A Ferrocene‐Functionalized Covalent Organic Framework for Enhancing Chemodynamic Therapy via Redox Dyshomeostasis

Nanocatalytic Theranostics with Glutathione Depletion and Enhanced Reactive Oxygen Species Generation for Efficient Cancer Therapy

(2021) Lian‐Hua Fu et al.   ADVANCED MATERIALS

Biomedicine Meets Fenton Chemistry

(2021) Zhongmin Tang et al.   CHEMICAL REVIEWS

Ferroptosis: mechanisms, biology and role in disease

(2021) Xuejun Jiang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Covalent Organic Frameworks for Biomedical Applications

(2021) Arezoo Esrafili et al.   Advanced Healthcare Materials

Synergistic Antibacterial and Anti‐Inflammatory Effects of a Drug‐Loaded Self‐Standing Porphyrin‐COF Membrane for Efficient Skin Wound Healing

(2021) Luo‐Gang Ding et al.   Advanced Healthcare Materials

Coordination-Driven Enhancement of Radiosensitization by Black Phosphorus via Regulating Tumor Metabolism

(2021) Leung Chan et al.   ACS Nano

Constructing Electron Levers in Perovskite Nanocrystals to Regulate the Local Electron Density for Intensive Chemodynamic Therapy

(2021) Peiran Zhao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Gram-Scale Synthesis of Cu(II)@COF via Solid-State Coordination Approach for Catalysis of Alkyne-Dihalomethane-Amine Coupling

(2021) Xuan Kan et al.   INORGANIC CHEMISTRY

Broadening horizons: the role of ferroptosis in cancer

(2021) Xin Chen et al.   Nature Reviews Clinical Oncology

Nanoscale Covalent Organic Frameworks with Donor–Acceptor Structure for Enhanced Photothermal Ablation of Tumors

(2021) Rui Xia et al.   ACS Nano

Pioneering Iodine-125-Labeled Nanoscale Covalent Organic Frameworks for Brachytherapy

(2021) Yijing Zhang et al.   BIOCONJUGATE CHEMISTRY

Light-Activated Hypoxia-Sensitive Covalent Organic Framework for Tandem-Responsive Drug Delivery

(2021) Lei Ge et al.   NANO LETTERS

Edge confined covalent organic framework with efficient biocompatibility and photothermic conversion

(2021) Bingjie Li et al.   Nano Today

Virus-Like Fe3O4@Bi2S3 Nanozymes with Resistance-Free Apoptotic Hyperthermia-Augmented Nanozymitic Activity for Enhanced Synergetic Cancer Therapy

(2020) Yajie Zhao et al.   ACS Applied Materials & Interfaces

Nanocarriers for the Delivery of Medical, Veterinary, and Agricultural Active Ingredients

(2020) Paul L. Chariou et al.   ACS Nano

The Chemistry of Reticular Framework Nanoparticles: MOF, ZIF, and COF Materials

(2020) Evelyn Ploetz et al.   ADVANCED FUNCTIONAL MATERIALS

A Corrole-Based Covalent Organic Framework Featuring Desymmetrized Topology

(2020) Yanming Zhao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

2D Covalent Organic Frameworks for Biomedical Applications

(2020) Sukanya Bhunia et al.   ADVANCED FUNCTIONAL MATERIALS

Directly targeting glutathione peroxidase 4 may be more effective than disrupting glutathione on ferroptosis-based cancer therapy

(2020) Yunpeng Wei et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Lipid peroxidation and ferroptosis: The role of GSH and GPx4

(2020) Fulvio Ursini et al.   FREE RADICAL BIOLOGY AND MEDICINE

The tumour microenvironment in pancreatic cancer — clinical challenges and opportunities

(2020) Won Jin Ho et al.   Nature Reviews Clinical Oncology

Platelet Membrane‐Camouflaged Magnetic Nanoparticles for Ferroptosis‐Enhanced Cancer Immunotherapy

(2020) Qin Jiang et al.   Small

Chemical and Colloidal Dynamics of MnO 2 Nanosheets in Biological Media Relevant for Nanosafety Assessment

(2020) Evan P. Gray et al.   Small

De-risking Drug Discovery of Intracellular Targeting Peptides: Screening Strategies to Eliminate False-Positive Hits

(2020) Simon Ng et al.   ACS Medicinal Chemistry Letters

Glutathione‐Depleting Nanoenzyme and Glucose Oxidase Combination for Hypoxia Modulation and Radiotherapy Enhancement

(2020) Meng Lyu et al.   Advanced Healthcare Materials

Tumor microenvironment-activatable Fe-doxorubicin preloaded amorphous CaCO3 nanoformulation triggers ferroptosis in target tumor cells

(2020) Chen-Cheng Xue et al.   Science Advances

A Tumor-Targeted Cascade Nanoreactor Based on Metal-Organic-Frameworks for Synergistic Ferroptosis−Starvation Anticancer Therapy

(2020) Xiuyan Wan et al.   ACS Nano

A Graphdiyne Oxide‐Based Iron Sponge with Photothermally Enhanced Tumor‐Specific Fenton Chemistry

(2020) Huan Min et al.   ADVANCED MATERIALS

Highly Chemoselective Self-Calibrated Fluorescent Probe Monitors Glutathione Dynamics in Nucleolus in Live Cells

(2020) Sabina Khatun et al.   ANALYTICAL CHEMISTRY

A Glycosylated Covalent Organic Framework Equipped with BODIPY and CaCO3 for Synergistic Tumor Therapy

(2020) Yu-Bin Dong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dinickelaferrocene: A Ferrocene Analogue with Two Aromatic Nickeloles Realized by Electron Back‐Donation from Iron

(2020) Zhe Huang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Homochiral Covalent Organic Framework for Catalytic Asymmetric Synthesis of a Drug Intermediate

(2020) Hui-Chao Ma et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Myocardial ischaemia–reperfusion injury and cardioprotection in perspective

(2020) Gerd Heusch   Nature Reviews Cardiology

Biodegradable Nickel Disulfide Nanozymes with GSH-Depleting Function for High-Efficiency Photothermal-Catalytic Antibacterial Therapy

(2020) Xianwen Wang et al.   iScience

Covalent Organic Framework-Based Nanocomposite for Synergetic Photo-, Chemodynamic-, and Immunotherapies

(2020) Sainan Liu et al.   ACS Applied Materials & Interfaces

An Ultrasmall SnFe 2 O 4 Nanozyme with Endogenous Oxygen Generation and Glutathione Depletion for Synergistic Cancer Therapy

(2020) Lili Feng et al.   ADVANCED FUNCTIONAL MATERIALS

Yolk‐Shell Structured Nanoflowers Induced Intracellular Oxidative/Thermal Stress Damage for Cancer Treatment

(2020) Miao‐Deng Liu et al.   ADVANCED FUNCTIONAL MATERIALS

GSH‐Depleted Nanozymes with Hyperthermia‐Enhanced Dual Enzyme‐Mimic Activities for Tumor Nanocatalytic Therapy

(2020) Shuming Dong et al.   ADVANCED MATERIALS

Colorectal Tumor Microenvironment‐Activated Bio‐Decomposable and Metabolizable Cu 2 O@CaCO 3 Nanocomposites for Synergistic Oncotherapy

(2020) Mengyu Chang et al.   ADVANCED MATERIALS

Tumor Microenvironment Stimuli‐Responsive Fluorescence Imaging and Synergistic Cancer Therapy by Carbon‐Dot–Cu 2+ Nanoassemblies

(2020) Shan Sun et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Upconverting Nanocarriers Enable Triggered Microtubule Inhibition and Concurrent Ferroptosis Induction for Selective Treatment of Triple-Negative Breast Cancer

(2020) Jundong Zhu et al.   NANO LETTERS

NRF2 in human neoplasm: Cancer biology and potential therapeutic target

(2020) Yang Liu et al.   PHARMACOLOGY & THERAPEUTICS

Biomolecular Corona Affects Controlled Release of Drug Payloads from Nanocarriers

(2020) Shahriar Sharifi et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Multicomponent Transition Metal Dichalcogenide Nanosheets for Imaging‐Guided Photothermal and Chemodynamic Therapy

(2020) Yu Zhu et al.   Advanced Science

A covalent organic framework-based multifunctional therapeutic platform for enhanced photodynamic therapy via catalytic cascade reactions

(2020) Lihan Cai et al.   Science China-Materials

Covalent Organic Frameworks: An Amazing Chemistry Platform for Designing Polymers

(2020) Donglin Jiang   Chem

GSH depletion liposome adjuvant for augmenting the photothermal immunotherapy of breast cancer

(2020) Zhanwei Zhou et al.   Science Advances

Lipid Droplets Maintain Energy Homeostasis and Glioblastoma Growth via Autophagic Release of Stored Fatty Acids

(2020) Xiaoning Wu et al.   iScience

Nanozyme‐Initiated In Situ Cascade Reactions for Self‐Amplified Biocatalytic Immunotherapy

(2020) Yajie Zhao et al.   ADVANCED MATERIALS

Ascorbate Tumor Chemotherapy by An Iron-Engineered Nanomedicine-Catalyzed Tumor-Specific Pro-Oxidation

(2020) Bowen Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inorganic nanoparticles in clinical trials and translations

(2020) Hui Huang et al.   Nano Today

Cathepsin B is an executioner of ferroptosis

(2020) Pandian Nagakannan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Guest-Dependent Dynamics in a 3D Covalent Organic Framework

(2019) Yichong Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease

(2019) D. Allan Butterfield et al.   NATURE REVIEWS NEUROSCIENCE

A mini-review and perspective on ferroptosis-inducing strategies in cancer therapy

(2019) Shuaifei Wang et al.   CHINESE CHEMICAL LETTERS

Targeting Ferroptosis to Iron Out Cancer

(2019) Behrouz Hassannia et al.   CANCER CELL

MS-based targeted metabolomics of eicosanoids and other oxylipins: Analytical and inter-individual variabilities

(2019) Cécile Gladine et al.   FREE RADICAL BIOLOGY AND MEDICINE

Tutorial on Powder X-ray Diffraction for Characterizing Nanoscale Materials

(2019) Cameron F. Holder et al.   ACS Nano

Nanoparticle Characterization: What to Measure?

(2019) Mario M. Modena et al.   ADVANCED MATERIALS

Nanocatalytic Medicine

(2019) Bowen Yang et al.   ADVANCED MATERIALS

Covalent Organic Frameworks: Chemical Approaches to Designer Structures and Built-in Functions

(2019) Donglin Jiang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of Copper Peroxide Nanodots for H2O2 Self-Supplying Chemodynamic Therapy

(2019) Li-Sen Lin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Photothermal conversion triggered thermal asymmetric catalysis within metal nanoparticles loaded homochiral covalent organic framework

(2019) Hui-Chao Ma et al.   Nature Communications

Covalent Organic Framework‐Supported Molecularly Dispersed Near‐Infrared Dyes Boost Immunogenic Phototherapy against Tumors

(2019) Shaoju Gan et al.   ADVANCED FUNCTIONAL MATERIALS

A Tumor‐Microenvironment‐Activated Nanozyme‐Mediated Theranostic Nanoreactor for Imaging‐Guided Combined Tumor Therapy

(2019) Feng Liu et al.   ADVANCED MATERIALS

Stable Radical Cation-Containing Covalent Organic Frameworks Exhibiting Remarkable Structure-Enhanced Photothermal Conversion

(2019) Zhen Mi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cyanine-Assisted Exfoliation of Covalent Organic Frameworks in Nanocomposites for Highly Efficient Chemo-Photothermal Tumor Therapy

(2019) Kui Wang et al.   ACS Applied Materials & Interfaces

Nanoscale Covalent Organic Framework for Combinatorial Antitumor Photodynamic and Photothermal Therapy

(2019) Qun Guan et al.   ACS Nano

Boosting H 2 O 2 ‐Guided Chemodynamic Therapy of Cancer by Enhancing Reaction Kinetics through Versatile Biomimetic Fenton Nanocatalysts and the Second Near‐Infrared Light Irradiation

(2019) Tingting Wang et al.   ADVANCED FUNCTIONAL MATERIALS

Recent Progress in Ferroptosis Inducers for Cancer Therapy

(2019) Chen Liang et al.   ADVANCED MATERIALS

Triggered All-Active Metal Organic Framework: Ferroptosis Machinery Contributes to the Apoptotic Photodynamic Antitumor Therapy

(2019) Xuan Meng et al.   NANO LETTERS

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

(2019) Kirill Bersuker et al.   NATURE

Triggered ferroptotic polymer micelles for reversing multidrug resistance to chemotherapy

(2019) Min Gao et al.   BIOMATERIALS

Porphyrin-based covalent organic framework nanoparticles for photoacoustic imaging-guided photodynamic and photothermal combination cancer therapy

(2019) Dianwei Wang et al.   BIOMATERIALS

Dual GSH-exhausting sorafenib loaded manganese-silica nanodrugs for inducing the ferroptosis of hepatocellular carcinoma cells

(2019) Hongxia Tang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Grand challenges in nanomedicine

(2019) Lin-Ping Wu et al.   Materials Science & Engineering C-Materials for Biological Applications

Enhanced Photodynamic Therapy by Reduced Levels of Intracellular Glutathione Obtained By Employing a Nano-MOF with CuII as the Active Center

(2018) Wei Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

NRF2 and the Hallmarks of Cancer

(2018) Montserrat Rojo de la Vega et al.   CANCER CELL

Glutathione metabolism in cancer progression and treatment resistance

(2018) Ankita Bansal et al.   JOURNAL OF CELL BIOLOGY

Leukotriene receptors as potential therapeutic targets

(2018) Takehiko Yokomizo et al.   JOURNAL OF CLINICAL INVESTIGATION

Water-dispersible PEG-curcumin/amine-functionalized covalent organic framework nanocomposites as smart carriers for in vivo drug delivery

(2018) Guiyang Zhang et al.   Nature Communications

Unsolved mysteries: How does lipid peroxidation cause ferroptosis?

(2018) Huizhong Feng et al.   PLOS BIOLOGY

Chemodynamic Therapy: Tumour Microenvironment-Mediated Fenton and Fenton-like Reaction

(2018) Zhongmin Tang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Molecular Engineering of Bandgaps in Covalent Organic Frameworks

(2018) Xing Li et al.   CHEMISTRY OF MATERIALS

Cancer Treatment through Nanoparticle-Facilitated Fenton Reaction

(2018) Hadi Ranji-Burachaloo et al.   ACS Nano

Arginine-Rich Manganese Silicate Nanobubbles as a Ferroptosis-Inducing Agent for Tumor-Targeted Theranostics

(2018) Shuaifei Wang et al.   ACS Nano

Ferrous-Supply-Regeneration Nanoengineering for Cancer-Cell-Specific Ferroptosis in Combination with Imaging-Guided Photodynamic Therapy

(2018) Tao Liu et al.   ACS Nano

Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer

(2018) Daiha Shin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Self-Assembled Copper–Amino Acid Nanoparticles for in Situ Glutathione “AND” H2O2 Sequentially Triggered Chemodynamic Therapy

(2018) Baojin Ma et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Acid sphingomyelinase promotes mitochondrial dysfunction due to glutamate-induced regulated necrosis

(2017) Sergei A. Novgorodov et al.   JOURNAL OF LIPID RESEARCH

Mitochondria Targeted Nanoscale Zeolitic Imidazole Framework-90 for ATP Imaging in Live Cells

(2017) Jingjing Deng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Targeted Drug Delivery in Covalent Organic Nanosheets (CONs) via Sequential Postsynthetic Modification

(2017) Shouvik Mitra et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tumor-selective catalytic nanomedicine by nanocatalyst delivery

(2017) Minfeng Huo et al.   Nature Communications

Diverse Ways of Perturbing the Human Arachidonic Acid Metabolic Network To Control Inflammation

(2015) Hu Meng et al.   ACCOUNTS OF CHEMICAL RESEARCH

Synthesis, Culture Medium Stability, and In Vitro and In Vivo Zebrafish Embryo Toxicity of Metal-Organic Framework Nanoparticles

(2014) Àngels Ruyra et al.   CHEMISTRY-A EUROPEAN JOURNAL

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

Unearthing the secrets of mitochondrial ROS and glutathione in bioenergetics

(2013) Ryan J. Mailloux et al.   TRENDS IN BIOCHEMICAL SCIENCES

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Leukotriene Receptors

(2011) Motonao Nakamura et al.   CHEMICAL REVIEWS

Guidelines for accurate EC50/IC50 estimation

(2010) J. L. Sebaugh   PHARMACEUTICAL STATISTICS

Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells

(2008) Wan Seok Yang et al.   CHEMISTRY & BIOLOGY