Epigenetic regulation in human cancer: the potential role of epi-drug in cancer therapy

LncRNA FAM83H-AS1 promotes triple-negative breast cancer progression by regulating the miR-136-5p/metadherin axis

(2020) Chunyong Han et al.   Aging-US

Emerging role of tumor-related functional peptides encoded by lncRNA and circRNA

(2020) Pan Wu et al.   Molecular Cancer

LY6K Promotes Glioblastoma Tumorigenicity via CAV-1-Mediated ERK1/2 Signaling Enhancement

(2020) Namratha G Sastry et al.   NEURO-ONCOLOGY

The EGFR-ZNF263 signaling axis silences SIX3 in glioblastoma epigenetically

(2020) Zhibin Yu et al.   ONCOGENE

SLC34A2 simultaneously promotes papillary thyroid carcinoma growth and invasion through distinct mechanisms

(2020) Jing He et al.   ONCOGENE

RASSF10 is frequently epigenetically inactivated in kidney cancer and its knockout promotes neoplasia in cancer prone mice

(2020) Antje M. Richter et al.   ONCOGENE

circRNA circFUT8 Upregulates Krüpple-like Factor 10 to Inhibit the Metastasis of Bladder Cancer via Sponging miR-570-3p

(2020) Qingqing He et al.   Molecular Therapy-Oncolytics

Potential of Exosomal microRNA-200b as Liquid Biopsy Marker in Pancreatic Ductal Adenocarcinoma

(2020) Moritz Reese et al.   Cancers

A Comprehensive Picture of Extracellular Vesicles and Their Contents. Molecular Transfer to Cancer Cells

(2020) Ancuta Jurj et al.   Cancers

Tumor-derived exosomal miR-619-5p promotes tumor angiogenesis and metastasis through the inhibition of RCAN1.4

(2020) Dong Ha Kim et al.   CANCER LETTERS

Targeting Multiple Receptors to Increase Checkpoint Blockade Efficacy

(2019) David Zahavi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The histone H3 Lys 27 demethylase KDM6B promotes migration and invasion of glioma cells partly by regulating the expression of SNAI1

(2019) Aixia Sui et al.   NEUROCHEMISTRY INTERNATIONAL

Preclinical Targeting of MicroRNA-214 in Cutaneous T-cell Lymphoma (CTCL)

(2019) Rebecca Kohnken et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The role of m6A RNA methylation in human cancer

(2019) Xiao-Yu Chen et al.   Molecular Cancer

The Potential for microRNA Therapeutics and Clinical Research

(2019) Johora Hanna et al.   Frontiers in Genetics

Colorectal cancer-derived extracellular vesicles induce transformation of fibroblasts into colon carcinoma cells

(2019) Mohamed Abdouh et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Genomic and Epigenomic Features of Primary and Recurrent Hepatocellular Carcinomas

(2019) Xiaofan Ding et al.   GASTROENTEROLOGY

Current concepts of non-coding RNA regulation of immune checkpoints in cancer

(2019) Maria Anna Smolle et al.   MOLECULAR ASPECTS OF MEDICINE

Exosomes in Cancer Radioresistance

(2019) Jie Ni et al.   Frontiers in Oncology

NSD2 overexpression drives clustered chromatin and transcriptional changes in a subset of insulated domains

(2019) Priscillia Lhoumaud et al.   Nature Communications

microRNA-181 serves as a dual-role regulator in the development of human cancers

(2019) Tayebeh Rezaei et al.   FREE RADICAL BIOLOGY AND MEDICINE

Tumor propagating cells: drivers of tumor plasticity, heterogeneity, and recurrence

(2019) Alexandre Teixeira Vessoni et al.   ONCOGENE

The Bivalent Genome: Characterization, Structure, and Regulation

(2019) Enrique Blanco et al.   TRENDS IN GENETICS

Zebularine exerts its antiproliferative activity through S phase delay and cell death in human malignant mesothelioma cells

(2018) Yukitoshi Takemura et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Epigenetic Regulation of CXCL12 Plays a Critical Role in Mediating Tumor Progression and the Immune Response In Osteosarcoma

(2018) Binghao Li et al.   CANCER RESEARCH

LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade

(2018) Wanqiang Sheng et al.   CELL

Multiple functions of m6A RNA methylation in cancer

(2018) Yutian Pan et al.   Journal of Hematology & Oncology

Next generation of immune checkpoint therapy in cancer: new developments and challenges

(2018) Julian A. Marin-Acevedo et al.   Journal of Hematology & Oncology

Enhancer of zeste homolog 2 (EZH2) inhibitors

(2018) Nitya Gulati et al.   LEUKEMIA & LYMPHOMA

DNA methyltransferase 3A isoform b contributes to repressing E-cadherin through cooperation of DNA methylation and H3K27/H3K9 methylation in EMT-related metastasis of gastric cancer

(2018) He Cui et al.   ONCOGENE

Therapeutic Targeting of Long Non-Coding RNAs in Cancer

(2018) Gayatri Arun et al.   TRENDS IN MOLECULAR MEDICINE

DNA methyltransferase inhibition upregulates MHC-I to potentiate cytotoxic T lymphocyte responses in breast cancer

(2018) Na Luo et al.   Nature Communications

EZH2 inhibitors sensitize myeloma cell lines to panobinostat resulting in unique combinatorial transcriptomic changes

(2018) Taylor Harding et al.   Oncotarget

DNA methylation and repressive H3K9 and H3K27 trimethylation in the promoter regions of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, and PD-L1 genes in human primary breast cancer

(2018) Varun Sasidharan Nair et al.   Clinical Epigenetics

Mogamulizumab versus vorinostat in previously treated cutaneous T-cell lymphoma (MAVORIC): an international, open-label, randomised, controlled phase 3 trial

(2018) Youn H Kim et al.   LANCET ONCOLOGY

FDA approves patisiran to treat hereditary transthyretin amyloidosis

(2018) Heather Wood   Nature Reviews Neurology

DNA methylation and repressive histones in the promoters of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, PD-L1, and galectin-9 genes in human colorectal cancer

(2018) Varun Sasidharan Nair et al.   Clinical Epigenetics

Enhanced anti-tumor efficacy of checkpoint inhibitors in combination with the histone deacetylase inhibitor Belinostat in a murine hepatocellular carcinoma model

(2018) Diana Llopiz et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

BRD4 and Cancer: going beyond transcriptional regulation

(2018) Benedetta Donati et al.   Molecular Cancer

IGF2BP1 promotes SRF-dependent transcription in cancer in a m6A- and miRNA-dependent manner

(2018) Simon Müller et al.   NUCLEIC ACIDS RESEARCH

Epigenetic silencing of ZNF132 mediated by methylation-sensitive Sp1 binding promotes cancer progression in esophageal squamous cell carcinoma

(2018) Dong Jiang et al.   Cell Death & Disease

Cancer-derived exosomal miR-25-3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis

(2018) Zhicheng Zeng et al.   Nature Communications

Loss-of-function but not dominant-negative intragenic IKZF1 deletions are associated with an adverse prognosis in adult BCR-ABL -negative acute lymphoblastic leukemia

(2017) Benjamin Kobitzsch et al.   HAEMATOLOGICA

Safety and activity of microRNA-loaded minicells in patients with recurrent malignant pleural mesothelioma: a first-in-man, phase 1, open-label, dose-escalation study

(2017) Nico van Zandwijk et al.   LANCET ONCOLOGY

Bivalent Epigenetic Control of Oncofetal Gene Expression in Cancer

(2017) Sayyed K. Zaidi et al.   MOLECULAR AND CELLULAR BIOLOGY

RUNX2 expression in thyroid and breast cancer requires the cooperation of three non-redundant enhancers under the control of BRD4 and c-JUN

(2017) Valentina Sancisi et al.   NUCLEIC ACIDS RESEARCH

Loss-of-function but not dominant-negative intragenic IKZF1 deletions are associated with an adverse prognosis in adult BCR-ABL -negative acute lymphoblastic leukemia

(2017) Benjamin Kobitzsch et al.   HAEMATOLOGICA

The Role of Panobinostat Plus Bortezomib and Dexamethasone in Treating Relapsed or Relapsed and Refractory Multiple Myeloma: A European Perspective

(2016) Jesus F. San-Miguel et al.   ADVANCES IN THERAPY

The Bromodomain Inhibitor JQ1 and the Histone Deacetylase Inhibitor Panobinostat Synergistically Reduce N-Myc Expression and Induce Anticancer Effects

(2016) J. Shahbazi et al.   CLINICAL CANCER RESEARCH

Oncofetal Epigenetic Bivalency in Breast Cancer Cells: H3K4 and H3K27 Tri-Methylation as a Biomarker for Phenotypic Plasticity

(2016) Terri L. Messier et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Resminostat plus sorafenib as second-line therapy of advanced hepatocellular carcinoma – The SHELTER study

(2016) Michael Bitzer et al.   JOURNAL OF HEPATOLOGY

METTL3 Gains R/W Access to the Epitranscriptome

(2016) Ulrike Schumann et al.   MOLECULAR CELL

m6A potentiates Sxl alternative pre-mRNA splicing for robust Drosophila sex determination

(2016) Irmgard U. Haussmann et al.   NATURE

An essential role for UTX in resolution and activation of bivalent promoters

(2016) Shilpa S. Dhar et al.   NUCLEIC ACIDS RESEARCH

Reversible lysine-specific demethylase 1 antagonist HCI-2509 inhibits growth and decreases c-MYC in castration- and docetaxel-resistant prostate cancer cells

(2016) S Gupta et al.   PROSTATE CANCER AND PROSTATIC DISEASES

The bromodomain inhibitor OTX015 (MK-8628) exerts anti-tumor activity in triple-negative breast cancer models as single agent and in combination with everolimus

(2016) Ramiro Vázquez et al.   Oncotarget

BET Bromodomain Inhibition Promotes Anti-tumor Immunity by Suppressing PD-L1 Expression

(2016) Hengrui Zhu et al.   Cell Reports

High-Resolution Mapping of RNA Polymerases Identifies Mechanisms of Sensitivity and Resistance to BET Inhibitors in t(8;21) AML

(2016) Yue Zhao et al.   Cell Reports

Bromodomain inhibitor OTX015 in patients with acute leukaemia: a dose-escalation, phase 1 study

(2016) Céline Berthon et al.   Lancet Haematology

Abstract 2625: Targeting prostate cancer stem cells (CSCs) with the novel BET bromodomain (BRD) protein inhibitor OTX015

(2015) Gianluca Civenni et al.   CANCER RESEARCH

Targeting EZH2 and PRC2 dependence as novel anticancer therapy

(2015) Bowen Xu et al.   EXPERIMENTAL HEMATOLOGY

Panobinostat: a novel pan-deacetylase inhibitor for the treatment of relapsed or relapsed and refractory multiple myeloma

(2015) Paul G Richardson et al.   Expert Review of Anticancer Therapy

A majority of m6A residues are in the last exons, allowing the potential for 3′ UTR regulation

(2015) Shengdong Ke et al.   GENES & DEVELOPMENT

Relationship between LSD1 expression and E-cadherin expression in prostate cancer

(2015) Min Wang et al.   INTERNATIONAL UROLOGY AND NEPHROLOGY

N6-methyladenosine marks primary microRNAs for processing

(2015) Claudio R. Alarcón et al.   NATURE

Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy

(2015) Dongjun Peng et al.   NATURE

Transcriptional plasticity promotes primary and acquired resistance to BET inhibition

(2015) Philipp Rathert et al.   NATURE

RNA–RNA interactions in gene regulation: the coding and noncoding players

(2015) Sonia Guil et al.   TRENDS IN BIOCHEMICAL SCIENCES

How Does Multistep Tumorigenesis Really Proceed?

(2015) Christine L. Chaffer et al.   Cancer Discovery

NCL1, a highly selective lysine-specific demethylase 1 inhibitor, suppresses prostate cancer without adverse effect

(2015) Toshiki Etani et al.   Oncotarget

TET proteins and the control of cytosine demethylation in cancer

(2015) Laurianne Scourzic et al.   Genome Medicine

Phase 2 clinical trial of 5-azacitidine, valproic acid, and all-trans retinoic acid in patients with high-risk acute myeloid leukemia or myelodysplastic syndrome

(2015)   Oncotarget

In VitroAntiviral Activity and Preclinical and Clinical Resistance Profile of Miravirsen, a Novel Anti-Hepatitis C Virus Therapeutic Targeting the Human Factor miR-122

(2014) Søren Ottosen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Multivariate and subgroup analyses of a randomized, multinational, phase 3 trial of decitabine vs treatment choice of supportive care or cytarabine in older patients with newly diagnosed acute myeloid leukemia and poor- or intermediate-risk cytogenetics

(2014) Jiří Mayer et al.   BMC CANCER

Novel DNA methyltransferase-1 (DNMT1) depleting anticancer nucleosides, 4′-thio-2′-deoxycytidine and 5-aza-4′-thio-2′-deoxycytidine

(2014) Jaideep V. Thottassery et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Loss of the Polycomb Mark from Bivalent Promoters Leads to Activation of Cancer-Promoting Genes in Colorectal Tumors

(2014) M. A. Hahn et al.   CANCER RESEARCH

Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase

(2014) Xiao-Li Ping et al.   CELL RESEARCH

Long Noncoding RNAs as Putative Biomarkers for Prostate Cancer Detection

(2014) Bongyong Lee et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Cancer Epigenetics: Tumor Heterogeneity, Plasticity of Stem-like States, and Drug Resistance

(2014) Hariharan Easwaran et al.   MOLECULAR CELL

Detecting and characterizing circular RNAs

(2014) William R Jeck et al.   NATURE BIOTECHNOLOGY

Stromal fibroblast-derived miR-409 promotes epithelial-to-mesenchymal transition and prostate tumorigenesis

(2014) S Josson et al.   ONCOGENE

Perturbation of m6A Writers Reveals Two Distinct Classes of mRNA Methylation at Internal and 5′ Sites

(2014) Schraga Schwartz et al.   Cell Reports

An Intact Immune System Is Required for the Anticancer Activities of Histone Deacetylase Inhibitors

(2013) A. C. West et al.   CANCER RESEARCH

Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers

(2013) Jakob Lovén et al.   CELL

Randomized Phase II, Double-Blind, Placebo-Controlled Study of Exemestane With or Without Entinostat in Postmenopausal Women With Locally Recurrent or Metastatic Estrogen Receptor-Positive Breast Cancer Progressing on Treatment With a Nonsteroidal Aromatase Inhibitor

(2013) Denise A. Yardley et al.   JOURNAL OF CLINICAL ONCOLOGY

Tet family of 5-methylcytosine dioxygenases in mammalian development

(2013) Hongbo Zhao et al.   JOURNAL OF HUMAN GENETICS

A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation

(2013) Jianzhao Liu et al.   Nature Chemical Biology

BET Inhibition Silences Expression of MYCN and BCL2 and Induces Cytotoxicity in Neuroblastoma Tumor Models

(2013) Anastasia Wyce et al.   PLoS One

Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2

(2013) S. K. Knutson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Architecture of epigenetic reprogramming following Twist1-mediated epithelial-mesenchymal transition

(2013) Gabriel G Malouf et al.   GENOME BIOLOGY

The DNA methyltransferase inhibitor zebularine induces mitochondria-mediated apoptosis in gastric cancer cells in vitro and in vivo

(2012) Wei Tan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

BET bromodomain inhibition targets both c-Myc and IL7R in high-risk acute lymphoblastic leukemia

(2012) C. J. Ott et al.   BLOOD

The Noncoding RNA MALAT1 Is a Critical Regulator of the Metastasis Phenotype of Lung Cancer Cells

(2012) T. Gutschner et al.   CANCER RESEARCH

Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons

(2012) Kate D. Meyer et al.   CELL

Aberrant DNA Methylation and Prostate Cancer

(2012) Sunipa Majumdar et al.   CURRENT GENOMICS

Effect of valproic acid on mitochondrial epigenetics

(2012) Hu Chen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Randomized Phase II Trial of Erlotinib With and Without Entinostat in Patients With Advanced Non–Small-Cell Lung Cancer Who Progressed on Prior Chemotherapy

(2012) Samir E. Witta et al.   JOURNAL OF CLINICAL ONCOLOGY

Combination therapy for hepatocellular carcinoma: Additive preclinical efficacy of the HDAC inhibitor panobinostat with sorafenib

(2012) Anja Lachenmayer et al.   JOURNAL OF HEPATOLOGY

Therapy with the histone deacetylase inhibitor pracinostat for patients with myelofibrosis

(2012) Alfonso Quintás-Cardama et al.   LEUKEMIA RESEARCH

Randomized phase II trial of first-line treatment with pemetrexed-cisplatin, followed sequentially by gefitinib or pemetrexed, in East Asian, never-smoker patients with advanced non-small cell lung cancer

(2012) Myung-Ju Ahn et al.   LUNG CANCER

Histone Lysine Methylation Dynamics: Establishment, Regulation, and Biological Impact

(2012) Joshua C. Black et al.   MOLECULAR CELL

ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility

(2012) Guanqun Zheng et al.   MOLECULAR CELL

Landscape of transcription in human cells

(2012) Sarah Djebali et al.   NATURE

Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia

(2012) Panagiotis Ntziachristos et al.   NATURE MEDICINE

Candidate DNA methylation drivers of acquired cisplatin resistance in ovarian cancer identified by methylome and expression profiling

(2012) C Zeller et al.   ONCOGENE

Sensitivity of human lung adenocarcinoma cell lines to targeted inhibition of BET epigenetic signaling proteins

(2012) W. W. Lockwood et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EZH2 Goes Solo

(2012) G. Cavalli   SCIENCE

A Phase II Trial of Panobinostat, a Histone Deacetylase Inhibitor, in the Treatment of Patients with Refractory Metastatic Renal Cell Carcinoma

(2011) John D. Hainsworth et al.   CANCER INVESTIGATION

Aberrations of EZH2 in Cancer

(2011) A. Chase et al.   CLINICAL CANCER RESEARCH

Mitochondrial toxicity of antiepileptic drugs and their tolerability in mitochondrial disorders

(2011) Josef Finsterer et al.   Expert Opinion on Drug Metabolism & Toxicology

Phase II Study of Belinostat in Patients With Recurrent or Refractory Advanced Thymic Epithelial Tumors

(2011) Giuseppe Giaccone et al.   JOURNAL OF CLINICAL ONCOLOGY

N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

(2011) Guifang Jia et al.   Nature Chemical Biology

Dynamic epigenetic regulation of the microRNA-200 family mediates epithelial and mesenchymal transitions in human tumorigenesis

(2011) V Davalos et al.   ONCOGENE

EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis

(2010) I. Velichutina et al.   BLOOD

CUDC-101, a Multitargeted Inhibitor of Histone Deacetylase, Epidermal Growth Factor Receptor, and Human Epidermal Growth Factor Receptor 2, Exerts Potent Anticancer Activity

(2010) Cheng-Jung Lai et al.   CANCER RESEARCH

Coordinated epigenetic repression of the miR-200 family and miR-205 in invasive bladder cancer

(2010) Erik D. Wiklund et al.   INTERNATIONAL JOURNAL OF CANCER

Histone deacetylase inhibitor vorinostat suppresses the growth of uterine sarcomas in vitro and in vivo

(2010) Andelko Hrzenjak et al.   Molecular Cancer

Role for DNA Methylation in the Regulation of miR-200c and miR-141 Expression in Normal and Cancer Cells

(2010) Lukas Vrba et al.   PLoS One

Targeting DNA methylation for epigenetic therapy

(2010) Xiaojing Yang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Azacytidine Inhibits RNA Methylation at DNMT2 Target Sites in Human Cancer Cell Lines

(2009) M. Schaefer et al.   CANCER RESEARCH

Histone Deacetylases Are Required for Androgen Receptor Function in Hormone-Sensitive and Castrate-Resistant Prostate Cancer

(2009) D. S. Welsbie et al.   CANCER RESEARCH

Combining PCI-24781, a Novel Histone Deacetylase Inhibitor, with Chemotherapy for the Treatment of Soft Tissue Sarcoma

(2009) G. Lopez et al.   CLINICAL CANCER RESEARCH

Human DNA methylomes at base resolution show widespread epigenomic differences

(2009) Ryan Lister et al.   NATURE

The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2

(2008) S.-M. Park et al.   GENES & DEVELOPMENT

Most mammalian mRNAs are conserved targets of microRNAs

(2008) R. C. Friedman et al.   GENOME RESEARCH

Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine

(2008) Carlo Stresemann et al.   INTERNATIONAL JOURNAL OF CANCER

Role of the Histone H3 Lysine 4 Methyltransferase, SET7/9, in the Regulation of NF-κB-dependent Inflammatory Genes

(2008) Yan Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

EZH1 Mediates Methylation on Histone H3 Lysine 27 and Complements EZH2 in Maintaining Stem Cell Identity and Executing Pluripotency

(2008) Xiaohua Shen et al.   MOLECULAR CELL

DNA methylation in development and human disease

(2008) Suhasni Gopalakrishnan et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1

(2008) Philip A. Gregory et al.   NATURE CELL BIOLOGY