   CHEMISTRY AND PHYSICS OF LIPIDS

TWINKLE is an essential mitochondrial helicase required for synthesis of nascent D-loop strands and complete mtDNA replication

(2013) D. Milenkovic et al.   HUMAN MOLECULAR GENETICS

MCJ/DnaJC15, an Endogenous Mitochondrial Repressor of the Respiratory Chain That Controls Metabolic Alterations

(2013) K. M. Hatle et al.   MOLECULAR AND CELLULAR BIOLOGY

Assembly factors for the membrane arm of human complex I

(2013) B. Andrews et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Supercomplex Assembly Determines Electron Flux in the Mitochondrial Electron Transport Chain

(2013) E. Lapuente-Brun et al.   SCIENCE

A stabilizing factor for mitochondrial respiratory supercomplex assembly regulates energy metabolism in muscle

(2013) Kazuhiro Ikeda et al.   Nature Communications

Structural analysis of cytochrome bc1 complexes: Implications to the mechanism of function

(2012) Di Xia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Identification of a Protein Mediating Respiratory Supercomplex Stability

(2012) Yu-Chan Chen et al.   Cell Metabolism

Mitochondrial Complex I Plays an Essential Role in Human Respirasome Assembly

(2012) David Moreno-Lastres et al.   Cell Metabolism

Rcf1 Mediates Cytochrome Oxidase Assembly and Respirasome Formation, Revealing Heterogeneity of the Enzyme Complex

(2012) Milena Vukotic et al.   Cell Metabolism

Arrangement of the Respiratory Chain Complexes inSaccharomyces cerevisiaeSupercomplex III2IV2Revealed by Single Particle Cryo-Electron Microscopy

(2012) Eugenia Mileykovskaya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rcf1 and Rcf2, Members of the Hypoxia-Induced Gene 1 Protein Family, Are Critical Components of the Mitochondrial Cytochrome bc1-Cytochrome c Oxidase Supercomplex

(2012) V. Strogolova et al.   MOLECULAR AND CELLULAR BIOLOGY

Arrangement of electron transport chain components in bovine mitochondrial supercomplex I1III2IV1

(2011) Thorsten Althoff et al.   EMBO JOURNAL

Altered dopamine metabolism and increased vulnerability to MPTP in mice with partial deficiency of mitochondrial complex I in dopamine neurons

(2011) F. H. Sterky et al.   HUMAN MOLECULAR GENETICS

Mitochondrial complex III stabilizes complex I in the absence of NDUFS4 to provide partial activity

(2011) M. A. Calvaruso et al.   HUMAN MOLECULAR GENETICS

The Mechanism of Superoxide Production by the Antimycin-inhibited Mitochondrial Q-cycle

(2011) Casey L. Quinlan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Superoxide Is Produced by the Reduced Flavin in Mitochondrial Complex I

(2011) Kenneth R. Pryde et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mice deleted for heart-type cytochrome c oxidase subunit 7a1 develop dilated cardiomyopathy

(2011) Maik Hüttemann et al.   MITOCHONDRION

Cells Lacking Rieske Iron-Sulfur Protein Have a Reactive Oxygen Species-Associated Decrease in Respiratory Complexes I and IV

(2011) F. Diaz et al.   MOLECULAR AND CELLULAR BIOLOGY

Interaction of complexes I, III, and IV within the bovine respirasome by single particle cryoelectron tomography

(2011) N. V. Dudkina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macromolecular organization of ATP synthase and complex I in whole mitochondria

(2011) K. M. Davies et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Questioning the functional relevance of mitochondrial supercomplexes by time-resolved analysis of the respiratory chain

(2011) M. Trouillard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolution of Respiratory Complex I

(2010) Chui-ying Yip et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Electronic Bus Bar Lies in the Core of Cytochrome bc1

(2010) M. Swierczek et al.   SCIENCE

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

The Q-cycle reviewed: How well does a monomeric mechanism of the bc1 complex account for the function of a dimeric complex?

(2008) Antony R. Crofts et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Respiratory Active Mitochondrial Supercomplexes

(2008) Rebeca Acín-Pérez et al.   MOLECULAR CELL