Targeted de-repression of neuronal Nrf2 inhibits α-synuclein accumulation

Safety and efficacy of omaveloxolone in patients with mitochondrial myopathy

(2020) Karen L. Madsen et al.   NEUROLOGY

Safety and Efficacy of Omaveloxolone in Friedreich's Ataxia ( MOXIe Study)

(2020) David R. Lynch et al.   ANNALS OF NEUROLOGY

Downregulation of Keap1 Confers Features of a Fasted Metabolic State

(2020) Elena V. Knatko et al.   iScience

The proteostasis network and its decline in ageing

(2019) Mark S. Hipp et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The proteostasis network provides targets for neurodegeneration

(2019) Timothy Mark Newton et al.   BRITISH JOURNAL OF PHARMACOLOGY

Pharmacokinetics and pharmacodynamics of the novel Nrf2 activator omaveloxolone in primates

(2019) Scott A Reisman et al.   Drug Design Development and Therapy

Mitochondrial biology in airway pathogenesis and the role of NRF2

(2019) Hye-Youn Cho et al.   ARCHIVES OF PHARMACAL RESEARCH

Rescue of Fragile X Syndrome Neurons by DNA Methylation Editing of the FMR1 Gene

(2018) X. Shawn Liu et al.   CELL

A CRISPR–dCas Toolbox for Genetic Engineering and Synthetic Biology

(2018) Xiaoshu Xu et al.   JOURNAL OF MOLECULAR BIOLOGY

Increased Oxidative Stress Exacerbates α-Synuclein Aggregation In Vivo

(2018) Owen Scudamore et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Synthetic far-red light-mediated CRISPR-dCas9 device for inducing functional neuronal differentiation

(2018) Jiawei Shao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antioxidant response elements: Discovery, classes, regulation and potential applications

(2018) Azhwar Raghunath et al.   Redox Biology

Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating α-synuclein transmission and neuroinflammation

(2018) Changyoun Kim et al.   Molecular Neurodegeneration

Safety, pharmacodynamics, and potential benefit of omaveloxolone in Friedreich ataxia

(2018) David R. Lynch et al.   Annals of Clinical and Translational Neurology

Safety, pharmacokinetics, and pharmacodynamics of oral omaveloxolone (RTA 408), a synthetic triterpenoid, in a first-in-human trial of patients with advanced solid tumors

(2017) Ben Creelan et al.   OncoTargets and Therapy

Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism

(2017) Philip Hasel et al.   Nature Communications

Diverse cellular actions of tert-butylhydroquinone, a food additive, on rat thymocytes

(2017) Norio Kamemura et al.   Toxicology Research

The KEAP1–NRF2 System in Cancer

(2017) Keiko Taguchi et al.   Frontiers in Oncology

The NRF2 transcriptional target, OSGIN1, contributes to monomethyl fumarate-mediated cytoprotection in human astrocytes

(2017) Melanie S. Brennan et al.   Scientific Reports

Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes

(2016) Marta Pajares et al.   Autophagy

Adaptive regulation of the brain’s antioxidant defences by neurons and astrocytes

(2016) Paul S. Baxter et al.   FREE RADICAL BIOLOGY AND MEDICINE

Alkylating Agent–Induced NRF2 Blocks Endoplasmic Reticulum Stress–Mediated Apoptosis via Control of Glutathione Pools and Protein Thiol Homeostasis

(2016) Alfeu Zanotto-Filho et al.   MOLECULAR CANCER THERAPEUTICS

Dimethyl fumarate treatment induces adaptive and innate immune modulation independent of Nrf2

(2016) Ulf Schulze-Topphoff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nrf2 mitigates LRRK2- and α-synuclein–induced neurodegeneration by modulating proteostasis

(2016) Gaia Skibinski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemical proteomic map of dimethyl fumarate–sensitive cysteines in primary human T cells

(2016) Megan M. Blewett et al.   Science Signaling

Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription

(2016) Eri H. Kobayashi et al.   Nature Communications

Chemical proteomic map of dimethyl fumarate–sensitive cysteines in primary human T cells

(2016) Megan M. Blewett et al.   Science Signaling

Astrocyte NMDA receptors' activity sustains neuronal survival through a Cdk5–Nrf2 pathway

(2015) D Jimenez-Blasco et al.   CELL DEATH AND DIFFERENTIATION

Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

(2015) Lauren E. Tebay et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nrf2—a therapeutic target for the treatment of neurodegenerative diseases

(2015) Delinda A. Johnson et al.   FREE RADICAL BIOLOGY AND MEDICINE

NRF2 promotes neuronal survival in neurodegeneration and acute nerve damage

(2015) Wenjun Xiong et al.   JOURNAL OF CLINICAL INVESTIGATION

Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex

(2015) Silvana Konermann et al.   NATURE

Ensembl 2016

(2015) Andrew Yates et al.   NUCLEIC ACIDS RESEARCH

Synaptic NMDA receptor activity is coupled to the transcriptional control of the glutathione system

(2015) Paul S. Baxter et al.   Nature Communications

Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2

(2015) Karen F.S. Bell et al.   Nature Communications

Cytotoxicity and DNA damage properties of tert-butylhydroquinone (TBHQ) food additive

(2014) Morteza Eskandani et al.   FOOD CHEMISTRY

Linking alpha-synuclein properties with oxidation: a hypothesis on a mechanism underling cellular aggregation

(2014) Suzanne Scarlata et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Nrf2 target genes can be controlled by neuronal activity in the absence of Nrf2 and astrocytes

(2014) R. F. Deighton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Axonopathy in an α-Synuclein Transgenic Model of Lewy Body Disease Is Associated with Extensive Accumulation of C-Terminal–Truncated α-Synuclein

(2013) Dora Games et al.   AMERICAN JOURNAL OF PATHOLOGY

Phosphoinositide 3-Kinases Upregulate System xc− via Eukaryotic Initiation Factor 2α and Activating Transcription Factor 4 – A Pathway Active in Glioblastomas and Epilepsy

(2013) Jan Lewerenz et al.   ANTIOXIDANTS & REDOX SIGNALING

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

Nrf2/ARE-mediated antioxidant actions of pro-electrophilic drugs

(2013) Takumi Satoh et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies

(2013) Stefan Schildknecht et al.   JOURNAL OF NEUROCHEMISTRY

Oxidative stress-induced posttranslational modifications of alpha-synuclein: Specific modification of alpha-synuclein by 4-hydroxy-2-nonenal increases dopaminergic toxicity

(2013) Wei Xiang et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Paradoxical cytotoxicity of tert-butylhydroquinone in vitro: what kills the untreated cells?

(2012) Albert Braeuning et al.   ARCHIVES OF TOXICOLOGY

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Human stem cell-derived astrocytes and their application to studying Nrf2-mediated neuroprotective pathways and therapeutics in neurodegeneration

(2012) Kunal Gupta et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

PGC-1  Negatively Regulates Extrasynaptic NMDAR Activity and Excitotoxicity

(2012) C. Puddifoot et al.   JOURNAL OF NEUROSCIENCE

NADPH Oxidase 1 Mediates  -Synucleinopathy in Parkinson's Disease

(2012) A. C. Cristovao et al.   JOURNAL OF NEUROSCIENCE

A Progressive Mouse Model of Parkinson’s Disease: The Thy1-aSyn (“Line 61”) Mice

(2012) Marie-Francoise Chesselet et al.   Neurotherapeutics

Nrf2–MafG heterodimers contribute globally to antioxidant and metabolic networks

(2012) Yosuke Hirotsu et al.   NUCLEIC ACIDS RESEARCH

Involvement of the Nrf2-proteasome pathway in the endoplasmic reticulum stress response in pancreatic β-cells

(2012) Sanghwan Lee et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway

(2011) Ralf A. Linker et al.   BRAIN

Human embryonic stem cell derived astrocytes mediate non-cell-autonomous neuroprotection through endogenous and drug-induced mechanisms

(2011) K Gupta et al.   CELL DEATH AND DIFFERENTIATION

The influence of synaptic activity on neuronal health

(2011) Karen FS Bell et al.   CURRENT OPINION IN NEUROBIOLOGY

Overexpression of Nrf2 Protects Cerebral Cortical Neurons from Ethanol-Induced Apoptotic Death

(2011) M. Narasimhan et al.   MOLECULAR PHARMACOLOGY

Activation of Nrf2-Regulated Glutathione Pathway Genes by Ischemic Preconditioning

(2011) Karen F. S. Bell et al.   Oxidative Medicine and Cellular Longevity

CNS Peroxiredoxins and Their Regulation in Health and Disease

(2010) Karen F.S. Bell et al.   ANTIOXIDANTS & REDOX SIGNALING

Regulation of Neuronal Oxidative and Nitrosative Stress by Endogenous Protective Pathways and Disease Processes

(2010) Giles E. Hardingham et al.   ANTIOXIDANTS & REDOX SIGNALING

Role of histone acetylation in the activity-dependent regulation of sulfiredoxin and sestrin 2

(2010) Francesc X. Soriano et al.   Epigenetics

Nuclear Erythroid Factor 2-mediated Proteasome Activation Delays Senescence in Human Fibroblasts

(2010) Suzanne Kapeta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p62/SQSTM1Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

(2010) Ashish Jain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis

(2010) Deepti Malhotra et al.   NUCLEIC ACIDS RESEARCH

Mild oxidative stress activates Nrf2 in astrocytes, which contributes to neuroprotective ischemic preconditioning

(2010) K. F. Bell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Nrf2–ARE cytoprotective pathway in astrocytes

(2009) Marcelo R. Vargas et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease

(2009) K. Kanninen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of sulfiredoxin expression and reduction of peroxiredoxin hyperoxidation by the neuroprotective Nrf2 activator 3H-1,2-dithiole-3-thione

(2008) Francesc X. Soriano et al.   JOURNAL OF NEUROCHEMISTRY

Nrf2 Activation in Astrocytes Protects against Neurodegeneration in Mouse Models of Familial Amyotrophic Lateral Sclerosis

(2008) M. R. Vargas et al.   JOURNAL OF NEUROSCIENCE

Hypoxic/ischemic conditions induce expression of the putative pro-death gene Clca1 via activation of extrasynaptic N-methyl-d-aspartate receptors

(2008) A.-S. Wahl et al.   NEUROSCIENCE