Article
Pharmacology & Pharmacy
Xiaofeng Huang, Shuo Li, Wenjie Shi, Ye Wang, Xinyu Wan, Jinzhi He, Yinggang Xu, Weiwei Zhang, Xiaoqing Shi, Rui Chen, Lu Xu, Xiaoming Zha, Jue Wang
Summary: This study suggests that PEG-rhG-CSF is more effective and convenient than rhG-CSF in the treatment of grades 3-4 neutropenia and febrile neutropenia in breast cancer patients, with manageable toxicity.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Oncology
Yantao Jiang, Ju Zhang, Jianxin Zhong, Hao Liao, Jiayang Zhang, Yaxin Liu, Yuehua Liang, Huiping Li
Summary: This study compared the clinical value of rhG-CSF and PEG-rhG-CSF in early-stage breast cancer patients receiving adjuvant chemotherapy. It also compared the efficacy of different doses of PEG-rhG-CSF and explored the timing of rhG-CSF rescue treatment.
Article
Pharmacology & Pharmacy
Jie Zhao, Gaoxing Qiao, Yan Liang, Jia Li, Wei Hu, Xu Zuo, Junfang Li, Chenglong Zhao, Xiaojian Zhang, Shuzhang Du
Summary: The study compared the cost-effectiveness of PEG-rhG-CSF versus rhG-CSF in stage II-IV breast cancer patients in central China. The results showed that PEG-rhG-CSF led to fewer episodes of adverse events but at a higher cost. Sensitivity analysis indicated that the cost of PEG-rhG-CSF and the risk of chemotherapy discontinuation have significant impacts on the cost-effectiveness.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Immacolata Maietta, Amparo Martinez-Perez, Rosana Alvarez, Angel R. De Lera, Africa Gonzalez-Fernandez, Rosana Simon-Vazquez
Summary: Epigenetic modifications play a crucial role in the proliferation, drug resistance, and metastasis of pancreatic ductal adenocarcinoma (PDAC). In this study, researchers tested the effects of different epigenetic enzyme inhibitors and a drug that restores p53 function on PDAC cell lines. The results showed that inhibiting certain enzymes or combining drugs with gemcitabine can significantly reduce cell viability and potentially serve as a new treatment strategy for PDAC. RNA-Seq analysis also identified potential biomarkers for synergy.
Article
Oncology
Chun-Hsiang Chang, Chi-Jui Chen, Ching-Fang Yu, Hui-Yu Tsai, Fang-Hsin Chen, Chi-Shiun Chiang
Summary: The study aimed to investigate the impact of boron neutron capture therapy (BNCT) on myeloid-derived suppressive cells (MDSCs) in head and neck squamous cell carcinoma (HNSCC) and explore the potential for MDSCs depletion combined with BNCT to reactivate antitumor immunity. The results showed that after BNCT treatment, there were temporary and persistent increases of moncytic-MDSCs (M-MDSCs) in the tumor microenvironment and peripheral blood. Inhibition of CSF-1 receptor hindered M-MDSCs infiltration, prolonged survival, and activated tumor immunity.
FRONTIERS IN ONCOLOGY
(2023)
Article
Immunology
Cheng Peng, Guangping Tu, Li Yu, Peng Wu, Xianlin Zhang, Zheng Li, Zhiqiang Li, Xiao Yu
Summary: This study investigates the macrophage profile and regulatory mechanisms in mouse pancreatitis, as well as its correlation with human chronic pancreatitis. The results show that the expression of TNF-alpha and IL-6 increases over time, while pancreatic fibrosis peaks at day 21. M2 macrophages also peak at day 21.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Julia Wollenhaupt, Janina Frisch, Eva Harlacher, Dickson W. L. Wong, Han Jin, Corinna Schulte, Sonja Vondenhoff, Julia Moellmann, Barbara Mara Klinkhammer, Li Zhang, Adelina Baleanu-Curaj, Elisa A. Liehn, Thimoteus Speer, Andrey Kazakov, Christian Werner, Emiel P. C. van der Vorst, Simina-Ramona Selejan, Mathias Hohl, Michael Bohm, Rafael Kramann, Erik A. L. Biessen, Michael Lehrke, Nikolaus Marx, Joachim Jankowski, Christoph Maack, Peter Boor, Leticia Prates Roma, Heidi Noels
Summary: CKD increases cardiac oxidative stress responses in the heart, but additional hits are required to induce uremic cardiomyopathy.
Article
Oncology
Kathrin Hedegger, Andreas Blutke, Theresa Hommel, Kerstin E. E. Auer, Nishanth B. B. Nataraj, Moshit Lindzen, Yosef Yarden, Maik Dahlhoff
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly deadly cancer, and targeted therapies for PDAC are still under development. This study shows that simultaneously blocking the entire ERBB receptor family, using a molecular decoy called TRAP-F-C, can effectively reduce pancreatic tumor burden and RAS activity in a mouse model of PDAC.
MOLECULAR ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tugba Kose, Paul A. Sharp, Gladys O. Latunde-Dada
Summary: Iron is involved in various physiological functions, but excess iron can cause oxidative stress and lead to metabolic syndromes. This study investigated the protective effect of phenolic acids against iron-induced oxidative stress in pancreatic cells and mice. The results showed that phenolic acids increased cell viability and reduced ROS levels, glutathione depletion, and lipid peroxidation. In mice, phenolic acids activated the Nrf2 antioxidant pathway and increased the expression of antioxidant genes in the pancreas.
Article
Physiology
David J. Culp, Bently Robinson, Melanie N. Cash
Summary: The study suggests that lack of salivary amylase in mice leads to increased severity of caries on smooth surface and sulcal surface when challenged with Streptococcus mutans and fed a sucrose-rich diet.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Physics, Multidisciplinary
Yaohua Li, Chao Liang, Chenyang Wang, Cuicui Lu, Yong-Chun Liu
Summary: The study reveals the gain-loss-induced hybrid second-order skin-topological effect and the PT phase transition in skin-topological modes. The localized behavior of topological edge modes on a special type of corner, in contrast to the extended bulk modes, is found to be related to the interplay between gain, loss, and the chiral edge currents induced by nonlocal flux. The research establishes a relation between the skin-topological effect and the PT symmetries belonging to different edges.
PHYSICAL REVIEW LETTERS
(2022)
Article
Immunology
Jin Wang, Xingchen Liu, Junsong Ji, Jianhua Luo, Yuanyu Zhao, Xiaonan Zhou, Jianming Zheng, Meng Guo, Yanfang Liu
Summary: This study describes the construction of a novel orthotopic PDAC model through implantation of tissue slices and discusses the resistance to immunotherapy from the perspective of a PDAC microenvironment. Results show that elimination of MDSCs by NKG2D CAR can rescue impaired CAR-T cell activity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Hyun-Ah Kim, Hyunsoo Kim, Min-Kyung Nam, Jong Kook Park, Moo-Yeal Lee, Seok Chung, Kyung-Mi Lee, Hyo-Jeong Kuh
Summary: This study investigated the effect of activated pancreatic stellate cells (aPSCs) on NK cell-mediated anticancer efficacy and established a TIME-on-chip model based on PANC-1 tumor spheroids, aPSCs, and NK-92 cells.
CANCER CELL INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Lucas Gabriel Viana Barbosa, Ellen Nayara Silva de Jesus, Lucas Botelho Jeronimo, Jamile Silva da Costa, Renata Cunha Silva, William N. Setzer, Joyce Kelly R. da Silva, Jofre Jacob da Silva Freitas, Pablo Luis B. Figueiredo
Summary: This study evaluated the chemical composition, antioxidant capacity, and antitumoral activity of S. guianensis essential oil. The results showed that the oil possesses significant antioxidant activity, inhibits tumor cell growth, and reduces oxidative stress.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Oncology
Carlos Heli Bezerra Leite, Carlos Diego Holanda Lopes, Caio Abner Vitorino Goncalves Leite, Dulce Andrade Terceiro, Gabriel Silva Lima, Jessica Andrade Freitas, Fernando Queiroz Cunha, Paulo Roberto Carvalho Almeida, Deysi Viviana Tenazoa Wong, Roberto Cesar Pereira Lima-Junior
Summary: We developed a novel animal model of actinic proctitis induced by HDR brachytherapy, marked by inflammatory damage and low animal mortality. The study involved subjecting C57BL/6 male mice to HDR (radiation source: Ir-192) through a cylindrical propylene tube inserted into the rectum. The results showed that HDR significantly reduced the animals' survival rate and caused rectum injury accompanied by an inflammatory response.
FRONTIERS IN ONCOLOGY
(2022)
Article
Physics, Multidisciplinary
A. Bru, D. Gomez-Castro, J. C. Nuno
PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS
(2017)
Article
Computer Science, Interdisciplinary Applications
A. Bru, D. Casero, S. De Franciscis, M. A. Herrero
MATHEMATICAL AND COMPUTER MODELLING
(2008)
Article
Cell Biology
Antonio Bru, Juan-Carlos Souto, Sonia Alcolea, Rosa Anton, Angel Remacha, Mercedes Camacho, Marta Soler, Isabel Bru, Amelia Porres, Luis Vila
MEDIATORS OF INFLAMMATION
(2009)
Article
Chemistry, Medicinal
Juan Carlos Souto, Luis Vila, Antonio Bru
MEDICINAL RESEARCH REVIEWS
(2011)
Article
Multidisciplinary Sciences
Antonio Bru, Pere-Joan Cardona
Article
Multidisciplinary Sciences
A. Bru, E. Alos, J. C. Nuno, M. Fernandez de Dios
SCIENTIFIC REPORTS
(2014)
Article
Multidisciplinary Sciences
Antonio Bru, David Gomez-Castro, Luis Vila, Isabel Bru, Juan Carlos Souto
Article
Biology
Marthe Maloy, Frode Maloy, Rafael Lahoz-Beltra, Juan Carlos Nuno, Antonio Bru
MATHEMATICAL BIOSCIENCES
(2019)
Article
Oncology
Antonio Bru, Carlos del Fresno, Alessandra Soares-Schanoski, Sonia Albertos, Isabel Bru, Amelia Porres, Eduardo Rollan-Landeras, Ana Dopazo, David Casero, Vanesa Gomez-Pina, Lourdes Garcia, Francisco Arnalich, Rebeca Alvarez, Alexandro Rodriguez-Rojas, Pablo Fuentes-Prior, Eduardo Lopez-Collazo
Article
Biology
A. Bru, D. Casero
JOURNAL OF THEORETICAL BIOLOGY
(2006)
Article
Soil Science
Antonio Bru, Juan Manuel Pastor
Article
Mathematics, Applied
Antonio Bru, Miguel A. Herrero
MATHEMATICAL MODELS & METHODS IN APPLIED SCIENCES
(2006)
Letter
Urology & Nephrology
Antonio Bru
JOURNAL OF UROLOGY
(2007)
Article
Soil Science
JJ Ibanez, MR Ramos, JA Zinck, A Bru
EURASIAN SOIL SCIENCE
(2005)