The KEAP1-NRF2 System and Neurodegenerative Diseases

Target Gene Diversity of the Nrf1-MafG Transcription Factor Revealed by a Tethered Heterodimer

(2022) Fumiki Katsuoka et al.   MOLECULAR AND CELLULAR BIOLOGY

Dimethyl fumarate decreases short-term but not long-term inflammation in a focal EAE model of neuroinflammation

(2022) S. K. Vainio et al.   EJNMMI Research

Dimethyl fumarate: A review of preclinical efficacy in models of neurodegenerative diseases

(2022) Irena Majkutewicz   EUROPEAN JOURNAL OF PHARMACOLOGY

Nrf2 protects against radiation-induced oral mucositis via antioxidation and keratin layer thickening

(2022) Shun Wakamori et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nonalcoholic steatohepatitis and mechanisms by which it is ameliorated by activation of the CNC-bZIP transcription factor Nrf2

(2022) Boushra Bathish et al.   FREE RADICAL BIOLOGY AND MEDICINE

The β-TrCP-Mediated Pathway Cooperates with the Keap1-Mediated Pathway in Nrf2 Degradation In Vivo

(2022) Ayumi Kuga et al.   MOLECULAR AND CELLULAR BIOLOGY

Emerging therapies to target CNS pathophysiology in multiple sclerosis

(2022) Jiwon Oh et al.   Nature Reviews Neurology

P301S‐hTau acetylates KEAP1 to trigger synaptic toxicity via inhibiting NRF2/ARE pathway: A novel mechanism underlying hTau‐induced synaptic toxicities

(2022) Jia‐Zhao Xie et al.   Clinical and Translational Medicine

Dimethyl itaconate reprograms neurotoxic to neuroprotective primary astrocytes through the regulation of NLRP3 inflammasome and NRF2/HO-1 pathways

(2022) Mohammad Darvish Khadem et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Efficacy of Omaveloxolone in Friedreich's Ataxia: Delayed‐Start Analysis of the MOXIe Extension

(2022) David R. Lynch et al.   MOVEMENT DISORDERS

Nrf2 deficiency deteriorates diabetic kidney disease in Akita model mice

(2022) Yexin Liu et al.   Redox Biology

Targeted de-repression of neuronal Nrf2 inhibits α-synuclein accumulation

(2021) Paul S. Baxter et al.   Cell Death & Disease

Molecular basis for the disruption of Keap1–Nrf2 interaction via Hinge & Latch mechanism

(2021) Yuta Horie et al.   Communications Biology

Nuclear factor E2-related factor 2 (NRF2) deficiency accelerates fast fibre type transition in soleus muscle during space flight

(2021) Takuto Hayashi et al.   Communications Biology

Brain-Protective Mechanisms of Transcription Factor NRF2: Toward a Common Strategy for Neurodegenerative Diseases

(2021) Antonio Cuadrado   Annual Review of Pharmacology and Toxicology

Gene expression changes related to bone mineralization, blood pressure and lipid metabolism in mouse kidneys after space travel

(2021) Norio Suzuki et al.   KIDNEY INTERNATIONAL

Bach1 derepression is neuroprotective in a mouse model of Parkinson’s disease

(2021) Manuj Ahuja et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Non-canonical Keap1-independent activation of Nrf2 in astrocytes by mild oxidative stress

(2021) Bashayer R. Al-Mubarak et al.   Redox Biology

Whole Blood Expression Pattern of Inflammation and Redox Genes in Mild Alzheimer’s Disease

(2021) Elena Milanesi et al.   Journal of Inflammation Research

Nrf2 plays a critical role in the metabolic response during and after spaceflight

(2021) Akira Uruno et al.   Communications Biology

Nrf2 Suppresses Oxidative Stress and Inflammation in App Knock-In Alzheimer’s Disease Model Mice

(2020) Akira Uruno et al.   MOLECULAR AND CELLULAR BIOLOGY

Activation of transcription factor Nrf2 to counteract mitochondrial dysfunction in Parkinson's disease

(2020) Claudia Bento‐Pereira et al.   MEDICINAL RESEARCH REVIEWS

Randomized Clinical Trial on the Effect of Bardoxolone Methyl on GFR in Diabetic Kidney Disease Patients (TSUBAKI Study)

(2020) Masaomi Nangaku et al.   Kidney International Reports

Nrf2 contributes to the weight gain of mice during space travel

(2020) Takafumi Suzuki et al.   Communications Biology

Efficacy of Nilotinib in Patients With Moderately Advanced Parkinson Disease

(2020) Tanya Simuni et al.   JAMA Neurology

Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases

(2019) Antonio Cuadrado et al.   NATURE REVIEWS DRUG DISCOVERY

Nrf2 represses the onset of type 1 diabetes in non-obese diabetic mice

(2019) Yoko Yagishita et al.   JOURNAL OF ENDOCRINOLOGY

A novel, highly-water-soluble apigenin derivative provides neuroprotection following ischemia in male rats by regulating the ERK/Nrf2/HO-1 pathway

(2019) Sen Zhang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Randomized phase I clinical trial of anti–α‐synuclein antibody BIIB054

(2019) Miroslaw Brys et al.   MOVEMENT DISORDERS

NRF2/ARE pathway negatively regulates BACE1 expression and ameliorates cognitive deficits in mouse Alzheimer’s models

(2019) Gahee Bahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Mechanism of Cellular Oxidative Stress Sensing by Keap1

(2019) Takafumi Suzuki et al.   Cell Reports

Systemic activation of Nrf2 pathway in Parkinson's disease

(2019) Sara Petrillo et al.   MOVEMENT DISORDERS

The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis

(2018) Masayuki Yamamoto et al.   PHYSIOLOGICAL REVIEWS

Safety and Tolerability of Multiple Ascending Doses of PRX002/RG7935, an Anti–α-Synuclein Monoclonal Antibody, in Patients With Parkinson Disease

(2018) Joseph Jankovic et al.   JAMA Neurology

Deficiency in the transcription factor NRF2 worsens inflammatory parameters in a mouse model with combined tauopathy and amyloidopathy

(2018) Ana I. Rojo et al.   Redox Biology

The NRF2 pathway as potential biomarker for dimethyl fumarate treatment in multiple sclerosis

(2018) Anna Hammer et al.   Annals of Clinical and Translational Neurology

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

(2018) Evanna L. Mills et al.   NATURE

Evidence supporting oxidative stress in a moderately affected area of the brain in Alzheimer’s disease

(2018) Priscilla Youssef et al.   Scientific Reports

The novel Nrf2 inducer TFM-735 ameliorates experimental autoimmune encephalomyelitis in mice

(2017) Chika Higashi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Genetic reduction of Nrf2 exacerbates cognitive deficits in a mouse model of Alzheimer’s disease

(2017) Caterina Branca et al.   HUMAN MOLECULAR GENETICS

Stress-sensing mechanisms and the physiological roles of the Keap1–Nrf2 system during cellular stress

(2017) Takafumi Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Systemic Activation of NRF2 Alleviates Lethal Autoimmune Inflammation in Scurfy Mice

(2017) Takuma Suzuki et al.   MOLECULAR AND CELLULAR BIOLOGY

Nrf2 Improves Leptin and Insulin Resistance Provoked by Hypothalamic Oxidative Stress

(2017) Yoko Yagishita et al.   Cell Reports

NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology

(2017) Ana I. Rojo et al.   Redox Biology

Modulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseases

(2017) Marta Pajares et al.   Redox Biology

Comparative profiling of cortical gene expression in Alzheimer’s disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation

(2017) Erika Castillo et al.   Scientific Reports

Repurposing the NRF2 Activator Dimethyl Fumarate as Therapy Against Synucleinopathy in Parkinson's Disease

(2016) Isabel Lastres-Becker et al.   ANTIOXIDANTS & REDOX SIGNALING

MRI differential diagnosis of suspected multiple sclerosis

(2016) J.J. Chen et al.   CLINICAL RADIOLOGY

Unique cistrome defined as CsMBE is strictly required for Nrf2-sMaf heterodimer function in cytoprotection

(2016) Akihito Otsuki et al.   FREE RADICAL BIOLOGY AND MEDICINE

Absolute Amounts and Status of the Nrf2-Keap1-Cul3 Complex within Cells

(2016) Tatsuro Iso et al.   MOLECULAR AND CELLULAR BIOLOGY

Nrf2-Mediated Regulation of Skeletal Muscle Glycogen Metabolism

(2016) Akira Uruno et al.   MOLECULAR AND CELLULAR BIOLOGY

Dimethyl fumarate treatment induces adaptive and innate immune modulation independent of Nrf2

(2016) Ulf Schulze-Topphoff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription

(2016) Eri H. Kobayashi et al.   Nature Communications

A Polymorphic Antioxidant Response Element Links NRF2/sMAF Binding to Enhanced MAPT Expression and Reduced Risk of Parkinsonian Disorders

(2016) Xuting Wang et al.   Cell Reports

The Keap1–Nrf2 system and diabetes mellitus

(2015) Akira Uruno et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Molecular basis of the Keap1–Nrf2 system

(2015) Takafumi Suzuki et al.   FREE RADICAL BIOLOGY AND MEDICINE

Characterizations of Three Major Cysteine Sensors of Keap1 in Stress Response

(2015) Ryota Saito et al.   MOLECULAR AND CELLULAR BIOLOGY

Comprehensive Assessment of Genetic Sequence Variants in the Antioxidant ‘Master Regulator’ Nrf2 in Idiopathic Parkinson’s Disease

(2015) Michael Todorovic et al.   PLoS One

Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2

(2015) Karen F.S. Bell et al.   Nature Communications

Nrf2 induces fibroblast growth factor 21 in diabetic mice

(2014) Yuki Furusawa et al.   GENES TO CELLS

Hydroxycarboxylic acid receptor 2 mediates dimethyl fumarate’s protective effect in EAE

(2014) Hui Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Single App knock-in mouse models of Alzheimer's disease

(2014) Takashi Saito et al.   NATURE NEUROSCIENCE

Nrf2 reduces levels of phosphorylated tau protein by inducing autophagy adaptor protein NDP52

(2014) Chulman Jo et al.   Nature Communications

Amyloid-β and Tau

(2014) George S. Bloom   JAMA Neurology

Efficacy and safety of BG-12 (dimethyl fumarate) and other disease-modifying therapies for the treatment of relapsing–remitting multiple sclerosis: a systematic review and mixed treatment comparison

(2013) Michael Hutchinson et al.   CURRENT MEDICAL RESEARCH AND OPINION

Nrf2 Protects Pancreatic  -Cells From Oxidative and Nitrosative Stress in Diabetic Model Mice

(2013) Y. Yagishita et al.   DIABETES

Adaptive Immune Responses in CNS Autoimmune Disease: Mechanisms and Therapeutic Opportunities

(2013) Rhoanne C. McPherson et al.   Journal of Neuroimmune Pharmacology

Kinetic, Thermodynamic, and Structural Characterizations of the Association between Nrf2-DLGex Degron and Keap1

(2013) Toshiaki Fukutomi et al.   MOLECULAR AND CELLULAR BIOLOGY

The Keap1-Nrf2 System Prevents Onset of Diabetes Mellitus

(2013) A. Uruno et al.   MOLECULAR AND CELLULAR BIOLOGY

Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy

(2013) Yoshinobu Ichimura et al.   MOLECULAR CELL

Neuronal activity regulates astrocytic Nrf2 signaling

(2013) A. Habas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming

(2012) Yoichiro Mitsuishi et al.   CANCER CELL

Validation of the multiple sensor mechanism of the Keap1-Nrf2 system

(2012) Kai Takaya et al.   FREE RADICAL BIOLOGY AND MEDICINE

α-Synuclein expression and Nrf2 deficiency cooperate to aggravate protein aggregation, neuronal death and inflammation in early-stage Parkinson's disease

(2012) Isabel Lastres-Becker et al.   HUMAN MOLECULAR GENETICS

Placebo-Controlled Phase 3 Study of Oral BG-12 or Glatiramer in Multiple Sclerosis

(2012) Robert J. Fox et al.   NEW ENGLAND JOURNAL OF MEDICINE

Placebo-Controlled Phase 3 Study of Oral BG-12 for Relapsing Multiple Sclerosis

(2012) Ralf Gold et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity

(2012) S Chowdhry et al.   ONCOGENE

Fumarate hydratase inactivation in renal tumors: HIF1 alpha, NRF2, and "cryptic targets" of transcription factors

(2012) Aikseng Ooi et al.   Chinese Journal of Cancer

Pharmacological Targeting of the Transcription Factor Nrf2 at the Basal Ganglia Provides Disease Modifying Therapy for Experimental Parkinsonism

(2011) Agnieszka Jazwa et al.   ANTIOXIDANTS & REDOX SIGNALING

α-Synuclein misfolding and Parkinson's disease

(2011) Leonid Breydo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

An Antioxidant Response Phenotype Shared between Hereditary and Sporadic Type 2 Papillary Renal Cell Carcinoma

(2011) Aikseng Ooi et al.   CANCER CELL

Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling

(2011) Julie Adam et al.   CANCER CELL

Dynamics of Nrf2 and Keap1 in ARE-MediatedNQO1Expression by Wasabi 6-(Methylsulfinyl)hexyl Isothiocyanate

(2011) De-Xing Hou et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Embryonic Lethality and Fetal Liver Apoptosis in Mice Lacking All Three Small Maf Proteins

(2011) H. Yamazaki et al.   MOLECULAR AND CELLULAR BIOLOGY

SCF/ -TrCP Promotes Glycogen Synthase Kinase 3-Dependent Degradation of the Nrf2 Transcription Factor in a Keap1-Independent Manner

(2011) P. Rada et al.   MOLECULAR AND CELLULAR BIOLOGY

The Keap1–Nrf2 system as an in vivo sensor for electrophiles

(2011) Akira Uruno et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Association of Nrf2-encoding NFE2L2 haplotypes with Parkinson's disease

(2010) Malin von Otter et al.   BMC Medical Genetics

Nrf2-encoding NFE2L2 haplotypes influence disease progression but not risk in Alzheimer's disease and age-related cataract

(2010) Malin von Otter et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Genetic Analysis of Cytoprotective Functions Supported by Graded Expression of Keap1

(2010) K. Taguchi et al.   MOLECULAR AND CELLULAR BIOLOGY

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

(2010) Masaaki Komatsu et al.   NATURE CELL BIOLOGY

Stress-Activated Cap'n'collar Transcription Factors in Aging and Human Disease

(2010) G. P. Sykiotis et al.   Science Signaling

Nrf2 regulates microglial dynamics and neuroinflammation in experimental Parkinson's disease

(2009) Ana I. Rojo et al.   GLIA

Triterpenoid CDDO-methylamide improves memory and decreases amyloid plaques in a transgenic mouse model of Alzheimer’s disease

(2009) Magali Dumont et al.   JOURNAL OF NEUROCHEMISTRY

Neuroprotective Effects of the Triterpenoid, CDDO Methyl Amide, a Potent Inducer of Nrf2-Mediated Transcription

(2009) Lichuan Yang et al.   PLoS One

Induction of sulfiredoxin expression and reduction of peroxiredoxin hyperoxidation by the neuroprotective Nrf2 activator 3H-1,2-dithiole-3-thione

(2008) Francesc X. Soriano et al.   JOURNAL OF NEUROCHEMISTRY

The Antioxidant Defense System Keap1-Nrf2 Comprises a Multiple Sensing Mechanism for Responding to a Wide Range of Chemical Compounds

(2008) M. Kobayashi et al.   MOLECULAR AND CELLULAR BIOLOGY