P301S‐hTau acetylates KEAP1 to trigger synaptic toxicity via inhibiting NRF2/ARE pathway: A novel mechanism underlying hTau‐induced synaptic toxicities

The Role of NRF2/KEAP1 Signaling Pathway in Cancer Metabolism

(2021) Moon-Young Song et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Long-Term Hydromethylthionine Treatment Is Associated with Delayed Clinical Onset and Slowing of Cerebral Atrophy in a Pre-Symptomatic P301S MAPT Mutation Carrier

(2021) Peter Bentham et al.   JOURNAL OF ALZHEIMERS DISEASE

P‐tau235: a novel biomarker for staging preclinical Alzheimer’s disease

(2021) Juan Lantero‐Rodriguez et al.   EMBO Molecular Medicine

Emerging roles of oxidative stress in brain aging and Alzheimer's disease

(2021) Andra Ionescu-Tucker et al.   NEUROBIOLOGY OF AGING

Noncanonical projections to the hippocampal CA3 regulate spatial learning and memory by modulating the feedforward hippocampal trisynaptic pathway

(2021) Xiaoxiao Lin et al.   PLOS BIOLOGY

Nrf2 Suppresses Oxidative Stress and Inflammation in App Knock-In Alzheimer’s Disease Model Mice

(2020) Akira Uruno et al.   MOLECULAR AND CELLULAR BIOLOGY

The Accumulation of Tau in Postsynaptic Structures: A Common Feature in Multiple Neurodegenerative Diseases?

(2020) Peter J. Teravskis et al.   NEUROSCIENTIST

The accumulation rate of tau aggregates is higher in females and younger amyloid-positive subjects

(2020) Ruben Smith et al.   BRAIN

Differential compartmental processing and phosphorylation of pathogenic human tau and native mouse tau in the line 66 model of frontotemporal dementia

(2020) Nora Lemke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Imaging of Tau Pathology in Neurodegenerative Diseases: An Update

(2020) Leonie Beyer et al.   SEMINARS IN NUCLEAR MEDICINE

Plasma N-terminal tau fragment levels predict future cognitive decline and neurodegeneration in healthy elderly individuals

(2020) Jasmeer P. Chhatwal et al.   Nature Communications

Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease

(2019) D. Allan Butterfield et al.   NATURE REVIEWS NEUROSCIENCE

CNS cell-type specific gene profiling of P301S tau transgenic mice identifies genes dysregulated by progressive tau accumulation

(2019) Yazi D Ke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NRF2/ARE pathway negatively regulates BACE1 expression and ameliorates cognitive deficits in mouse Alzheimer’s models

(2019) Gahee Bahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Age at symptom onset and death and disease duration in genetic frontotemporal dementia: an international retrospective cohort study

(2019) Katrina M Moore et al.   LANCET NEUROLOGY

Measurement of Tau Filament Fragmentation Provides Insights into Prion-like Spreading

(2018) Franziska Kundel et al.   ACS Chemical Neuroscience

A Novel MicroRNA-124/PTPN1 Signal Pathway Mediates Synaptic and Memory Deficits in Alzheimer’s Disease

(2018) Xiong Wang et al.   BIOLOGICAL PSYCHIATRY

Antioxidant response elements: Discovery, classes, regulation and potential applications

(2018) Azhwar Raghunath et al.   Redox Biology

Astrocyte-specific overexpression of Nrf2 protects against optic tract damage and behavioural alterations in a mouse model of cerebral hypoperfusion

(2018) Emma Sigfridsson et al.   Scientific Reports

NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology

(2017) Ana I. Rojo et al.   Redox Biology

Increased Total TAU But Not Amyloid-β42; in Cerebrospinal Fluid Correlates with Short-Term Memory Impairment in Alzheimer's Disease

(2017) Yuh-Te Lin et al.   JOURNAL OF ALZHEIMERS DISEASE

Discovery and Development of Kelch-like ECH-Associated Protein 1. Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein–Protein Interaction Inhibitors: Achievements, Challenges, and Future Directions

(2016) Zheng-Yu Jiang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Sequence determinants of improved CRISPR sgRNA design

(2015) Han Xu et al.   GENOME RESEARCH

Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2

(2015) Karen F.S. Bell et al.   Nature Communications

Pattern separation of emotional information in hippocampal dentate and CA3

(2014) Stephanie L. Leal et al.   HIPPOCAMPUS

The microtubule-associated tau protein has intrinsic acetyltransferase activity

(2013) Todd J Cohen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Brain on Stress: Vulnerability and Plasticity of the Prefrontal Cortex over the Life Course

(2013) Bruce S. McEwen et al.   NEURON

P301S Mutant Human Tau Transgenic Mice Manifest Early Symptoms of Human Tauopathies with Dementia and Altered Sensorimotor Gating

(2011) Hiroki Takeuchi et al.   PLoS One

Nrf1 and Nrf2 Play Distinct Roles in Activation of Antioxidant Response Element-dependent Genes

(2008) Makiko Ohtsuji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclear Erythroid 2-Related Factor 2-Antioxidative Response Element Signaling Pathway in Motor Cortex and Spinal Cord in Amyotrophic Lateral Sclerosis

(2008) Alexander Sarlette et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY