Proteomic interrogation of HSP90 and insights for medical research

A chemical compound inhibiting the Aha1–Hsp90 chaperone complex

(2017) Sandrine C. Stiegler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novobiocin Analogs as Potential Anticancer Agents

(2017) Angelika Dlugosz et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

The HSP90 chaperone machinery

(2017) Florian H. Schopf et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

HSP90 stabilizes B-cell receptor kinases in a multi-client interactome: PU-H71 induces CLL apoptosis in a cytoprotective microenvironment

(2017) A Guo et al.   ONCOGENE

Hsp90 activator Aha1 drives production of pathological tau aggregates

(2017) Lindsey B. Shelton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Design and biological testing of peptidic dimerization inhibitors of human Hsp90 that target the C-terminal domain

(2016) Bertan Bopp et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Synthesis and Biological Evaluation of Novobiocin Core Analogues as Hsp90 Inhibitors

(2016) Katherine M. Byrd et al.   CHEMISTRY-A EUROPEAN JOURNAL

Reinventing Hsp90 Inhibitors: Blocking C-Terminal Binding Events to Hsp90 by Using Dimerized Inhibitors

(2016) Yen Chin Koay et al.   CHEMISTRY-A EUROPEAN JOURNAL

Development of Glucose Regulated Protein 94-Selective Inhibitors Based on the BnIm and Radamide Scaffold

(2016) Vincent M. Crowley et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mutational Analysis of Glycogen Synthase Kinase 3β Protein Kinase Together with Kinome-Wide Binding and Stability Studies Suggests Context-Dependent Recognition of Kinases by the Chaperone Heat Shock Protein 90

(2016) Jing Jin et al.   MOLECULAR AND CELLULAR BIOLOGY

The epichaperome is an integrated chaperome network that facilitates tumour survival

(2016) Anna Rodina et al.   NATURE

The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding

(2016) Mark R. Woodford et al.   Nature Communications

Mps1 Mediated Phosphorylation of Hsp90 Confers Renal Cell Carcinoma Sensitivity and Selectivity to Hsp90 Inhibitors

(2016) Mark R. Woodford et al.   Cell Reports

Combinatorial targeting of nuclear export and translation of RNA inhibits aggressive B-cell lymphomas

(2015) B. Culjkovic-Kraljacic et al.   BLOOD

Tumor-specific HSP90 inhibition as a therapeutic approach in JAK-mutant acute lymphoblastic leukemias

(2015) N. Kucine et al.   BLOOD

Novel Hsp90 inhibitor FW-04-806 displays potent antitumor effects in HER2-positive breast cancer cells as a single agent or in combination with lapatinib

(2015) Wei Huang et al.   CANCER LETTERS

Regulation and function of the human HSP90AA1 gene

(2015) Abbey D. Zuehlke et al.   GENE

Tumor Necrosis Factor Receptor-associated Protein 1 (TRAP1) Mutation and TRAP1 Inhibitor Gamitrinib-triphenylphosphonium (G-TPP) Induce a Forkhead Box O (FOXO)-dependent Cell Protective Signal from Mitochondria

(2015) Hyunjin Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure–Activity Relationship in a Purine-Scaffold Compound Series with Selectivity for the Endoplasmic Reticulum Hsp90 Paralog Grp94

(2015) Hardik J. Patel et al.   JOURNAL OF MEDICINAL CHEMISTRY

Quantitative proteomics of the yeast Hsp70/Hsp90 interactomes during DNA damage reveal chaperone-dependent regulation of ribonucleotide reductase

(2015) Andrew W. Truman et al.   Journal of Proteomics

Hsp90 inhibition induces both protein-specific and global changes in the ubiquitinome

(2015) Manfredo Quadroni et al.   Journal of Proteomics

Development of a Mitochondria-Targeted Hsp90 Inhibitor Based on the Crystal Structures of Human TRAP1

(2015) Changwook Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular Chaperone Hsp90 Is a Therapeutic Target for Noroviruses

(2015) Surender Vashist et al.   JOURNAL OF VIROLOGY

The Human Tau Interactome: Binding to the Ribonucleoproteome, and Impaired Binding of the Proline-to-Leucine Mutant at Position 301 (P301L) to Chaperones and the Proteasome

(2015) C. Geeth Gunawardana et al.   MOLECULAR & CELLULAR PROTEOMICS

Hsp90: Breaking the Symmetry

(2015) Matthias P. Mayer et al.   MOLECULAR CELL

Targeting TRAP1 as a downstream effector of BRAF cytoprotective pathway: a novel strategy for human BRAF-driven colorectal carcinoma

(2015) Valentina Condelli et al.   Oncotarget

A Hyperactive Signalosome in Acute Myeloid Leukemia Drives Addiction to a Tumor-Specific Hsp90 Species

(2015) Hongliang Zong et al.   Cell Reports

Chikungunya virus nsP3 & nsP4 interacts with HSP-90 to promote virus replication: HSP-90 inhibitors reduce CHIKV infection and inflammation in vivo

(2014) Abhay P.S. Rathore et al.   ANTIVIRAL RESEARCH

A Quantitative Chaperone Interaction Network Reveals the Architecture of Cellular Protein Homeostasis Pathways

(2014) Mikko Taipale et al.   CELL

Hsp90-Tau Complex Reveals Molecular Basis for Specificity in Chaperone Action

(2014) G. Elif Karagöz et al.   CELL

Differential Scales of Protein Quality Control

(2014) Suzanne Wolff et al.   CELL

Heat shock protein 90 inhibitors in the treatment of cancer: current status and future directions

(2014) Komal Jhaveri et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

The Hsp90-Dependent Proteome Is Conserved and Enriched for Hub Proteins with High Levels of Protein–Protein Connectivity

(2014) Rajaneesh Karimpurath Gopinath et al.   Genome Biology and Evolution

Interactome Analysis of the Human Respiratory Syncytial Virus RNA Polymerase Complex Identifies Protein Chaperones as Important Cofactors That Promote L-Protein Stability and RNA Synthesis

(2014) Diane C. Munday et al.   JOURNAL OF VIROLOGY

Evaluating Melanoma Drug Response and Therapeutic Escape with Quantitative Proteomics

(2014) Vito W. Rebecca et al.   MOLECULAR & CELLULAR PROTEOMICS

FW-04-806 inhibits proliferation and induces apoptosis in human breast cancer cells by binding to N-terminus of Hsp90 and disrupting Hsp90-Cdc37 complex formation

(2014) Wei Huang et al.   Molecular Cancer

Selective targeting of the stress chaperome as a therapeutic strategy

(2014) Tony Taldone et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Targeting the Hsp90-associated viral oncoproteome in gammaherpesvirus-associated malignancies

(2013) U. Nayar et al.   BLOOD

Hsp90, an unlikely ally in the war on cancer

(2013) Jared J. Barrott et al.   FEBS Journal

Contributions of co-chaperones and post-translational modifications towards Hsp90 drug sensitivity

(2013) Annerleim Walton-Diaz et al.   Future Medicinal Chemistry

Experimental and Structural Testing Module to Analyze Paralogue-Specificity and Affinity in the Hsp90 Inhibitors Series

(2013) Tony Taldone et al.   JOURNAL OF MEDICINAL CHEMISTRY

Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2

(2013) Pallav D Patel et al.   Nature Chemical Biology

Dynamic Impacts of the Inhibition of the Molecular Chaperone Hsp90 on the T-Cell Proteome Have Implications for Anti-Cancer Therapy

(2013) Ivo Fierro-Monti et al.   PLoS One

An Hsp90 modulator that exhibits a unique mechanistic profile

(2012) Deborah M. Ramsey et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Hsp90 inhibition differentially destabilises MAP kinase and TGF-beta signalling components in cancer cells revealed by kinase-targeted chemoproteomics

(2012) Armin Haupt et al.   BMC CANCER

Targeting the molecular chaperone heat shock protein 90 (HSP90): Lessons learned and future directions

(2012) David S. Hong et al.   CANCER TREATMENT REVIEWS

Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition

(2012) Mikko Taipale et al.   CELL

HSF1 Drives a Transcriptional Program Distinct from Heat Shock to Support Highly Malignant Human Cancers

(2012) Marc L. Mendillo et al.   CELL

Tumor-Intrinsic and Tumor-Extrinsic Factors Impacting Hsp90- Targeted Therapy

(2012) S.V. Alarcon et al.   CURRENT MOLECULAR MEDICINE

The Therapeutic Target Hsp90 and Cancer Hallmarks

(2012) Yoshihiko Miyata et al.   CURRENT PHARMACEUTICAL DESIGN

The network interaction of the human cytosolic 90kDa heat shock protein Hsp90: A target for cancer therapeutics

(2012) Viviane C.H. da Silva et al.   Journal of Proteomics

Identification of RNA-Protein Interaction Networks Involved in the Norovirus Life Cycle

(2012) S. Vashist et al.   JOURNAL OF VIROLOGY

Systematic Identification of the HSP90 Regulated Proteome

(2012) Zhixiang Wu et al.   MOLECULAR & CELLULAR PROTEOMICS

Conformational Switching of the Molecular Chaperone Hsp90 via Regulated Phosphorylation

(2012) Joanna Soroka et al.   MOLECULAR CELL

Heat shock protein 90 in neurodegenerative diseases

(2012) Wenjie Luo et al.   Molecular Neurodegeneration

Approaches for defining the Hsp90-dependent proteome

(2011) Steven D. Hartson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The ‘active life’ of Hsp90 complexes

(2011) Chrisostomos Prodromou   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Hsp90 chaperone machinery: Conformational dynamics and regulation by co-chaperones

(2011) Jing Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The role of Hsp90 in protein complex assembly

(2011) Taras Makhnevych et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Post-translational modifications of Hsp90 and their contributions to chaperone regulation

(2011) Mehdi Mollapour et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Broad action of Hsp90 as a host chaperone required for viral replication

(2011) Ron Geller et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Quantitative Proteomics Reveals That Hsp90 Inhibition Preferentially Targets Kinases and the DNA Damage Response

(2011) Kirti Sharma et al.   MOLECULAR & CELLULAR PROTEOMICS

Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome

(2011) Woong Kim et al.   MOLECULAR CELL

Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90

(2011) Kamalika Moulick et al.   Nature Chemical Biology

Geldanamycin-Induced PCNA Degradation in Isolated Hsp90 Complex from Cancer Cells

(2010) Xing Wang et al.   CANCER INVESTIGATION

Targeting heat shock proteins in cancer

(2010) Gaëtan Jego et al.   CANCER LETTERS

HSP90 at the hub of protein homeostasis: emerging mechanistic insights

(2010) Mikko Taipale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mixed Hsp90–cochaperone complexes are important for the progression of the reaction cycle

(2010) Jing Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Hsp90 regulates tau pathology through co-chaperone complexes in Alzheimer's disease

(2010) Antero Salminen et al.   PROGRESS IN NEUROBIOLOGY

Quantitative Phosphoproteomics Reveals Widespread Full Phosphorylation Site Occupancy During Mitosis

(2010) J. V. Olsen et al.   Science Signaling

Novel Hsp90 partners discovered using complementary proteomic approaches

(2009) Pavel A. Tsaytler et al.   CELL STRESS & CHAPERONES

A Proteomic Investigation of Ligand-dependent HSP90 Complexes Reveals CHORDC1 as a Novel ADP-dependent HSP90-interacting Protein

(2009) Jacob J. Gano et al.   MOLECULAR & CELLULAR PROTEOMICS

An atlas of chaperone–protein interactions in Saccharomyces cerevisiae: implications to protein folding pathways in the cell

(2009) Yunchen Gong et al.   Molecular Systems Biology

A purine scaffold Hsp90 inhibitor destabilizes BCL-6 and has specific antitumor activity in BCL-6–dependent B cell lymphomas

(2009) Leandro C Cerchietti et al.   NATURE MEDICINE

Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models

(2009) E. Caldas-Lopes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA