Journal
INFLAMMOPHARMACOLOGY
Volume 29, Issue 5, Pages 1307-1315Publisher
SPRINGER BASEL AG
DOI: 10.1007/s10787-021-00846-3
Keywords
MDSC; Autoimmunity; Rheumatoid arthritis; Diabetes; multiple sclerosis
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Myeloid suppressor cells play a crucial role in autoimmune diseases by regulating T cell function, making them a potential target for therapy. Despite significant progress in understanding their involvement in autoimmune diseases, many questions surrounding MDSC activation and functions remain unanswered.
Myeloid suppressor cells (MDSCs) are an important class of immune-regulating cells that can suppress T cell function. Most of our knowledge about the function of MDSC comes from studies of cancer models. Recent studies, however, have greatly contributed to the description of MDSC involvement in autoimmune diseases. They are known as a cell population that may negatively affect immune responses by regulating the function of CD4(+) and CD8(+) cells, which makes them an attractive target for autoimmune diseases therapy. However, many questions about MDSC activation, differentiation, and inhibitory functions remain unanswered. In this study, we have summarized the role of MDSCs in various autoimmune diseases, and the potential of targeting them for therapeutic benefits has been discussed.
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