Liquid–liquid phase separation: a principal organizer of the cell’s biochemical activity architecture
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Title
Liquid–liquid phase separation: a principal organizer of the cell’s biochemical activity architecture
Authors
Keywords
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Journal
TRENDS IN PHARMACOLOGICAL SCIENCES
Volume 42, Issue 10, Pages 845-856
Publisher
Elsevier BV
Online
2021-08-07
DOI
10.1016/j.tips.2021.07.003
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Note: Only part of the references are listed.- cGAS phase separation inhibits TREX1-mediated DNA degradation and enhances cytosolic DNA sensing
- (2021) Wen Zhou et al. MOLECULAR CELL
- Biochemical Activity Architectures Visualized–Using Genetically Encoded Fluorescent Biosensors to Map the Spatial Boundaries of Signaling Compartments
- (2021) Sohum Mehta et al. ACCOUNTS OF CHEMICAL RESEARCH
- Kinase-mediated RAS signaling via membraneless cytoplasmic protein granules
- (2021) Asmin Tulpule et al. CELL
- Learning the molecular grammar of protein condensates from sequence determinants and embeddings
- (2021) Kadi L. Saar et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Physical Principles Underlying the Complex Biology of Intracellular Phase Transitions
- (2020) Jeong-Mo Choi et al. Annual Review of Biophysics
- Liquid-liquid phase separation and extracellular multivalent interactions in the tale of galectin-3
- (2020) Yi-Ping Chiu et al. Nature Communications
- Hypoxia Drives the Assembly of the Multi-Enzyme Purinosome Complex
- (2020) Cyrielle Doigneaux et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Phase separation directs ubiquitination of gene-body nucleosomes
- (2020) Laura D. Gallego et al. NATURE
- Phase separation of TAZ compartmentalizes the transcription machinery to promote gene expression
- (2020) Yi Lu et al. NATURE CELL BIOLOGY
- Metabolomics and mass spectrometry imaging reveal channeled de novo purine synthesis in cells
- (2020) Vidhi Pareek et al. SCIENCE
- Par complex cluster formation mediated by phase separation
- (2020) Ziheng Liu et al. Nature Communications
- GIT/PIX Condensates Are Modular and Ideal for Distinct Compartmentalized Cell Signaling
- (2020) Jinwei Zhu et al. MOLECULAR CELL
- Partitioning of cancer therapeutics in nuclear condensates
- (2020) Isaac A. Klein et al. SCIENCE
- Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and Oncogenic Signaling
- (2020) Jason Z. Zhang et al. CELL
- Optical Mapping of cAMP Signaling at the Nanometer Scale
- (2020) Andreas Bock et al. CELL
- SARS‐CoV‐2 nucleocapsid protein phase‐separates with RNA and with human hnRNPs
- (2020) Theodora Myrto Perdikari et al. EMBO JOURNAL
- Aberrant Phase Transitions: Side Effects and Novel Therapeutic Strategies in Human Disease
- (2019) Veronica Verdile et al. Frontiers in Genetics
- Structures of the PKA RIα Holoenzyme with the FLHCC Driver J-PKAcα or Wild-Type PKAcα
- (2019) Baohua Cao et al. STRUCTURE
- A molecular assembly phase transition and kinetic proofreading modulate Ras activation by SOS
- (2019) William Y. C. Huang et al. SCIENCE
- Stoichiometry controls activity of phase-separated clusters of actin signaling proteins
- (2019) Lindsay B. Case et al. SCIENCE
- Phase separation of ligand-activated enhancers licenses cooperative chromosomal enhancer assembly
- (2019) Sreejith J. Nair et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Optogenetic tools light up phase separation
- (2019) Lei Tang NATURE METHODS
- Matter over mind: Liquid phase separation and neurodegeneration
- (2019) Shana Elbaum-Garfinkle JOURNAL OF BIOLOGICAL CHEMISTRY
- Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates
- (2019) Simon Alberti et al. CELL
- Liquid–Liquid Phase Separation in Disease
- (2019) Simon Alberti et al. Annual Review of Genetics
- LLPSDB: a database of proteins undergoing liquid–liquid phase separation in vitro
- (2019) Qian Li et al. NUCLEIC ACIDS RESEARCH
- First-generation predictors of biological protein phase separation
- (2019) Robert M Vernon et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Phase separation of YAP reorganizes genome topology for long-term YAP target gene expression
- (2019) Danfeng Cai et al. NATURE CELL BIOLOGY
- Gas Cluster Ion Beams for Secondary Ion Mass Spectrometry
- (2018) Nicholas Winograd Annual Review of Analytical Chemistry
- Phase Transitions in the Assembly and Function of Human miRISC
- (2018) Jessica Sheu-Gruttadauria et al. CELL
- Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules
- (2018) Sebastian Markmiller et al. CELL
- A Molecular Grammar Governing the Driving Forces for Phase Separation of Prion-like RNA Binding Proteins
- (2018) Jie Wang et al. CELL
- Tau protein liquid–liquid phase separation can initiate tau aggregation
- (2018) Susanne Wegmann et al. EMBO JOURNAL
- A Liquid to Solid Phase Transition Underlying Pathological Huntingtin Exon1 Aggregation
- (2018) Thomas R. Peskett et al. MOLECULAR CELL
- Coactivator condensation at super-enhancers links phase separation and gene control
- (2018) Benjamin R. Sabari et al. SCIENCE
- Protein Phase Separation: A New Phase in Cell Biology
- (2018) Steven Boeynaems et al. TRENDS IN CELL BIOLOGY
- The role of dynamic enzyme assemblies and substrate channelling in metabolic regulation
- (2018) Lee J. Sweetlove et al. Nature Communications
- Reconsideration of Amyloid Hypothesis and Tau Hypothesis in Alzheimer's Disease
- (2018) Fuyuki Kametani et al. Frontiers in Neuroscience
- Methods for Physical Characterization of Phase-Separated Bodies and Membrane-less Organelles
- (2018) Diana M. Mitrea et al. JOURNAL OF MOLECULAR BIOLOGY
- Cancer Mutations of the Tumor Suppressor SPOP Disrupt the Formation of Active, Phase-Separated Compartments
- (2018) Jill J. Bouchard et al. MOLECULAR CELL
- Kinase-controlled phase transition of membraneless organelles in mitosis
- (2018) Arpan Kumar Rai et al. NATURE
- Mapping Local and Global Liquid Phase Behavior in Living Cells Using Photo-Oligomerizable Seeds
- (2018) Dan Bracha et al. CELL
- Genetically Encoded Fluorescent Biosensors Illuminate the Spatiotemporal Regulation of Signaling Networks
- (2018) Eric C. Greenwald et al. CHEMICAL REVIEWS
- Biomolecular condensates: organizers of cellular biochemistry
- (2017) Salman F. Banani et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Experimental and mathematical analysis of cAMP nanodomains
- (2017) Christian Lohse et al. PLoS One
- DNAJB1–PRKACAfusion kinase interacts with β-catenin and the liver regenerative response to drive fibrolamellar hepatocellular carcinoma
- (2017) Edward R. Kastenhuber et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A New View into the Regulation of Purine Metabolism: The Purinosome
- (2017) Anthony M. Pedley et al. TRENDS IN BIOCHEMICAL SCIENCES
- Mechanism of SOS PR-domain autoinhibition revealed by single-molecule assays on native protein from lysate
- (2017) Young Kwang Lee et al. Nature Communications
- Compositional Control of Phase-Separated Cellular Bodies
- (2016) Salman F. Banani et al. CELL
- Phase separation in biology; functional organization of a higher order
- (2016) Diana M. Mitrea et al. Cell Communication and Signaling
- Liquid–liquid phase separation in cellular signaling systems
- (2016) P Andrew Chong et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
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- (2016) Edward M Courchaine et al. EMBO JOURNAL
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- (2016) Dennis J Selkoe et al. EMBO Molecular Medicine
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- (2016) Melissa V. Gammons et al. MOLECULAR CELL
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- (2016) Kevin M. Riggle et al. PEDIATRIC RESEARCH
- A scalable strategy for high-throughput GFP tagging of endogenous human proteins
- (2016) Manuel D. Leonetti et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Phosphotyrosine-mediated LAT assembly on membranes drives kinetic bifurcation in recruitment dynamics of the Ras activator SOS
- (2016) William Y. C. Huang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Spatial colocalization and functional link of purinosomes with mitochondria
- (2016) J. B. French et al. SCIENCE
- Phase separation of signaling molecules promotes T cell receptor signal transduction
- (2016) Xiaolei Su et al. SCIENCE
- Versatile protein tagging in cells with split fluorescent protein
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- Phase Separation by Low Complexity Domains Promotes Stress Granule Assembly and Drives Pathological Fibrillization
- (2015) Amandine Molliex et al. CELL
- The Linker for Activation of T Cells (LAT) Signaling Hub: From Signaling Complexes to Microclusters
- (2015) Lakshmi Balagopalan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Phase Transition of a Disordered Nuage Protein Generates Environmentally Responsive Membraneless Organelles
- (2015) Timothy J. Nott et al. MOLECULAR CELL
- Structural insights into mis-regulation of protein kinase A in human tumors
- (2015) Jonah Cheung et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Liquid-Liquid Phase Separation in Biology
- (2014) Anthony A. Hyman et al. Annual Review of Cell and Developmental Biology
- Detection of a Recurrent DNAJB1-PRKACA Chimeric Transcript in Fibrolamellar Hepatocellular Carcinoma
- (2014) J. N. Honeyman et al. SCIENCE
- The purinosome, a multi-protein complex involved in the de novo biosynthesis of purines in humans
- (2013) Hong Zhao et al. CHEMICAL COMMUNICATIONS
- Mutational and expressional analyses ofSPOP, a candidate tumor suppressor gene, in prostate, gastric and colorectal cancers
- (2012) Min S. Kim et al. APMIS
- Phase transitions in the assembly of multivalent signalling proteins
- (2012) Pilong Li et al. NATURE
- How scaffolds shape MAPK signaling: what we know and opportunities for systems approaches
- (2012) Franziska Witzel et al. Frontiers in Physiology
- Engineering supported membranes for cell biology
- (2010) Cheng-han Yu et al. MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
- Fibrolamellar hepatocellular carcinoma – Prolonged survival with multimodality therapy
- (2009) V. Maniaci et al. EJSO
- The role of membrane microdomains in shaping β2-adrenergic receptor-mediated cAMP dynamics
- (2009) Lisa M. DiPilato et al. Molecular BioSystems
- Germline P Granules Are Liquid Droplets That Localize by Controlled Dissolution/Condensation
- (2009) C. P. Brangwynne et al. SCIENCE
- Reversible Compartmentalization of de Novo Purine Biosynthetic Complexes in Living Cells
- (2008) S. An et al. SCIENCE
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