Targeting GPX4 in human cancer: Implications of ferroptosis induction for tackling cancer resilience

Copper-dependent autophagic degradation of GPX4 drives ferroptosis

(2023) Qian Xue et al.   Autophagy

Lipid metabolism alterations and ferroptosis in cancer: Paving the way for solving cancer resistance

(2023) Jaewang Lee et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Multienzyme-like Reactivity Cooperatively Impairs Glutathione Peroxidase 4 and Ferroptosis Suppressor Protein 1 Pathways in Triple-Negative Breast Cancer for Sensitized Ferroptosis Therapy

(2022) Ke Li et al.   ACS Nano

EBV infection-induced GPX4 promotes chemoresistance and tumor progression in nasopharyngeal carcinoma

(2022) Li Yuan et al.   CELL DEATH AND DIFFERENTIATION

Sanguinarine represses the growth and metastasis of non-small cell lung cancer by facilitating ferroptosis

(2022) Rongzhong Xu et al.   CURRENT PHARMACEUTICAL DESIGN

Bufotalin induces ferroptosis in non-small cell lung cancer cells by facilitating the ubiquitination and degradation of GPX4

(2022) Wen Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

MicroRNA-1287-5p promotes ferroptosis of osteosarcoma cells through inhibiting GPX4

(2022) Zhengquan Xu et al.   FREE RADICAL RESEARCH

Ophiopogonin B induces gastric cancer cell death by blocking the GPX4/xCT‑dependent ferroptosis pathway

(2022) Liyi Zhang et al.   Oncology Letters

MicroRNA‑15a promotes prostate cancer cell ferroptosis by inhibiting GPX4 expression

(2022) Po Xu et al.   Oncology Letters

Epigenetic Regulation of Ferroptosis-Associated Genes and Its Implication in Cancer Therapy

(2022) Yanzi Pei et al.   Frontiers in Oncology

Cell-Specific Metabolic Reprogramming of Tumors for Bioactivatable Ferroptosis Therapy

(2022) Yanan Li et al.   ACS Nano

Carbon Quantum Dots-Based Nanozyme from Coffee Induces Cancer Cell Ferroptosis to Activate Antitumor Immunity

(2022) Lu Yao et al.   ACS Nano

Iron ion and sulfasalazine-loaded polydopamine nanoparticles for Fenton reaction and glutathione peroxidase 4 inactivation for enhanced cancer ferrotherapy

(2022) Xiaokang Zhu et al.   Acta Biomaterialia

Targeting NQO1/GPX4-mediated ferroptosis by plumbagin suppresses in vitro and in vivo glioma growth

(2022) Sheng Zhan et al.   BRITISH JOURNAL OF CANCER

Arsenic trioxide increases apoptosis of SK-N-BE (2) cells partially by inducing GPX4-mediated ferroptosis

(2022) Chuchu Feng et al.   MOLECULAR BIOLOGY REPORTS

Red ginseng polysaccharide exhibits anticancer activity through GPX4 downregulation-induced ferroptosis

(2022) Feng-guo Zhai et al.   PHARMACEUTICAL BIOLOGY

Phyto-sesquiterpene lactones DET and DETD-35 induce ferroptosis in vemurafenib sensitive and resistant melanoma via GPX4 inhibition and metabolic reprogramming

(2022) Meng-Ting Chang et al.   PHARMACOLOGICAL RESEARCH

Transsulfuration, minor player or crucial for cysteine homeostasis in cancer

(2022) Hai-Feng Zhang et al.   TRENDS IN CELL BIOLOGY

Metal ions/nucleotide coordinated nanoparticles comprehensively suppress tumor by synergizing ferroptosis with energy metabolism interference

(2022) Yanqiu Wang et al.   JOURNAL OF NANOBIOTECHNOLOGY

Tetrandrine Citrate Suppresses Breast Cancer via Depletion of Glutathione Peroxidase 4 and Activation of Nuclear Receptor Coactivator 4-Mediated Ferritinophagy

(2022) Jiameng Yin et al.   Frontiers in Pharmacology

Identification of GPX4 as a therapeutic target for lung adenocarcinoma after EGFR-TKI resistance

(2022) Chuanfen Zhang et al.   Translational Lung Cancer Research

Post-Translational Modification of GPX4 is a Promising Target for Treating Ferroptosis-Related Diseases

(2022) Can Cui et al.   Frontiers in Molecular Biosciences

The Selenoprotein Glutathione Peroxidase 4: From Molecular Mechanisms to Novel Therapeutic Opportunities

(2022) Kamari Weaver et al.   Biomedicines

An all-in-one biomimetic iron-small interfering RNA nanoplatform induces ferroptosis for cancer therapy

(2022) Siming Huang et al.   Acta Biomaterialia

GPX4: old lessons, new features

(2022) Thamara Nishida Xavier da Silva et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

LncRNA OIP5-AS1 Knockdown Facilitated the Ferroptosis and Immune Evasion by Modulating the GPX4 in Oesophageal Carcinoma

(2022) Junyi Hou et al.   Computational and Mathematical Methods in Medicine

A white paper on Phospholipid Hydroperoxide Glutathione Peroxidase (GPx4) forty years later

(2022) Fulvio Ursini et al.   FREE RADICAL BIOLOGY AND MEDICINE

Silenced LINC01134 Enhances Oxaliplatin Sensitivity by Facilitating Ferroptosis Through GPX4 in Hepatocarcinoma

(2022) Xiaofeng Kang et al.   Frontiers in Oncology

METTL16 epigenetically enhances GPX4 expression via m6A modification to promote breast cancer progression by inhibiting ferroptosis

(2022) Feng Ye et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Induction of ferroptosis in head and neck cancer: A novel bridgehead for fighting cancer resilience

(2022) Jaewang Lee et al.   CANCER LETTERS

Regulators of epigenetic change in ferroptosis‑associated cancer (Review)

(2022) Jiaming Wu et al.   ONCOLOGY REPORTS

A Class of Disulfide Compounds Suppresses Ferroptosis by Stabilizing GPX4

(2022) Jin-Pin Liu et al.   ACS Chemical Biology

Ferroptosis induction via targeting metabolic alterations in head and neck cancer

(2022) Jaewang Lee et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

CST1 inhibits ferroptosis and promotes gastric cancer metastasis by regulating GPX4 protein stability via OTUB1

(2022) Dongbao Li et al.   ONCOGENE

JUND/linc00976 promotes cholangiocarcinoma progression and metastasis, inhibits ferroptosis by regulating the miR-3202/GPX4 axis

(2022) Shan Lei et al.   Cell Death & Disease

Identification of a small molecule as inducer of ferroptosis and apoptosis through ubiquitination of GPX4 in triple negative breast cancer cells

(2021) Yahui Ding et al.   Journal of Hematology & Oncology

Co-Administration of iRGD with Sorafenib-Loaded Iron-Based Metal-Organic Framework as a Targeted Ferroptosis Agent for Liver Cancer Therapy

(2021) Xianchuang Liu et al.   International Journal of Nanomedicine

The Hippo Pathway Effector YAP Promotes Ferroptosis via the E3 Ligase SKP2

(2021) Wen-Hsuan Yang et al.   MOLECULAR CANCER RESEARCH

mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation

(2021) Yilei Zhang et al.   Nature Communications

Down-regulation of Glutathione Peroxidase 4 in Oral Cancer Inhibits Tumor Growth Through SREBP1 Signaling

(2021) MASAKATSU FUKUDA et al.   ANTICANCER RESEARCH

miR-324-3p reverses cisplatin resistance by inducing GPX4-mediated ferroptosis in lung adenocarcinoma cell line A549

(2021) Shi-hua Deng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The common region of lncRNAs UCA1 and UCA1α contributes to the bladder cancer tumorigenesis

(2021) Yu Wang et al.   EUROPEAN JOURNAL OF CANCER PREVENTION

CREB stimulates GPX4 transcription to inhibit ferroptosis in lung adenocarcinoma

(2021) Zhixian Wang et al.   ONCOLOGY REPORTS

Molecular Mechanisms of Chemotherapy Resistance in Head and Neck Cancers

(2021) Yuzuka Kanno et al.   Frontiers in Oncology

DHODH and cancer: promising prospects to be explored

(2021) Yue Zhou et al.   Cancer & Metabolism

Circular RNA circKIF4A facilitates the malignant progression and suppresses ferroptosis by sponging miR-1231 and upregulating GPX4 in papillary thyroid cancer

(2021) Wenkuan Chen et al.   Aging-US

SMG9 drives ferroptosis by directly inhibiting GPX4 degradation

(2021) Leng Han et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

ZEB1 directly inhibits GPX4 transcription contributing to ROS accumulation in breast cancer cells

(2021) Xiao Han et al.   BREAST CANCER RESEARCH AND TREATMENT

A Ferrocene‐Functionalized Covalent Organic Framework for Enhancing Chemodynamic Therapy via Redox Dyshomeostasis

(2021) Le‐Le Zhou et al.   Small

Ketamine Induces Ferroptosis of Liver Cancer Cells by Targeting lncRNA PVT1/miR-214-3p/GPX4

(2021) Guan-Nan He et al.   Drug Design Development and Therapy

Orlistat induces ferroptosis-like cell death of lung cancer cells

(2021) Wenjing Zhou et al.   Frontiers of Medicine

CircDTL Functions as an Oncogene and Regulates Both Apoptosis and Ferroptosis in Non-small Cell Lung Cancer Cells

(2021) Wang Shanshan et al.   Frontiers in Genetics

Glutathione-Responsive Chemodynamic Therapy of Manganese(III/IV) Cluster Nanoparticles Enhanced by Electrochemical Stimulation via Oxidative Stress Pathway

(2021) Yang Chen et al.   BIOCONJUGATE CHEMISTRY

TRIM46 contributes to high glucose-induced ferroptosis and cell growth inhibition in human retinal capillary endothelial cells by facilitating GPX4 ubiquitination

(2021) Jingfa Zhang et al.   EXPERIMENTAL CELL RESEARCH

Contribution of Lipid Oxidation and Ferroptosis to Radiotherapy Efficacy

(2021) Ashley N. Pearson et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MiR‐15a‐3p regulates ferroptosis via targeting glutathione peroxidase GPX4 in colorectal cancer

(2021) Liurong Liu et al.   MOLECULAR CARCINOGENESIS

Mechanisms Affecting the Biosynthesis and Incorporation Rate of Selenocysteine

(2021) Jing-Jing Peng et al.   MOLECULES

Development of therapies for rare genetic disorders of GPX4: roadmap and opportunities

(2021) Dorian M. Cheff et al.   Orphanet Journal of Rare Diseases

Metal‐Polyphenol‐Network Coated Prussian Blue Nanoparticles for Synergistic Ferroptosis and Apoptosis via Triggered GPX4 Inhibition and Concurrent In Situ Bleomycin Toxification

(2021) Lulu Zhou et al.   Small

Fin56-induced ferroptosis is supported by autophagy-mediated GPX4 degradation and functions synergistically with mTOR inhibition to kill bladder cancer cells

(2021) Yadong Sun et al.   Cell Death & Disease

Ferroptosis-Inducing Nanomedicine for Cancer Therapy

(2021) Yang Wang et al.   Frontiers in Pharmacology

Circular RNA CircPVT1 Inhibits 5-Fluorouracil Chemosensitivity by Regulating Ferroptosis Through MiR-30a-5p/FZD3 Axis in Esophageal Cancer Cells

(2021) Wenjian Yao et al.   Frontiers in Oncology

Oncogenic Activation of YAP Signaling Sensitizes Ferroptosis of Hepatocellular Carcinoma via ALOXE3-Mediated Lipid Peroxidation Accumulation

(2021) Yifei Qin et al.   Frontiers in Cell and Developmental Biology

miR-539 activates the SAPK/JNK signaling pathway to promote ferropotosis in colorectal cancer by directly targeting TIPE

(2021) Yan Yang et al.   Cell Death Discovery

Undermining Glutaminolysis Bolsters Chemotherapy While NRF2 Promotes Chemoresistance in KRAS-Driven Pancreatic Cancers

(2020) Suman Mukhopadhyay et al.   CANCER RESEARCH

Lipid rafts as signaling hubs in cancer cell survival/death and invasion: implications in tumor progression and therapy

(2020) Faustino Mollinedo et al.   JOURNAL OF LIPID RESEARCH

Directly targeting glutathione peroxidase 4 may be more effective than disrupting glutathione on ferroptosis-based cancer therapy

(2020) Yunpeng Wei et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Epigenetic regulation in human cancer: the potential role of epi-drug in cancer therapy

(2020) Yuanjun Lu et al.   Molecular Cancer

Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles

(2020) John K. Eaton et al.   Nature Chemical Biology

Redox Responsive Metal Organic Framework Nanoparticles Induces Ferroptosis for Cancer Therapy

(2020) Haozhe He et al.   Small

Broad Spectrum Deubiquitinase Inhibition Induces Both Apoptosis and Ferroptosis in Cancer Cells

(2020) Li Yang et al.   Frontiers in Oncology

Glioblastoma Therapy Using Codelivery of Cisplatin and Glutathione Peroxidase Targeting siRNA from Iron Oxide Nanoparticles

(2020) Yulin Zhang et al.   ACS Applied Materials & Interfaces

Solasonine promotes ferroptosis of hepatoma carcinoma cells via glutathione peroxidase 4-induced destruction of the glutathione redox system

(2020) Mingming Jin et al.   BIOMEDICINE & PHARMACOTHERAPY

Functional Long Non-coding RNAs Evolve from Junk Transcripts

(2020) Alexander F. Palazzo et al.   CELL

CircIL4R facilitates the tumorigenesis and inhibits ferroptosis in hepatocellular carcinoma by regulating the miR‐541‐3p/GPX4 axis

(2020) Qinhong Xu et al.   CELL BIOLOGY INTERNATIONAL

xCT: A Critical Molecule That Links Cancer Metabolism to Redox Signaling

(2020) Jinyun Liu et al.   MOLECULAR THERAPY

Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy

(2020) Pranavi Koppula et al.   Protein & Cell

Circular RNA: metabolism, functions and interactions with proteins

(2020) Wei-Yi Zhou et al.   Molecular Cancer

Role of GPX4-Mediated Ferroptosis in the Sensitivity of Triple Negative Breast Cancer Cells to Gefitinib

(2020) Xiang Song et al.   Frontiers in Oncology

NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

(2019) Matthew Dodson et al.   Redox Biology

GPX4 at the Crossroads of Lipid Homeostasis and Ferroptosis

(2019) Giovanni C. Forcina et al.   PROTEOMICS

Global Positioning System: Understanding Long Noncoding RNAs through Subcellular Localization

(2019) Joana Carlevaro-Fita et al.   MOLECULAR CELL

Long noncoding RNA LINC00336 inhibits ferroptosis in lung cancer by functioning as a competing endogenous RNA

(2019) Min Wang et al.   CELL DEATH AND DIFFERENTIATION

Targeting Ferroptosis to Iron Out Cancer

(2019) Behrouz Hassannia et al.   CANCER CELL

The role of m6A RNA methylation in human cancer

(2019) Xiao-Yu Chen et al.   Molecular Cancer

Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling

(2019) Junfeng Bi et al.   Cell Metabolism

Intercellular interaction dictates cancer cell ferroptosis via NF2–YAP signalling

(2019) Jiao Wu et al.   NATURE

A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis

(2019) Yilong Zou et al.   Nature Communications

The multi-factorial nature of clinical multidrug resistance in cancer

(2019) Yehuda G. Assaraf et al.   DRUG RESISTANCE UPDATES

The Hippo Pathway Effector TAZ Regulates Ferroptosis in Renal Cell Carcinoma

(2019) Wen-Hsuan Yang et al.   Cell Reports

Inactivation of the glutathione peroxidase GPx4 by the ferroptosis‐inducing molecule RSL3 requires the adaptor protein 14‐3‐3ε

(2019) Ana‐Marija Vučković et al.   FEBS LETTERS

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

(2019) Kirill Bersuker et al.   NATURE

Epigenetic regulation of AURKA by miR-4715-3p in upper gastrointestinal cancers

(2019) Ahmed Gomaa et al.   Scientific Reports

GTP Cyclohydrolase 1/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling

(2019) Vanessa A. N. Kraft et al.   ACS Central Science

Protective effects of the mechanistic target of rapamycin against excess iron and ferroptosis in cardiomyocytes

(2018) Yuichi Baba et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Targeting Dependency on the GPX4 Lipid Peroxide Repair Pathway for Cancer Therapy

(2018) Hengrui Liu et al.   BIOCHEMISTRY

A G3BP1-interacting lncRNA promotes ferroptosis and apoptosis in cancer via nuclear sequestration of p53

(2018) Chao Mao et al.   CANCER RESEARCH

Fumarate hydratase inactivation in hereditary leiomyomatosis and renal cell cancer is synthetic lethal with ferroptosis induction

(2018) Michael J. Kerins et al.   CANCER SCIENCE

Metazoan MicroRNAs

(2018) David P. Bartel   CELL

Selenium and GPX4, a vital symbiosis

(2018) José Pedro Friedmann Angeli et al.   FREE RADICAL BIOLOGY AND MEDICINE

NF2/Merlin Inactivation and Potential Therapeutic Targets in Mesothelioma

(2018) Tatsuhiro Sato et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma

(2018) Behrouz Hassannia et al.   JOURNAL OF CLINICAL INVESTIGATION

Understanding the diversity of membrane lipid composition

(2018) Takeshi Harayama et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites

(2018) Vyacheslav Akimov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites

(2018) Vyacheslav Akimov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Unsolved mysteries: How does lipid peroxidation cause ferroptosis?

(2018) Huizhong Feng et al.   PLOS BIOLOGY

Metabolic reprogramming of oncogene-addicted cancer cells to OXPHOS as a mechanism of drug resistance

(2018) Jayshree Hirpara et al.   Redox Biology

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

(2017) Matthew J. Hangauer et al.   NATURE

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

(2017) Vasanthi S. Viswanathan et al.   NATURE

The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer

(2017) Angela M. Krebs et al.   NATURE CELL BIOLOGY

Systemic Therapy for Metastatic Renal-Cell Carcinoma

(2017) Toni K. Choueiri et al.   NEW ENGLAND JOURNAL OF MEDICINE

YAP/TAZ at the Roots of Cancer

(2016) Francesca Zanconato et al.   CANCER CELL

Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis

(2016) Kenichi Shimada et al.   Nature Chemical Biology

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

(2016) Wan Seok Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elucidating Compound Mechanism of Action by Network Perturbation Analysis

(2015) Jung Hoon Woo et al.   CELL

The basics of thiols and cysteines in redox biology and chemistry

(2015) Leslie B. Poole   FREE RADICAL BIOLOGY AND MEDICINE

Metabolic reprogramming: the emerging concept and associated therapeutic strategies

(2015) Go J. Yoshida   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Thioredoxin-related protein of 14 kDa is an efficient L-cystine reductase and S-denitrosylase

(2014) I. Pader et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selenium and selenocysteine: roles in cancer, health, and development

(2014) Dolph L. Hatfield et al.   TRENDS IN BIOCHEMICAL SCIENCES

Glutathione: new roles in redox signaling for an old antioxidant

(2014) Katia Aquilano et al.   Frontiers in Pharmacology

Glutathione peroxidases

(2012) Regina Brigelius-Flohé et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Development of small-molecule probes that selectively kill cells induced to express mutant RAS

(2011) Michel Weïwer et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Induction of Glutathione Peroxidase 4 Expression during Enterocytic Cell Differentiation

(2011) Bodo Speckmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Succination of Proteins by Fumarate

(2008) Matthew Blatnik et al.   Annals of the New York Academy of Sciences

Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death

(2008) Alexander Seiler et al.   Cell Metabolism

Glutathione: Overview of its protective roles, measurement, and biosynthesis

(2008) Henry Jay Forman et al.   MOLECULAR ASPECTS OF MEDICINE