Dimethyl fumarate: A review of preclinical efficacy in models of neurodegenerative diseases

Dimethyl Fumarate as the Peripheral Blood Inflammatory Mediators Inhibitor in Prevention of Streptozotocin-Induced Neuroinflammation in Aged Rats

(2022) Danuta Wrona et al.   Journal of Inflammation Research

SH-SY5Y-derived neurons: a human neuronal model system for investigating TAU sorting and neuronal subtype-specific TAU vulnerability

(2021) Michael Bell et al.   REVIEWS IN THE NEUROSCIENCES

Dimethyl fumarate abridged tauo-/amyloidopathy in a D-Galactose/ovariectomy-induced Alzheimer's-like disease: Modulation of AMPK/SIRT-1, AKT/CREB/BDNF, AKT/GSK-3β, adiponectin/Adipo1R, and NF-κB/IL-1β/ROS trajectories

(2021) Israa M. Abd El-Fatah et al.   NEUROCHEMISTRY INTERNATIONAL

Safety and efficacy of dimethyl fumarate in ALS: randomised controlled study

(2021) Steve Vucic et al.   Annals of Clinical and Translational Neurology

Dimethyl fumarate does not mitigate cognitive decline and β-amyloidosis in female APPPS1 mice

(2021) Luisa Möhle et al.   BRAIN RESEARCH

Dimethyl Fumarate is a Potential Therapeutic Option for Alzheimer’s Disease

(2021) Xiaodi Sun et al.   JOURNAL OF ALZHEIMERS DISEASE

Dimethyl Fumarate Alleviates NLRP3 Inflammasome Activation in Microglia and Sickness Behavior in LPS-Challenged Mice

(2021) Bora Tastan et al.   Frontiers in Immunology

Antioxidant and Anti-inflammatory Effect of Nrf2 Inducer Dimethyl Fumarate in Neurodegenerative Diseases

(2020) Sarah A. Scuderi et al.   Antioxidants

Interaction of Oxidative Stress and Misfolded Proteins in the Mechanism of Neurodegeneration

(2020) Andrey Y. Abramov et al.   Life-Basel

Enhanced activity of glycolytic enzymes in Drosophila and human cell models of Parkinson's disease based on DJ-1 deficiency

(2020) Cristina Solana-Manrique et al.   FREE RADICAL BIOLOGY AND MEDICINE

Calcium Modulation, Anti-Oxidant and Anti-Inflammatory Effect of Skin Allergens Targeting the Nrf2 Signaling Pathway in Alzheimer’s Disease Cellular Models

(2020) Ana Silva et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dimethyl Fumarate Mitigates Tauopathy in Aβ-Induced Neuroblastoma SH-SY5Y Cells

(2020) Mithun Singh Rajput et al.   NEUROCHEMICAL RESEARCH

Dimethyl fumarate induced lymphopenia in multiple sclerosis: A review of the literature

(2020) Cinzia Dello Russo et al.   PHARMACOLOGY & THERAPEUTICS

Succination inactivates gasdermin D and blocks pyroptosis

(2020) Fiachra Humphries et al.   SCIENCE

Dimethyl fumarate exerts neuroprotection by modulating calcineurin/NFAT1 and NFκB dependent BACE1 activity in Aβ1-42 treated neuroblastoma SH-SY5Y cells

(2020) Mithun Singh Rajput et al.   BRAIN RESEARCH BULLETIN

Dimethyl fumarate, a two-edged drug: Current status and future directions

(2019) Nathaniel Edward Bennett Saidu et al.   MEDICINAL RESEARCH REVIEWS

Dimethyl Fumarate Disrupts Human Innate Immune Signaling by Targeting the IRAK4–MyD88 Complex

(2019) Balyn W. Zaro et al.   JOURNAL OF IMMUNOLOGY

Inflammasomes in neuroinflammatory and neurodegenerative diseases

(2019) Sofie Voet et al.   EMBO Molecular Medicine

Advance of sporadic Alzheimer's disease animal models

(2019) Lili Zhang et al.   MEDICINAL RESEARCH REVIEWS

Masitinib as an add-on therapy to riluzole in patients with amyotrophic lateral sclerosis: a randomized clinical trial

(2019) Jesus S. Mora et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Modeling Alzheimer’s disease with iPSC-derived brain cells

(2019) Jay Penney et al.   MOLECULAR PSYCHIATRY

NLRP3 inflammasome activation drives tau pathology

(2019) Christina Ising et al.   NATURE

Age-dependent effects of dimethyl fumarate on cognitive and neuropathological features in the streptozotocin-induced rat model of Alzheimer’s disease

(2018) Irena Majkutewicz et al.   BRAIN RESEARCH

Therapeutic Targeting of TAZ and YAP by Dimethyl Fumarate in Systemic Sclerosis Fibrosis

(2018) Tetsuo Toyama et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity

(2018) Michael D. Kornberg et al.   SCIENCE

Nrf2-p62 autophagy pathway and its response to oxidative stress in hepatocellular carcinoma

(2018) Desirée Bartolini et al.   Translational Research

The Pharmacokinetics of Fumaric Acid Esters Reveal Their In Vivo Effects

(2018) Ulrich Mrowietz et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Association of Regulatory T-Cell Expansion With Progression of Amyotrophic Lateral Sclerosis

(2018) Rebecca K. Sheean et al.   JAMA Neurology

Deficiency in the transcription factor NRF2 worsens inflammatory parameters in a mouse model with combined tauopathy and amyloidopathy

(2018) Ana I. Rojo et al.   Redox Biology

The Nrf2-Antioxidant Response Element Signaling Pathway Controls Fibrosis and Autoimmunity in Scleroderma

(2018) Niloufar Kavian et al.   Frontiers in Immunology

Identification of Novel Protein Targets of Dimethyl Fumarate Modification in Neurons and Astrocytes Reveals Actions Independent of Nrf2 Stabilization

(2018) Gerardo G. Piroli et al.   MOLECULAR & CELLULAR PROTEOMICS

Pharmacodynamics of Dimethyl Fumarate Are Tissue Specific and Involve NRF2-Dependent and -Independent Mechanisms

(2016) Melanie S. Brennan et al.   ANTIOXIDANTS & REDOX SIGNALING

Repurposing the NRF2 Activator Dimethyl Fumarate as Therapy Against Synucleinopathy in Parkinson's Disease

(2016) Isabel Lastres-Becker et al.   ANTIOXIDANTS & REDOX SIGNALING

Dimethyl fumarate attenuates intracerebroventricular streptozotocin-induced spatial memory impairment and hippocampal neurodegeneration in rats

(2016) Irena Majkutewicz et al.   BEHAVIOURAL BRAIN RESEARCH

Dimethyl fumarate ameliorates dextran sulfate sodium-induced murine experimental colitis by activating Nrf2 and suppressing NLRP3 inflammasome activation

(2016) Xiuting Liu et al.   BIOCHEMICAL PHARMACOLOGY

Distinct Nrf2 Signaling Mechanisms of Fumaric Acid Esters and Their Role in Neuroprotection against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Experimental Parkinson's-Like Disease

(2016) M. Ahuja et al.   JOURNAL OF NEUROSCIENCE

Protective effects of monomethyl fumarate at the inflamed blood–brain barrier

(2016) Jamie L. Lim et al.   MICROVASCULAR RESEARCH

Modeling ALS with motor neurons derived from human induced pluripotent stem cells

(2016) Samuel Sances et al.   NATURE NEUROSCIENCE

Fumarates modulate microglia activation through a novel HCAR2 signaling pathway and rescue synaptic dysregulation in inflamed CNS

(2015) Benedetta Parodi et al.   ACTA NEUROPATHOLOGICA

Glio-vascular changes during ageing in wild-type and Alzheimer׳s disease-like APP/PS1 mice

(2015) C.S. Janota et al.   BRAIN RESEARCH

Dimethyl Fumarate Protects Neural Stem/Progenitor Cells and Neurons from Oxidative Damage through Nrf2-ERK1/2 MAPK Pathway

(2015) Qin Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dimethyl Fumarate Inhibits the Nuclear Factor κB Pathway in Breast Cancer Cells by Covalent Modification of p65 Protein

(2015) Irida Kastrati et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DMF, but not other fumarates, inhibits NF-κB activity in vitro in an Nrf2-independent manner

(2015) Geoffrey O. Gillard et al.   JOURNAL OF NEUROIMMUNOLOGY

Parkinson's disease

(2015) Lorraine V Kalia et al.   LANCET

The Essential Role of Soluble Aβ Oligomers in Alzheimer’s Disease

(2015) Zi-Xuan Wang et al.   MOLECULAR NEUROBIOLOGY

Neuropathology of Amyotrophic Lateral Sclerosis and Its Variants

(2015) Shahram Saberi et al.   NEUROLOGIC CLINICS

Dimethyl fumarate attenuates 6-OHDA-induced neurotoxicity in SH-SY5Y cells and in animal model of Parkinson’s disease by enhancing Nrf2 activity

(2015) X. Jing et al.   NEUROSCIENCE

The Role of Oxidative Stress-Induced Epigenetic Alterations in Amyloid-βProduction in Alzheimer’s Disease

(2015) Li Zuo et al.   Oxidative Medicine and Cellular Longevity

Role of the Keap1/Nrf2 pathway in neurodegenerative diseases

(2015) Hiromi Yamazaki et al.   PATHOLOGY INTERNATIONAL

Dimethyl Fumarate Ameliorates Lewis Rat Experimental Autoimmune Neuritis and Mediates Axonal Protection

(2015) Kalliopi Pitarokoili et al.   PLoS One

The Role of Oxidative Stress in Neurodegenerative Diseases

(2015) Geon Ha Kim et al.   Experimental Neurobiology

Hydroxycarboxylic acid receptor 2 mediates dimethyl fumarate’s protective effect in EAE

(2014) Hui Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Evidence for peripheral immune activation in amyotrophic lateral sclerosis

(2014) Xueping Chen et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Age-associated dysregulation of microglial activation is coupled with enhanced blood-brain barrier permeability and pathology in APP/PS1 mice

(2014) Aedín M. Minogue et al.   NEUROBIOLOGY OF AGING

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

(2014) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Amyloid-β induces NLRP1-dependent neuronal pyroptosis in models of Alzheimer’s disease

(2014) M-S Tan et al.   Cell Death & Disease

Metabolic Pathways in Immune Cell Activation and Quiescence

(2013) Erika L. Pearce et al.   IMMUNITY

MafK positively regulates NF-κB activity by enhancing CBP-mediated p65 acetylation

(2013) Yu-Jin Hwang et al.   Scientific Reports

Calcium, Bioenergetics, and Neuronal Vulnerability in Parkinson's Disease

(2012) D. James Surmeier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

What have we learned from the streptozotocin-induced animal model of sporadic Alzheimer’s disease, about the therapeutic strategies in Alzheimer’s research

(2012) Melita Salkovic-Petrisic et al.   JOURNAL OF NEURAL TRANSMISSION

Effects of dimethyl fumarate on neuroprotection and immunomodulation

(2012) Philipp Albrecht et al.   Journal of Neuroinflammation

The Absence of Nrf2 Enhances NF-B-Dependent Inflammation following Scratch Injury in Mouse Primary Cultured Astrocytes

(2012) Hao Pan et al.   MEDIATORS OF INFLAMMATION

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Placebo-Controlled Phase 3 Study of Oral BG-12 for Relapsing Multiple Sclerosis

(2012) Ralf Gold et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Anti-Inflammatory Effects of Dimethyl Fumarate in Astrocytes Involve Glutathione and Haem Oxygenase-1

(2011) Shao Xia Lin et al.   ASN Neuro

Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway

(2011) Ralf A. Linker et al.   BRAIN

Endogenous regulatory T lymphocytes ameliorate amyotrophic lateral sclerosis in mice and correlate with disease progression in patients with amyotrophic lateral sclerosis

(2011) David R. Beers et al.   BRAIN

In vitro modelling of Alzheimer's disease: Degeneration and cell death induced by viral delivery of amyloid and tau

(2011) Sandra Stoppelkamp et al.   EXPERIMENTAL NEUROLOGY

Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis

(2011) Arie Neymotin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nrf2 regulates NGF mRNA induction by carnosic acid in T98G glioblastoma cells and normal human astrocytes

(2011) Junsei Mimura et al.   JOURNAL OF BIOCHEMISTRY

Efficacy of Fumaric Acid Esters in the R6/2 and YAC128 Models of Huntington's Disease

(2011) Gisa Ellrichmann et al.   PLoS One

AMPK and SIRT1: a long-standing partnership?

(2010) Neil B. Ruderman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The relevance of iron in the pathogenesis of Parkinson’s disease

(2010) Jeswinder Sian-Hülsmann et al.   JOURNAL OF NEUROCHEMISTRY

Inflammatory Neurodegeneration and Mechanisms of Microglial Killing of Neurons

(2010) Guy C. Brown et al.   MOLECULAR NEUROBIOLOGY

SOD1 mRNA expression in sporadic amyotrophic lateral sclerosis

(2010) Stella Gagliardi et al.   NEUROBIOLOGY OF DISEASE

Genetic Animal Models of Parkinson's Disease

(2010) Ted M. Dawson et al.   NEURON

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Non–cell autonomous toxicity in neurodegenerative disorders: ALS and beyond

(2009) Hristelina Ilieva et al.   JOURNAL OF CELL BIOLOGY

Acetylation of Nrf2 by p300/CBP Augments Promoter-Specific DNA Binding of Nrf2 during the Antioxidant Response

(2009) Z. Sun et al.   MOLECULAR AND CELLULAR BIOLOGY

KEAP1 E3 Ligase-Mediated Downregulation of NF-κB Signaling by Targeting IKKβ

(2009) Dung-Fang Lee et al.   MOLECULAR CELL

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

The psoriasis drug monomethylfumarate is a potent nicotinic acid receptor agonist

(2008) Hua Tang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NF-κB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK

(2008) Guang-Hui Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Nuclear Erythroid 2-Related Factor 2-Antioxidative Response Element Signaling Pathway in Motor Cortex and Spinal Cord in Amyotrophic Lateral Sclerosis

(2008) Alexander Sarlette et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY