Circular RNA: metabolism, functions and interactions with proteins

N6-methyladenosine modification of FAAH mRNA in circSTAG1-regulated astrocyte dysfunction and depressive-like behaviors

(2020) Rongrong Huang et al.   BIOLOGICAL PSYCHIATRY

Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis

(2020) Douglas Hanniford et al.   CANCER CELL

m6A-dependent biogenesis of circular RNAs in male germ cells

(2020) Chong Tang et al.   CELL RESEARCH

Exosomes from CD133 + cells carrying circ‐ABCC1 mediate cell stemness and metastasis in colorectal cancer

(2020) Hong Zhao et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Circular RNA (circ‐0075804) promotes the proliferation of retinoblastoma via combining heterogeneous nuclear ribonucleoprotein K (HNRNPK) to improve the stability of E2F transcription factor 3 E2F3

(2020) Wenbo Zhao et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

CircBACH1 (hsa_circ_0061395) promotes hepatocellular carcinoma growth by regulating p27 repression via HuR

(2020) Bingqi Liu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Interaction between HuR and circPABPN1 Modulates Autophagy in the Intestinal Epithelium by Altering ATG16L1 Translation

(2020) Xiao-Xue Li et al.   MOLECULAR AND CELLULAR BIOLOGY

Translation and functional roles of circular RNAs in human cancer

(2020) Ming Lei et al.   Molecular Cancer

CircPTK2 (hsa_circ_0005273) as a novel therapeutic target for metastatic colorectal cancer

(2020) Hongbao Yang et al.   Molecular Cancer

CircMUC16 promotes autophagy of epithelial ovarian cancer via interaction with ATG13 and miR-199a

(2020) Xiaoling Gan et al.   Molecular Cancer

Structure-Mediated RNA Decay by UPF1 and G3BP1

(2020) Joseph W. Fischer et al.   MOLECULAR CELL

circSamd4 represses myogenic transcriptional activity of PUR proteins

(2020) Poonam R Pandey et al.   NUCLEIC ACIDS RESEARCH

Role of circular RNAs in brain development and CNS diseases

(2020) Suresh L. Mehta et al.   PROGRESS IN NEUROBIOLOGY

Identification of mecciRNAs and their roles in the mitochondrial entry of proteins

(2020) Xu Liu et al.   Science China-Life Sciences

Biogenesis and Functions of Circular RNAs Come into Focus

(2020) Mei-Sheng Xiao et al.   TRENDS IN CELL BIOLOGY

CircFOXK2 Promotes Growth and Metastasis of Pancreatic Ductal Adenocarcinoma by Complexing with RNA Binding Proteins and Sponging MiR-942

(2020) Chi Hin Wong et al.   CANCER RESEARCH

Extracellular Vesicle-Mediated Delivery of CircSCMH1 Promotes Functional Recovery in Rodent and Nonhuman Primate Ischemic Stroke Models

(2020) Li Yang et al.   CIRCULATION

CircMRPS35 suppresses gastric cancer progression via recruiting KAT7 to govern histone modification

(2020) Mengmeng Jie et al.   Molecular Cancer

A novel protein encoded by circFNDC3B inhibits tumor progression and EMT through regulating Snail in colon cancer

(2020) Zihao Pan et al.   Molecular Cancer

The Circular RNA circSKA3 Binds Integrin β1 to Induce Invadopodium Formation Enhancing Breast Cancer Invasion

(2020) William W. Du et al.   MOLECULAR THERAPY

The expanding regulatory mechanisms and cellular functions of circular RNAs

(2020) Ling-Ling Chen   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Modulation of circRNA Metabolism by m6A Modification

(2020) Gaia Di Timoteo et al.   Cell Reports

Circular RNA 406961 interacts with ILF2 to regulate PM2.5-induced inflammatory responses in human bronchial epithelial cells via activation of STAT3/JNK pathways

(2020) Yangyang Jia et al.   ENVIRONMENT INTERNATIONAL

A novel circular RNA, circ‐CCAC1, contributes to CCA progression, induces angiogenesis, and disrupts vascular endothelial barriers

(2020) Yi Xu et al.   HEPATOLOGY

The role of N6-methyladenosine (m6A) modification in the regulation of circRNAs

(2020) Lele Zhang et al.   Molecular Cancer

Circ-GLI1 promotes metastasis in melanoma through interacting with p70S6K2 to activate Hedgehog/GLI1 and Wnt/β-catenin pathways and upregulate Cyr61

(2020) Jun Chen et al.   Cell Death & Disease

Mitochondrial Genome-Derived circRNA mc-COX2 Functions as an Oncogene in Chronic Lymphocytic Leukemia

(2020) Zijuan Wu et al.   Molecular Therapy-Nucleic Acids

Biosynthesis of Circular RNA ciRS-7/CDR1as Is Mediated by Mammalian-wide Interspersed Repeats

(2020) Rei Yoshimoto et al.   iScience

Targeting Mitochondria-Located circRNA SCAR Alleviates NASH via Reducing mROS Output

(2020) Qiyi Zhao et al.   CELL

CircRNA inhibits DNA damage repair by interacting with host gene

(2020) Xiaolong Xu et al.   Molecular Cancer

Circular RNA CDR1as disrupts the p53/MDM2 complex to inhibit Gliomagenesis

(2020) Jiacheng Lou et al.   Molecular Cancer

CircECE1 activates energy metabolism in osteosarcoma by stabilizing c-Myc

(2020) Shuying Shen et al.   Molecular Cancer

An inducible circular RNA circKcnt2 inhibits ILC3 activation to facilitate colitis resolution

(2020) Benyu Liu et al.   Nature Communications

circRNA Hipk3 Induces Cardiac Regeneration after Myocardial Infarction in Mice by Binding to Notch1 and miR-133a

(2020) Xiaoyun Si et al.   Molecular Therapy-Nucleic Acids

IL-13 secreted by ILC2s promotes the self-renewal of intestinal stem cells through circular RNA circPan3

(2019) Pingping Zhu et al.   NATURE IMMUNOLOGY

CircSMARCA5 Regulates VEGFA mRNA Splicing and Angiogenesis in Glioblastoma Multiforme Through the Binding of SRSF1

(2019) Davide Barbagallo et al.   Cancers

Endoribonucleolytic Cleavage of m6A-Containing RNAs by RNase P/MRP Complex

(2019) Ok Hyun Park et al.   MOLECULAR CELL

Circular RNA circ-DONSON facilitates gastric cancer growth and invasion via NURF complex dependent activation of transcription factor SOX4

(2019) Lixian Ding et al.   Molecular Cancer

The Landscape of Circular RNA in Cancer

(2019) Josh N. Vo et al.   CELL

Circ_0075932 in adipocyte-derived exosomes induces inflammation and apoptosis in human dermal keratinocytes by directly binding with PUM2 and promoting PUM2-mediated activation of AuroraA/NF-κB pathway

(2019) Xi Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structure and Degradation of Circular RNAs Regulate PKR Activation in Innate Immunity

(2019) Chu-Xiao Liu et al.   CELL

Translation of yes-associated protein (YAP) was antagonized by its circular RNA via suppressing the assembly of the translation initiation machinery

(2019) Nan Wu et al.   CELL DEATH AND DIFFERENTIATION

FNDC3B circular RNA promotes the migration and invasion of gastric cancer cells via the regulation of E‐cadherin and CD44 expression

(2019) Yuling Hong et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Transcription factors and 3D genome conformation in cell-fate decisions

(2019) Ralph Stadhouders et al.   NATURE

Circular RNAs open a new chapter in cardiovascular biology

(2019) Simona Aufiero et al.   Nature Reviews Cardiology

CircACC1 Regulates Assembly and Activation of AMPK Complex under Metabolic Stress

(2019) Qidong Li et al.   Cell Metabolism

Intragenic antagonistic roles of protein and circRNA in tumorigenesis

(2019) Jlenia Guarnerio et al.   CELL RESEARCH

Guidance of circular RNAs to proteins’ behavior as binding partners

(2019) Junyun Luo et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Loss of Super-Enhancer-Regulated circRNA Nfix Induces Cardiac Regeneration After Myocardial Infarction in Adult Mice

(2019) Senlin Huang et al.   CIRCULATION

Circular RNA circRHOT1 promotes hepatocellular carcinoma progression by initiation of NR2F6 expression

(2019) Liyan Wang et al.   Molecular Cancer

Exosomal circRNAs: biogenesis, effect and application in human diseases

(2019) Yangxia Wang et al.   Molecular Cancer

Roles of circular RNAs in immune regulation and autoimmune diseases

(2019) Zheng Zhou et al.   Cell Death & Disease

Transforming activity of an oncoprotein-encoding circular RNA from human papillomavirus

(2019) Jiawei Zhao et al.   Nature Communications

Circular RNA expression profiling identifies hsa_circ_0011460 as a novel molecule in severe preeclampsia

(2019) Na Deng et al.   Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health

CircMYBL2, a circRNA from MYBL2, Regulates FLT3 Translation by Recruiting PTBP1 to Promote FLT3-ITD AML Progression

(2019) Yu-Meng Sun et al.   BLOOD

Circular RNA CDR1as sponges miR-7-5p to enhance E2F3 stability and promote the growth of nasopharyngeal carcinoma

(2019) Qiong Zhong et al.   Cancer Cell International

The circular RNA circ-Ccnb1 dissociates Ccnb1/Cdk1 complex suppressing cell invasion and tumorigenesis

(2019) Ling Fang et al.   CANCER LETTERS

A circular RNA derived from MMP9 facilitates oral squamous cell carcinoma metastasis through regulation of MMP9 mRNA stability

(2019) Bing Xia et al.   CELL TRANSPLANTATION

A circRNA signature predicts postoperative recurrence in stage II/III colon cancer

(2019) Huai‐Qiang Ju et al.   EMBO Molecular Medicine

A unified mechanism for intron and exon definition and back-splicing

(2019) Xueni Li et al.   NATURE

The biogenesis, biology and characterization of circular RNAs

(2019) Lasse S. Kristensen et al.   NATURE REVIEWS GENETICS

Reading, writing and erasing mRNA methylation

(2019) Sara Zaccara et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Defining an evolutionarily conserved role of GW182 in circular RNA degradation

(2019) Ruirui Jia et al.   Cell Discovery

The Role of Circular RNA CDR1as/ciRS-7 in Regulating Tumor Microenvironment: A Pan-Cancer Analysis

(2019) Zou et al.   Biomolecules

Therapeutic targeting of circ‐ CUX 1 / EWSR 1/ MAZ axis inhibits glycolysis and neuroblastoma progression

(2019) Huanhuan Li et al.   EMBO Molecular Medicine

Circ-HuR suppresses HuR expression and gastric cancer progression by inhibiting CNBP transactivation

(2019) Feng Yang et al.   Molecular Cancer

circGSK3β promotes metastasis in esophageal squamous cell carcinoma by augmenting β-catenin signaling

(2019) Xueting Hu et al.   Molecular Cancer

Circular RNA FOXP1 promotes tumor progression and Warburg effect in gallbladder cancer by regulating PKLR expression

(2019) Shouhua Wang et al.   Molecular Cancer

Circular RNA circERBB2 promotes gallbladder cancer progression by regulating PA2G4-dependent rDNA transcription

(2019) Xince Huang et al.   Molecular Cancer

N6-Methyladenosine Modification Controls Circular RNA Immunity

(2019) Y. Grace Chen et al.   MOLECULAR CELL

Circular RNA circ0005276 promotes the proliferation and migration of prostate cancer cells by interacting with FUS to transcriptionally activate XIAP

(2019) Yang Feng et al.   Cell Death & Disease

Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis

(2019) Venkata Naga Srikanth Garikipati et al.   Nature Communications

CircAnks1a in the spinal cord regulates hypersensitivity in a rodent model of neuropathic pain

(2019) Su-Bo Zhang et al.   Nature Communications

N6-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis

(2019) Ri-Xin Chen et al.   Nature Communications

Circular RNA NF1-419 enhances autophagy to ameliorate senile dementia by binding Dynamin-1 and Adaptor protein 2 B1 in AD-like mice

(2019) Chen Diling et al.   Aging-US

Posttranscriptional regulation of AKT by circular RNA angiomotin- like 1 mediates chemoresistance against paclitaxel in breast cancer cells

(2019) Jian Ma et al.   Aging-US

Knock-down of circular RNA H19 induces human adipose-derived stem cells adipogenic differentiation via a mechanism involving the polypyrimidine tract-binding protein 1

(2019) Yiyi Zhu et al.   EXPERIMENTAL CELL RESEARCH

circFBXW7 Inhibits Malignant Progression by Sponging miR-197-3p and Encoding a 185-aa Protein in Triple-Negative Breast Cancer

(2019) Feng Ye et al.   Molecular Therapy-Nucleic Acids

Circ‐MALAT1 Functions as Both an mRNA Translation Brake and a microRNA Sponge to Promote Self‐Renewal of Hepatocellular Cancer Stem Cells

(2019) Liang Chen et al.   Advanced Science

Circ-UBR5: An exonic circular RNA and novel small nuclear RNA involved in RNA splicing

(2018) Meilin Qin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Enhanced breast cancer progression by mutant p53 is inhibited by the circular RNA circ-Ccnb1

(2018) Ling Fang et al.   CELL DEATH AND DIFFERENTIATION

A length-dependent evolutionarily conserved pathway controls nuclear export of circular RNAs

(2018) Chuan Huang et al.   GENES & DEVELOPMENT

A Circular RNA Protects Dormant Hematopoietic Stem Cells from DNA Sensor cGAS-Mediated Exhaustion

(2018) Pengyan Xia et al.   IMMUNITY

CircSMARCA5 Inhibits Migration of Glioblastoma Multiforme Cells by Regulating a Molecular Axis Involving Splicing Factors SRSF1/SRSF3/PTB

(2018) Davide Barbagallo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Roadblocks and resolutions in eukaryotic translation

(2018) Anthony P. Schuller et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A circular RNA circ-DNMT1 enhances breast cancer progression by activating autophagy

(2018) William W. Du et al.   ONCOGENE

circRNA Mediates Silica-Induced Macrophage Activation Via HECTD1/ZC3H12A-Dependent Ubiquitination

(2018) Zewei Zhou et al.   Theranostics

Cis-acting circ-CTNNB1 promotes β-catenin signaling and cancer progression via DDX3-mediated transactivation of YY1

(2018) Feng Yang et al.   CANCER RESEARCH

The circular RNA ACR attenuates myocardial ischemia/reperfusion injury by suppressing autophagy via modulation of the Pink1/ FAM65B pathway

(2018) Lu-Yu Zhou et al.   CELL DEATH AND DIFFERENTIATION

CircRNA circRNA_102171 promotes papillary thyroid cancer progression through modulating CTNNBIP1-dependent activation of β-catenin pathway

(2018) Wen Bi et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Circular RNA circNOL10 Inhibits Lung Cancer Development by Promoting SCLM1-Mediated Transcriptional Regulation of the Humanin Polypeptide Family

(2018) Aruo Nan et al.   Advanced Science

Novel Role of FBXW7 Circular RNA in Repressing Glioma Tumorigenesis

(2017) Yibing Yang et al.   JNCI-Journal of the National Cancer Institute

Translation of CircRNAs

(2017) Nagarjuna Reddy Pamudurti et al.   MOLECULAR CELL

Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis

(2017) Ivano Legnini et al.   MOLECULAR CELL

The Output of Protein-Coding Genes Shifts to Circular RNAs When the Pre-mRNA Processing Machinery Is Limiting

(2017) Dongming Liang et al.   MOLECULAR CELL

Coordinated circRNA Biogenesis and Function with NF90/NF110 in Viral Infection

(2017) Xiang Li et al.   MOLECULAR CELL

The Circular RNA Interacts with STAT3, Increasing Its Nuclear Translocation and Wound Repair by Modulating Dnmt3a and miR-17 Function

(2017) Zhen-Guo Yang et al.   MOLECULAR THERAPY

DHX9 suppresses RNA processing defects originating from the Alu invasion of the human genome

(2017) Tuğçe Aktaş et al.   NATURE

Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1

(2017) Kotb Abdelmohsen et al.   RNA Biology

Identifying and Characterizing circRNA-Protein Interaction

(2017) William W Du et al.   Theranostics

A Circular RNA Binds To and Activates AKT Phosphorylation and Nuclear Localization Reducing Apoptosis and Enhancing Cardiac Repair

(2017) Yan Zeng et al.   Theranostics

Genome-Wide Maps of m6A circRNAs Identify Widespread and Cell-Type-Specific Methylation Patterns that Are Distinct from mRNAs

(2017) Chan Zhou et al.   Cell Reports

Novel Role of FBXW7 Circular RNA in Repressing Glioma Tumorigenesis

(2017) Yibing Yang et al.   JNCI-Journal of the National Cancer Institute

Induction of tumor apoptosis through a circular RNA enhancing Foxo3 activity

(2016) William W Du et al.   CELL DEATH AND DIFFERENTIATION

Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

(2016) Qi Chen et al.   NATURE IMMUNOLOGY

Endogenous microRNA sponges: evidence and controversy

(2016) Daniel W. Thomson et al.   NATURE REVIEWS GENETICS

Detecting circular RNAs: bioinformatic and experimental challenges

(2016) Linda Szabo et al.   NATURE REVIEWS GENETICS

Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2

(2016) William W. Du et al.   NUCLEIC ACIDS RESEARCH

Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans

(2016) Lesca M. Holdt et al.   Nature Communications

Circular RNAs Co-Precipitate with Extracellular Vesicles: A Possible Mechanism for circRNA Clearance

(2016) Erika Lasda et al.   PLoS One

CircRNA-protein complexes: IMP3 protein component defines subfamily of circRNPs

(2016) Tim Schneider et al.   Scientific Reports

Regulation of ribosomal RNA synthesis in T cells: requirement for GTP and Ebp1

(2015) L. X. T. Nguyen et al.   BLOOD

The RNA Binding Protein Quaking Regulates Formation of circRNAs

(2015) Simon J. Conn et al.   CELL

Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis

(2015) Yan Li et al.   CELL RESEARCH

Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed

(2015) Agnieszka Rybak-Wolf et al.   MOLECULAR CELL

Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity

(2015) Xintian You et al.   NATURE NEUROSCIENCE

Exon-intron circular RNAs regulate transcription in the nucleus

(2015) Zhaoyong Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Foxo3 activity promoted by non-coding effects of circular RNA and Foxo3 pseudogene in the inhibition of tumor growth and angiogenesis

(2015) W Yang et al.   ONCOGENE

Regulation of circRNA biogenesis

(2015) Ling-Ling Chen et al.   RNA Biology

Exon-intron circular RNAs regulate transcription in the nucleus

(2015) Zhaoyong Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Exon Circularization Requires Canonical Splice Signals

(2015) Stefan Starke et al.   Cell Reports

Correlation of circular RNA abundance with proliferation – exemplified with colorectal and ovarian cancer, idiopathic lung fibrosis and normal human tissues

(2015) Anna Bachmayr-Heyda et al.   Scientific Reports

A dual role of p53 in the control of autophagy

(2014) Ezgi Tasdemir et al.   Autophagy

Complementary Sequence-Mediated Exon Circularization

(2014) Xiao-Ou Zhang et al.   CELL

circRNA Biogenesis Competes with Pre-mRNA Splicing

(2014) Reut Ashwal-Fluss et al.   MOLECULAR CELL

Endogenous miRNA and Target Concentrations Determine Susceptibility to Potential ceRNA Competition

(2014) Andrew D. Bosson et al.   MOLECULAR CELL

The multilayered complexity of ceRNA crosstalk and competition

(2014) Yvonne Tay et al.   NATURE

Detecting and characterizing circular RNAs

(2014) William R Jeck et al.   NATURE BIOTECHNOLOGY

Rolling Circle Amplification in a Prokaryotic Translation System Using Small Circular RNA

(2013) Naoko Abe et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Circular Intronic Long Noncoding RNAs

(2013) Yang Zhang et al.   MOLECULAR CELL

Circular RNAs are a large class of animal RNAs with regulatory potency

(2013) Sebastian Memczak et al.   NATURE

Circular RNAs Are the Predominant Transcript Isoform from Hundreds of Human Genes in Diverse Cell Types

(2012) Julia Salzman et al.   PLoS One

Circular RNAs are abundant, conserved, and associated with ALU repeats

(2012) W. R. Jeck et al.   RNA

miRNA-dependent gene silencing involving Ago2-mediated cleavage of a circular antisense RNA

(2011) Thomas B Hansen et al.   EMBO JOURNAL

The mechanism of eukaryotic translation initiation and principles of its regulation

(2010) Richard J. Jackson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Splicing factors PTBP1 and PTBP2 promote proliferation and migration of glioma cell lines

(2009) Hannah C. Cheung et al.   BRAIN