The Selenoprotein Glutathione Peroxidase 4: From Molecular Mechanisms to Novel Therapeutic Opportunities

Ferroptosis inducers are a novel therapeutic approach for advanced prostate cancer

(2021) Ali Ghoochani et al.   CANCER RESEARCH

Ferroptosis: mechanisms, biology and role in disease

(2021) Xuejun Jiang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ferroptosis-Related Genes in Neurodevelopment and Central Nervous System

(2021) Soo-Whee Kim et al.   Biology-Basel

Mutant Huntingtin stalls ribosomes and represses protein synthesis in a cellular model of Huntington disease

(2021) Mehdi Eshraghi et al.   Nature Communications

Roles of Selenoproteins in Brain Function and the Potential Mechanism of Selenium in Alzheimer’s Disease

(2021) Zhong-Hao Zhang et al.   Frontiers in Neuroscience

Role of Ferroptosis in Lung Diseases

(2021) Wenting Xu et al.   Journal of Inflammation Research

Electrostatic Drivers of GPx4 Interactions with Membrane, Lipids, and DNA

(2021) Courtney L. Labrecque et al.   BIOCHEMISTRY

Holistic drug design for multiparameter optimization in modern small molecule drug discovery

(2021) Lewis D. Pennington et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Mitochondrial regulation of ferroptosis

(2021) Boyi Gan   JOURNAL OF CELL BIOLOGY

Ferroptosis as a mechanism of neurodegeneration in Alzheimer's disease

(2021) Md. Jakaria et al.   JOURNAL OF NEUROCHEMISTRY

Implication of ferroptosis in aging

(2021) Maryam Mazhar et al.   Cell Death Discovery

The effect of Phoenix dactylifera pollen on the expression of NRF2, SOD2, CAT, and GPX4 genes, and sperm parameters of fertile and infertile men: A controlled clinical trial

(2021) Soghra Fallahi et al.   International Journal of Reproductive Biomedicine

The molecular mechanisms of ferroptosis and its role in cardiovascular disease

(2021) Yang Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

The emerging role of selenium metabolic pathways in cancer: New therapeutic targets for cancer

(2021) Kalishwaralal Kalimuthu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Mechanisms Affecting the Biosynthesis and Incorporation Rate of Selenocysteine

(2021) Jing-Jing Peng et al.   MOLECULES

Characterization of a patient-derived variant of GPX4 for precision therapy

(2021) Hengrui Liu et al.   Nature Chemical Biology

The role of ferroptosis in lung cancer

(2021) Sikai Wu et al.   Biomarker Research

Ferroptosis as a Major Factor and Therapeutic Target for Neuroinflammation in Parkinson’s Disease

(2021) Chih-Jan Ko et al.   Biomedicines

Going Forward and Back: The Complex Evolutionary History of the GPx

(2021) Thomaz Stumpf Trenz et al.   Biology-Basel

Ferroptosis, a novel pharmacological mechanism of anti-cancer drugs

(2020) Yanwei Su et al.   CANCER LETTERS

New Insights into the Role of Glutathione in the Mechanism of Fever

(2020) Sylwia Wrotek et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ferroptosis: past, present and future

(2020) Jie Li et al.   Cell Death & Disease

Selenium and selenoproteins: it’s role in regulation of inflammation

(2020) Sneha Hariharan et al.   INFLAMMOPHARMACOLOGY

Directly targeting glutathione peroxidase 4 may be more effective than disrupting glutathione on ferroptosis-based cancer therapy

(2020) Yunpeng Wei et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The multifaceted role of reactive oxygen species in tumorigenesis

(2020) Anuradha Kirtonia et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Lipid peroxidation and ferroptosis: The role of GSH and GPx4

(2020) Fulvio Ursini et al.   FREE RADICAL BIOLOGY AND MEDICINE

Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles

(2020) John K. Eaton et al.   Nature Chemical Biology

Oxidative stress and diabetes: antioxidative strategies

(2020) Pengju Zhang et al.   Frontiers of Medicine

The role of glutathione redox imbalance in autism spectrum disorder: A review

(2020) Geir Bjørklund et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative Stress and Neuroinflammation Potentiate Each Other to Promote Progression of Dopamine Neurodegeneration

(2020) Jingyi He et al.   Oxidative Medicine and Cellular Longevity

Ferroptosis and its potential role in the physiopathology of Parkinson’s Disease

(2020) Laura Mahoney-Sánchez et al.   PROGRESS IN NEUROBIOLOGY

Emerging Mechanisms and Disease Relevance of Ferroptosis

(2020) Brent R. Stockwell et al.   TRENDS IN CELL BIOLOGY

Role of Glutathione in Cancer: From Mechanisms to Therapies

(2020) Luke Kennedy et al.   Biomolecules

The Metabolic Underpinnings of Ferroptosis

(2020) Jiashuo Zheng et al.   Cell Metabolism

Role of GPX4-Mediated Ferroptosis in the Sensitivity of Triple Negative Breast Cancer Cells to Gefitinib

(2020) Xiang Song et al.   Frontiers in Oncology

Clinical and Biological Significances of a Ferroptosis-Related Gene Signature in Glioma

(2020) Shenghua Zhuo et al.   Frontiers in Oncology

GPX4 at the Crossroads of Lipid Homeostasis and Ferroptosis

(2019) Giovanni C. Forcina et al.   PROTEOMICS

Oxidative Stress and Cancer

(2019) James E. Klaunig   CURRENT PHARMACEUTICAL DESIGN

Cell death: a review of the major forms of apoptosis, necrosis and autophagy

(2019) Mark S D’Arcy   CELL BIOLOGY INTERNATIONAL

The molecular machinery of regulated cell death

(2019) Daolin Tang et al.   CELL RESEARCH

Chemical Biology Approaches to Interrogate the Selenoproteome

(2019) Jennifer C. Peeler et al.   ACCOUNTS OF CHEMICAL RESEARCH

Selenium intake, status, and health: a complex relationship

(2019) Margaret P Rayman   Hormones-International Journal of Endocrinology and Metabolism

Lipid peroxidation in neurodegeneration

(2019) Carmen Peña-Bautista et al.   CLINICA CHIMICA ACTA

Regulatory Phenomena in the Glutathione Peroxidase Superfamily

(2019) Regina Brigelius-Flohé et al.   ANTIOXIDANTS & REDOX SIGNALING

GPx4, Lipid Peroxidation, and Cell Death: Discoveries, Rediscoveries, and Open Issues

(2018) Matilde Maiorino et al.   ANTIOXIDANTS & REDOX SIGNALING

Crystal structure and functional characterization of selenocysteine-containing glutathione peroxidase 4 suggests an alternative mechanism of peroxide reduction

(2018) Astrid Borchert et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis

(2018) Irina Ingold et al.   CELL

Selenium and GPX4, a vital symbiosis

(2018) José Pedro Friedmann Angeli et al.   FREE RADICAL BIOLOGY AND MEDICINE

Association of GPX1 and GPX4 polymorphisms with episodic memory and Alzheimer’s disease

(2018) Tatiane Jacobsen da Rocha et al.   NEUROSCIENCE LETTERS

GPX2 promotes development of bladder cancer with squamous cell differentiation through the control of apoptosis

(2018) Taku Naiki et al.   Oncotarget

Resolving the Role of Lipoxygenases in the Initiation and Execution of Ferroptosis

(2018) Ron Shah et al.   ACS Central Science

Role of GPX4 in ferroptosis and its pharmacological implication

(2018) Tobias M. Seibt et al.   FREE RADICAL BIOLOGY AND MEDICINE

BAP1 links metabolic regulation of ferroptosis to tumour suppression

(2018) Yilei Zhang et al.   NATURE CELL BIOLOGY

Role of Mitochondria in Ferroptosis

(2018) Minghui Gao et al.   MOLECULAR CELL

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

(2017) Matthew J. Hangauer et al.   NATURE

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

(2017) Vasanthi S. Viswanathan et al.   NATURE

A scaffold protein that chaperones a cysteine-sulfenic acid in H2O2 signaling

(2017) Antoine Bersweiler et al.   Nature Chemical Biology

The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity

(2017) Yangchun Xie et al.   Cell Reports

Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration

(2017) William Sealy Hambright et al.   Redox Biology

Why Nature Chose Selenium

(2016) Hans J. Reich et al.   ACS Chemical Biology

Selenocysteine vs Cysteine: Tuning the Derivatization on Benzenesulfonyl Moiety of a Triazole Linked Dansyl Connected Glycoconjugate for Selective Recognition of Selenocysteine and the Applicability of the Conjugate in Buffer, in Serum, on Silica Gel, and in HepG2 Cells

(2016) Sivaiah Areti et al.   ANALYTICAL CHEMISTRY

Epigenetic and Glucocorticoid Receptor-Mediated Regulation of Glutathione Peroxidase 3 in Lung Cancer Cells

(2016) Byung Chull An et al.   MOLECULES AND CELLS

Crystal and solution structural studies of mouse phospholipid hydroperoxide glutathione peroxidase 4

(2016) Robert Janowski et al.   Acta Crystallographica Section F-Structural Biology Communications

Expression of a Catalytically Inactive Mutant Form of Glutathione Peroxidase 4 (Gpx4) Confers a Dominant-negative Effect in Male Fertility

(2015) Irina Ingold et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

T cell lipid peroxidation induces ferroptosis and prevents immunity to infection

(2015) Mai Matsushita et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Why Is Mammalian Thioredoxin Reductase 1 So Dependent upon the Use of Selenium?

(2014) Adam P. Lothrop et al.   BIOCHEMISTRY

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Selenoproteins: Molecular Pathways and Physiological Roles

(2014) Vyacheslav M. Labunskyy et al.   PHYSIOLOGICAL REVIEWS

Selenium and selenocysteine: roles in cancer, health, and development

(2014) Dolph L. Hatfield et al.   TRENDS IN BIOCHEMICAL SCIENCES

Oxidative stress in Alzheimer’s disease

(2014) Zhichun Chen et al.   Neuroscience Bulletin

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

(2014) Scott J Dixon et al.   eLife

Physiological functions of GPx2 and its role in inflammation-triggered carcinogenesis

(2012) Regina Brigelius-Flohé et al.   Annals of the New York Academy of Sciences

Glutathione peroxidases

(2012) Regina Brigelius-Flohé et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Glutathione peroxidase 4 has a major role in protecting mitochondria from oxidative damage and maintaining oxidative phosphorylation complexes in gut epithelial cells

(2012) Patience Cole-Ezea et al.   FREE RADICAL BIOLOGY AND MEDICINE

p53-induced Gene 3 Mediates Cell Death Induced by Glutathione Peroxidase 3

(2012) Hui Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reactive oxygen species: from health to disease

(2012) K Brieger et al.   SWISS MEDICAL WEEKLY

Two Endoplasmic Reticulum PDI Peroxidases Increase the Efficiency of the Use of Peroxide during Disulfide Bond Formation

(2011) Van Dat Nguyen et al.   JOURNAL OF MOLECULAR BIOLOGY

Selenoproteins—What unique properties can arise with selenocysteine in place of cysteine?

(2010) Elias S.J. Arnér   EXPERIMENTAL CELL RESEARCH

Loss of GPx2 increases apoptosis, mitosis, and GPx1 expression in the intestine of mice

(2010) Simone Florian et al.   FREE RADICAL BIOLOGY AND MEDICINE

System xc−and Thioredoxin Reductase 1 Cooperatively Rescue Glutathione Deficiency

(2010) Pankaj Kumar Mandal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glutathione peroxidases in different stages of carcinogenesis

(2009) Regina Brigelius-Flohé et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Epididymis seleno-independent glutathione peroxidase 5 maintains sperm DNA integrity in mice

(2009) Eléonore Chabory et al.   JOURNAL OF CLINICAL INVESTIGATION

The Catalytic Site of Glutathione Peroxidases

(2008) Silvio C. E. Tosatto et al.   ANTIOXIDANTS & REDOX SIGNALING

Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death

(2008) Alexander Seiler et al.   Cell Metabolism

Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells

(2008) Wan Seok Yang et al.   CHEMISTRY & BIOLOGY

Glutathione peroxidase family - an evolutionary overview

(2008) Rogerio Margis et al.   FEBS Journal

Glutathione: Overview of its protective roles, measurement, and biosynthesis

(2008) Henry Jay Forman et al.   MOLECULAR ASPECTS OF MEDICINE