Composition, organization and mechanisms of the transition zone, a gate for the cilium

SARS-CoV-2 ORF10 impairs cilia by enhancing CUL2ZYG11B activity

(2022) Liying Wang et al.   JOURNAL OF CELL BIOLOGY

Rpgrip1l controls ciliary gating by ensuring the proper amount of Cep290 at the vertebrate transition zone

(2021) Antonia Wiegering et al.   MOLECULAR BIOLOGY OF THE CELL

CDKL kinase regulates the length of the ciliary proximal segment

(2021) Kwangjin Park et al.   CURRENT BIOLOGY

Superresolution Microscopy Reveals Distinct Phosphoinositide Subdomains Within the Cilia Transition Zone

(2021) Sarah E. Conduit et al.   Frontiers in Cell and Developmental Biology

The structural basis of intraflagellar transport at a glance

(2021) Mareike A. Jordan et al.   JOURNAL OF CELL SCIENCE

IFT trains overcome an NPHP module barrier at the transition zone

(2021) Kwangjin Park et al.   JOURNAL OF CELL BIOLOGY

WDR60-mediated dynein-2 loading into cilia powers retrograde IFT and transition zone crossing

(2021) Ana R.G. De-Castro et al.   JOURNAL OF CELL BIOLOGY

Evolutionarily conserved genetic interactions between nphp-4 and bbs-5 mutations exacerbate ciliopathy phenotypes

(2021) Melissa R Bentley-Ford et al.   GENETICS

The inner junction complex of the cilia is an interaction hub that involves tubulin post-translational modifications

(2020) Ahmad Abdelzaher Zaki Khalifa et al.   eLife

Membrane Shape and the Regulation of Biological Processes

(2020) José Carlos Bozelli et al.   JOURNAL OF MOLECULAR BIOLOGY

Role of cilia in the pathogenesis of congenital heart disease

(2020) George C. Gabriel et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Cilia signaling and obesity

(2020) Staci E. Engle et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

MKS-NPHP module proteins control ciliary shedding at the transition zone

(2020) Delphine Gogendeau et al.   PLOS BIOLOGY

Ankmy2 Prevents Smoothened-Independent Hyperactivation of the Hedgehog Pathway via Cilia-Regulated Adenylyl Cyclase Signaling

(2020) Bandarigoda Nipunika Somatilaka et al.   DEVELOPMENTAL CELL

COVID‐19, cilia, and smell

(2020) Wei Li et al.   FEBS Journal

The structure and symmetry of radial spoke protein complex in Chlamydomonas flagella

(2020) E. Poghosyan et al.   JOURNAL OF CELL SCIENCE

Formation of the B9-domain protein complex MKS1–B9D2–B9D1 is essential as a diffusion barrier for ciliary membrane proteins

(2020) Misato Okazaki et al.   MOLECULAR BIOLOGY OF THE CELL

Primary cilia biogenesis and associated retinal ciliopathies

(2020) Holly Y. Chen et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Developmental and regenerative paradigms of cilia regulated hedgehog signaling

(2020) Daniel Kopinke et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Intraflagellar transport trains and motors: Insights from structure

(2020) Stephanie Webb et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

A Proximity Mapping Journey into the Biology of the Mammalian Centrosome/Cilium Complex

(2020) Melis Dilara Arslanhan et al.   Cells

The Enigmatic Role of Lipids in Cilia Signaling

(2020) Inna V. Nechipurenko   Frontiers in Cell and Developmental Biology

Phosphoinositide lipids in primary cilia biology

(2020) Sarah E. Conduit et al.   BIOCHEMICAL JOURNAL

Motile cilia genetics and cell biology: big results from little mice

(2020) Lance Lee et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Ciliary Tip Signaling Compartment Is Formed and Maintained by Intraflagellar Transport

(2020) Servaas N. van der Burght et al.   CURRENT BIOLOGY

Diffusion rather than intraflagellar transport likely provides most of the tubulin required for axonemal assembly in Chlamydomonas

(2020) Julie Craft Van De Weghe et al.   JOURNAL OF CELL SCIENCE

Cilia interactome with predicted protein–protein interactions reveals connections to Alzheimer’s disease, aging and other neuropsychiatric processes

(2020) Kalyani B. Karunakaran et al.   Scientific Reports

Motile ciliopathies

(2020) Julia Wallmeier et al.   Nature Reviews Disease Primers

Nucleoporin NUP205 plays a critical role in cilia and congenital disease

(2020) Jonathan Marquez et al.   DEVELOPMENTAL BIOLOGY

CEP290 is essential for the initiation of ciliary transition zone assembly

(2020) Zhimao Wu et al.   PLOS BIOLOGY

Defective INPP5E distribution in NPHP1‐related Senior–Loken syndrome

(2020) Ke Ning et al.   Molecular Genetics & Genomic Medicine

Patched1–ArhGAP36–PKA–Inversin axis determines the ciliary translocation of Smoothened for Sonic Hedgehog pathway activation

(2019) Boyan Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular signalling by primary cilia in development, organ function and disease

(2019) Zeinab Anvarian et al.   Nature Reviews Nephrology

Single-particle tracking localization microscopy reveals nonaxonemal dynamics of intraflagellar transport proteins at the base of mammalian primary cilia

(2019) T. Tony Yang et al.   MOLECULAR BIOLOGY OF THE CELL

The Nuclear Arsenal of Cilia

(2019) Colin A. Johnson et al.   DEVELOPMENTAL CELL

Establishing and regulating the composition of cilia for signal transduction

(2019) Maxence V. Nachury et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cilia and development

(2019) Vrinda Sreekumar et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

The photoreceptor cilium and its diseases

(2019) Ruxandra Bachmann-Gagescu et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

New Twists and Turns in Bacterial Locomotion and Signal Transduction

(2019) Kylie J. Watts et al.   JOURNAL OF BACTERIOLOGY

CiliaCarta: An integrated and validated compendium of ciliary genes

(2019) Teunis J. P. van Dam et al.   PLoS One

The Caenorhabditis elegans Tubby homolog dynamically modulates olfactory cilia membrane morphogenesis and phospholipid composition

(2019) Danielle DiTirro et al.   eLife

Cryo-EM of dynein microtubule-binding domains shows how an axonemal dynein distorts the microtubule

(2019) Samuel E Lacey et al.   eLife

Lipid Modifications in Cilia Biology

(2019) Kasturi Roy et al.   Journal of Clinical Medicine

NPHP proteins are binding partners of nucleoporins at the base of the primary cilium

(2019) T. Lynne Blasius et al.   PLoS One

Structure of the Decorated Ciliary Doublet Microtubule

(2019) Meisheng Ma et al.   CELL

ESCRT subunit CHMP4B localizes to primary cilia and is required for the structural integrity of the ciliary membrane

(2019) Eunji Jung et al.   FASEB JOURNAL

The myosin-tail homology domain of centrosomal protein 290 is essential for protein confinement between the inner and outer segments in photoreceptors

(2019) Poppy Datta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expansion microscopy for the analysis of centrioles and cilia

(2019) N. SAHABANDU et al.   JOURNAL OF MICROSCOPY

Simple Method To Characterize the Ciliary Proteome of Multiciliated Cells

(2019) Hyo Jung Sim et al.   JOURNAL OF PROTEOME RESEARCH

Defining the layers of a sensory cilium with STORM and cryoelectron nanoscopy

(2019) Michael A. Robichaux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diffuse or hitch a ride: how photoreceptor lipidated proteins get from here to there

(2019) Jeanne M. Frederick et al.   BIOLOGICAL CHEMISTRY

Electron cryotomography of intact motile cilia defines the basal body to axoneme transition

(2019) Garrett A. Greenan et al.   JOURNAL OF CELL BIOLOGY

Length-dependent disassembly maintains four different flagellar lengths in Giardia

(2019) Shane G McInally et al.   eLife

Dzip1 and Fam92 form a ciliary transition zone complex with cell type specific roles in Drosophila

(2019) Jean-André Lapart et al.   eLife

Axon initial segments: structure, function, and disease

(2018) Claire Yu-Mei Huang et al.   Annals of the New York Academy of Sciences

How the Ciliary Membrane Is Organized Inside-Out to Communicate Outside-In

(2018) Galo Garcia et al.   CURRENT BIOLOGY

NUP98 Sets the Size-Exclusion Diffusion Limit through the Ciliary Base

(2018) S. Joseph Endicott et al.   CURRENT BIOLOGY

Assembly, Functions and Evolution of Archaella, Flagella and Cilia

(2018) Shahid Khan et al.   CURRENT BIOLOGY

The molecular machines that traffic signaling receptors into and out of cilia

(2018) Maxence V Nachury   CURRENT OPINION IN CELL BIOLOGY

Centrosomal protein Dzip1l binds Cby, promotes ciliary bud formation, and acts redundantly with Bromi to regulate ciliogenesis in the mouse

(2018) Chengbing Wang et al.   DEVELOPMENT

Cell type‐specific regulation of ciliary transition zone assembly in vertebrates

(2018) Antonia Wiegering et al.   EMBO JOURNAL

SPATA7 maintains a novel photoreceptor-specific zone in the distal connecting cilium

(2018) Rachayata Dharmat et al.   JOURNAL OF CELL BIOLOGY

BBSome trains remove activated GPCRs from cilia by enabling passage through the transition zone

(2018) Fan Ye et al.   JOURNAL OF CELL BIOLOGY

STEM tomography analysis of the trypanosome transition zone

(2018) Sylvain Trépout et al.   JOURNAL OF STRUCTURAL BIOLOGY

Differential regulation of transition zone and centriole proteins contributes to ciliary base diversity

(2018) Swadhin Chandra Jana et al.   NATURE CELL BIOLOGY

Super-resolution architecture of mammalian centriole distal appendages reveals distinct blade and matrix functional components

(2018) T. Tony Yang et al.   Nature Communications

CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function

(2018) Peter Canning et al.   Cell Reports

The regulation of cilium assembly and disassembly in development and disease

(2018) Lei Wang et al.   DEVELOPMENT

RPGRIP1L helps to establish the ciliary gate for entry of proteins

(2018) Huawen Lin et al.   JOURNAL OF CELL SCIENCE

Phosphatidylinositol 4,5-bisphosphate regulates cilium transition zone maturation inDrosophila melanogaster

(2018) Alind Gupta et al.   JOURNAL OF CELL SCIENCE

TULP3 is required for localization of membrane-associated proteins ARL13B and INPP5E to primary cilia

(2018) Sarina Han et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Intraflagellar Transport Complex A Genes Differentially Regulate Cilium Formation and Transition Zone Gating

(2018) Noémie Scheidel et al.   CURRENT BIOLOGY

Role for intraflagellar transport in building a functional transition zone

(2018) Victor L Jensen et al.   EMBO REPORTS

Trafficking of ciliary membrane proteins by the intraflagellar transport/BBSome machinery

(2018) Jenna L. Wingfield et al.   Essays in Biochemistry

Insights into photoreceptor ciliogenesis revealed by animal models

(2018) Wolfgang Baehr et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Membrane association and remodeling by intraflagellar transport protein IFT172

(2018) Qianmin Wang et al.   Nature Communications

Microtubule asters anchored by FSD1 control axoneme assembly and ciliogenesis

(2018) Hai-Qing Tu et al.   Nature Communications

Interplay between Ciliary Ultrastructure and IFT-Train Dynamics Revealed by Single-Molecule Super-resolution Imaging

(2018) Felix Oswald et al.   Cell Reports

Dynein-2 intermediate chains play crucial but distinct roles in primary cilia formation and function

(2018) Laura Vuolo et al.   eLife

Coordinating the uncoordinated: UNC119 trafficking in cilia

(2017) Francesca Jean et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Trafficking to the primary cilium membrane

(2017) Saikat Mukhopadhyay et al.   MOLECULAR BIOLOGY OF THE CELL

The Ciliary Transition Zone: Finding the Pieces and Assembling the Gate

(2017) João Gonçalves et al.   MOLECULES AND CELLS

Super-resolution microscopy reveals that disruption of ciliary transition-zone architecture causes Joubert syndrome

(2017) Xiaoyu Shi et al.   NATURE CELL BIOLOGY

Cyclic di-GMP: second messenger extraordinaire

(2017) Urs Jenal et al.   NATURE REVIEWS MICROBIOLOGY

Genes and molecular pathways underpinning ciliopathies

(2017) Jeremy F. Reiter et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Cilium: Cellular Antenna and Central Processing Unit

(2017) Jarema J. Malicki et al.   TRENDS IN CELL BIOLOGY

Photoreceptor Cilia and Retinal Ciliopathies

(2017) Kinga M. Bujakowska et al.   Cold Spring Harbor Perspectives in Biology

KIF13B establishes a CAV1-enriched microdomain at the ciliary transition zone to promote Sonic hedgehog signalling

(2017) Kenneth B. Schou et al.   Nature Communications

CEP19 cooperates with FOP and CEP350 to drive early steps in the ciliogenesis programme

(2017) Bahareh A. Mojarad et al.   Open Biology

The Meckel syndrome- associated protein MKS1 functionally interacts with components of the BBSome and IFT complexes to mediate ciliary trafficking and hedgehog signaling

(2017) Sarah C. Goetz et al.   PLoS One

Shuttling and sorting lipid-modified cargo into the cilia

(2016) Louise A. Stephen et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Permeability barriers for generating a unique ciliary protein and lipid composition

(2016) Kristen J Verhey et al.   CURRENT OPINION IN CELL BIOLOGY

Congenital Heart Disease Genetics Uncovers Context-Dependent Organization and Function of Nucleoporins at Cilia

(2016) Florencia del Viso et al.   DEVELOPMENTAL CELL

INPP5E regulates phosphoinositide-dependent cilia transition zone function

(2016) Jennifer M. Dyson et al.   JOURNAL OF CELL BIOLOGY

Drosophilasensory cilia lacking MKS proteins exhibit striking defects in development but only subtle defects in adults

(2016) Metta B. Pratt et al.   JOURNAL OF CELL SCIENCE

Motile and non-motile cilia in human pathology: from function to phenotypes

(2016) Hannah M Mitchison et al.   JOURNAL OF PATHOLOGY

BAR Domain-Containing FAM92 Proteins Interact with Chibby1 To Facilitate Ciliogenesis

(2016) Feng-Qian Li et al.   MOLECULAR AND CELLULAR BIOLOGY

The nuclear pore complex: understanding its function through structural insight

(2016) Martin Beck et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cilium transition zone proteome reveals compartmentalization and differential dynamics of ciliopathy complexes

(2016) Samuel Dean et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transport Selectivity of Nuclear Pores, Phase Separation, and Membraneless Organelles

(2016) H. Broder Schmidt et al.   TRENDS IN BIOCHEMICAL SCIENCES

p73 and FoxJ1: Programming Multiciliated Epithelia

(2016) Peter K. Jackson et al.   TRENDS IN CELL BIOLOGY

Evolution of Cilia

(2016) David R. Mitchell   Cold Spring Harbor Perspectives in Biology

Ciliopathies

(2016) Daniela A. Braun et al.   Cold Spring Harbor Perspectives in Biology

Open Sesame: How Transition Fibers and the Transition Zone Control Ciliary Composition

(2016) Francesc R. Garcia-Gonzalo et al.   Cold Spring Harbor Perspectives in Biology

MKS5 and CEP290 Dependent Assembly Pathway of the Ciliary Transition Zone

(2016) Chunmei Li et al.   PLOS BIOLOGY

Whole-Organism Developmental Expression Profiling Identifies RAB-28 as a Novel Ciliary GTPase Associated with the BBSome and Intraflagellar Transport

(2016) Victor L. Jensen et al.   PLoS Genetics

A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface

(2015) Gagan D. Gupta et al.   CELL

Gated entry into the ciliary compartment

(2015) Daisuke Takao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Shared and Distinct Mechanisms of Compartmentalized and Cytosolic Ciliogenesis

(2015) Tomer Avidor-Reiss et al.   CURRENT BIOLOGY

Proteomic Analysis of Isolated Ciliary Transition Zones Reveals the Presence of ESCRT Proteins

(2015) Dennis R. Diener et al.   CURRENT BIOLOGY

The essential roles of transition fibers in the context of cilia

(2015) Qing Wei et al.   CURRENT OPINION IN CELL BIOLOGY

The NIMA-like kinase Nek2 is a key switch balancing cilia biogenesis and resorption in the development of left-right asymmetry

(2015) S. J. Endicott et al.   DEVELOPMENT

Hierarchical Microtubule Organization Controls Axon Caliber and Transport and Determines Synaptic Structure and Stability

(2015) Raiko Stephan et al.   DEVELOPMENTAL CELL

Phosphoinositides Regulate Ciliary Protein Trafficking to Modulate Hedgehog Signaling

(2015) Francesc R. Garcia-Gonzalo et al.   DEVELOPMENTAL CELL

Formation of the transition zone by Mks5/Rpgrip1L establishes a ciliary zone of exclusion (CIZE) that compartmentalises ciliary signalling proteins and controls PIP2 ciliary abundance

(2015) V. L. Jensen et al.   EMBO JOURNAL

TMEM231, mutated in orofaciodigital and Meckel syndromes, organizes the ciliary transition zone

(2015) Elle C. Roberson et al.   JOURNAL OF CELL BIOLOGY

Barriers to the free diffusion of proteins and lipids in the plasma membrane

(2015) William S. Trimble et al.   JOURNAL OF CELL BIOLOGY

The ciliary transition zone functions in cell adhesion but is dispensable for axoneme assembly inC. elegans

(2015) Clementine Schouteden et al.   JOURNAL OF CELL BIOLOGY

Membrane curvature at a glance

(2015) H. T. McMahon et al.   JOURNAL OF CELL SCIENCE

MKS1 regulates ciliary INPP5E levels in Joubert syndrome

(2015) Gisela G Slaats et al.   JOURNAL OF MEDICAL GENETICS

Anks3 interacts with nephronophthisis proteins and is required for normal renal development

(2015) Toma A. Yakulov et al.   KIDNEY INTERNATIONAL

Functional differentiation of cooperating kinesin-2 motors orchestrates cargo import and transport in C. elegans cilia

(2015) Bram Prevo et al.   NATURE CELL BIOLOGY

TMEM107 recruits ciliopathy proteins to subdomains of the ciliary transition zone and causes Joubert syndrome

(2015) Nils J. Lambacher et al.   NATURE CELL BIOLOGY

Early steps in primary cilium assembly require EHD1/EHD3-dependent ciliary vesicle formation

(2015) Quanlong Lu et al.   NATURE CELL BIOLOGY

Superresolution Pattern Recognition Reveals the Architectural Map of the Ciliary Transition Zone

(2015) T. Tony Yang et al.   Scientific Reports

Ablation of retinal ciliopathy protein RPGR results in altered photoreceptor ciliary composition

(2015) Kollu N. Rao et al.   Scientific Reports

Conserved Genetic Interactions between Ciliopathy Complexes Cooperatively Support Ciliogenesis and Ciliary Signaling

(2015) Laura E. Yee et al.   PLoS Genetics

Flagellar membranes are rich in raft-forming phospholipids

(2015) M. Serricchio et al.   Biology Open

Specialized Cilia in Mammalian Sensory Systems

(2015) Nathalie Falk et al.   Cells

Photoreceptor Sensory Cilium: Traversing the Ciliary Gate

(2015) Hemant Khanna   Cells

Nephrocystin proteins NPHP5 and Cep290 regulate BBSome integrity, ciliary trafficking and cargo delivery

(2015) Marine Barbelanne et al.   HUMAN MOLECULAR GENETICS

Bioinformatic analysis of ciliary transition zone proteins reveals insights into the evolution of ciliopathy networks

(2014) Amy R Barker et al.   BMC GENOMICS

Expansion of Biological Pathways Based on Evolutionary Inference

(2014) Yang Li et al.   CELL

An Assay for Clogging the Ciliary Pore Complex Distinguishes Mechanisms of Cytosolic and Membrane Protein Entry

(2014) Daisuke Takao et al.   CURRENT BIOLOGY

A Migrating Ciliary Gate Compartmentalizes the Site of Axoneme Assembly in Drosophila Spermatids

(2014) Marcus L. Basiri et al.   CURRENT BIOLOGY

Diverse Cell Type-Specific Mechanisms Localize G Protein-Coupled Receptors to Caenorhabditis elegans Sensory Cilia

(2014) Andrea G. Brear et al.   GENETICS

Role of the ANKMY2-FKBP38 Axis in Regulation of the Sonic Hedgehog (Shh) Signaling Pathway

(2014) Shotaro Saita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NPHP4 controls ciliary trafficking of membrane proteins and large soluble proteins at the transition zone

(2014) J. Awata et al.   JOURNAL OF CELL SCIENCE

Ciliopathy proteins establish a bipartite signaling compartment in a C. elegans thermosensory neuron

(2014) P. A. T. Nguyen et al.   JOURNAL OF CELL SCIENCE

RFX7 is required for the formation of cilia in the neural tube

(2014) Zarko Manojlovic et al.   MECHANISMS OF DEVELOPMENT

Proteomic Analysis of Intact Flagella of ProcyclicTrypanosoma bruceiCells Identifies Novel Flagellar Proteins with Unique Sub-localization and Dynamics

(2014) Ines Subota et al.   MOLECULAR & CELLULAR PROTEOMICS

Cby1 promotes Ahi1 recruitment to a ring-shaped domain at the centriole–cilium interface and facilitates proper cilium formation and function

(2014) Yin Loon Lee et al.   MOLECULAR BIOLOGY OF THE CELL

Primary Cilia in the Developing and Mature Brain

(2014) Alicia Guemez-Gamboa et al.   NEURON

Compartments within a compartment

(2014) Oliver E Blacque et al.   Organogenesis

C2 Domains as Protein-Protein Interaction Modules in the Ciliary Transition Zone

(2014) Kim Remans et al.   Cell Reports

Architectural Insights into a Ciliary Partition

(2013) Puey Ounjai et al.   CURRENT BIOLOGY

The interplay between RPGR, PDEδ and Arl2/3 regulate the ciliary targeting of farnesylated cargo

(2013) Denise Wätzlich et al.   EMBO REPORTS

Centriole distal appendages promote membrane docking, leading to cilia initiation

(2013) B. E. Tanos et al.   GENES & DEVELOPMENT

An in vitro assay for entry into cilia reveals unique properties of the soluble diffusion barrier

(2013) David K. Breslow et al.   JOURNAL OF CELL BIOLOGY

Septins 2, 7 and 9 and MAP4 colocalize along the axoneme in the primary cilium and control ciliary length

(2013) R. Ghossoub et al.   JOURNAL OF CELL SCIENCE

Disruption of CEP290 microtubule/membrane-binding domains causes retinal degeneration

(2013) Theodore G. Drivas et al.   JOURNAL OF CLINICAL INVESTIGATION

CDKL5 regulates flagellar length and localizes to the base of the flagella in Chlamydomonas

(2013) Lai-Wa Tam et al.   MOLECULAR BIOLOGY OF THE CELL

The roles of evolutionarily conserved functional modules in cilia-related trafficking

(2013) Ching-Hwa Sung et al.   NATURE CELL BIOLOGY

Chemically inducible diffusion trap at cilia reveals molecular sieve–like barrier

(2013) Yu-Chun Lin et al.   Nature Chemical Biology

ANKS6 is a central component of a nephronophthisis module linking NEK8 to INVS and NPHP3

(2013) Sylvia Hoff et al.   NATURE GENETICS

Primary cilia in neurodevelopmental disorders

(2013) Enza Maria Valente et al.   Nature Reviews Neurology

Transcriptional Program of Ciliated Epithelial Cells Reveals New Cilium and Centrosome Components and Links to Human Disease

(2013) Ramona A. Hoh et al.   PLoS One

Compensatory Role of Inositol 5-Phosphatase INPP5B to OCRL in Primary Cilia Formation in Oculocerebrorenal Syndrome of Lowe

(2013) Na Luo et al.   PLoS One

Evolution of modular intraflagellar transport from a coatomer-like progenitor

(2013) T. J. P. van Dam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transition fibre protein FBF1 is required for the ciliary entry of assembled intraflagellar transport complexes

(2013) Qing Wei et al.   Nature Communications

Active Transport and Diffusion Barriers Restrict Joubert Syndrome-Associated ARL13B/ARL-13 to an Inv-like Ciliary Membrane Subdomain

(2013) Sebiha Cevik et al.   PLoS Genetics

Single molecule imaging reveals a major role for diffusion in the exploration of ciliary space by signaling receptors

(2013) Fan Ye et al.   eLife

Novel transglutaminase-like peptidase and C2 domains elucidate the structure, biogenesis and evolution of the ciliary compartment

(2012) Dapeng Zhang et al.   CELL CYCLE

Proteomic Analysis of Mammalian Primary Cilia

(2012) Hiroaki Ishikawa et al.   CURRENT BIOLOGY

The base of the cilium: roles for transition fibres and the transition zone in ciliary formation, maintenance and compartmentalization

(2012) Jeremy F Reiter et al.   EMBO REPORTS

OCRL localizes to the primary cilium: a new role for cilia in Lowe syndrome

(2012) Na Luo et al.   HUMAN MOLECULAR GENETICS

Scoring a backstage pass: Mechanisms of ciliogenesis and ciliary access

(2012) Francesc R. Garcia-Gonzalo et al.   JOURNAL OF CELL BIOLOGY

Cep164 mediates vesicular docking to the mother centriole during early steps of ciliogenesis

(2012) Kerstin N. Schmidt et al.   JOURNAL OF CELL BIOLOGY

Ciliogenesis in Caenorhabditis elegans requires genetic interactions between ciliary middle segment localized NPHP-2 (inversin) and transition zone-associated proteins

(2012) S. R. F. Warburton-Pitt et al.   JOURNAL OF CELL SCIENCE

Proteomic analysis of the cilia membrane of Paramecium tetraurelia

(2012) Junji Yano et al.   Journal of Proteomics

A size-exclusion permeability barrier and nucleoporins characterize a ciliary pore complex that regulates transport into cilia

(2012) Hooi Lynn Kee et al.   NATURE CELL BIOLOGY

ARL13B, PDE6D, and CEP164 form a functional network for INPP5E ciliary targeting

(2012) M. C. Humbert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective loss of RPGRIP1-dependent ciliary targeting of NPHP4, RPGR and SDCCAG8 underlies the degeneration of photoreceptor neurons

(2012) H Patil et al.   Cell Death & Disease

Proteomic analysis of multiple primary cilia reveals a novel mode of ciliary development in mammals

(2012) K. Narita et al.   Biology Open

TMEM237 Is Mutated in Individuals with a Joubert Syndrome Related Disorder and Expands the Role of the TMEM Family at the Ciliary Transition Zone

(2011) Lijia Huang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Septins at the annulus of mammalian sperm

(2011) Aminata Toure et al.   BIOLOGICAL CHEMISTRY

Ultrastructure of cilia and flagella - back to the future!

(2011) Cathy Fisch et al.   BIOLOGY OF THE CELL

Mapping the NPHP-JBTS-MKS Protein Network Reveals Ciliopathy Disease Genes and Pathways

(2011) Liyun Sang et al.   CELL

Transcriptional profiling of C. elegans DAF-19 uncovers a ciliary base-associated protein and a CDK/CCRK/LF2p-related kinase required for intraflagellar transport

(2011) Prasad Phirke et al.   DEVELOPMENTAL BIOLOGY

Inversin, Wnt signaling and primary cilia

(2011) Soeren Lienkamp et al.   DIFFERENTIATION

Nephrocystins and MKS proteins interact with IFT particle and facilitate transport of selected ciliary cargos

(2011) Chengtian Zhao et al.   EMBO JOURNAL

The evolution of the cytoskeleton

(2011) Bill Wickstead et al.   JOURNAL OF CELL BIOLOGY

Tracing the origins of centrioles, cilia, and flagella

(2011) Zita Carvalho-Santos et al.   JOURNAL OF CELL BIOLOGY

MKS and NPHP modules cooperate to establish basal body/transition zone membrane associations and ciliary gate function during ciliogenesis

(2011) Corey L. Williams et al.   JOURNAL OF CELL BIOLOGY

Subunit-dependent modulation of septin assembly: Budding yeast septin Shs1 promotes ring and gauze formation

(2011) Galo Garcia et al.   JOURNAL OF CELL BIOLOGY

A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain

(2011) Ben Chih et al.   NATURE CELL BIOLOGY

A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition

(2011) Francesc R Garcia-Gonzalo et al.   NATURE GENETICS

Ciliogenesis: building the cell's antenna

(2011) Hiroaki Ishikawa et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Trafficking to the Ciliary Membrane: How to Get Across the Periciliary Diffusion Barrier?

(2010) Maxence V. Nachury et al.   Annual Review of Cell and Developmental Biology

Transcriptional control of genes involved in ciliogenesis: a first step in making cilia

(2010) Joëlle Thomas et al.   BIOLOGY OF THE CELL

Convergent evolution of RFX transcription factors and ciliary genes predated the origin of metazoans

(2010) Jeffrey SC Chu et al.   BMC EVOLUTIONARY BIOLOGY

The ciliary membrane

(2010) Rajat Rohatgi et al.   CURRENT OPINION IN CELL BIOLOGY

Centrioles are freed from cilia by severing prior to mitosis

(2010) Jeremy D.K. Parker et al.   Cytoskeleton

Inv acts as a molecular anchor for Nphp3 and Nek8 in the proximal segment of primary cilia

(2010) Dai Shiba et al.   Cytoskeleton

TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia

(2010) S. Mukhopadhyay et al.   GENES & DEVELOPMENT

Joubert syndrome Arl13b functions at ciliary membranes and stabilizes protein transport inCaenorhabditis elegans

(2010) Sebiha Cevik et al.   JOURNAL OF CELL BIOLOGY

CEP290 tethers flagellar transition zone microtubules to the membrane and regulates flagellar protein content

(2010) Branch Craige et al.   JOURNAL OF CELL BIOLOGY

Ancestral centriole and flagella proteins identified by analysis of Naegleria differentiation

(2010) Lillian K. Fritz-Laylin et al.   JOURNAL OF CELL SCIENCE

Reconstructing the evolutionary history of the centriole from protein components

(2010) M. E. Hodges et al.   JOURNAL OF CELL SCIENCE

Lipidomic Analysis of Porcine Olfactory Epithelial Membranes and Cilia

(2010) Simona Lobasso et al.   LIPIDS

CSPP Is a Ciliary Protein Interacting with Nephrocystin 8 and Required for Cilia Formation

(2010) Sebastian Patzke et al.   MOLECULAR BIOLOGY OF THE CELL

The physiological acquisition of amoeboid motility in nematode sperm: Is the tail the only thing the sperm lost?

(2010) Juan J. Fraire-Zamora et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Ciliary entry of the kinesin-2 motor KIF17 is regulated by importin-β2 and RanGTP

(2010) John F. Dishinger et al.   NATURE CELL BIOLOGY

The primary cilium: a signalling centre during vertebrate development

(2010) Sarah C. Goetz et al.   NATURE REVIEWS GENETICS

Planar Cell Polarity Acts Through Septins to Control Collective Cell Movement and Ciliogenesis

(2010) Su Kyoung Kim et al.   SCIENCE

A Septin Diffusion Barrier at the Base of the Primary Cilium Maintains Ciliary Membrane Protein Distribution

(2010) Q. Hu et al.   SCIENCE

cAMP and cGMP signaling: sensory systems with prokaryotic roots adopted by eukaryotic cilia

(2010) Jacque-Lynne F. Johnson et al.   TRENDS IN CELL BIOLOGY

Septin structure and function in yeast and beyond

(2010) Younghoon Oh et al.   TRENDS IN CELL BIOLOGY

A Novel zf-MYND Protein, CHB-3, Mediates Guanylyl Cyclase Localization to Sensory Cilia and Controls Body Size of Caenorhabditis elegans

(2010) Manabi Fujiwara et al.   PLoS Genetics

Localization of a Guanylyl Cyclase to Chemosensory Cilia Requires the Novel Ciliary MYND Domain Protein DAF-25

(2010) Victor L. Jensen et al.   PLoS Genetics

Lipids and Membrane Lateral Organization

(2010) Sandro Sonnino et al.   Frontiers in Physiology

Mutations in SPATA7 Cause Leber Congenital Amaurosis and Juvenile Retinitis Pigmentosa

(2009) Hui Wang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Nephrocystin-1 and nephrocystin-4 are required for epithelial morphogenesis and associate with PALS1/PATJ and Par6

(2009) Marion Delous et al.   HUMAN MOLECULAR GENETICS

Ciliary and centrosomal defects associated with mutation and depletion of the Meckel syndrome genes MKS1 and MKS3

(2009) Rachaneekorn Tammachote et al.   HUMAN MOLECULAR GENETICS

Lattices, rafts, and scaffolds: domain regulation of receptor signaling at the plasma membrane

(2009) Patrick Lajoie et al.   JOURNAL OF CELL BIOLOGY

Functional interactions between the ciliopathy-associated Meckel syndrome 1 (MKS1) protein and two novel MKS1-related (MKSR) proteins

(2009) N. J. Bialas et al.   JOURNAL OF CELL SCIENCE

INPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in human and mouse

(2009) Monique Jacoby et al.   NATURE GENETICS

Mutations in INPP5E, encoding inositol polyphosphate-5-phosphatase E, link phosphatidyl inositol signaling to the ciliopathies

(2009) Stephanie L Bielas et al.   NATURE GENETICS

Ankyrin-G Promotes Cyclic Nucleotide-Gated Channel Transport to Rod Photoreceptor Sensory Cilia

(2009) K. Kizhatil et al.   SCIENCE

The Rfx4 Transcription Factor Modulates Shh Signaling by Regional Control of Ciliogenesis

(2009) A. M. Ashique et al.   Science Signaling

Intraflagellar transport and the generation of dynamic, structurally and functionally diverse cilia

(2009) Michael A. Silverman et al.   TRENDS IN CELL BIOLOGY

CC2D2A Is Mutated in Joubert Syndrome and Interacts with the Ciliopathy-Associated Basal Body Protein CEP290

(2008) Nicholas T. Gorden et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Localization of Inv in a distinctive intraciliary compartment requires the C-terminal ninein-homolog-containing region

(2008) D. Shiba et al.   JOURNAL OF CELL SCIENCE

Jouberin localizes to collecting ducts and interacts with nephrocystin-1

(2008) Lorraine Eley et al.   KIDNEY INTERNATIONAL

Functional Redundancy of the B9 Proteins and Nephrocystins in Caenorhabditis elegans Ciliogenesis

(2008) Corey L. Williams et al.   MOLECULAR BIOLOGY OF THE CELL

Hypomorphic mutations in syndromic encephalocele genes are associated with Bardet-Biedl syndrome

(2008) Carmen C Leitch et al.   NATURE GENETICS

The proteome of rat olfactory sensory cilia

(2008) Ulrich Mayer et al.   PROTEOMICS