DHODH and cancer: promising prospects to be explored

Dihydroorotate dehydrogenase in oxidative phosphorylation and cancer

(2020) Stepana Boukalova et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Cancer statistics, 2020

(2020) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Replication and ribosomal stress induced by targeting pyrimidine synthesis and cellular checkpoints suppress p53-deficient tumors

(2020) Sona Hubackova et al.   Cell Death & Disease

Safety, Tolerability and Pharmacokinetics of Vidofludimus calcium (IMU-838) After Single and Multiple Ascending Oral Doses in Healthy Male Subjects

(2020) Andreas Muehler et al.   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

Genetic ablation of the mitoribosome in the malaria parasite Plasmodium falciparum sensitizes it to antimalarials that target mitochondrial functions

(2020) Liqin Ling et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability

(2020) Gergana Popova et al.   JOURNAL OF MEDICINAL CHEMISTRY

Lead Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series for the Treatment of Malaria

(2020) Sreekanth Kokkonda et al.   JOURNAL OF MEDICINAL CHEMISTRY

RNA helicase DDX21 mediates nucleotide stress responses in neural crest and melanoma cells

(2020) Cristina Santoriello et al.   NATURE CELL BIOLOGY

Precision Medicine with Leflunomide: Consideration of DHODH Haplotype and Plasma Teriflunomide Concentration can Substantially Modify Outcomes in Patients with Rheumatoid Arthritis

(2020) Michael D Wiese et al.   ARTHRITIS CARE & RESEARCH

Natural product piperine alleviates experimental allergic encephalomyelitis in mice by targeting dihydroorotate dehydrogenase

(2020) Zehui Liu et al.   BIOCHEMICAL PHARMACOLOGY

Bifunctional Naphtho[2,3-d][1,2,3]triazole-4,9-dione Compounds Exhibit Antitumor Effects In Vitro and In Vivo by Inhibiting Dihydroorotate Dehydrogenase and Inducing Reactive Oxygen Species Production

(2020) Zeping Zuo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2

(2020) Rui Xiong et al.   Protein & Cell

Structural basis for the design of selective inhibitors for Schistosoma mansoni dihydroorotate dehydrogenase

(2019) M.Cristina Nonato et al.   BIOCHIMIE

Ligand-based design, synthesis and biochemical evaluation of potent and selective inhibitors of Schistosoma mansoni dihydroorotate dehydrogenase

(2019) Felipe A. Calil et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The novel dihydroorotate dehydrogenase (DHODH) inhibitor BAY 2402234 triggers differentiation and is effective in the treatment of myeloid malignancies

(2019) Sven Christian et al.   LEUKEMIA

Teriflunomide treatment for multiple sclerosis modulates T cell mitochondrial respiration with affinity-dependent effects

(2019) Luisa Klotz et al.   Science Translational Medicine

Leflunomide Synergizes with Gemcitabine in Growth Inhibition of Pancreatic Cancer Cells and Impairs c-Myc Signaling through PIM Kinase Targeting

(2019) Ralf Buettner et al.   Molecular Therapy-Oncolytics

Suppression of pyrimidine biosynthesis by targeting DHODH enzyme robustly inhibits rotavirus replication

(2019) Sunrui Chen et al.   ANTIVIRAL RESEARCH

Phytophthora infestans Dihydroorotate Dehydrogenase Is a Potential Target for Chemical Control – A Comparison With the Enzyme From Solanum tuberosum

(2019) Manuel F. Garavito et al.   Frontiers in Microbiology

Discovery of small molecule inhibitors of human uridine-cytidine kinase 2 by high-throughput screening

(2019) Ayse Okesli-Armlovich et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Targeting pyrimidine synthesis accentuates molecular therapy response in glioblastoma stem cells

(2019) Xiuxing Wang et al.   Science Translational Medicine

UVB-induced DHODH upregulation, which is driven by STAT3, is a promising target for chemoprevention and combination therapy of photocarcinogenesis

(2019) Mohsen Hosseini et al.   Oncogenesis

Antiviral effects of selected IMPDH and DHODH inhibitors against foot and mouth disease virus

(2019) Gong Mei-jiao et al.   BIOMEDICINE & PHARMACOTHERAPY

Cerpegin-derived furo[3,4-c]pyridine-3,4(1H,5H)-diones enhance cellular response to interferons by de novo pyrimidine biosynthesis inhibition

(2019) Simon Hayek et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Madurella mycetomatis, the main causative agent of eumycetoma, is highly susceptible to olorofim

(2019) Wilson Lim et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

In vitro selection predicts malaria parasite resistance to dihydroorotate dehydrogenase inhibitors in a mouse infection model

(2019) Rebecca E. K. Mandt et al.   Science Translational Medicine

Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers

(2018) Fang Huang et al.   Cell Metabolism

Cancer Metabolism: Current Understanding and Therapies

(2018) Jessica L. Counihan et al.   CHEMICAL REVIEWS

Pharmacologic inhibition of dihydroorotate dehydrogenase induces apoptosis and differentiation in acute myeloid leukemia cells

(2018) Dang Wu et al.   HAEMATOLOGICA

Targeting Myeloid Differentiation Using Potent 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold-Based Human Dihydroorotate Dehydrogenase Inhibitors

(2018) Stefano Sainas et al.   JOURNAL OF MEDICINAL CHEMISTRY

Use of human Dihydroorotate Dehydrogenase (hDHODH) Inhibitors in Autoimmune Diseases and New Perspectives in Cancer Therapy

(2018) Marco L. Lolli et al.   Recent Patents on Anti-Cancer Drug Discovery

Structural absorption by barbule microstructures of super black bird of paradise feathers

(2018) Dakota E. McCoy et al.   Nature Communications

Energy Metabolism Rewiring Precedes UVB-Induced Primary Skin Tumor Formation

(2018) Mohsen Hosseini et al.   Cell Reports

Pharmacologic inhibition of dihydroorotate dehydrogenase induces apoptosis and differentiation in acute myeloid leukemia cells

(2018) Dang Wu et al.   HAEMATOLOGICA

Selective Cytotoxicity of Dihydroorotate Dehydrogenase Inhibitors to Human Cancer Cells Under Hypoxia and Nutrient-Deprived Conditions

(2018) Yukiko Miyazaki et al.   Frontiers in Pharmacology

Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells

(2018) Martina Bajzikova et al.   Cell Metabolism

The emergence of dihydroorotate dehydrogenase (DHODH) as a therapeutic target in acute myeloid leukemia

(2018) David B. Sykes   EXPERT OPINION ON THERAPEUTIC TARGETS

Targeting of Hematologic Malignancies with PTC299, A Novel Potent Inhibitor of Dihydroorotate Dehydrogenase with Favorable Pharmaceutical Properties

(2018) Liangxian Cao et al.   MOLECULAR CANCER THERAPEUTICS

Revisiting the role of dihydroorotate dehydrogenase as a therapeutic target for cancer

(2018) Joseph T. Madak et al.   PHARMACOLOGY & THERAPEUTICS

Identification and Mechanistic Understanding of Dihydroorotate Dehydrogenase Point Mutations in Plasmodium falciparum that Confer in Vitro Resistance to the Clinical Candidate DSM265

(2018) John White et al.   ACS Infectious Diseases

Synergistic inhibition of melanoma xenografts by Brequinar sodium and Doxorubicin

(2018) Mathura Subangari Dorasamy et al.   BIOMEDICINE & PHARMACOTHERAPY

Mitochondrial ROS control of cancer

(2017) María del Pilar Sosa Idelchik et al.   SEMINARS IN CANCER BIOLOGY

ATR inhibition facilitates targeting of leukemia dependence on convergent nucleotide biosynthetic pathways

(2017) Thuc M. Le et al.   Nature Communications

PTEN Regulates Glutamine Flux to Pyrimidine Synthesis and Sensitivity to Dihydroorotate Dehydrogenase Inhibition

(2017) Deepti Mathur et al.   Cancer Discovery

Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness

(2017) Michiru Nishita et al.   Scientific Reports

Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia

(2016) David B. Sykes et al.   CELL

Mitochondrial ROS regulation of proliferating cells

(2016) Lauren Diebold et al.   FREE RADICAL BIOLOGY AND MEDICINE

O-GlcNAcylation: a bridge between glucose and cell differentiation

(2016) Chao Sun et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity

(2016) Sreekanth Kokkonda et al.   JOURNAL OF MEDICINAL CHEMISTRY

In vitro evaluation of physiologically relevant concentrations of teriflunomide on activation and proliferation of primary rodent microglia

(2016) Tanja Wostradowski et al.   Journal of Neuroinflammation

Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification

(2016) Richard M Deans et al.   Nature Chemical Biology

Development of ML390: A Human DHODH Inhibitor That Induces Differentiation in Acute Myeloid Leukemia

(2016) Timothy A. Lewis et al.   ACS Medicinal Chemistry Letters

Metabolomics profiles delineate uridine deficiency contributes to mitochondria-mediated apoptosis induced by celastrol in human acute promyelocytic leukemia cells

(2016) Xiaoling Zhang et al.   Oncotarget

Inhibition of canonical WNT/β-catenin signaling is involved in leflunomide (LEF)-mediated cytotoxic effects on renal carcinoma cells

(2016) Yicheng Chen et al.   Oncotarget

Benzimidazole derivatives as potential dual inhibitors for PARP-1 and DHODH

(2015) Iskandar Abdullah et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Skin cancer and new treatment perspectives: A review

(2015) M.C.F. Simões et al.   CANCER LETTERS

Regulation of mammalian nucleotide metabolism and biosynthesis

(2015) Andrew N. Lane et al.   NUCLEIC ACIDS RESEARCH

Skin Cancer

(2015) Miguel A. Linares et al.   PRIMARY CARE

A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

(2015) Margaret A. Phillips et al.   Science Translational Medicine

Small cell lung cancer: Where do we go from here?

(2014) Lauren Averett Byers et al.   CANCER

Production of superoxide/H2O2 by dihydroorotate dehydrogenase in rat skeletal muscle mitochondria

(2014) Martin Hey-Mogensen et al.   FREE RADICAL BIOLOGY AND MEDICINE

A New Small Molecule For Treating Inflammation and Chorioretinal Neovascularization in Relapsing-Remitting and Chronic Experimental Autoimmune Uveitis

(2014) M. Diedrichs-Mohring et al.   INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Phase I and pharmacokinetic trial of PTC299 in pediatric patients with refractory or recurrent central nervous system tumors: a PBTC study

(2014) Roger J. Packer et al.   JOURNAL OF NEURO-ONCOLOGY

On Dihydroorotate Dehydrogenases and Their Inhibitors and Uses

(2013) Hélène Munier-Lehmann et al.   JOURNAL OF MEDICINAL CHEMISTRY

Colorectal cancer

(2013) Hermann Brenner et al.   LANCET

Inhibition of the mitochondrial pyrimidine biosynthesis enzyme dihydroorotate dehydrogenase by doxorubicin and brequinar sensitizes cancer cells to TRAIL-induced apoptosis

(2013) T He et al.   ONCOGENE

Inhibition of Pyrimidine Biosynthesis Pathway Suppresses Viral Growth through Innate Immunity

(2013) Marianne Lucas-Hourani et al.   PLoS Pathogens

O-GlcNAcylation: A New Cancer Hallmark?

(2013) Yann Fardini et al.   Frontiers in Endocrinology

Mitochondrial Uncoupling and the Reprograming of Intermediary Metabolism in Leukemia Cells

(2013) Juliana Vélez et al.   Frontiers in Oncology

Management of Small Cell Lung Cancer

(2012) Raffaele Califano et al.   DRUGS

The Increase inO-LinkedN-Acetylglucosamine Protein Modification Stimulates Chondrogenic Differentiation Bothin Vitroandin Vivo

(2012) Jessica Andrés-Bergós et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of autophagy and tumor growth in colon cancer by miR-502

(2012) H Zhai et al.   ONCOGENE

Teriflunomide for oral therapy in multiple sclerosis

(2012) Athina Papadopoulou et al.   Expert Review of Clinical Pharmacology

Evidence supporting a role for dihydroorotate dehydrogenase, bioenergetics, and p53 in selective teriflunomide-induced apoptosis in transformed versus normal human keratinocytes

(2011) Numsen Hail et al.   APOPTOSIS

Nucleotide Deficiency Promotes Genomic Instability in Early Stages of Cancer Development

(2011) Assaf C. Bester et al.   CELL

Recent Developments in the Medicinal Chemistry and Therapeutic Potential of Dihydroorotate Dehydrogenase (DHODH) Inhibitors

(2011) V. K. Vyas et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome

(2011) Woong Kim et al.   MOLECULAR CELL

DHODH modulates transcriptional elongation in the neural crest and melanoma

(2011) Richard Mark White et al.   NATURE

Randomized Trial of Oral Teriflunomide for Relapsing Multiple Sclerosis

(2011) Paul O'Connor et al.   NEW ENGLAND JOURNAL OF MEDICINE

PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse

(2011) P. V. Hornbeck et al.   NUCLEIC ACIDS RESEARCH

Miller syndrome with novel dihydroorotate dehydrogenase gene mutations

(2011) Fumiko Kinoshita et al.   PEDIATRICS INTERNATIONAL

Identification of broad-spectrum antiviral compounds and assessment of the druggability of their target for efficacy against respiratory syncytial virus (RSV)

(2011) A. Bonavia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

4SC-101, A Novel Small Molecule Dihydroorotate Dehydrogenase Inhibitor, Suppresses Systemic Lupus Erythematosus in MRL-(Fas)lpr Mice

(2010) Onkar P. Kulkarni et al.   AMERICAN JOURNAL OF PATHOLOGY

Exploring the Human Leukocyte Phosphoproteome Using a Microfluidic Reversed-Phase−TiO2−Reversed-Phase High-Performance Liquid Chromatography Phosphochip Coupled to a Quadrupole Time-of-Flight Mass Spectrometer

(2010) Reinout Raijmakers et al.   ANALYTICAL CHEMISTRY

Characteristic increase in nucleocytoplasmic protein glycosylation by O -GlcNAc in 3T3-L1 adipocyte differentiation

(2010) Katsunori Ishihara et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The mitochondrial respiratory chain

(2010) Peter R. Rich et al.   Essays in Biochemistry

Treatment of extensive-stage small cell lung carcinoma: current status and future prospects

(2010) I. K. Demedts et al.   EUROPEAN RESPIRATORY JOURNAL

Dihydroorotate dehydrogenase is required for N-(4-hydroxyphenyl)retinamide-induced reactive oxygen species production and apoptosis

(2010) Numsen Hail et al.   FREE RADICAL BIOLOGY AND MEDICINE

4SC-101, a novel immunosuppressive drug, inhibits IL-17 and attenuates colitis in two murine models of inflammatory bowel disease†

(2010) Leo R. Fitzpatrick et al.   INFLAMMATORY BOWEL DISEASES

Pyrimidine biosynthesis links mitochondrial respiration to the p53 pathway

(2010) A. A. Khutornenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signaling to p53: Ribosomal Proteins Find Their Way

(2009) Yanping Zhang et al.   CANCER CELL

Dihydroorotate dehydrogenase inhibitor A771726 (leflunomide) induces apoptosis and diminishes proliferation of multiple myeloma cells

(2009) P. Baumann et al.   MOLECULAR CANCER THERAPEUTICS

The Structures of Human Dihydroorotate Dehydrogenase with and without Inhibitor Reveal Conformational Flexibility in the Inhibitor and Substrate Binding Sites†

(2008) Björn Walse et al.   BIOCHEMISTRY