Contribution of Lipid Oxidation and Ferroptosis to Radiotherapy Efficacy

Polycysteine as a new type of radio-protector ameliorated tissue injury through inhibiting ferroptosis in mice

(2021) Junling Zhang et al.   Cell Death & Disease

Total body irradiation causes a chronic decrease in antioxidant levels

(2021) Lue Sun et al.   Scientific Reports

Ferroptosis, radiotherapy, and combination therapeutic strategies

(2021) Guang Lei et al.   Protein & Cell

MiR-7-5p Is Involved in Ferroptosis Signaling and Radioresistance Thru the Generation of ROS in Radioresistant HeLa and SAS Cell Lines

(2021) Kazuo Tomita et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Translation of DNA Damage Response Inhibitors as Chemoradiation Sensitizers From the Laboratory to the Clinic

(2021) Leslie A. Parsels et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

CLTRN, Regulated by NRF1/RAN/DLD Protein Complex, Enhances Radiation Sensitivity of Hepatocellular Carcinoma Cells Through Ferroptosis Pathway

(2021) Yin Yuan et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

SLC7A11 regulated by NRF2 modulates esophageal squamous cell carcinoma radiosensitivity by inhibiting ferroptosis

(2021) Lei Feng et al.   Journal of Translational Medicine

Radiation-Induced Lipid Peroxidation Triggers Ferroptosis and Synergizes with Ferroptosis Inducers

(2020) Ling F. Ye et al.   ACS Chemical Biology

Undermining Glutaminolysis Bolsters Chemotherapy While NRF2 Promotes Chemoresistance in KRAS-Driven Pancreatic Cancers

(2020) Suman Mukhopadhyay et al.   CANCER RESEARCH

The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression

(2020) Guang Lei et al.   CELL RESEARCH

Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis

(2020) Yilong Zou et al.   Nature Chemical Biology

Anti-Ferroptosis Drug Enhances Total-Body Irradiation Mitigation by Drugs that Block Apoptosis and Necroptosis

(2020) Stephanie Thermozier et al.   RADIATION RESEARCH

Regulation of ferroptosis in KRas mutant cancer cells

(2020) Byeong Hyeok Choi et al.   FASEB JOURNAL

Cysteine depletion induces pancreatic tumor ferroptosis in mice

(2020) Michael A. Badgley et al.   SCIENCE

Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers

(2020) Mariluz Soula et al.   Nature Chemical Biology

The Intersection of DNA Damage Response and Ferroptosis—A Rationale for Combination Therapeutics

(2020) Po-Han Chen et al.   Biology-Basel

Plasticity of ether lipids promotes ferroptosis susceptibility and evasion

(2020) Yilong Zou et al.   NATURE

Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy

(2020) Pranavi Koppula et al.   Protein & Cell

Iron Metabolism in Ferroptosis

(2020) Xin Chen et al.   Frontiers in Cell and Developmental Biology

The Metabolic Underpinnings of Ferroptosis

(2020) Jiashuo Zheng et al.   Cell Metabolism

Erastin decreases radioresistance of NSCLC cells partially by inducing GPX4‑mediated ferroptosis

(2019) Xiaofen Pan et al.   Oncology Letters

Ferroptosis inhibitor alleviates Radiation-induced lung fibrosis (RILF) via down-regulation of TGF-β1

(2019) Xuan Li et al.   Journal of Inflammation-London

CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

(2019) Weimin Wang et al.   NATURE

Radiotherapy and immunotherapy promote tumoral lipid oxidation and ferroptosis via synergistic repression of SLC7A11

(2019) Xueting Lang et al.   Cancer Discovery

Role of ferroptosis in the process of acute radiation-induced lung injury in mice

(2019) Xuan Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis

(2019) Lian-Jiu Su et al.   Oxidative Medicine and Cellular Longevity

Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion

(2019) Robert D. Leone et al.   SCIENCE

GTP Cyclohydrolase 1/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling

(2019) Vanessa A. N. Kraft et al.   ACS Central Science

A G3BP1-interacting lncRNA promotes ferroptosis and apoptosis in cancer via nuclear sequestration of p53

(2018) Chao Mao et al.   CANCER RESEARCH

Unsolved mysteries: How does lipid peroxidation cause ferroptosis?

(2018) Huizhong Feng et al.   PLOS BIOLOGY

The Development of the Concept of Ferroptosis

(2018) Tal Hirschhorn et al.   FREE RADICAL BIOLOGY AND MEDICINE

Discovery of Novel, Drug-Like Ferroptosis Inhibitors with in Vivo Efficacy

(2018) Lars Devisscher et al.   JOURNAL OF MEDICINAL CHEMISTRY

Role of Mitochondria in Ferroptosis

(2018) Minghui Gao et al.   MOLECULAR CELL

Antioxidants and HNE in redox homeostasis

(2017) Wojciech Łuczaj et al.   FREE RADICAL BIOLOGY AND MEDICINE

Glutathione peroxidase 4-catalyzed reduction of lipid hydroperoxides in membranes: The polar head of membrane phospholipids binds the enzyme and addresses the fatty acid hydroperoxide group toward the redox center

(2017) Giorgio Cozza et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nrf2-Keap1 pathway promotes cell proliferation and diminishes ferroptosis

(2017) Z Fan et al.   Oncogenesis

Nrf2 inhibition reverses the resistance of cisplatin-resistant head and neck cancer cells to artesunate-induced ferroptosis

(2017) Jong-Lyel Roh et al.   Redox Biology

Radiation-induced autophagy: mechanisms and consequences

(2016) Madhuri Chaurasia et al.   FREE RADICAL RESEARCH

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

(2016) Wan Seok Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutaminolysis and Transferrin Regulate Ferroptosis

(2015) Minghui Gao et al.   MOLECULAR CELL

Ferroptosis as a p53-mediated activity during tumour suppression

(2015) Le Jiang et al.   NATURE

Oncogenic KRAS Confers Chemoresistance by Upregulating NRF2

(2014) S. Tao et al.   CANCER RESEARCH

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Past, present and future of radiotherapy for the benefit of patients

(2012) Juliette Thariat et al.   Nature Reviews Clinical Oncology

Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury

(2011) Edouard I. Azzam et al.   CANCER LETTERS

Solute carrier protein family may involve in radiation-induced radioresistance of non-small cell lung cancer

(2011) Li Xie et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Oxidative Lipidomics of γ-Radiation-Induced Lung Injury: Mass Spectrometric Characterization of Cardiolipin and Phosphatidylserine Peroxidation

(2011) Yulia Y. Tyurina et al.   RADIATION RESEARCH

Necroptosis is a novel mechanism of radiation-induced cell death in anaplastic thyroid and adrenocortical cancers

(2011) Matthew A. Nehs et al.   SURGERY