The Ontogeny of a Neutrophil: Mechanisms of Granulopoiesis and Homeostasis

Hemangioblast, hemogenic endothelium, and primitive versus definitive hematopoiesis

(2017) Georges Lacaud et al.   EXPERIMENTAL HEMATOLOGY

A molecular roadmap of the AGM region reveals BMPER as a novel regulator of HSC maturation

(2017) Alison C. McGarvey et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Age-Appropriate Functions and Dysfunctions of the Neonatal Neutrophil

(2017) Shelley Melissa Lawrence et al.   Frontiers in Pediatrics

Developing HSCs become Notch independent by the end of maturation in the AGM region

(2016) C. Souilhol et al.   BLOOD

Advances in understanding erythropoiesis: evolving perspectives

(2016) Satish K. Nandakumar et al.   BRITISH JOURNAL OF HAEMATOLOGY

Myeloperoxidase Stimulates Neutrophil Degranulation

(2016) D. V. Grigorieva et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Alterations in neonatal neutrophil function attributable to increased immature forms

(2016) Marjorie Makoni et al.   EARLY HUMAN DEVELOPMENT

Hematopoietic stem cell-independent hematopoiesis: emergence of erythroid, megakaryocyte, and myeloid potential in the mammalian embryo

(2016) James Palis   FEBS LETTERS

The embryonic origins and genetic programming of emerging haematopoietic stem cells

(2016) Aldo Ciau-Uitz et al.   FEBS LETTERS

Granulopoiesis and granules of human neutrophils

(2016) Jack B. Cowland et al.   IMMUNOLOGICAL REVIEWS

Death-associated Protein Kinase-1 Expression and Autophagy in Chronic Lymphocytic Leukemia Are Dependent on Activating Transcription Factor-6 and CCAAT/Enhancer-binding Protein-β

(2016) Padmaja Gade et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A view of human haematopoietic development from the Petri dish

(2016) Andrea Ditadi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Epigenetic regulation of neutrophil development and function

(2016) Renato Ostuni et al.   SEMINARS IN IMMUNOLOGY

Inductive interactions mediated by interplay of asymmetric signalling underlie development of adult haematopoietic stem cells

(2016) Céline Souilhol et al.   Nature Communications

Acetylation of C/EBPα inhibits its granulopoietic function

(2016) Deepak Bararia et al.   Nature Communications

Neutrophil-Mediated Regulation of Innate and Adaptive Immunity: The Role of Myeloperoxidase

(2016) Dragana Odobasic et al.   Journal of Immunology Research

Lactoferrin Is an Allosteric Enhancer of the Proteolytic Activity of Cathepsin G

(2016) Steffen Eipper et al.   PLoS One

Acetylation of C/EBP  is a prerequisite for terminal neutrophil differentiation

(2015) M. Bartels et al.   BLOOD

Non-steady-state hematopoiesis regulated by the C/EBPβ transcription factor

(2015) Hideyo Hirai et al.   CANCER SCIENCE

Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors

(2015) Franziska Paul et al.   CELL

Myeloid Cell-Derived Reactive Oxygen Species Externally Regulate the Proliferation of Myeloid Progenitors in Emergency Granulopoiesis

(2015) Hyun-Jeong Kwak et al.   IMMUNITY

Mechanisms of fate decision and lineage commitment during haematopoiesis

(2015) Ana Cvejic   IMMUNOLOGY AND CELL BIOLOGY

A Novel In-Frame Deletion in the Leucine Zipper Domain of C/EBPε Leads to Neutrophil-Specific Granule Deficiency

(2015) Taizo Wada et al.   JOURNAL OF IMMUNOLOGY

The voltage-gated proton channel Hv1/VSOP inhibits neutrophil granule release

(2015) Yoshifumi Okochi et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Tamm-Horsfall Protein Regulates Granulopoiesis and Systemic Neutrophil Homeostasis

(2015) R. Micanovic et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The multifaceted functions of C/EBPα in normal and malignant haematopoiesis

(2015) E Ohlsson et al.   LEUKEMIA

Hematopoietic activity in putative mouse primordial germ cell populations

(2015) Maria Lucia Scaldaferri et al.   MECHANISMS OF DEVELOPMENT

Neutrophil ageing is regulated by the microbiome

(2015) Dachuan Zhang et al.   NATURE

Early-Onset Neutropenia in Small-for-Gestational-Age Infants

(2015) R. D. Christensen et al.   PEDIATRICS

Distinct routes of lineage development reshape the human blood hierarchy across ontogeny

(2015) F. Notta et al.   SCIENCE

Early hematopoiesis and macrophage development

(2015) Kathleen E. McGrath et al.   SEMINARS IN IMMUNOLOGY

Neutrophil Leukocyte: Combustive Microbicidal Action and Chemiluminescence

(2015) Robert C. Allen   Journal of Immunology Research

Immunomodulatory effects of lactoferrin

(2014) Tania Siqueiros-Cendón et al.   ACTA PHARMACOLOGICA SINICA

SLPI is essential for granulopoiesis

(2014) M. A. Nolte   BLOOD

miRNA-130a regulates C/EBP-  expression during granulopoiesis

(2014) M. T. Larsen et al.   BLOOD

Infection Mobilizes Hematopoietic Stem Cells through Cooperative NOD-like Receptor and Toll-like Receptor Signaling

(2014) Aaron Burberry et al.   Cell Host & Microbe

Early-Onset Neonatal Sepsis

(2014) K. A. Simonsen et al.   CLINICAL MICROBIOLOGY REVIEWS

Discrete Notch signaling requirements in the specification of hematopoietic stem cells

(2014) A. D. Kim et al.   EMBO JOURNAL

Developmental hematopoiesis: Ontogeny, genetic programming and conservation

(2014) Aldo Ciau-Uitz et al.   EXPERIMENTAL HEMATOLOGY

Clinical Course in a Patient With Neutrophil-Specific Granule Deficiency and Rapid Detection of Neutrophil Granules as a Screening Test

(2014) Tomonari Shigemura et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Munc13-4 Regulates Granule Secretion in Human Neutrophils

(2014) C. Pivot-Pajot et al.   JOURNAL OF IMMUNOLOGY

Resistin Inhibits Essential Functions of Polymorphonuclear Leukocytes

(2014) G. Cohen et al.   JOURNAL OF IMMUNOLOGY

Microbiota-Derived Compounds Drive Steady-State Granulopoiesis via MyD88/TICAM Signaling

(2014) Maria L. Balmer et al.   JOURNAL OF IMMUNOLOGY

Central Role of Conventional Dendritic Cells in Regulation of Bone Marrow Release and Survival of Neutrophils

(2014) J. Jiao et al.   JOURNAL OF IMMUNOLOGY

Signal Regulatory Protein Alpha Is Present in Several Neutrophil Granule Populations and Is Rapidly Mobilized to the Cell Surface to Negatively Fine-Tune Neutrophil Accumulation in Inflammation

(2014) Åsa Stenberg et al.   Journal of Innate Immunity

An essential role of syntaxin 3 protein for granule exocytosis and secretion of IL-1α , IL-1β , IL-12b, and CCL4 from differentiated HL-60 cells

(2014) Isabelle Naegelen et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Early Empiric Antibiotic Use in Preterm Infants Is Associated with Lower Bacterial Diversity and Higher Relative Abundance of Enterobacter

(2014) Corryn Greenwood et al.   JOURNAL OF PEDIATRICS

Jam1a–Jam2a interactions regulate haematopoietic stem cell fate through Notch signalling

(2014) Isao Kobayashi et al.   NATURE

Neutrophils at work

(2014) William M Nauseef et al.   NATURE IMMUNOLOGY

The microbiota regulates neutrophil homeostasis and host resistance to Escherichia coli K1 sepsis in neonatal mice

(2014) Hitesh S Deshmukh et al.   NATURE MEDICINE

Granulopoiesis Requires Increased C/EBPα Compared to Monopoiesis, Correlated with Elevated Cebpa in Immature G-CSF Receptor versus M-CSF Receptor Expressing Cells

(2014) Ou Ma et al.   PLoS One

Granule Protein Processing and Regulated Secretion in Neutrophils

(2014) Avinash Sheshachalam et al.   Frontiers in Immunology

A lack of secretory leukocyte protease inhibitor (SLPI) causes defects in granulocytic differentiation

(2013) O. Klimenkova et al.   BLOOD

The hemangioblast: a state of competence

(2013) E. Amaya   BLOOD

The Many Faces of C/EBPδ and their Relevance for Inflammation and Cancer

(2013) Kuppusamy Balamurugan et al.   International Journal of Biological Sciences

Olfm4 deletion enhances defense against Staphylococcus aureus in chronic granulomatous disease

(2013) Wenli Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Neutrophil mobilization via plerixafor-mediated CXCR4 inhibition arises from lung demargination and blockade of neutrophil homing to the bone marrow

(2013) Sapna Devi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

NSP4 Is Stored in Azurophil Granules and Released by Activated Neutrophils as Active Endoprotease with Restricted Specificity

(2013) N. C. Perera et al.   JOURNAL OF IMMUNOLOGY

Infection-Induced Changes in Hematopoiesis

(2013) A. G. Zaretsky et al.   JOURNAL OF IMMUNOLOGY

Regulation of Circulating Neutrophil Numbers under Homeostasis and in Disease

(2013) Natasha Strydom et al.   Journal of Innate Immunity

Whatˈs your age again? Determination of human neutrophil half-lives revisited

(2013) Tamar Tak et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Proteome profiling of human neutrophil granule subsets, secretory vesicles, and cell membrane: correlation with transcriptome profiling of neutrophil precursors

(2013) Sara Rørvig et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The Human Neutrophil Subsets Defined by the Presence or Absence of OLFM4 Both Transmigrate into Tissue In Vivo and Give Rise to Distinct NETs In Vitro

(2013) Amanda Welin et al.   PLoS One

Toll-like receptor TLR2 and TLR9 ligation triggers neutrophil activation in granulomatosis with polyangiitis

(2013) J. U. Holle et al.   RHEUMATOLOGY

Myeloperoxidase modulates human platelet aggregation via actin cytoskeleton reorganization and store-operated calcium entry

(2013) Irina V. Gorudko et al.   Biology Open

Steady-state neutrophil homeostasis is dependent on TLR4/TRIF signaling

(2012) S. Bugl et al.   BLOOD

Runx1 deletion or dominant inhibition reduces Cebpa transcription via conserved promoter and distal enhancer sites to favor monopoiesis over granulopoiesis

(2012) H. Guo et al.   BLOOD

The embryonic origins of erythropoiesis in mammals

(2012) M. H. Baron et al.   BLOOD

Gfi-1 inhibits the expression of eosinophil major basic protein (MBP) during G-CSF-induced neutrophilic differentiation

(2012) Qingquan Liu et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

MUNC13-4 Protein Regulates the Oxidative Response and Is Essential for Phagosomal Maturation and Bacterial Killing in Neutrophils

(2012) Jlenia Monfregola et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Olfactomedin 4 Inhibits Cathepsin C-Mediated Protease Activities, Thereby Modulating Neutrophil Killing of Staphylococcus aureus and Escherichia coli in Mice

(2012) W. Liu et al.   JOURNAL OF IMMUNOLOGY

Signal transduction pathways regulating hematopoietic stem cell biology: Introduction to a series of Spotlight Reviews

(2012) T C Luis et al.   LEUKEMIA

Endothelial and perivascular cells maintain haematopoietic stem cells

(2012) Lei Ding et al.   NATURE

Serglycin participates in retention of  -defensin in granules during myelopoiesis

(2011) A. Glenthoj et al.   BLOOD

Embryonic origin of the adult hematopoietic system: advances and questions

(2011) A. Medvinsky et al.   DEVELOPMENT

Olfactomedin 4 defines a subset of human neutrophils

(2011) Stine N. Clemmensen et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A somitic Wnt16/Notch pathway specifies haematopoietic stem cells

(2011) Wilson K. Clements et al.   NATURE

Myeloperoxidase attracts neutrophils by physical forces

(2010) A. Klinke et al.   BLOOD

Live imaging of Runx1 expression in the dorsal aorta tracks the emergence of blood progenitors from endothelial cells

(2010) E. Y. N. Lam et al.   BLOOD

Biosynthesis, processing and sorting of neutrophil proteins: insight into neutrophil granule development

(2010) Urban Gullberg et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Neutrophils, from Marrow to Microbes

(2010) Niels Borregaard   IMMUNITY

Blood stem cells emerge from aortic endothelium by a novel type of cell transition

(2010) Karima Kissa et al.   NATURE

Haematopoietic stem cells derive directly from aortic endothelium during development

(2010) Julien Y. Bertrand et al.   NATURE

Revised map of the human progenitor hierarchy shows the origin of macrophages and dendritic cells in early lymphoid development

(2010) Sergei Doulatov et al.   NATURE IMMUNOLOGY

In vivo two-photon imaging reveals monocyte-dependent neutrophil extravasation during pulmonary inflammation

(2010) D. Kreisel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophil kinetics in health and disease

(2010) Charlotte Summers et al.   TRENDS IN IMMUNOLOGY

Resistin is stored in neutrophil granules being released upon challenge with inflammatory stimuli

(2009) Elisabeth A. Boström et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Lactoferrin as a Natural Immune Modulator

(2009) Jeffrey Actor et al.   CURRENT PHARMACEUTICAL DESIGN

Apoptotic Cells Promote Their Own Clearance and Immune Tolerance through Activation of the Nuclear Receptor LXR

(2009) Noelia A-Gonzalez et al.   IMMUNITY

Hv1 proton channels are required for high-level NADPH oxidase-dependent superoxide production during the phagocyte respiratory burst

(2009) I. S. Ramsey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Involvement of Munc18 isoforms in the regulation of granule exocytosis in neutrophils

(2008) Cristiana Brochetta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Migration across the sinusoidal endothelium regulates neutrophil mobilization in response to ELR + CXC chemokines

(2008) Peter C. E. Burdon et al.   BRITISH JOURNAL OF HAEMATOLOGY

Hematopoiesis: An Evolving Paradigm for Stem Cell Biology

(2008) Stuart H. Orkin et al.   CELL

Canonical Notch Signaling Is Dispensable for the Maintenance of Adult Hematopoietic Stem Cells

(2008) Ivan Maillard et al.   Cell Stem Cell

Granulocyte colony-stimulating factor: Molecular mechanisms of action during steady state and ‘emergency’ hematopoiesis

(2008) Athanasia D. Panopoulos et al.   CYTOKINE

LPS/TLR4 signal transduction pathway

(2008) Yong-Chen Lu et al.   CYTOKINE

Neutrophil apoptosis and the resolution of infection

(2008) Adam D. Kennedy et al.   IMMUNOLOGIC RESEARCH

Expected ranges for blood neutrophil concentrations of neonates: the Manroe and Mouzinho charts revisited

(2008) N Schmutz et al.   Journal of Perinatology

Of lineage and legacy: the development of mammalian hematopoietic stem cells

(2008) Elaine Dzierzak et al.   NATURE IMMUNOLOGY

Changing Patterns in Neonatal Escherichia coli Sepsis and Ampicillin Resistance in the Era of Intrapartum Antibiotic Prophylaxis

(2008) M. J. Bizzarro et al.   PEDIATRICS

Prolonged Duration of Initial Empirical Antibiotic Treatment Is Associated With Increased Rates of Necrotizing Enterocolitis and Death for Extremely Low Birth Weight Infants

(2008) C. M. Cotten et al.   PEDIATRICS