Dimethyl itaconate reprograms neurotoxic to neuroprotective primary astrocytes through the regulation of NLRP3 inflammasome and NRF2/HO-1 pathways

Suppression of Lipopolysaccharide-Induced Inflammatory and Oxidative Response by 5-Aminolevulinic Acid in RAW 264.7 Macrophages and Zebrafish Larvae

(2021) Seon Yeong Ji et al.   Biomolecules & Therapeutics

Dimethyl itaconate inhibits LPS‑induced microglia inflammation and inflammasome‑mediated pyroptosis via inducing autophagy and regulating the Nrf‑2/HO‑1 signaling pathway

(2021) Su Yang et al.   Molecular Medicine Reports

Altered substrate metabolism in neurodegenerative disease: new insights from metabolic imaging

(2021) Nicholas R. W. Cleland et al.   Journal of Neuroinflammation

The role of astrocytes in oxidative stress of central nervous system: A mixed blessing

(2020) Yaxing Chen et al.   CELL PROLIFERATION

Inhibition of the NLRP3-inflammasome prevents cognitive deficits in experimental autoimmune encephalomyelitis mice via the alteration of astrocyte phenotype

(2020) Baohua Hou et al.   Cell Death & Disease

The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation

(2020) Alexander Hooftman et al.   Cell Metabolism

Glia Crosstalk in Neuroinflammatory Diseases

(2020) Ada Bernaus et al.   Frontiers in Cellular Neuroscience

Melatonin/Nrf2/NLRP3 Connection in Mouse Heart Mitochondria during Aging

(2020) Marisol Fernández-Ortiz et al.   Antioxidants

Exploring the evolutionary roots and physiological function of itaconate

(2020) Thekla Cordes et al.   CURRENT OPINION IN BIOTECHNOLOGY

A colorimetric method to measure oxidized, reduced and total glutathione levels in erythrocytes

(2019) Murat Alisik et al.   Journal of Laboratory Medicine

Epigenetic regulation of astrocyte function in neuroinflammation and neurodegeneration

(2018) Matthew Neal et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

(2018) Evanna L. Mills et al.   NATURE

Four-octyl itaconate activates Keap1-Nrf2 signaling to protect neuronal cells from hydrogen peroxide

(2018) Hua Liu et al.   Cell Communication and Signaling

CNS inflammation and neurodegeneration

(2017) Tanuja Chitnis et al.   JOURNAL OF CLINICAL INVESTIGATION

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

The Role of Astrocyte Dysfunction in Parkinson’s Disease Pathogenesis

(2017) Heather D.E. Booth et al.   TRENDS IN NEUROSCIENCES

Transformation of Astrocytes to a Neuroprotective Phenotype by Microglia via P2Y 1 Receptor Downregulation

(2017) Youichi Shinozaki et al.   Cell Reports

Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

(2016) Vicky Lampropoulou et al.   Cell Metabolism

Gas1 up-regulation is inducible and contributes to cell apoptosis in reactive astrocytes in the substantia nigra of LPS and MPTP models

(2016) Xiao-Long Sun et al.   Journal of Neuroinflammation

Metabolic and Inflammatory Adaptation of Reactive Astrocytes: Role of PPARs

(2016) José Iglesias et al.   MOLECULAR NEUROBIOLOGY

Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription

(2016) Eri H. Kobayashi et al.   Nature Communications

Negative regulation of the inflammasome: keeping inflammation under control

(2015) Gustavo Pedraza-Alva et al.   IMMUNOLOGICAL REVIEWS

Quercetin Attenuates Inflammatory Responses in BV-2 Microglial Cells: Role of MAPKs on the Nrf2 Pathway and Induction of Heme Oxygenase-1

(2015) Grace Y. Sun et al.   PLoS One

Oxidative stress: the mitochondria-dependent and mitochondria-independent pathways of apoptosis

(2013) Krishnendu Sinha et al.   ARCHIVES OF TOXICOLOGY

Nrf2 suppresses lupus nephritis through inhibition of oxidative injury and the NF-κB-mediated inflammatory response

(2013) Tao Jiang et al.   KIDNEY INTERNATIONAL

The Nrf2–ARE cytoprotective pathway in astrocytes

(2009) Marcelo R. Vargas et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

The Proinflammatory Cytokine-Induced IRG1 Protein Associates with Mitochondria

(2008) Daniel Degrandi et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH