Functional cross-talk between allosteric effects of activating and inhibiting ligands underlies PKM2 regulation
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Functional cross-talk between allosteric effects of activating and inhibiting ligands underlies PKM2 regulation
Authors
Keywords
-
Journal
eLife
Volume 8, Issue -, Pages -
Publisher
eLife Sciences Publications, Ltd
Online
2019-07-02
DOI
10.7554/elife.45068
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- An allostatic mechanism for M2 pyruvate kinase as an amino-acid sensor
- (2018) Meng Yuan et al. BIOCHEMICAL JOURNAL
- Native Mass Spectrometry Gives Insight into the Allosteric Binding Mechanism of M2 Pyruvate Kinase to Fructose-1,6-Bisphosphate
- (2018) Agni F. M. Gavriilidou et al. BIOCHEMISTRY
- Glucose Metabolism in Cancer: The Saga of Pyruvate Kinase Continues
- (2018) Annamarie E. Allen et al. CANCER CELL
- Deciphering the Dynamic Interaction Profile of an Intrinsically Disordered Protein by NMR Exchange Spectroscopy
- (2018) Elise Delaforge et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering
- (2018) Daniel A Keedy et al. eLife
- An engineered photoswitchable mammalian pyruvate kinase
- (2017) Stefanie Gehrig et al. FEBS Journal
- Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction
- (2017) Weier Qi et al. NATURE MEDICINE
- O-GlcNAcylation destabilizes the active tetrameric PKM2 to promote the Warburg effect
- (2017) Yang Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hybrid Mass Spectrometry Approaches to Determine How L-Histidine Feedback Regulates the Enzyzme MtATP-Phosphoribosyltransferase
- (2017) Kamila J. Pacholarz et al. STRUCTURE
- Allosteric pyruvate kinase-based “logic gate” synergistically senses energy and sugar levels in Mycobacterium tuberculosis
- (2017) Wenhe Zhong et al. Nature Communications
- SIRT5 Desuccinylates and Activates Pyruvate Kinase M2 to Block Macrophage IL-1β Production and to Prevent DSS-Induced Colitis in Mice
- (2017) Fang Wang et al. Cell Reports
- Succinyl-5-aminoimidazole-4-carboxamide-1-ribose 5′-Phosphate (SAICAR) Activates Pyruvate Kinase Isoform M2 (PKM2) in Its Dimeric Form
- (2016) Ming Yan et al. BIOCHEMISTRY
- What Mutagenesis Can and Cannot Reveal About Allostery
- (2016) Gerald M. Carlson et al. BIOPHYSICAL JOURNAL
- EGFR Signaling Enhances Aerobic Glycolysis in Triple-Negative Breast Cancer Cells to Promote Tumor Growth and Immune Escape
- (2016) S.-O. Lim et al. CANCER RESEARCH
- Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma
- (2016) Talya L. Dayton et al. GENES & DEVELOPMENT
- Synergistic Allosteric Mechanism of Fructose-1,6-bisphosphate and Serine for Pyruvate Kinase M2 via Dynamics Fluctuation Network Analysis
- (2016) Jingxu Yang et al. Journal of Chemical Information and Modeling
- Multi-Timescale Dynamics in Intrinsically Disordered Proteins from NMR Relaxation and Molecular Simulation
- (2016) Nicola Salvi et al. Journal of Physical Chemistry Letters
- Mass spectrometry locates local and allosteric conformational changes that occur on cofactor binding
- (2016) Rebecca Beveridge et al. Nature Communications
- PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation
- (2016) Min Xie et al. Nature Communications
- A Molecular Dynamics Study of Allosteric Transitions in Leishmania mexicana Pyruvate Kinase
- (2015) Ankita Naithani et al. BIOPHYSICAL JOURNAL
- Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages
- (2015) Eva M. Palsson-McDermott et al. Cell Metabolism
- Pyruvate Kinase Isoform Expression Alters Nucleotide Synthesis to Impact Cell Proliferation
- (2015) Sophia Y. Lunt et al. MOLECULAR CELL
- SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance
- (2015) Dohoon Kim et al. NATURE
- Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma
- (2015) Saverio Tardito et al. NATURE CELL BIOLOGY
- The energy landscape of adenylate kinase during catalysis
- (2015) S Jordan Kerns et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- ASD v3.0: unraveling allosteric regulation with structural mechanisms and biological networks
- (2015) Qiancheng Shen et al. NUCLEIC ACIDS RESEARCH
- Multiple binding sites in the nicotinic acetylcholine receptors: An opportunity for polypharmacolgy
- (2015) Patricio Iturriaga-Vásquez et al. PHARMACOLOGICAL RESEARCH
- The energy landscape of adenylate kinase during catalysis
- (2015) S Jordan Kerns et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Dynamics of Intact Immunoglobulin G Explored by Drift-Tube Ion-Mobility Mass Spectrometry and Molecular Modeling
- (2014) Kamila J. Pacholarz et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Action at a Distance: Allostery and the Development of Drugs to Target Cancer Cell Metabolism
- (2014) Byron DeLaBarre et al. CHEMISTRY & BIOLOGY
- The ensemble nature of allostery
- (2014) Hesam N. Motlagh et al. NATURE
- Mapping the Population of Protein Conformational Energy Sub-States from NMR Dipolar Couplings
- (2013) Paul Guerry et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- GSATools: analysis of allosteric communication and functional local motions using a structural alphabet
- (2013) Alessandro Pandini et al. BIOINFORMATICS
- Allostery in Disease and in Drug Discovery
- (2013) Ruth Nussinov et al. CELL
- Specialized Dynamical Properties of Promiscuous Residues Revealed by Simulated Conformational Ensembles
- (2013) Arianna Fornili et al. Journal of Chemical Theory and Computation
- Mitogenic and Oncogenic Stimulation of K433 Acetylation Promotes PKM2 Protein Kinase Activity and Nuclear Localization
- (2013) Lei Lv et al. MOLECULAR CELL
- M2 pyruvate kinase provides a mechanism for nutrient sensing and regulation of cell proliferation
- (2013) H. P. Morgan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Evaluation of Coupling Reversed Phase, Aqueous Normal Phase, and Hydrophilic Interaction Liquid Chromatography with Orbitrap Mass Spectrometry for Metabolomic Studies of Human Urine
- (2012) Tong Zhang et al. ANALYTICAL CHEMISTRY
- 1-(sulfonyl)-5-(arylsulfonyl)indoline as activators of the tumor cell specific M2 isoform of pyruvate kinase
- (2012) Avihai Yacovan et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Serine is a natural ligand and allosteric activator of pyruvate kinase M2
- (2012) Barbara Chaneton et al. NATURE
- Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis
- (2012) Dimitrios Anastasiou et al. Nature Chemical Biology
- Equilibrium fluctuations of a single folded protein reveal a multitude of potential cryptic allosteric sites
- (2012) G. R. Bowman et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- SAICAR Stimulates Pyruvate Kinase Isoform M2 and Promotes Cancer Cell Survival in Glucose-Limited Conditions
- (2012) K. E. Keller et al. SCIENCE
- Rocking cell metabolism: revised functions of the key glycolytic regulator PKM2 in cancer
- (2012) Barbara Chaneton et al. TRENDS IN BIOCHEMICAL SCIENCES
- Regulation and control of metabolic fluxes in microbes
- (2011) Luca Gerosa et al. CURRENT OPINION IN BIOTECHNOLOGY
- Definition and testing of the GROMOS force-field versions 54A7 and 54B7
- (2011) Nathan Schmid et al. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
- Detection of allosteric signal transmission by information-theoretic analysis of protein dynamics
- (2011) Alessandro Pandini et al. FASEB JOURNAL
- An Automated Force Field Topology Builder (ATB) and Repository: Version 1.0
- (2011) Alpeshkumar K. Malde et al. Journal of Chemical Theory and Computation
- Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses
- (2011) D. Anastasiou et al. SCIENCE
- Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase
- (2010) Jian-kang Jiang et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Structural alphabets derived from attractors in conformational space
- (2010) Alessandro Pandini et al. BMC BIOINFORMATICS
- Pyruvate kinase type M2: A key regulator of the metabolic budget system in tumor cells
- (2010) Sybille Mazurek INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Differential Behavior of Missense Mutations in the Intersubunit Contact Domain of the Human Pyruvate Kinase M2Isozyme
- (2009) Kamal Akhtar et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Evaluation of SubstitutedN,N′-Diarylsulfonamides as Activators of the Tumor Cell Specific M2 Isoform of Pyruvate Kinase
- (2009) Matthew B. Boxer et al. JOURNAL OF MEDICINAL CHEMISTRY
- Toward a Unified Representation of Protein Structural Dynamics in Solution
- (2009) Phineus R. L. Markwick et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth
- (2009) T. Hitosugi et al. Science Signaling
- The Origin of Allosteric Functional Modulation: Multiple Pre-existing Pathways
- (2009) Antonio del Sol et al. STRUCTURE
- GROMACS 4: Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation
- (2008) Berk Hess et al. Journal of Chemical Theory and Computation
- Pyruvate kinase M2 is a phosphotyrosine-binding protein
- (2008) Heather R. Christofk et al. NATURE
- The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
- (2008) Heather R. Christofk et al. NATURE
- Ion mobility–mass spectrometry analysis of large protein complexes
- (2008) Brandon T Ruotolo et al. Nature Protocols
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now