Journal
JOURNAL OF CELL BIOLOGY
Volume 221, Issue 1, Pages -Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.202112015
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Funding
- Canadian Institutes of Health Research [MOP-142243, PJT-156042]
- Michael Smith Foundation for Health Research
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The transition zone of cilia plays a crucial role in controlling intraflagellar transport particles.
Cilia harbor diffusion barriers for soluble and membrane proteins within their proximal-most transitionzone (TZ) region and employ an intraflagellar transport (IFT) system to form dynamic motile and signaling compartments. In this issue, De-Castro and colleagues (2021. J. Cell Biol.https://doi.org/10.1083/jcb.202010178) uncover a long-suspected role for the TZ in gating IFT particles.
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