N1 versus N2 and PMN‐MDSC: A critical appraisal of current concepts on tumor‐associated neutrophils and new directions for human oncology

The Bilateral Interplay between Cancer Immunotherapies and Neutrophils` Phenotypes and Sub-Populations

(2022) Naomi Kaisar-Iluz et al.   Cells

CXCR2 inhibition enables NASH-HCC immunotherapy

(2022) Jack Leslie et al.   GUT

Neutrophil phenotypes and functions in cancer: A consensus statement

(2022) Daniela F. Quail et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD66b−CD64dimCD115− cells in the human bone marrow represent neutrophil-committed progenitors

(2022) Federica Calzetti et al.   NATURE IMMUNOLOGY

Gold Nanorods Induce Endoplasmic Reticulum Stress and Autocrine Inflammatory Activation in Human Neutrophils

(2022) Ronja Schirrmann et al.   ACS Nano

PMN‐MDSC in newborns: Regulation of the regulators

(2022) Jadwiga Jablonska et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation

(2021) Yansen Xiao et al.   CANCER CELL

Identification of a subset of immunosuppressive P2RX1-negative neutrophils in pancreatic cancer liver metastasis

(2021) Xu Wang et al.   Nature Communications

Analysis of classical neutrophils and polymorphonuclear myeloid-derived suppressor cells in cancer patients and tumor-bearing mice

(2021) Filippo Veglia et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inhibition of Arginase 1 Liberates Potent T Cell Immunostimulatory Activity of Human Neutrophil Granulocytes

(2021) Verena Vonwirth et al.   Frontiers in Immunology

Neutrophil elastase selectively kills cancer cells and attenuates tumorigenesis

(2021) Chang Cui et al.   CELL

MDSC: Markers, development, states, and unaddressed complexity

(2021) Samarth Hegde et al.   IMMUNITY

Augmented antibody-based anticancer therapeutics boost neutrophil cytotoxicity

(2021) Niels Heemskerk et al.   JOURNAL OF CLINICAL INVESTIGATION

Neutrophil dynamics in the tumor microenvironment

(2021) Amanda J. McFarlane et al.   JOURNAL OF CLINICAL INVESTIGATION

Combination immunotherapy using G-CSF and oncolytic virotherapy reduces tumor growth in osteosarcoma

(2021) Alvaro Morales-Molina et al.   Journal for ImmunoTherapy of Cancer

G-CSF in tumors: Aggressiveness, tumor microenvironment and immune cell regulation

(2021) Ioannis Karagiannidis et al.   CYTOKINE

Suppression of tumor-associated neutrophils by lorlatinib attenuates pancreatic cancer growth and improves treatment with immune checkpoint blockade

(2021) Sebastian R. Nielsen et al.   Nature Communications

Inhibition of the DNA damage response phosphatase PPM1D reprograms neutrophils to enhance anti-tumor immune responses

(2021) Burhan Uyanik et al.   Nature Communications

FcγR engagement reprograms neutrophils into antigen cross-presenting cells that elicit acquired anti-tumor immunity

(2021) Vijayashree Mysore et al.   Nature Communications

Transcriptional Profiling and Functional Analysis of N1/N2 Neutrophils Reveal an Immunomodulatory Effect of S100A9-Blockade on the Pro-Inflammatory N1 Subpopulation

(2021) Andreea C. Mihaila et al.   Frontiers in Immunology

Role of Myeloid-derived suppressor cell (MDSC) in autoimmunity and its potential as a therapeutic target

(2021) Ehsan Nourbakhsh et al.   INFLAMMOPHARMACOLOGY

The PD-L1/PD-1 Axis Blocks Neutrophil Cytotoxicity in Cancer

(2021) Olga Yajuk et al.   Cells

Neutrophils as emerging therapeutic targets

(2020) Tamás Németh et al.   NATURE REVIEWS DRUG DISCOVERY

High-density neutrophils in MGUS and multiple myeloma are dysfunctional and immune-suppressive due to increased STAT3 downstream signaling

(2020) A. Romano et al.   Scientific Reports

Deciphering the Crosstalk Between Myeloid-Derived Suppressor Cells and Regulatory T Cells in Pancreatic Ductal Adenocarcinoma

(2020) Carole Siret et al.   Frontiers in Immunology

Defining the emergence of myeloid-derived suppressor cells in breast cancer using single-cell transcriptomics

(2020) Hamad Alshetaiwi et al.   Science Immunology

Immunogenomic identification and characterization of granulocytic myeloid derived suppressor cells in multiple myeloma

(2020) Cristina Perez et al.   BLOOD

Disruption of CCR1-mediated myeloid cell accumulation suppresses colorectal cancer progression in mice

(2020) Yoshiyuki Kiyasu et al.   CANCER LETTERS

CXCR1 and CXCR2 Chemokine Receptor Agonists Produced by Tumors Induce Neutrophil Extracellular Traps that Interfere with Immune Cytotoxicity

(2020) Álvaro Teijeira et al.   IMMUNITY

An Attempt to Polarize Human Neutrophils Toward N1 and N2 Phenotypes in vitro

(2020) Mareike Ohms et al.   Frontiers in Immunology

Myeloid-derived suppressor cells are essential partners for immune checkpoint inhibitors in the treatment of cisplatin-resistant bladder cancer

(2020) Yuji Takeyama et al.   CANCER LETTERS

Expansion of myeloid-derived suppressor cells in patients with severe coronavirus disease (COVID-19)

(2020) Chiara Agrati et al.   CELL DEATH AND DIFFERENTIATION

Combinatorial Single-Cell Analyses of Granulocyte-Monocyte Progenitor Heterogeneity Reveals an Early Uni-potent Neutrophil Progenitor

(2020) Immanuel Kwok et al.   IMMUNITY

Co-option of Neutrophil Fates by Tissue Environments

(2020) Iván Ballesteros et al.   CELL

Coexpression of CD71 and CD117 Identifies an Early Unipotent Neutrophil Progenitor Population in Human Bone Marrow

(2020) Huy Q. Dinh et al.   IMMUNITY

Tumor-Promoting Ly-6G+ SiglecFhigh Cells Are Mature and Long-Lived Neutrophils

(2020) Christina Pfirschke et al.   Cell Reports

Plasticity in Pro- and Anti-tumor Activity of Neutrophils: Shifting the Balance

(2020) Charita Furumaya et al.   Frontiers in Immunology

Myeloid-Derived Suppressor Cells in Pregnancy and the Neonatal Period

(2020) Natascha Köstlin-Gille et al.   Frontiers in Immunology

Differential expansion of circulating human MDSC subsets in patients with cancer, infection and inflammation

(2020) Luca Cassetta et al.   Journal for ImmunoTherapy of Cancer

Fractionation, chemical characterization and immunostimulatory activity of β-glucan and galactoglucan from Russula vinosa Lindblad

(2020) Hui Zhang et al.   CARBOHYDRATE POLYMERS

Neutrophil-induced genomic instability impedes resolution of inflammation and wound healing

(2019) Veronika Butin-Israeli et al.   JOURNAL OF CLINICAL INVESTIGATION

Antitumoral effect of maintained neutrophilia induced by rhG-CSF in a murine model of pancreatic cancer

(2019) A. Brú et al.   Scientific Reports

KRAS-IRF2 Axis Drives Immune Suppression and Immune Therapy Resistance in Colorectal Cancer

(2019) Wenting Liao et al.   CANCER CELL

Neutrophil plasticity in the tumor microenvironment

(2019) Morgan Giese et al.   BLOOD

Single-Cell Transcriptomics of Human and Mouse Lung Cancers Reveals Conserved Myeloid Populations across Individuals and Species

(2019) Rapolas Zilionis et al.   IMMUNITY

Fatty acid transport protein 2 reprograms neutrophils in cancer

(2019) Filippo Veglia et al.   NATURE

IL ‐7‐dependent compositional changes within the γδ T cell pool in lymph nodes during ageing lead to an unbalanced anti‐tumour response

(2019) Hung‐Chang Chen et al.   EMBO REPORTS

Tumour-associated neutrophils in patients with cancer

(2019) Merav E. Shaul et al.   Nature Reviews Clinical Oncology

Granulopoiesis and Neutrophil Homeostasis: A Metabolic, Daily Balancing Act

(2019) Laurent Yvan-Charvet et al.   TRENDS IN IMMUNOLOGY

Neutrophil Diversity in Health and Disease

(2019) Carlos Silvestre-Roig et al.   TRENDS IN IMMUNOLOGY

Immature Low-Density Neutrophils Exhibit Metabolic Flexibility that Facilitates Breast Cancer Liver Metastasis

(2019) Brian E. Hsu et al.   Cell Reports

Distinct Spatio-Temporal Dynamics of Tumor-Associated Neutrophils in Small Tumor Lesions

(2019) Simon Sody et al.   Frontiers in Immunology

Regulatory Interactions Between Neutrophils, Tumor Cells and T Cells

(2019) Hans-Heinrich Oberg et al.   Frontiers in Immunology

Neutrophil Cathepsin G and Tumor Cell RAGE Facilitate Neutrophil Anti-Tumor Cytotoxicity

(2019) Ronit Vogt Sionov et al.   OncoImmunology

Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis

(2019) Rene Jackstadt et al.   CANCER CELL

Neutrophils as Suppressors of T Cell Proliferation: Does Age Matter?

(2019) Cathelijn E. M. Aarts et al.   Frontiers in Immunology

IgA-Mediated Killing of Tumor Cells by Neutrophils Is Enhanced by CD47–SIRPα Checkpoint Inhibition

(2019) Louise W. Treffers et al.   Cancer Immunology Research

Tumor Associated Neutrophils. Their Role in Tumorigenesis, Metastasis, Prognosis and Therapy

(2019) Maria Teresa Masucci et al.   Frontiers in Oncology

Multidimensional imaging provides evidence for down-regulation of T cell effector function by MDSC in human cancer tissue

(2019) Yu Si et al.   Science Immunology

Neutrophils suppress tumor‐infiltrating T cells in colon cancer via matrix metalloproteinase‐mediated activation of TGF β

(2019) Markus Germann et al.   EMBO Molecular Medicine

TRPM2 Mediates Neutrophil Killing of Disseminated Tumor Cells

(2018) Maya Gershkovitz et al.   CANCER RESEARCH

Nitric Oxide Production by Myeloid-Derived Suppressor Cells Plays a Role in Impairing Fc Receptor–Mediated Natural Killer Cell Function

(2018) Andrew Stiff et al.   CLINICAL CANCER RESEARCH

Clinical relevance and suppressive capacity of human MDSC subsets

(2018) Stephan Lang et al.   CLINICAL CANCER RESEARCH

Plasticity and biological diversity of myeloid derived suppressor cells

(2018) Kerem Ben-Meir et al.   CURRENT OPINION IN IMMUNOLOGY

Developmental Analysis of Bone Marrow Neutrophils Reveals Populations Specialized in Expansion, Trafficking, and Effector Functions

(2018) Maximilien Evrard et al.   IMMUNITY

CXCL5 Facilitates Melanoma Cell–Neutrophil Interaction and Lymph Node Metastasis

(2018) Ana Soler-Cardona et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The Ontogeny of a Neutrophil: Mechanisms of Granulopoiesis and Homeostasis

(2018) Shelley M. Lawrence et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Myeloid-derived suppressor cells coming of age

(2018) Filippo Veglia et al.   NATURE IMMUNOLOGY

Pharmacological activation of estrogen receptor beta augments innate immunity to suppress cancer metastasis

(2018) Linjie Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophils and PMN-MDSC: Their biological role and interaction with stromal cells

(2018) Jie Zhou et al.   SEMINARS IN IMMUNOLOGY

Tumor-associated neutrophils suppress pro-tumoral IL-17+ γδ T cells through induction of oxidative stress

(2018) Sofia Mensurado et al.   PLOS BIOLOGY

Beta-glucan-induced inflammatory monocytes mediate antitumor efficacy in the murine lung

(2018) Matthew P. Alexander et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Myeloid-derived suppressor cells inhibit T cell activation through nitrating LCK in mouse cancers

(2018) Shan Feng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of an Early Unipotent Neutrophil Progenitor with Pro-tumoral Activity in Mouse and Human Bone Marrow

(2018) Yanfang Peipei Zhu et al.   Cell Reports

Tumour-infiltrating neutrophils counteract anti-VEGF therapy in metastatic colorectal cancer

(2018) Lars Mortimer Schiffmann et al.   BRITISH JOURNAL OF CANCER

MDSCs in infectious diseases: regulation, roles, and readjustment

(2018) Anca Dorhoi et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Unique pattern of neutrophil migration and function during tumor progression

(2018) Sima Patel et al.   NATURE IMMUNOLOGY

Targeting both tumour-associated CXCR2+neutrophils and CCR2+macrophages disrupts myeloid recruitment and improves chemotherapeutic responses in pancreatic ductal adenocarcinoma

(2017) Timothy M Nywening et al.   GUT

Tumour-activated neutrophils in gastric cancer foster immune suppression and disease progression through GM-CSF-PD-L1 pathway

(2017) Ting-ting Wang et al.   GUT

Reactive Neutrophil Responses Dependent on the Receptor Tyrosine Kinase c-MET Limit Cancer Immunotherapy

(2017) Nicole Glodde et al.   IMMUNITY

IL-17C mediates the recruitment of tumor-associated neutrophils and lung tumor growth

(2017) C Jungnickel et al.   ONCOGENE

Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhighneutrophils

(2017) Camilla Engblom et al.   SCIENCE

Cabozantinib Eradicates Advanced Murine Prostate Cancer by Activating Antitumor Innate Immunity

(2017) Akash Patnaik et al.   Cancer Discovery

Neutrophils and Snail Orchestrate the Establishment of a Pro-tumor Microenvironment in Lung Cancer

(2017) Julien Faget et al.   Cell Reports

Myeloid-Derived Suppressor Cells

(2017) Dmitry I. Gabrilovich   Cancer Immunology Research

CD39/CD73 upregulation on myeloid-derived suppressor cells via TGF-β-mTOR-HIF-1 signaling in patients with non-small cell lung cancer

(2017) Jieyao Li et al.   OncoImmunology

Tumor-associated neutrophils induce apoptosis of non-activated CD8 T-cells in a TNFα and NO-dependent mechanism, promoting a tumor-supportive environment

(2017) Janna Michaeli et al.   OncoImmunology

Human neutrophil kinetics: modeling of stable isotope labeling data supports short blood neutrophil half-lives

(2016) Julio Lahoz-Beneytez et al.   BLOOD

Origin and Role of a Subset of Tumor-Associated Neutrophils with Antigen-Presenting Cell Features in Early-Stage Human Lung Cancer

(2016) Sunil Singhal et al.   CANCER CELL

Toward harmonized phenotyping of human myeloid-derived suppressor cells by flow cytometry: results from an interim study

(2016) Susanna Mandruzzato et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Neutrophil Extracellular Traps Promote the Development and Progression of Liver Metastases after Surgical Stress

(2016) Samer Tohme et al.   CANCER RESEARCH

Temporal neutrophil polarization following myocardial infarction

(2016) Yonggang Ma et al.   CARDIOVASCULAR RESEARCH

Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors

(2016) Franziska Paul et al.   CELL

Myeloid-Derived Suppressor Cell Subset Accumulation in Renal Cell Carcinoma Parenchyma Is Associated with Intratumoral Expression of IL1β, IL8, CXCL5, and Mip-1α

(2016) Yana G. Najjar et al.   CLINICAL CANCER RESEARCH

Tumor-Associated Neutrophils Recruit Macrophages and T-Regulatory Cells to Promote Progression of Hepatocellular Carcinoma and Resistance to Sorafenib

(2016) Shao-Lai Zhou et al.   GASTROENTEROLOGY

Time-dependent homeostasis between glucose uptake and consumption in astrocytes exposed to CoCl2 treatment

(2016) PENG WANG et al.   Molecular Medicine Reports

Reactive Oxygen Species Regulate T Cell Immune Response in the Tumor Microenvironment

(2016) Xinfeng Chen et al.   Oxidative Medicine and Cellular Longevity

Key role for neutrophils in radiation-induced antitumor immune responses: Potentiation with G-CSF

(2016) Tsuguhide Takeshima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophils in the Tumor Microenvironment

(2016) Davalyn R. Powell et al.   TRENDS IN IMMUNOLOGY

The Nature of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment

(2016) Vinit Kumar et al.   TRENDS IN IMMUNOLOGY

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

(2016) Vincenzo Bronte et al.   Nature Communications

Neutrophils Suppress Intraluminal NK Cell-Mediated Tumor Cell Clearance and Enhance Extravasation of Disseminated Carcinoma Cells

(2016) A. Spiegel et al.   Cancer Discovery

G-CSF is a key modulator of MDSC and could be a potential therapeutic target in colitis-associated colorectal cancers

(2016) Wenbin Li et al.   Protein & Cell

Tumor-associated neutrophils display a distinct N1 profile following TGFβ modulation: A transcriptomics analysis of pro- vs. antitumor TANs

(2016) Merav E. Shaul et al.   OncoImmunology

TLR9-Targeted STAT3 Silencing Abrogates Immunosuppressive Activity of Myeloid-Derived Suppressor Cells from Prostate Cancer Patients

(2015) D. M. S. Hossain et al.   CLINICAL CANCER RESEARCH

Type IIFNs induce anti-tumor polarization of tumor associated neutrophils in mice and human

(2015) Lisa Andzinski et al.   INTERNATIONAL JOURNAL OF CANCER

Peritumoural neutrophils negatively regulate adaptive immunity via the PD-L1/PD-1 signalling pathway in hepatocellular carcinoma

(2015) Gaixia He et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Cancer-Associated Oxidoreductase ERO1-α Drives the Production of Tumor-Promoting Myeloid-Derived Suppressor Cells via Oxidative Protein Folding

(2015) Tsutomu Tanaka et al.   JOURNAL OF IMMUNOLOGY

Transcriptional regulation of myeloid-derived suppressor cells

(2015) Thomas Condamine et al.   JOURNAL OF LEUKOCYTE BIOLOGY

MET is required for the recruitment of anti-tumoural neutrophils

(2015) Veronica Finisguerra et al.   NATURE

Neutrophils support lung colonization of metastasis-initiating breast cancer cells

(2015) Stefanie K. Wculek et al.   NATURE

IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis

(2015) Seth B. Coffelt et al.   NATURE

The prognostic landscape of genes and infiltrating immune cells across human cancers

(2015) Andrew J Gentles et al.   NATURE MEDICINE

Invasive breast cancer reprograms early myeloid differentiation in the bone marrow to generate immunosuppressive neutrophils

(2015) Amy-Jo Casbon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lung inflammation promotes metastasis through neutrophil protease-mediated degradation of Tsp-1

(2015) Tina El Rayes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intratumoral neutrophil granulocytes contribute to epithelial-mesenchymal transition in lung adenocarcinoma cells

(2015) Pingping Hu et al.   TUMOR BIOLOGY

NFκB1 is a suppressor of neutrophil-driven hepatocellular carcinoma

(2015) C. L. Wilson et al.   Nature Communications

Infiltrating neutrophils increase bladder cancer cell invasion via modulation of androgen receptor (AR)/MMP13 signals

(2015) ChangYi Lin et al.   Oncotarget

CD11b+Ly6G+ cells inhibit tumor growth by suppressing IL-17 production at early stages of tumorigenesis

(2015) Yuhong Liu et al.   OncoImmunology

Angiotensin converting enzyme inhibitors and angiotensin II receptor antagonist attenuate tumor growth via polarization of neutrophils toward an antitumor phenotype

(2015) Sanjeeb Shrestha et al.   OncoImmunology

BioTextQuest + : a knowledge integration platform for literature mining and concept discovery

(2014) Nikolas Papanikolaou et al.   BIOINFORMATICS

Interactions between neutrophils and non-small cell lung cancer cells: enhancement of tumor proliferation and inflammatory mediator synthesis

(2014) Katja Hattar et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Targeted depletion of an MDSC subset unmasks pancreatic ductal adenocarcinoma to adaptive immunity

(2014) Ingunn M Stromnes et al.   GUT

Neutrophils recruit regulatory T-cells into tumorsviasecretion of CCL17-A new mechanism of impaired antitumor immunity

(2014) Inbal Mishalian et al.   INTERNATIONAL JOURNAL OF CANCER

Inflammatory Cytokine Production by Human Neutrophils Involves C/EBP Transcription Factors

(2014) A. Cloutier et al.   JOURNAL OF IMMUNOLOGY

Eradication of metastatic mouse cancers resistant to immune checkpoint blockade by suppression of myeloid-derived cells

(2014) K. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disruption of CXCR2-Mediated MDSC Tumor Trafficking Enhances Anti-PD1 Efficacy

(2014) S. L. Highfill et al.   Science Translational Medicine

Tissue-Infiltrating Neutrophils Constitute the Major In Vivo Source of Angiogenesis-Inducing MMP-9 in the Tumor Microenvironment

(2014) Elena I. Deryugina et al.   NEOPLASIA

Radiation fosters dose-dependent and chemotherapy-induced immunogenic cell death

(2014) Encouse B Golden et al.   OncoImmunology

Granulocyte colony-stimulating factor receptor signalling via Janus kinase 2/signal transducer and activator of transcription 3 in ovarian cancer

(2013) J Kumar et al.   BRITISH JOURNAL OF CANCER

Tumor-associated neutrophils (TAN) develop pro-tumorigenic properties during tumor progression

(2013) Inbal Mishalian et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Subpopulations of myeloid-derived suppressor cells impair T cell responses through independent nitric oxide-related pathways

(2013) Patrick L. Raber et al.   INTERNATIONAL JOURNAL OF CANCER

Immunostimulatory properties and antitumor activities of glucans

(2013) LUCA VANNUCCI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis

(2013) Jonathan Cools-Lartigue et al.   JOURNAL OF CLINICAL INVESTIGATION

Cutting Edge: An Inactive Chromatin Configuration at the IL-10 Locus in Human Neutrophils

(2013) N. Tamassia et al.   JOURNAL OF IMMUNOLOGY

Myeloid-Derived Suppressor Cells Suppress Antitumor Immune Responses through IDO Expression and Correlate with Lymph Node Metastasis in Patients with Breast Cancer

(2013) J. Yu et al.   JOURNAL OF IMMUNOLOGY

Promoting effect of neutrophils on lung tumorigenesis is mediated by CXCR2 and neutrophil elastase

(2013) Lei Gong et al.   Molecular Cancer

Oncogenic RAS pathway activation promotes resistance to anti-VEGF therapy through G-CSF-induced neutrophil recruitment

(2013) V. T. Phan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The dichotomy of neutrophil granulocytes in cancer

(2013) Sven Brandau   SEMINARS IN CANCER BIOLOGY

The kinship of neutrophils and granulocytic myeloid-derived suppressor cells in cancer: Cousins, siblings or twins?

(2013) Sven Brandau et al.   SEMINARS IN CANCER BIOLOGY

Tumor-Derived Granulocyte-Macrophage Colony-Stimulating Factor Regulates Myeloid Inflammation and T Cell Immunity in Pancreatic Cancer

(2012) Lauren J. Bayne et al.   CANCER CELL

Neutrophils and granulocytic myeloid-derived suppressor cells: immunophenotyping, cell biology and clinical relevance in human oncology

(2012) Claudia A. Dumitru et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Tumor-associated neutrophils: friend or foe?

(2012) Z. G. Fridlender et al.   CARCINOGENESIS

Epithelial-to-Mesenchymal Transition in Pancreatic Ductal Adenocarcinoma and Pancreatic Tumor Cell Lines: The Role of Neutrophils and Neutrophil-Derived Elastase

(2012) Thomas Große-Steffen et al.   Clinical & Developmental Immunology

Cyclophosphamide-induced Myeloid-derived Suppressor Cell Population Is Immunosuppressive But Not Identical to Myeloid-derived Suppressor Cells Induced By Growing TC-1 Tumors

(2012) Romana Mikyšková et al.   JOURNAL OF IMMUNOTHERAPY

Myeloid Suppressor Cell Depletion Augments Antitumor Activity in Lung Cancer

(2012) Minu K. Srivastava et al.   PLoS One

CXCL17 Expression by Tumor Cells Recruits CD11b+Gr1highF4/80− Cells and Promotes Tumor Progression

(2012) Aya Matsui et al.   PLoS One

Protumor and antitumor functions of neutrophil granulocytes

(2012) Sven Brandau et al.   Seminars in Immunopathology

Tumor Entrained Neutrophils Inhibit Seeding in the Premetastatic Lung

(2011) Zvi Granot et al.   CANCER CELL

Neutrophil Degranulation and Immunosuppression in Patients with GBM: Restoration of Cellular Immune Function by Targeting Arginase I

(2011) T. R. Sippel et al.   CLINICAL CANCER RESEARCH

On the dual roles and polarized phenotypes of neutrophils in tumor development and progression

(2011) H. Piccard et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Circulating and tumor-infiltrating myeloid cell subsets in patients with bladder cancer

(2011) Evgeniy Eruslanov et al.   INTERNATIONAL JOURNAL OF CANCER

Tumor-infiltrating myeloid cells induce tumor cell resistance to cytotoxic T cells in mice

(2011) Tangying Lu et al.   JOURNAL OF CLINICAL INVESTIGATION

A subset of neutrophils in human systemic inflammation inhibits T cell responses through Mac-1

(2011) Janesh Pillay et al.   JOURNAL OF CLINICAL INVESTIGATION

Exocytosis of azurophil and arginase 1-containing granules by activated polymorphonuclear neutrophils is required to inhibit T lymphocyte proliferation

(2011) R. Rotondo et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Neutrophils promote motility of cancer cells via a hyaluronan-mediated TLR4/PI3K activation loop

(2011) Yan Wu et al.   JOURNAL OF PATHOLOGY

Failure to detect production of IL-10 by activated human neutrophils

(2011) Martin S Davey et al.   NATURE IMMUNOLOGY

Tumor-Derived G-CSF Facilitates Neoplastic Growth through a Granulocytic Myeloid-Derived Suppressor Cell-Dependent Mechanism

(2011) Jeremy D. Waight et al.   PLoS One

STAT3 controls myeloid progenitor growth during emergency granulopoiesis

(2010) H. Zhang et al.   BLOOD

In vivo labeling with 2H2O reveals a human neutrophil lifespan of 5.4 days

(2010) J. Pillay et al.   BLOOD

Immature Immunosuppressive CD14+HLA-DR−/low Cells in Melanoma Patients Are Stat3hi and Overexpress CD80, CD83, and DC-Sign

(2010) Isabel Poschke et al.   CANCER RESEARCH

Neutrophils, from Marrow to Microbes

(2010) Niels Borregaard   IMMUNITY

Tumor-Induced Tolerance and Immune Suppression Depend on the C/EBPβ Transcription Factor

(2010) Ilaria Marigo et al.   IMMUNITY

Neutrophils: key mediators of tumour angiogenesis

(2010) Simon Tazzyman et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Neutrophils responsive to endogenous IFN-β regulate tumor angiogenesis and growth in a mouse tumor model

(2010) Jadwiga Jablonska et al.   JOURNAL OF CLINICAL INVESTIGATION

CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow

(2010) Kyle J. Eash et al.   JOURNAL OF CLINICAL INVESTIGATION

Myeloid-derived suppressor cells in the peripheral blood of cancer patients contain a subset of immature neutrophils with impaired migratory properties

(2010) Sven Brandau et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Neutrophil elastase–mediated degradation of IRS-1 accelerates lung tumor growth

(2010) A McGarry Houghton et al.   NATURE MEDICINE

CXCR1 and CXCR2 enhances human melanoma tumourigenesis, growth and invasion

(2009) S Singh et al.   BRITISH JOURNAL OF CANCER

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

(2009) Zvi G. Fridlender et al.   CANCER CELL

Arginase I–Producing Myeloid-Derived Suppressor Cells in Renal Cell Carcinoma Are a Subpopulation of Activated Granulocytes

(2009) Paulo C. Rodriguez et al.   CANCER RESEARCH

Myeloid-Derived Suppressor Cells Inhibit T-Cell Activation by Depleting Cystine and Cysteine

(2009) M. K. Srivastava et al.   CANCER RESEARCH

Sunitinib Mediates Reversal of Myeloid-Derived Suppressor Cell Accumulation in Renal Cell Carcinoma Patients

(2009) J. S. Ko et al.   CLINICAL CANCER RESEARCH

Hierarchy of immunosuppressive strength among myeloid-derived suppressor cell subsets is determined by GM-CSF

(2009) Luigi Dolcetti et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Population alterations of l-arginase- and inducible nitric oxide synthase-expressed CD11b+/CD14−/CD15+/CD33+ myeloid-derived suppressor cells and CD8+ T lymphocytes in patients with advanced-stage non-small cell lung cancer

(2009) Chien-Ying Liu et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Mechanism Regulating Reactive Oxygen Species in Tumor-Induced Myeloid-Derived Suppressor Cells

(2009) C. A. Corzo et al.   JOURNAL OF IMMUNOLOGY

Genotoxic effects of neutrophils and hypochlorous acid

(2009) N. Gungor et al.   MUTAGENESIS

Inflaming metastasis

(2009) Alberto Mantovani   NATURE

Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity

(2008) K. Movahedi et al.   BLOOD

Myeloid-Derived Suppressor Cells Promote Cross-Tolerance in B-Cell Lymphoma by Expanding Regulatory T Cells

(2008) P. Serafini et al.   CANCER RESEARCH

A New Population of Myeloid-Derived Suppressor Cells in Hepatocellular Carcinoma Patients Induces CD4+CD25+Foxp3+ T Cells

(2008) Bastian Hoechst et al.   GASTROENTEROLOGY

Role of Bv8 in neutrophil-dependent angiogenesis in a transgenic model of cancer progression

(2008) F. Shojaei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

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