Transcriptional regulation of myeloid-derived suppressor cells

Endoplasmic Reticulum Stress in Immunity

(2015) Sarah E. Bettigole et al.   Annual Review of Immunology

Regulation of Tumor Metastasis by Myeloid-Derived Suppressor Cells

(2015) Thomas Condamine et al.   Annual Review of Medicine

IRF8 acts in lineage-committed rather than oligopotent progenitors to control neutrophil vs monocyte production

(2015) A. Yanez et al.   BLOOD

Regulation of myelopoiesis by the transcription factor IRF8

(2015) Tomohiko Tamura et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

F-box protein FBXW7 inhibits cancer metastasis in a non-cell-autonomous manner

(2015) Kanae Yumimoto et al.   JOURNAL OF CLINICAL INVESTIGATION

IFN Regulatory Factor 8 Represses GM-CSF Expression in T Cells To Affect Myeloid Cell Lineage Differentiation

(2015) Amy V. Paschall et al.   JOURNAL OF IMMUNOLOGY

Exosomal Hsp70 mediates immunosuppressive activity of the myeloid-derived suppressor cells via phosphorylation of Stat3

(2015) Jianjun Diao et al.   MEDICAL ONCOLOGY

Invasive breast cancer reprograms early myeloid differentiation in the bone marrow to generate immunosuppressive neutrophils

(2015) Amy-Jo Casbon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of inflammasome activation: recent advances and novel insights

(2015) Sivapriya K. Vanaja et al.   TRENDS IN CELL BIOLOGY

Nifuroxazide induces apoptosis and impairs pulmonary metastasis in breast cancer model

(2015) F Yang et al.   Cell Death & Disease

Id1 suppresses anti-tumour immune responses and promotes tumour progression by impairing myeloid cell maturation

(2015) Marianna Papaspyridonos et al.   Nature Communications

SOCS3 Deficiency in Myeloid Cells Promotes Tumor Development: Involvement of STAT3 Activation and Myeloid-Derived Suppressor Cells

(2015) H. Yu et al.   Cancer Immunology Research

IL-1RT1 signaling antagonizes IL-11 induced STAT3 dependent cardiac and antral stomach tumor development through myeloid cell enrichment

(2015) Jon N Buzzelli et al.   Oncotarget

Elevated endoplasmic reticulum stress reinforced immunosuppression in the tumor microenvironment via myeloid-derived suppressor cells

(2015) Bo-Ra Lee et al.   Oncotarget

IL-6-stimulated CD11b+ CD14+ HLA-DR− myeloid-derived suppressor cells, are associated with progression and poor prognosis in squamous cell carcinoma of the esophagus

(2015) Miao-Fen Chen et al.   Oncotarget

IRF-8 Controls Melanoma Progression by Regulating the Cross Talk between Cancer and Immune Cells within the Tumor Microenvironment

(2015) Fabrizio Mattei et al.   NEOPLASIA

Blockade of A2b Adenosine Receptor Reduces Tumor Growth and Immune Suppression Mediated by Myeloid-Derived Suppressor Cells in a Mouse Model of Melanoma

(2015) Raffaella Iannone et al.   NEOPLASIA

Myeloid-derived suppressor cell heterogeneity in human cancers

(2014) Samantha Solito et al.   Annals of the New York Academy of Sciences

Axitinib augments antitumor activity in renal cell carcinoma via STAT3-dependent reversal of myeloid-derived suppressor cell accumulation

(2014) Huaqin Yuan et al.   BIOMEDICINE & PHARMACOTHERAPY

Tumor-induced myeloid dysfunction and its implications for cancer immunotherapy

(2014) Michelle N. Messmer et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Inhibition of Tumor-Derived Prostaglandin-E2 Blocks the Induction of Myeloid-Derived Suppressor Cells and Recovers Natural Killer Cell Activity

(2014) Y. Mao et al.   CLINICAL CANCER RESEARCH

Complexity and challenges in defining myeloid-derived suppressor cells

(2014) Vera Damuzzo et al.   CYTOMETRY PART B-CLINICAL CYTOMETRY

Serum amyloid A3 exacerbates cancer by enhancing the suppressive capacity of myeloid-derived suppressor cells via TLR2-dependent STAT3 activation

(2014) Jung-Mi Lee et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IFN-γ regulates survival and function of tumor-induced CD11b+Gr-1highmyeloid derived suppressor cells by modulating the anti-apoptotic molecule Bcl2a1

(2014) José Medina-Echeverz et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Stress-Response Sensor Chop Regulates the Function and Accumulation of Myeloid-Derived Suppressor Cells in Tumors

(2014) Paul T. Thevenot et al.   IMMUNITY

Can the Suppressive Activity of Myeloid-Derived Suppressor Cells Be “Chop”ped?

(2014) Thomas Condamine et al.   IMMUNITY

ER stress regulates myeloid-derived suppressor cell fate through TRAIL-R–mediated apoptosis

(2014) Thomas Condamine et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of STAT3 Promotes the Efficacy of Adoptive Transfer Therapy Using Type-1 CTLs by Modulation of the Immunological Microenvironment in a Murine Intracranial Glioma

(2014) M. Fujita et al.   JOURNAL OF IMMUNOLOGY

Cancer-Expanded Myeloid-Derived Suppressor Cells Induce Anergy of NK Cells through Membrane-Bound TGF- 1

(2014) H. Li et al.   JOURNAL OF IMMUNOLOGY

Subsets of Myeloid-Derived Suppressor Cells in Tumor-Bearing Mice

(2014) J.-I. Youn et al.   JOURNAL OF IMMUNOLOGY

Cellular Stress Amplifies TLR3/4-Induced CXCL1/2 Gene Transcription in Mononuclear Phagocytes via RIPK1

(2014) Chenyang Zhao et al.   JOURNAL OF IMMUNOLOGY

A Reporter Mouse Reveals Lineage-Specific and Heterogeneous Expression of IRF8 during Lymphoid and Myeloid Cell Differentiation

(2014) Hongsheng Wang et al.   JOURNAL OF IMMUNOLOGY

The Anthelmintic Drug Niclosamide Induces Apoptosis, Impairs Metastasis and Reduces Immunosuppressive Cells in Breast Cancer Model

(2014) Tinghong Ye et al.   PLoS One

IRF8 inhibits C/EBPα activity to restrain mononuclear phagocyte progenitors from differentiating into neutrophils

(2014) Daisuke Kurotaki et al.   Nature Communications

NOD-Like Receptors: Master Regulators of Inflammation and Cancer

(2014) Mansi Saxena et al.   Frontiers in Immunology

GM-CSF Promotes the Immunosuppressive Activity of Glioma-Infiltrating Myeloid Cells through Interleukin-4 Receptor- 

(2013) G. Kohanbash et al.   CANCER RESEARCH

Effects of Notch Signaling on Regulation of Myeloid Cell Differentiation in Cancer

(2013) P. Cheng et al.   CANCER RESEARCH

Melanoma-Educated CD14 + Cells Acquire a Myeloid-Derived Suppressor Cell Phenotype through COX-2–Dependent Mechanisms

(2013) Yumeng Mao et al.   CANCER RESEARCH

Regulation of monocyte differentiation by specific signaling modules and associated transcription factor networks

(2013) René Huber et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mapping the crossroads of immune activation and cellular stress response pathways

(2013) Nuno Cláudio et al.   EMBO JOURNAL

Polyunsaturated fatty acids promote the expansion of myeloid-derived suppressor cells by activating the JAK/STAT3 pathway

(2013) Dehong Yan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Tumor-induced myeloid-derived suppressor cell subsets exert either inhibitory or stimulatory effects on distinct CD8+T-cell activation events

(2013) Elio Schouppe et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

LPS converts Gr-1+CD115+ myeloid-derived suppressor cells from M2 to M1 via P38 MAPK

(2013) Yi Yang et al.   EXPERIMENTAL CELL RESEARCH

Tumor Necrosis Factor-α Blocks Differentiation and Enhances Suppressive Activity of Immature Myeloid Cells during Chronic Inflammation

(2013) Moshe Sade-Feldman et al.   IMMUNITY

Modulation of CD8+ T-cell activation events by monocytic and granulocytic myeloid-derived suppressor cells

(2013) Elio Schouppe et al.   IMMUNOBIOLOGY

Myeloid-derived suppressor cells: the dark knight or the joker in viral infections?

(2013) Celeste Goh et al.   IMMUNOLOGICAL REVIEWS

Deregulation of Apoptotic Factors Bcl-xL and Bax Confers Apoptotic Resistance to Myeloid-derived Suppressor Cells and Contributes to Their Persistence in Cancer

(2013) Xiaolin Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myeloid-derived suppressor cell development is regulated by a STAT/IRF-8 axis

(2013) Jeremy D. Waight et al.   JOURNAL OF CLINICAL INVESTIGATION

Transmembrane TNF-  Promotes Suppressive Activities of Myeloid-Derived Suppressor Cells via TNFR2

(2013) X. Hu et al.   JOURNAL OF IMMUNOLOGY

Reciprocal Relationship between Myeloid-Derived Suppressor Cells and T Cells

(2013) S. Nagaraj et al.   JOURNAL OF IMMUNOLOGY

Targeted STAT3 disruption in myeloid cells alters immunosuppressor cell abundance in a murine model of spontaneous medulloblastoma

(2013) Catalina Abad et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Blood CD33(+)HLA-DR(−) myeloid-derived suppressor cells are increased with age and a history of cancer

(2013) Chris P. Verschoor et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Epigenetic silencing of retinoblastoma gene regulates pathologic differentiation of myeloid cells in cancer

(2013) Je-In Youn et al.   NATURE IMMUNOLOGY

Multipotent Human Mesenchymal Stromal Cells Mediate Expansion of Myeloid-Derived Suppressor Cells via Hepatocyte Growth Factor/c-Met and STAT3

(2013) B. Linju Yen et al.   Stem Cell Reports

Tumor-Derived Granulocyte-Macrophage Colony-Stimulating Factor Regulates Myeloid Inflammation and T Cell Immunity in Pancreatic Cancer

(2012) Lauren J. Bayne et al.   CANCER CELL

Mitigating Age-Related Immune Dysfunction Heightens the Efficacy of Tumor Immunotherapy in Aged Mice

(2012) V. Hurez et al.   CANCER RESEARCH

NLRP3 Suppresses NK Cell-Mediated Responses to Carcinogen-Induced Tumors and Metastases

(2012) M. T. Chow et al.   CANCER RESEARCH

Aptamer-Mediated Blockade of IL4R  Triggers Apoptosis of MDSCs and Limits Tumor Progression

(2012) F. Roth et al.   CANCER RESEARCH

Tumor-induced myeloid-derived suppressor cell function is independent of IFN-γ and IL-4Rα

(2012) Pratima Sinha et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Immune Suppression: The Hallmark of Myeloid Derived Suppressor Cells

(2012) Lydia A Haile et al.   IMMUNOLOGICAL INVESTIGATIONS

PGE2-Driven Induction and Maintenance of Cancer-Associated Myeloid-Derived Suppressor Cells

(2012) Nataša Obermajer et al.   IMMUNOLOGICAL INVESTIGATIONS

Blockade of Myd88 signaling induces antitumor effects by skewing the immunosuppressive function of myeloid-derived suppressor cells

(2012) Eun-Hye Hong et al.   INTERNATIONAL JOURNAL OF CANCER

TNF signaling drives myeloid-derived suppressor cell accumulation

(2012) Xueqiang Zhao et al.   JOURNAL OF CLINICAL INVESTIGATION

Endoplasmic Reticulum Stress Regulates the Innate Immunity Critical Transcription Factor IRF3

(2012) Yi-Ping Liu et al.   JOURNAL OF IMMUNOLOGY

Significance of IL-6 in the transition of hormone-resistant prostate cancer and the induction of myeloid-derived suppressor cells

(2012) Chun-Te Wu et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Polysaccharide from Lentinus edodes Inhibits the Immunosuppressive Function of Myeloid-Derived Suppressor Cells

(2012) Hao Wu et al.   PLoS One

Cell-Extrinsic Effects of Tumor ER Stress Imprint Myeloid Dendritic Cells and Impair CD8+ T Cell Priming

(2012) Navin R. Mahadevan et al.   PLoS One

Inhibition of PPAR  in myeloid-lineage cells induces systemic inflammation, immunosuppression, and tumorigenesis

(2011) L. Wu et al.   BLOOD

Positive feedback between PGE2 and COX2 redirects the differentiation of human dendritic cells toward stable myeloid-derived suppressor cells

(2011) N. Obermajer et al.   BLOOD

Curcumin Induces the Differentiation of Myeloid-Derived Suppressor Cells and Inhibits Their Interaction with Cancer Cells and Related Tumor Growth

(2011) S. P. Tu et al.   Cancer Prevention Research

PGE2-Induced CXCL12 Production and CXCR4 Expression Controls the Accumulation of Human MDSCs in Ovarian Cancer Environment

(2011) N. Obermajer et al.   CANCER RESEARCH

COX-2 Blockade Suppresses Gliomagenesis by Inhibiting Myeloid-Derived Suppressor Cells

(2011) M. Fujita et al.   CANCER RESEARCH

MDSC as a mechanism of tumor escape from sunitinib mediated anti-angiogenic therapy

(2011) James Finke et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Tumor-infiltrating myeloid cells induce tumor cell resistance to cytotoxic T cells in mice

(2011) Tangying Lu et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumor Stress Inside Out: Cell-Extrinsic Effects of the Unfolded Protein Response in Tumor Cells Modulate the Immunological Landscape of the Tumor Microenvironment

(2011) N. R. Mahadevan et al.   JOURNAL OF IMMUNOLOGY

Adenosinergic Regulation of the Expansion and Immunosuppressive Activity of CD11b+Gr1+ Cells

(2011) S. Ryzhov et al.   JOURNAL OF IMMUNOLOGY

Characterization of the nature of granulocytic myeloid-derived suppressor cells in tumor-bearing mice

(2011) Je-In Youn et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Tumor-Derived G-CSF Facilitates Neoplastic Growth through a Granulocytic Myeloid-Derived Suppressor Cell-Dependent Mechanism

(2011) Jeremy D. Waight et al.   PLoS One

Transmission of endoplasmic reticulum stress and pro-inflammation from tumor cells to myeloid cells

(2011) N. R. Mahadevan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Contribution of MyD88 to the Tumor Exosome-Mediated Induction of Myeloid Derived Suppressor Cells

(2010) Yuelong Liu et al.   AMERICAN JOURNAL OF PATHOLOGY

TLR2-Mediated Expansion of MDSCs Is Dependent on the Source of Tumor Exosomes

(2010) Xiaoyu Xiang et al.   AMERICAN JOURNAL OF PATHOLOGY

Bone marrow myeloid-derived suppressor cells (MDSCs) inhibit graft-versus-host disease (GVHD) via an arginase-1-dependent mechanism that is up-regulated by interleukin-13

(2010) S. L. Highfill et al.   BLOOD

COX-2 inhibition improves immunotherapy and is associated with decreased numbers of myeloid-derived suppressor cells in mesothelioma. Celecoxib influences MDSC function

(2010) Joris D Veltman et al.   BMC CANCER

Regulation of immunity and oncogenesis by the IRF transcription factor family

(2010) David Savitsky et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

The Inflammasome Component Nlrp3 Impairs Antitumor Vaccine by Enhancing the Accumulation of Tumor-Associated Myeloid-Derived Suppressor Cells

(2010) H. W. van Deventer et al.   CANCER RESEARCH

Direct and Differential Suppression of Myeloid-Derived Suppressor Cell Subsets by Sunitinib Is Compartmentally Constrained

(2010) Jennifer S. Ko et al.   CANCER RESEARCH

The biology of myeloid-derived suppressor cells: The blessing and the curse of morphological and functional heterogeneity

(2010) Je-In Youn et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IL-1β regulates a novel myeloid-derived suppressor cell subset that impairs NK cell development and function

(2010) Moshe Elkabets et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Tumor-Induced Tolerance and Immune Suppression Depend on the C/EBPβ Transcription Factor

(2010) Ilaria Marigo et al.   IMMUNITY

Interferon regulatory factor-8 modulates the development of tumour-induced CD11b+Gr-1+ myeloid cells

(2010) Trina J. Stewart et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

XBP-1 Couples Endoplasmic Reticulum Stress to Augmented IFN-  Induction via a cis-Acting Enhancer in Macrophages

(2010) L. Zeng et al.   JOURNAL OF IMMUNOLOGY

Characterization of Cytokine-Induced Myeloid-Derived Suppressor Cells from Normal Human Peripheral Blood Mononuclear Cells

(2010) M. G. Lechner et al.   JOURNAL OF IMMUNOLOGY

TLR4/MyD88-induced CD11b+Gr-1intF4/80+ non-migratory myeloid cells suppress Th2 effector function in the lung

(2010) M Arora et al.   Mucosal Immunology

Endoplasmic reticulum stress-induced transcription factor, CHOP, is crucial for dendritic cell IL-23 expression

(2010) Jane C. Goodall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G+Ly6C+ granulocytes

(2010) M. Kowanetz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular mechanisms regulating myeloid-derived suppressor cell differentiation and function

(2010) Thomas Condamine et al.   TRENDS IN IMMUNOLOGY

Stat 6-Dependent Induction of Myeloid Derived Suppressor Cells After Physical Injury Regulates Nitric Oxide Response to Endotoxin

(2009) Veronica Munera et al.   ANNALS OF SURGERY

GM-CSF is one of the main breast tumor-derived soluble factors involved in the differentiation of CD11b-Gr1- bone marrow progenitor cells into myeloid-derived suppressor cells

(2009) Johanna K. Morales et al.   BREAST CANCER RESEARCH AND TREATMENT

Sunitinib Inhibition of Stat3 Induces Renal Cell Carcinoma Tumor Cell Apoptosis and Reduces Immunosuppressive Cells

(2009) H. Xin et al.   CANCER RESEARCH

Hierarchy of immunosuppressive strength among myeloid-derived suppressor cell subsets is determined by GM-CSF

(2009) Luigi Dolcetti et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A multi-functional role of interferon regulatory factor-8 in solid tumor and myeloid cell biology

(2009) Scott I. Abrams   IMMUNOLOGIC RESEARCH

Mammary tumor heterogeneity in the expansion of myeloid-derived suppressor cells

(2009) Moses K. Donkor et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Modulating the Expression of IFN Regulatory Factor 8 Alters the Protumorigenic Behavior of CD11b+Gr-1+ Myeloid Cells

(2009) T. J. Stewart et al.   JOURNAL OF IMMUNOLOGY

Mechanism Regulating Reactive Oxygen Species in Tumor-Induced Myeloid-Derived Suppressor Cells

(2009) C. A. Corzo et al.   JOURNAL OF IMMUNOLOGY

Inflammation enhances myeloid-derived suppressor cell cross-talk by signaling through Toll-like receptor 4

(2009) Stephanie K. Bunt et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity

(2008) K. Movahedi et al.   BLOOD

Overexpression of Interleukin-1β Induces Gastric Inflammation and Cancer and Mobilizes Myeloid-Derived Suppressor Cells in Mice

(2008) Shuiping Tu et al.   CANCER CELL

Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein

(2008) Pingyan Cheng et al.   JOURNAL OF EXPERIMENTAL MEDICINE

From endoplasmic-reticulum stress to the inflammatory response

(2008) Kezhong Zhang et al.   NATURE