A white paper on Phospholipid Hydroperoxide Glutathione Peroxidase (GPx4) forty years later

Mitochondrial regulation during male germ cell development

(2022) Xiaoli Wang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology

(2022) Helmut Sies et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Machine Learning Classifies Ferroptosis and Apoptosis Cell Death Modalities with TfR1 Immunostaining

(2022) Jenny Jin et al.   ACS Chemical Biology

Selenium inhibits ferroptosis and ameliorates autistic-like behaviors of BTBR mice by regulating the Nrf2/GPx4 pathway

(2022) Hongmei Wu et al.   BRAIN RESEARCH BULLETIN

Ferroptosis: mechanisms, biology and role in disease

(2021) Xuejun Jiang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Crystal structures of the selenoprotein glutathione peroxidase 4 in its apo form and in complex with the covalently bound inhibitor ML162

(2021) Dieter Moosmayer et al.   Acta Crystallographica Section D-Structural Biology

Aerobic pyruvate metabolism sensitizes cells to ferroptosis primed by GSH depletion

(2021) Ana-Marija Vučković et al.   FREE RADICAL BIOLOGY AND MEDICINE

mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation

(2021) Yilei Zhang et al.   Nature Communications

CREB stimulates GPX4 transcription to inhibit ferroptosis in lung adenocarcinoma

(2021) Zhixian Wang et al.   ONCOLOGY REPORTS

Electrostatic Drivers of GPx4 Interactions with Membrane, Lipids, and DNA

(2021) Courtney L. Labrecque et al.   BIOCHEMISTRY

ZEB1 directly inhibits GPX4 transcription contributing to ROS accumulation in breast cancer cells

(2021) Xiao Han et al.   BREAST CANCER RESEARCH AND TREATMENT

Glutathione peroxidase 4–regulated neutrophil ferroptosis induces systemic autoimmunity

(2021) Pengchong Li et al.   NATURE IMMUNOLOGY

Targeting oxidative stress in disease: promise and limitations of antioxidant therapy

(2021) Henry Jay Forman et al.   NATURE REVIEWS DRUG DISCOVERY

Characterization of a patient-derived variant of GPX4 for precision therapy

(2021) Hengrui Liu et al.   Nature Chemical Biology

Targeting Ferroptosis: Pathological Mechanism and Treatment of Ischemia-Reperfusion Injury

(2021) Xinye Li et al.   Oxidative Medicine and Cellular Longevity

The transcription factor NF-Y participates to stem cell fate decision and regeneration in adult skeletal muscle

(2021) Giovanna Rigillo et al.   Nature Communications

Production and purification of homogenous recombinant human selenoproteins reveals a unique codon skipping event in E. coli and GPX4-specific affinity to bromosulfophthalein

(2021) Qing Cheng et al.   Redox Biology

Ferroptosis Suppressor Protein 1 (FSP1) and Coenzyme Q10 Cooperatively Suppress Ferroptosis

(2020) Kamyar Hadian   BIOCHEMISTRY

Lipid peroxidation and ferroptosis: The role of GSH and GPx4

(2020) Fulvio Ursini et al.   FREE RADICAL BIOLOGY AND MEDICINE

Characterization of the ER-resident peroxidases GPx7 and GPx8 shows the higher oxidative activity of GPx7 and its linkage to oxidative protein folding

(2020) Shingo Kanemura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers

(2020) Mariluz Soula et al.   Nature Chemical Biology

Redox homeostasis maintained by GPX4 facilitates STING activation

(2020) Mutian Jia et al.   NATURE IMMUNOLOGY

Broad Spectrum Deubiquitinase Inhibition Induces Both Apoptosis and Ferroptosis in Cancer Cells

(2020) Li Yang et al.   Frontiers in Oncology

Targeting Ferroptosis: New Hope for As-Yet-Incurable Diseases

(2020) Marcus Conrad et al.   TRENDS IN MOLECULAR MEDICINE

The Metabolic Underpinnings of Ferroptosis

(2020) Jiashuo Zheng et al.   Cell Metabolism

Ferroptosis: molecular mechanisms and health implications

(2020) Daolin Tang et al.   CELL RESEARCH

AMP-activated protein kinase: the current landscape for drug development

(2019) Gregory R. Steinberg et al.   NATURE REVIEWS DRUG DISCOVERY

Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke

(2019) Ishraq Alim et al.   CELL

Glutathione peroxidase 4 and vitamin E control reticulocyte maturation, stress erythropoiesis and iron homeostasis

(2019) Sandro Altamura et al.   HAEMATOLOGICA

A Compendium of Genetic Modifiers of Mitochondrial Dysfunction Reveals Intra-organelle Buffering

(2019) Tsz-Leung To et al.   CELL

Inactivation of the glutathione peroxidase GPx4 by the ferroptosis‐inducing molecule RSL3 requires the adaptor protein 14‐3‐3ε

(2019) Ana‐Marija Vučković et al.   FEBS LETTERS

Regulatory Phenomena in the Glutathione Peroxidase Superfamily

(2019) Regina Brigelius-Flohé et al.   ANTIOXIDANTS & REDOX SIGNALING

Insight into the mechanism of ferroptosis inhibition by ferrostatin-1

(2019) Giovanni Miotto et al.   Redox Biology

Protective effects of the mechanistic target of rapamycin against excess iron and ferroptosis in cardiomyocytes

(2018) Yuichi Baba et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Crystal structure and functional characterization of selenocysteine-containing glutathione peroxidase 4 suggests an alternative mechanism of peroxide reduction

(2018) Astrid Borchert et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Generation of superoxide and hydrogen peroxide by side reactions of mitochondrial 2-oxoacid dehydrogenase complexes in isolation and in cells

(2018) Victoria I. Bunik et al.   BIOLOGICAL CHEMISTRY

Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis

(2018) Irina Ingold et al.   CELL

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Lipid Peroxidation Drives Gasdermin D-Mediated Pyroptosis in Lethal Polymicrobial Sepsis

(2018) Rui Kang et al.   Cell Host & Microbe

Quantitative Profiling of Protein Carbonylations in Ferroptosis by an Aniline-Derived Probe

(2018) Ying Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites

(2018) Vyacheslav Akimov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites

(2018) Vyacheslav Akimov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Oxytosis/Ferroptosis—(Re-) Emerging Roles for Oxidative Stress-Dependent Non-apoptotic Cell Death in Diseases of the Central Nervous System

(2018) Jan Lewerenz et al.   Frontiers in Neuroscience

Targeting Nrf2 to Suppress Ferroptosis and Mitochondrial Dysfunction in Neurodegeneration

(2018) Moataz Abdalkader et al.   Frontiers in Neuroscience

Resolving the Role of Lipoxygenases in the Initiation and Execution of Ferroptosis

(2018) Ron Shah et al.   ACS Central Science

Detection of Microbial Infections Through Innate Immune Sensing of Nucleic Acids

(2018) Xiaojun Tan et al.   Annual Review of Microbiology

Role of Mitochondria in Ferroptosis

(2018) Minghui Gao et al.   MOLECULAR CELL

Activation of Glutathione Peroxidase 4 as a Novel Anti-inflammatory Strategy

(2018) Cong Li et al.   Frontiers in Pharmacology

Glutathione peroxidase 4-catalyzed reduction of lipid hydroperoxides in membranes: The polar head of membrane phospholipids binds the enzyme and addresses the fatty acid hydroperoxide group toward the redox center

(2017) Giorgio Cozza et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

(2017) Vasanthi S. Viswanathan et al.   NATURE

The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer

(2017) Angela M. Krebs et al.   NATURE CELL BIOLOGY

Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration

(2017) William Sealy Hambright et al.   Redox Biology

How Mammalian Cells Acquire Copper: An Essential but Potentially Toxic Metal

(2016) Jack H. Kaplan et al.   BIOPHYSICAL JOURNAL

Proteogenomics connects somatic mutations to signalling in breast cancer

(2016) Philipp Mertins et al.   NATURE

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

(2016) Valerian E Kagan et al.   Nature Chemical Biology

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Glutathione peroxidase 4 and vitamin E cooperatively prevent hepatocellular degeneration

(2016) Bradley A. Carlson et al.   Redox Biology

Expression of Inactive Glutathione Peroxidase 4 Leads to Embryonic Lethality, and Inactivation of the Alox15 Gene Does Not Rescue Such Knock-In Mice

(2015) Simone Hanna Brütsch et al.   ANTIOXIDANTS & REDOX SIGNALING

On the role of 4-hydroxynonenal in health and disease

(2015) Miklós Csala et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Glutathione peroxidase 4 prevents necroptosis in mouse erythroid precursors

(2015) O. Canli et al.   BLOOD

Selenocysteine oxidation in glutathione peroxidase catalysis: an MS-supported quantum mechanics study

(2015) Laura Orian et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ablation of the Ferroptosis Inhibitor Glutathione Peroxidase 4 in Neurons Results in Rapid Motor Neuron Degeneration and Paralysis

(2015) Liuji Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

T cell lipid peroxidation induces ferroptosis and prevents immunity to infection

(2015) Mai Matsushita et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Glutaminolysis and Transferrin Regulate Ferroptosis

(2015) Minghui Gao et al.   MOLECULAR CELL

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Obesity in a model of gpx4 haploinsufficiency uncovers a causal role for lipid-derived aldehydes in human metabolic disease and cardiomyopathy

(2015) Lalage A. Katunga et al.   Molecular Metabolism

A novel role for 12/15-lipoxygenase in regulating autophagy

(2015) Alwena H. Morgan et al.   Redox Biology

Absence of Glutathione Peroxidase 4 Affects Tumor Angiogenesis through Increased 12/15-Lipoxygenase Activity

(2015) Manuela Schneider et al.   NEOPLASIA

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Structurally Distinct Ca2+ Signaling Domains of Sperm Flagella Orchestrate Tyrosine Phosphorylation and Motility

(2014) Jean-Ju Chung et al.   CELL

Mutations in the enzyme glutathione peroxidase 4 cause Sedaghatian-type spondylometaphyseal dysplasia

(2014) Amanda C Smith et al.   JOURNAL OF MEDICAL GENETICS

Ischemia in Tumors Induces Early and Sustained Phosphorylation Changes in Stress Kinase Pathways but Does Not Affect Global Protein Levels

(2014) Philipp Mertins et al.   MOLECULAR & CELLULAR PROTEOMICS

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Selenoproteins: Molecular Pathways and Physiological Roles

(2014) Vyacheslav M. Labunskyy et al.   PHYSIOLOGICAL REVIEWS

Protein disulfide isomerase and glutathione are alternative substrates in the one Cys catalytic cycle of glutathione peroxidase 7

(2013) Valentina Bosello-Travain et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Combined Deficiency in Glutathione Peroxidase 4 and Vitamin E Causes Multiorgan Thrombus Formation and Early Death in Mice

(2013) Markus Wortmann et al.   CIRCULATION RESEARCH

Targeted Disruption of Glutathione Peroxidase 4 in Mouse Skin Epithelial Cells Impairs Postnatal Hair Follicle Morphogenesis that Is Partially Rescued through Inhibition of COX-2

(2013) Aniruddha Sengupta et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Gpx4 ablation in adult mice results in a lethal phenotype accompanied by neuronal loss in brain

(2012) Si-Eun Yoo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Proteomic Analyses Reveal Divergent Ubiquitylation Site Patterns in Murine Tissues

(2012) Sebastian A. Wagner et al.   MOLECULAR & CELLULAR PROTEOMICS

Proteomic Analysis of Lysine Acetylation Sites in Rat Tissues Reveals Organ Specificity and Subcellular Patterns

(2012) Alicia Lundby et al.   Cell Reports

Free Radical Lipid Peroxidation: Mechanisms and Analysis

(2011) Huiyong Yin et al.   CHEMICAL REVIEWS

Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory Development

(2011) Gerritje J.W. van der Windt et al.   IMMUNITY

Induction of Glutathione Peroxidase 4 Expression during Enterocytic Cell Differentiation

(2011) Bodo Speckmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glutathione Peroxidase 4 Is Required for Maturation of Photoreceptor Cells

(2011) Takashi Ueta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Proteome-wide, Quantitative Survey of In Vivo Ubiquitylation Sites Reveals Widespread Regulatory Roles

(2011) Sebastian A. Wagner et al.   MOLECULAR & CELLULAR PROTEOMICS

Delineating the Role of Glutathione Peroxidase 4 in Protecting Cells Against Lipid Hydroperoxide Damage and in Alzheimer's Disease

(2009) Min-Hyuk Yoo et al.   ANTIOXIDANTS & REDOX SIGNALING

Hierarchical regulation of selenoprotein expression and sex-specific effects of selenium

(2009) Lutz Schomburg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Catalytic mechanisms and specificities of glutathione peroxidases: Variations of a basic scheme

(2009) Stefano Toppo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Mitochondrial glutathione peroxidase 4 disruption causes male infertility

(2009) Manuela Schneider et al.   FASEB JOURNAL

Neuronal selenoprotein expression is required for interneuron development and prevents seizures and neurodegeneration

(2009) Eva K. Wirth et al.   FASEB JOURNAL

Short Form Glutathione Peroxidase 4 Is the Essential Isoform Required for Survival and Somatic Mitochondrial Functions

(2009) Hanyu Liang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Depletion of Selenoprotein GPx4 in Spermatocytes Causes Male Infertility in Mice

(2009) Hirotaka Imai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE

The Catalytic Site of Glutathione Peroxidases

(2008) Silvio C. E. Tosatto et al.   ANTIOXIDANTS & REDOX SIGNALING

Evolutionary and Structural Insights Into the Multifaceted Glutathione Peroxidase (Gpx) Superfamily

(2008) Stefano Toppo et al.   ANTIOXIDANTS & REDOX SIGNALING

Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death

(2008) Alexander Seiler et al.   Cell Metabolism

The Peroxiredoxin and Glutathione Peroxidase Families in Chlamydomonas reinhardtii

(2008) R. Dayer et al.   GENETICS