Establishing and regulating the composition of cilia for signal transduction

A global analysis of IFT-A function reveals specialization for transport of membrane-associated proteins into cilia

(2019) Tyler Picariello et al.   JOURNAL OF CELL SCIENCE

Single-particle tracking localization microscopy reveals nonaxonemal dynamics of intraflagellar transport proteins at the base of mammalian primary cilia

(2019) T. Tony Yang et al.   MOLECULAR BIOLOGY OF THE CELL

Structural Basis of Smoothened Activation in Hedgehog Signaling

(2018) Pengxiang Huang et al.   CELL

How the Ciliary Membrane Is Organized Inside-Out to Communicate Outside-In

(2018) Galo Garcia et al.   CURRENT BIOLOGY

The molecular machines that traffic signaling receptors into and out of cilia

(2018) Maxence V Nachury   CURRENT OPINION IN CELL BIOLOGY

CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog

(2018) Ganesh V. Pusapati et al.   DEVELOPMENTAL CELL

Cell type‐specific regulation of ciliary transition zone assembly in vertebrates

(2018) Antonia Wiegering et al.   EMBO JOURNAL

Cilia‐localized LKB1 regulates chemokine signaling, macrophage recruitment, and tissue homeostasis in the kidney

(2018) Amandine Viau et al.   EMBO JOURNAL

Regulation of ciliary membrane protein trafficking and signalling by kinesin motor proteins

(2018) Stine Kjaer Morthorst et al.   FEBS Journal

SPATA7 maintains a novel photoreceptor-specific zone in the distal connecting cilium

(2018) Rachayata Dharmat et al.   JOURNAL OF CELL BIOLOGY

Interaction of heterotrimeric kinesin-II with IFT-B–connecting tetramer is crucial for ciliogenesis

(2018) Teruki Funabashi et al.   JOURNAL OF CELL BIOLOGY

BBSome trains remove activated GPCRs from cilia by enabling passage through the transition zone

(2018) Fan Ye et al.   JOURNAL OF CELL BIOLOGY

The Joubert syndrome protein ARL13B binds tubulin to maintain uniform distribution of proteins along the ciliary membrane

(2018) Ekaterina Revenkova et al.   JOURNAL OF CELL SCIENCE

Adenylyl cyclase 5 deficiency reduces renal cyclic AMP and cyst growth in an orthologous mouse model of polycystic kidney disease

(2018) Qian Wang et al.   KIDNEY INTERNATIONAL

The IDA3 adapter, required for intraflagellar transport of I1 dynein, is regulated by ciliary length

(2018) Emily L. Hunter et al.   MOLECULAR BIOLOGY OF THE CELL

Intraflagellar transport is deeply integrated in hedgehog signaling

(2018) Thibaut Eguether et al.   MOLECULAR BIOLOGY OF THE CELL

Differential regulation of transition zone and centriole proteins contributes to ciliary base diversity

(2018) Swadhin Chandra Jana et al.   NATURE CELL BIOLOGY

A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies

(2018) David K. Breslow et al.   NATURE GENETICS

Subcellular localization of MC4R with ADCY3 at neuronal primary cilia underlies a common pathway for genetic predisposition to obesity

(2018) Jacqueline E. Siljee et al.   NATURE GENETICS

Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes

(2018) Niels Grarup et al.   NATURE GENETICS

Loss-of-function mutations in ADCY3 cause monogenic severe obesity

(2018) Sadia Saeed et al.   NATURE GENETICS

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Bardet–Biedl syndrome protein complex is an adapter expanding the cargo range of intraflagellar transport trains for ciliary export

(2018) Peiwei Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for the recognition of Sonic Hedgehog by human Patched1

(2018) Xin Gong et al.   SCIENCE

Super-resolution architecture of mammalian centriole distal appendages reveals distinct blade and matrix functional components

(2018) T. Tony Yang et al.   Nature Communications

Polycystin-2 is an essential ion channel subunit in the primary cilium of the renal collecting duct epithelium

(2018) Xiaowen Liu et al.   eLife

Mks6 mutations reveal tissue- and cell type-specific roles for the cilia transition zone

(2018) Wesley R. Lewis et al.   FASEB JOURNAL

Structures of human Patched and its complex with native palmitoylated sonic hedgehog

(2018) Xiaofeng Qi et al.   NATURE

Two Patched molecules engage distinct sites on Hedgehog yielding a signaling-competent complex

(2018) Xiaofeng Qi et al.   SCIENCE

Structural Basis for Cholesterol Transport-like Activity of the Hedgehog Receptor Patched

(2018) Yunxiao Zhang et al.   CELL

Intraflagellar Transport Complex A Genes Differentially Regulate Cilium Formation and Transition Zone Gating

(2018) Noémie Scheidel et al.   CURRENT BIOLOGY

Role for intraflagellar transport in building a functional transition zone

(2018) Victor L Jensen et al.   EMBO REPORTS

Trafficking of ciliary membrane proteins by the intraflagellar transport/BBSome machinery

(2018) Jenna L. Wingfield et al.   Essays in Biochemistry

Cilia-Associated Oxysterols Activate Smoothened

(2018) David R. Raleigh et al.   MOLECULAR CELL

The cryo-EM structure of intraflagellar transport trains reveals how dynein is inactivated to ensure unidirectional anterograde movement in cilia

(2018) Mareike A. Jordan et al.   NATURE CELL BIOLOGY

When trafficking and signaling mix: how subcellular location shapes GPCR activation of heterotrimeric G proteins

(2018) Braden T. Lobingier et al.   TRAFFIC

Interplay between Ciliary Ultrastructure and IFT-Train Dynamics Revealed by Single-Molecule Super-resolution Imaging

(2018) Felix Oswald et al.   Cell Reports

Single-Molecule Turnarounds of Intraflagellar Transport at the C. elegans Ciliary Tip

(2018) Jona Mijalkovic et al.   Cell Reports

Dynein-2 intermediate chains play crucial but distinct roles in primary cilia formation and function

(2018) Laura Vuolo et al.   eLife

Ciliary protein trafficking mediated by IFT and BBSome complexes with the aid of kinesin-2 and dynein-2 motors

(2017) Kazuhisa Nakayama et al.   JOURNAL OF BIOCHEMISTRY

Biochemical characterization of purified mammalian ARL13B protein indicates that it is an atypical GTPase and ARL3 guanine nucleotide exchange factor (GEF)

(2017) Anna A. Ivanova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Palmitoylation of the ciliary GTPase ARL13b is necessary for its stability and its role in cilia formation

(2017) Kasturi Roy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis of outer dynein arm intraflagellar transport by the transport adaptor protein ODA16 and the intraflagellar transport protein IFT46

(2017) Michael Taschner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Photoreceptor discs form through peripherin-dependent suppression of ciliary ectosome release

(2017) Raquel Y. Salinas et al.   JOURNAL OF CELL BIOLOGY

Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins

(2017) Hemant B. Badgandi et al.   JOURNAL OF CELL BIOLOGY

BLOC-1 is required for selective membrane protein trafficking from endosomes to primary cilia

(2017) William J. Monis et al.   JOURNAL OF CELL BIOLOGY

Centrioles initiate cilia assembly but are dispensable for maturation and maintenance inC. elegans

(2017) Daniel Serwas et al.   JOURNAL OF CELL BIOLOGY

The N-terminus of IFT46 mediates intraflagellar transport of outer arm dynein and its cargo-adaptor ODA16

(2017) Yuqing Hou et al.   MOLECULAR BIOLOGY OF THE CELL

RABL2 interacts with the intraflagellar transport-B complex and CEP19 and participates in ciliary assembly

(2017) Yuya Nishijima et al.   MOLECULAR BIOLOGY OF THE CELL

Intraflagellar transport-A complex mediates ciliary entry and retrograde trafficking of ciliary G protein–coupled receptors

(2017) Tomoaki Hirano et al.   MOLECULAR BIOLOGY OF THE CELL

The Ciliary Transition Zone: Finding the Pieces and Assembling the Gate

(2017) João Gonçalves et al.   MOLECULES AND CELLS

Super-resolution microscopy reveals that disruption of ciliary transition-zone architecture causes Joubert syndrome

(2017) Xiaoyu Shi et al.   NATURE CELL BIOLOGY

Genes and molecular pathways underpinning ciliopathies

(2017) Jeremy F. Reiter et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Sperm Sensory Signaling

(2017) Dagmar Wachten et al.   Cold Spring Harbor Perspectives in Biology

Ciliary Mechanisms of Cyst Formation in Polycystic Kidney Disease

(2017) Ming Ma et al.   Cold Spring Harbor Perspectives in Biology

KIF13B establishes a CAV1-enriched microdomain at the ciliary transition zone to promote Sonic hedgehog signalling

(2017) Kenneth B. Schou et al.   Nature Communications

Dynamics of the IFT machinery at the ciliary tip

(2017) Alexander Chien et al.   eLife

A recombinant BBSome core complex and how it interacts with ciliary cargo

(2017) Björn Udo Klink et al.   eLife

Centriolar remodeling underlies basal body maturation during ciliogenesis in Caenorhabditis elegans

(2017) Inna V Nechipurenko et al.   eLife

IFT trains in different stages of assembly queue at the ciliary base for consecutive release into the cilium

(2017) Jenna L Wingfield et al.   eLife

Shuttling and sorting lipid-modified cargo into the cilia

(2016) Louise A. Stephen et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Cellular Cholesterol Directly Activates Smoothened in Hedgehog Signaling

(2016) Pengxiang Huang et al.   CELL

Extracellular Vesicles from Trypanosoma brucei Mediate Virulence Factor Transfer and Cause Host Anemia

(2016) Anthony J. Szempruch et al.   CELL

Comparative Analysis of Ciliary Membranes and Ectosomes

(2016) Huan Long et al.   CURRENT BIOLOGY

The primary cilium as a cellular receiver: organizing ciliary GPCR signaling

(2016) Keren I Hilgendorf et al.   CURRENT OPINION IN CELL BIOLOGY

Smoothened determines β-arrestin–mediated removal of the G protein–coupled receptor Gpr161 from the primary cilium

(2016) Kasturi Pal et al.   JOURNAL OF CELL BIOLOGY

Regulation of ciliary retrograde protein trafficking by the Joubert syndrome proteins ARL13B and INPP5E

(2016) Shohei Nozaki et al.   JOURNAL OF CELL SCIENCE

Together, the IFT81 and IFT74 N-termini form the main module for intraflagellar transport of tubulin

(2016) Tomohiro Kubo et al.   JOURNAL OF CELL SCIENCE

Progress in ciliary ion channel physiology

(2016) Juan Lorenzo Pablo et al.   JOURNAL OF GENERAL PHYSIOLOGY

Single-particle imaging reveals intraflagellar transport–independent transport and accumulation of EB1 in Chlamydomonas flagella

(2016) J. Aaron Harris et al.   MOLECULAR BIOLOGY OF THE CELL

Primary cilia are not calcium-responsive mechanosensors

(2016) M. Delling et al.   NATURE

Cilia have high cAMP levels that are inhibited by Sonic Hedgehog-regulated calcium dynamics

(2016) Bryn S. Moore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microtubule doublets are double-track railways for intraflagellar transport trains

(2016) L. Stepanek et al.   SCIENCE

Endocytic Control of Cellular Signaling at the Primary Cilium

(2016) Lotte B. Pedersen et al.   TRENDS IN BIOCHEMICAL SCIENCES

Transport Selectivity of Nuclear Pores, Phase Separation, and Membraneless Organelles

(2016) H. Broder Schmidt et al.   TRENDS IN BIOCHEMICAL SCIENCES

Primary Cilia and Mammalian Hedgehog Signaling

(2016) Fiona Bangs et al.   Cold Spring Harbor Perspectives in Biology

Ciliopathies

(2016) Daniela A. Braun et al.   Cold Spring Harbor Perspectives in Biology

Open Sesame: How Transition Fibers and the Transition Zone Control Ciliary Composition

(2016) Francesc R. Garcia-Gonzalo et al.   Cold Spring Harbor Perspectives in Biology

The hydrolethalus syndrome protein HYLS-1 regulates formation of the ciliary gate

(2016) Qing Wei et al.   Nature Communications

PDE6δ-mediated sorting of INPP5E into the cilium is determined by cargo-carrier affinity

(2016) Eyad Kalawy Fansa et al.   Nature Communications

GTP-binding of ARL-3 is activated by ARL-13 as a GEF and stabilized by UNC-119

(2016) Qing Zhang et al.   Scientific Reports

Role for the IFT-A Complex in Selective Transport to the Primary Cilium

(2016) Wenxiang Fu et al.   Cell Reports

Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling

(2016) Giovanni Luchetti et al.   eLife

A novel biosensor to study cAMP dynamics in cilia and flagella

(2016) Shatanik Mukherjee et al.   eLife

Relaxation of Loaded ESCRT-III Spiral Springs Drives Membrane Deformation

(2015) Nicolas Chiaruttini et al.   CELL

Proteomic Analysis of Isolated Ciliary Transition Zones Reveals the Presence of ESCRT Proteins

(2015) Dennis R. Diener et al.   CURRENT BIOLOGY

Assembly of IFT Trains at the Ciliary Base Depends on IFT74

(2015) Jason M. Brown et al.   CURRENT BIOLOGY

Proteomics of Primary Cilia by Proximity Labeling

(2015) David U. Mick et al.   DEVELOPMENTAL CELL

Modulation of Ciliary Phosphoinositide Content Regulates Trafficking and Sonic Hedgehog Signaling Output

(2015) Marcelo Chávez et al.   DEVELOPMENTAL CELL

Phosphoinositides Regulate Ciliary Protein Trafficking to Modulate Hedgehog Signaling

(2015) Francesc R. Garcia-Gonzalo et al.   DEVELOPMENTAL CELL

Formation of the transition zone by Mks5/Rpgrip1L establishes a ciliary zone of exclusion (CIZE) that compartmentalises ciliary signalling proteins and controls PIP2 ciliary abundance

(2015) V. L. Jensen et al.   EMBO JOURNAL

ESCRTs are everywhere

(2015) J. H. Hurley   EMBO JOURNAL

Ins and outs of GPCR signaling in primary cilia

(2015) K. B. Schou et al.   EMBO REPORTS

TMEM231, mutated in orofaciodigital and Meckel syndromes, organizes the ciliary transition zone

(2015) Elle C. Roberson et al.   JOURNAL OF CELL BIOLOGY

Barriers to the free diffusion of proteins and lipids in the plasma membrane

(2015) William S. Trimble et al.   JOURNAL OF CELL BIOLOGY

Tubulin transport by IFT is upregulated during ciliary growth by a cilium-autonomous mechanism

(2015) Julie M. Craft et al.   JOURNAL OF CELL BIOLOGY

Ciliary adenylyl cyclases control the Hedgehog pathway

(2015) L. Vuolo et al.   JOURNAL OF CELL SCIENCE

TMEM107 recruits ciliopathy proteins to subdomains of the ciliary transition zone and causes Joubert syndrome

(2015) Nils J. Lambacher et al.   NATURE CELL BIOLOGY

Loss of the BBSome perturbs endocytic trafficking and disrupts virulence ofTrypanosoma brucei

(2015) Gerasimos Langousis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-molecule imaging of Hedgehog pathway protein Smoothened in primary cilia reveals binding events regulated by Patched1

(2015) Ljiljana Milenkovic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Accumulation of non-outer segment proteins in the outer segment underlies photoreceptor degeneration in Bardet–Biedl syndrome

(2015) Poppy Datta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IFT–Cargo Interactions and Protein Transport in Cilia

(2015) Karl F. Lechtreck   TRENDS IN BIOCHEMICAL SCIENCES

Ciliary ectosomes: transmissions from the cell's antenna

(2015) Christopher R. Wood et al.   TRENDS IN CELL BIOLOGY

Natural paniceins from mediterranean sponge inhibit the multidrug resistance activity of patched and increase chemotherapy efficiency on melanoma cells

(2015) Laura Fiorini et al.   Oncotarget

Ciliary Phosphoinositide Regulates Ciliary Protein Trafficking in Drosophila

(2015) Jina Park et al.   Cell Reports

Conserved Genetic Interactions between Ciliopathy Complexes Cooperatively Support Ciliogenesis and Ciliary Signaling

(2015) Laura E. Yee et al.   PLoS Genetics

Uni-directional ciliary membrane protein trafficking by a cytoplasmic retrograde IFT motor and ciliary ectosome shedding

(2015) Muqing Cao et al.   eLife

A G-protein activation cascade from Arl13B to Arl3 and implications for ciliary targeting of lipidated proteins

(2015) Katja Gotthardt et al.   eLife

Flagellar membranes are rich in raft-forming phospholipids

(2015) M. Serricchio et al.   Biology Open

C. elegans Ciliated Sensory Neurons Release Extracellular Vesicles that Function in Animal Communication

(2014) Juan Wang et al.   CURRENT BIOLOGY

Cytokinetic Abscission: Molecular Mechanisms and Temporal Control

(2014) Beata Mierzwa et al.   DEVELOPMENTAL CELL

The Intraflagellar Transport Protein IFT27 Promotes BBSome Exit from Cilia through the GTPase ARL6/BBS3

(2014) Gerald M. Liew et al.   DEVELOPMENTAL CELL

IFT27 Links the BBSome to IFT for Maintenance of the Ciliary Signaling Compartment

(2014) Thibaut Eguether et al.   DEVELOPMENTAL CELL

Diverse Cell Type-Specific Mechanisms Localize G Protein-Coupled Receptors to Caenorhabditis elegans Sensory Cilia

(2014) Andrea G. Brear et al.   GENETICS

NPHP4 controls ciliary trafficking of membrane proteins and large soluble proteins at the transition zone

(2014) J. Awata et al.   JOURNAL OF CELL SCIENCE

Ciliopathy proteins establish a bipartite signaling compartment in a C. elegans thermosensory neuron

(2014) P. A. T. Nguyen et al.   JOURNAL OF CELL SCIENCE

The kinesin-4 protein Kif7 regulates mammalian Hedgehog signalling by organizing the cilium tip compartment

(2014) Mu He et al.   NATURE CELL BIOLOGY

Apical Abscission Alters Cell Polarity and Dismantles the Primary Cilium During Neurogenesis

(2014) R. M. Das et al.   SCIENCE

The PPFIA1-PP2A protein complex promotes trafficking of Kif7 to the ciliary tip and Hedgehog signaling

(2014) Y. C. Liu et al.   Science Signaling

Regulated Membrane Protein Entry into Flagella Is Facilitated by Cytoplasmic Microtubules and Does Not Require IFT

(2013) Olivier Belzile et al.   CURRENT BIOLOGY

The Cilium Secretes Bioactive Ectosomes

(2013) Christopher R. Wood et al.   CURRENT BIOLOGY

IGF-1 Activates a Cilium-Localized Noncanonical Gβγ Signaling Pathway that Regulates Cell-Cycle Progression

(2013) Celine Yeh et al.   DEVELOPMENTAL CELL

Centriole distal appendages promote membrane docking, leading to cilia initiation

(2013) B. E. Tanos et al.   GENES & DEVELOPMENT

Cycling of the signaling protein phospholipase D through cilia requires the BBSome only for the export phase

(2013) Karl F. Lechtreck et al.   JOURNAL OF CELL BIOLOGY

An in vitro assay for entry into cilia reveals unique properties of the soluble diffusion barrier

(2013) David K. Breslow et al.   JOURNAL OF CELL BIOLOGY

Adenylyl Cyclase 6 Deficiency Ameliorates Polycystic Kidney Disease

(2013) S. Rees et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Direct recording and molecular identification of the calcium channel of primary cilia

(2013) Paul G. DeCaen et al.   NATURE

Primary cilia are specialized calcium signalling organelles

(2013) Markus Delling et al.   NATURE

Chemically inducible diffusion trap at cilia reveals molecular sieve–like barrier

(2013) Yu-Chun Lin et al.   Nature Chemical Biology

Loss of cilia suppresses cyst growth in genetic models of autosomal dominant polycystic kidney disease

(2013) Ming Ma et al.   NATURE GENETICS

A Role for the Membrane in Regulating Chlamydomonas Flagellar Length

(2013) William Dentler   PLoS One

Evolution of modular intraflagellar transport from a coatomer-like progenitor

(2013) T. J. P. van Dam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Basis of Tubulin Transport Within the Cilium by IFT74 and IFT81

(2013) S. Bhogaraju et al.   SCIENCE

Neuropeptide Y Family Receptors Traffic via the Bardet-Biedl Syndrome Pathway to Signal in Neuronal Primary Cilia

(2013) Alexander V. Loktev et al.   Cell Reports

TGF-β Signaling Is Associated with Endocytosis at the Pocket Region of the Primary Cilium

(2013) Christian Alexandro Clement et al.   Cell Reports

dTULP, the Drosophila melanogaster Homolog of Tubby, Regulates Transient Receptor Potential Channel Localization in Cilia

(2013) Jina Park et al.   PLoS Genetics

Active Transport and Diffusion Barriers Restrict Joubert Syndrome-Associated ARL13B/ARL-13 to an Inv-like Ciliary Membrane Subdomain

(2013) Sebiha Cevik et al.   PLoS Genetics

Single molecule imaging reveals a major role for diffusion in the exploration of ciliary space by signaling receptors

(2013) Fan Ye et al.   eLife

The ciliary pocket

(2012) Alexandre Benmerah   CURRENT OPINION IN CELL BIOLOGY

Structural basis for Arl3-specific release of myristoylated ciliary cargo from UNC119

(2012) Shehab A Ismail et al.   EMBO JOURNAL

The IFT-A complex regulates Shh signaling through cilia structure and membrane protein trafficking

(2012) Karel F. Liem et al.   JOURNAL OF CELL BIOLOGY

A size-exclusion permeability barrier and nucleoporins characterize a ciliary pore complex that regulates transport into cilia

(2012) Hooi Lynn Kee et al.   NATURE CELL BIOLOGY

ARL13B, PDE6D, and CEP164 form a functional network for INPP5E ciliary targeting

(2012) M. C. Humbert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ultrastructure of cilia and flagella - back to the future!

(2011) Cathy Fisch et al.   BIOLOGY OF THE CELL

A Role for the Primary Cilium in Notch Signaling and Epidermal Differentiation during Skin Development

(2011) Ellen J. Ezratty et al.   CELL

Mapping the NPHP-JBTS-MKS Protein Network Reveals Ciliopathy Disease Genes and Pathways

(2011) Liyun Sang et al.   CELL

An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium

(2011) K. J. Wright et al.   GENES & DEVELOPMENT

MKS and NPHP modules cooperate to establish basal body/transition zone membrane associations and ciliary gate function during ciliogenesis

(2011) Corey L. Williams et al.   JOURNAL OF CELL BIOLOGY

A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain

(2011) Ben Chih et al.   NATURE CELL BIOLOGY

Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo

(2011) Shehab A Ismail et al.   Nature Chemical Biology

Complex interactions between genes controlling trafficking in primary cilia

(2011) Polloneal Jymmiel R Ocbina et al.   NATURE GENETICS

UNC119 is required for G protein trafficking in sensory neurons

(2011) Houbin Zhang et al.   NATURE NEUROSCIENCE

The Retrograde IFT Machinery of C. elegans Cilia: Two IFT Dynein Complexes?

(2011) Limin Hao et al.   PLoS One

The Hedgehog Receptor Patched Is Involved in Cholesterol Transport

(2011) Michel Bidet et al.   PLoS One

Steric volume exclusion sets soluble protein concentrations in photoreceptor sensory cilia

(2011) M. Najafi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bardet-Biedl syndrome 3 (Bbs3) knockout mouse model reveals common BBS-associated phenotypes and Bbs3 unique phenotypes

(2011) Q. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multivesicular bodies in neurons: Distribution, protein content, and trafficking functions

(2011) Christopher S. Von Bartheld et al.   PROGRESS IN NEUROBIOLOGY

Trafficking to the Ciliary Membrane: How to Get Across the Periciliary Diffusion Barrier?

(2010) Maxence V. Nachury et al.   Annual Review of Cell and Developmental Biology

The Conserved Bardet-Biedl Syndrome Proteins Assemble a Coat that Traffics Membrane Proteins to Cilia

(2010) Hua Jin et al.   CELL

Actin Dynamics Drive Membrane Reorganization and Scission in Clathrin-Independent Endocytosis

(2010) Winfried Römer et al.   CELL

Primary cilium-dependent mechanosensing is mediated by adenylyl cyclase 6 and cyclic AMP in bone cells

(2010) Ronald Y. Kwon et al.   FASEB JOURNAL

TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia

(2010) S. Mukhopadhyay et al.   GENES & DEVELOPMENT

The retinitis pigmentosa protein RP2 interacts with polycystin 2 and regulates cilia-mediated vertebrate development

(2010) Toby Hurd et al.   HUMAN MOLECULAR GENETICS

The retinitis pigmentosa protein RP2 links pericentriolar vesicle transport between the Golgi and the primary cilium

(2010) R. Jane Evans et al.   HUMAN MOLECULAR GENETICS

The small GTPases ARL-13 and ARL-3 coordinate intraflagellar transport and ciliogenesis

(2010) Yujie Li et al.   JOURNAL OF CELL BIOLOGY

Joubert syndrome Arl13b functions at ciliary membranes and stabilizes protein transport inCaenorhabditis elegans

(2010) Sebiha Cevik et al.   JOURNAL OF CELL BIOLOGY

CEP290 tethers flagellar transition zone microtubules to the membrane and regulates flagellar protein content

(2010) Branch Craige et al.   JOURNAL OF CELL BIOLOGY

The cytoplasmic tail of fibrocystin contains a ciliary targeting sequence

(2010) John A. Follit et al.   JOURNAL OF CELL BIOLOGY

Sensory reception is an attribute of both primary cilia and motile cilia

(2010) R. A. Bloodgood   JOURNAL OF CELL SCIENCE

Molecular mechanisms of protein and lipid targeting to ciliary membranes

(2010) B. T. Emmer et al.   JOURNAL OF CELL SCIENCE

Diffusion of a soluble protein, photoactivatable GFP, through a sensory cilium

(2010) Peter D. Calvert et al.   JOURNAL OF GENERAL PHYSIOLOGY

Lipidomic Analysis of Porcine Olfactory Epithelial Membranes and Cilia

(2010) Simona Lobasso et al.   LIPIDS

Signaling by olfactory receptor neurons near threshold

(2010) V. Bhandawat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The major  -tubulin K40 acetyltransferase  TAT1 promotes rapid ciliogenesis and efficient mechanosensation

(2010) T. Shida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Septin Diffusion Barrier at the Base of the Primary Cilium Maintains Ciliary Membrane Protein Distribution

(2010) Q. Hu et al.   SCIENCE

cAMP and cGMP signaling: sensory systems with prokaryotic roots adopted by eukaryotic cilia

(2010) Jacque-Lynne F. Johnson et al.   TRENDS IN CELL BIOLOGY

The Mammalian Cos2 Homolog Kif7 Plays an Essential Role in Modulating Hh Signal Transduction during Development

(2009) Setsu Endoh-Yamagami et al.   CURRENT BIOLOGY

Nephrocystin-1 and nephrocystin-4 are required for epithelial morphogenesis and associate with PALS1/PATJ and Par6

(2009) Marion Delous et al.   HUMAN MOLECULAR GENETICS

The ubiquitin conjugation system is involved in the disassembly of cilia and flagella

(2009) Kaiyao Huang et al.   JOURNAL OF CELL BIOLOGY

TheChlamydomonas reinhardtiiBBSome is an IFT cargo required for export of specific signaling proteins from flagella

(2009) Karl-Ferdinand Lechtreck et al.   JOURNAL OF CELL BIOLOGY

Identification of a palmitoyl acyltransferase required for protein sorting to the flagellar membrane

(2009) B. T. Emmer et al.   JOURNAL OF CELL SCIENCE

Flagellar membrane localization via association with lipid rafts

(2009) K. M. Tyler et al.   JOURNAL OF CELL SCIENCE

Membrane scission by the ESCRT-III complex

(2009) Thomas Wollert et al.   NATURE

The Kinesin Protein Kif7 Is a Critical Regulator of Gli Transcription Factors in Mammalian Hedgehog Signaling

(2009) H. O.-L. Cheung et al.   Science Signaling

Intraflagellar transport, cilia, and mammalian Hedgehog signaling: Analysis in mouse embryonic fibroblasts

(2008) Polloneal Jymmiel R. Ocbina et al.   DEVELOPMENTAL DYNAMICS

The outer segment serves as a default destination for the trafficking of membrane proteins in photoreceptors

(2008) Sheila A. Baker et al.   JOURNAL OF CELL BIOLOGY

The keratin-binding protein Albatross regulates polarization of epithelial cells

(2008) Masahiko Sugimoto et al.   JOURNAL OF CELL BIOLOGY

Dynein-2 Affects the Regulation of Ciliary Length but Is Not Required for Ciliogenesis in Tetrahymena thermophila

(2008) Vidyalakshmi Rajagopalan et al.   MOLECULAR BIOLOGY OF THE CELL

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