WDR60-mediated dynein-2 loading into cilia powers retrograde IFT and transition zone crossing

Cytoplasmic dynein-2 at a glance

(2020) Laura Vuolo et al.   JOURNAL OF CELL SCIENCE

Intraflagellar transport trains and motors: Insights from structure

(2020) Stephanie Webb et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

IFT54 directly interacts with kinesin‐II and IFT dynein to regulate anterograde intraflagellar transport

(2020) Xin Zhu et al.   EMBO JOURNAL

Interactions of the dynein-2 intermediate chain WDR34 with the light chains are required for ciliary retrograde protein trafficking

(2019) Yuta Tsurumi et al.   MOLECULAR BIOLOGY OF THE CELL

Cell type-specific structural plasticity of the ciliary transition zone in C. elegans

(2019) Jyothi S. Akella et al.   BIOLOGY OF THE CELL

Establishing and regulating the composition of cilia for signal transduction

(2019) Maxence V. Nachury et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structure of the dynein-2 complex and its assembly with intraflagellar transport trains

(2019) Katerina Toropova et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Biallelic mutations in DYNC2LI1 are a rare cause of Ellis-van Creveld syndrome

(2018) M. Niceta et al.   CLINICAL GENETICS

Interaction of WDR60 intermediate chain with TCTEX1D2 light chain of the dynein-2 complex is crucial for ciliary protein trafficking

(2018) Yuki Hamada et al.   MOLECULAR BIOLOGY OF THE CELL

Differential regulation of transition zone and centriole proteins contributes to ciliary base diversity

(2018) Swadhin Chandra Jana et al.   NATURE CELL BIOLOGY

Emerging mechanisms of dynein transport in the cytoplasm versus the cilium

(2018) Anthony J. Roberts   BIOCHEMICAL SOCIETY TRANSACTIONS

Intraflagellar Transport Complex A Genes Differentially Regulate Cilium Formation and Transition Zone Gating

(2018) Noémie Scheidel et al.   CURRENT BIOLOGY

Role for intraflagellar transport in building a functional transition zone

(2018) Victor L Jensen et al.   EMBO REPORTS

Interplay between Ciliary Ultrastructure and IFT-Train Dynamics Revealed by Single-Molecule Super-resolution Imaging

(2018) Felix Oswald et al.   Cell Reports

Dynein-2 intermediate chains play crucial but distinct roles in primary cilia formation and function

(2018) Laura Vuolo et al.   eLife

Intraflagellar transport: mechanisms of motor action, cooperation, and cargo delivery

(2017) Bram Prevo et al.   FEBS Journal

Loss of dynein-2 intermediate chain Wdr34 results in defects in retrograde ciliary protein trafficking and Hedgehog signaling in the mouse

(2017) Chuanqing Wu et al.   HUMAN MOLECULAR GENETICS

Intraflagellar transport dynein is autoinhibited by trapping of its mechanical and track-binding elements

(2017) Katerina Toropova et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ensemble and single-molecule dynamics of IFT dynein in Caenorhabditis elegans cilia

(2017) Jona Mijalkovic et al.   Nature Communications

Intraflagellar transport dynein is autoinhibited by trapping of its mechanical and track-binding elements

(2017) Katerina Toropova et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

New mutations in DYNC2H1 and WDR60 genes revealed by whole-exome sequencing in two unrelated Sardinian families with Jeune asphyxiating thoracic dystrophy

(2016) Carla Cossu et al.   CLINICA CHIMICA ACTA

The role of the dynein light intermediate chain in retrograde IFT and flagellar function in Chlamydomonas

(2016) Jaimee Reck et al.   MOLECULAR BIOLOGY OF THE CELL

KymographClear and KymographDirect: two tools for the automated quantitative analysis of molecular and cellular dynamics using kymographs

(2016) Pierre Mangeol et al.   MOLECULAR BIOLOGY OF THE CELL

Open Sesame: How Transition Fibers and the Transition Zone Control Ciliary Composition

(2016) Francesc R. Garcia-Gonzalo et al.   Cold Spring Harbor Perspectives in Biology

MKS5 and CEP290 Dependent Assembly Pathway of the Ciliary Transition Zone

(2016) Chunmei Li et al.   PLOS BIOLOGY

Structural and Functional Recovery of Sensory Cilia in C. elegans IFT Mutants upon Aging

(2016) Astrid Cornils et al.   PLoS Genetics

Formation of the transition zone by Mks5/Rpgrip1L establishes a ciliary zone of exclusion (CIZE) that compartmentalises ciliary signalling proteins and controls PIP2 ciliary abundance

(2015) V. L. Jensen et al.   EMBO JOURNAL

Dynein and intraflagellar transport

(2015) Yuqing Hou et al.   EXPERIMENTAL CELL RESEARCH

The ciliary transition zone functions in cell adhesion but is dispensable for axoneme assembly inC. elegans

(2015) Clementine Schouteden et al.   JOURNAL OF CELL BIOLOGY

Functional differentiation of cooperating kinesin-2 motors orchestrates cargo import and transport in C. elegans cilia

(2015) Bram Prevo et al.   NATURE CELL BIOLOGY

TMEM107 recruits ciliopathy proteins to subdomains of the ciliary transition zone and causes Joubert syndrome

(2015) Nils J. Lambacher et al.   NATURE CELL BIOLOGY

Mutations in DYNC2LI1 disrupt cilia function and cause short rib polydactyly syndrome

(2015) S. Paige Taylor et al.   Nature Communications

TCTEX1D2 mutations underlie Jeune asphyxiating thoracic dystrophy with impaired retrograde intraflagellar transport

(2015) Miriam Schmidts et al.   Nature Communications

NPHP4 controls ciliary trafficking of membrane proteins and large soluble proteins at the transition zone

(2014) J. Awata et al.   JOURNAL OF CELL SCIENCE

Subunit composition of the human cytoplasmic dynein-2 complex

(2014) D. Asante et al.   JOURNAL OF CELL SCIENCE

The intraflagellar transport dynein complex of trypanosomes is made of a heterodimer of dynein heavy chains and of light and intermediate chains of distinct functions

(2014) Thierry Blisnick et al.   MOLECULAR BIOLOGY OF THE CELL

Compartments within a compartment

(2014) Oliver E Blacque et al.   Organogenesis

WDR34 Mutations that Cause Short-Rib Polydactyly Syndrome Type III/Severe Asphyxiating Thoracic Dysplasia Reveal a Role for the NF-κB Pathway in Cilia

(2013) Céline Huber et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Short-Rib Polydactyly and Jeune Syndromes Are Caused by Mutations in WDR60

(2013) Aideen M. McInerney-Leo et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mutations in the Gene Encoding IFT Dynein Complex Component WDR34 Cause Jeune Asphyxiating Thoracic Dystrophy

(2013) Miriam Schmidts et al.   AMERICAN JOURNAL OF HUMAN GENETICS

WD60/FAP163 is a dynein intermediate chain required for retrograde intraflagellar transport in cilia

(2013) Ramila S. Patel-King et al.   MOLECULAR BIOLOGY OF THE CELL

Intraflagellar transport drives flagellar surface motility

(2013) Sheng Min Shih et al.   eLife

Cilia functions in development

(2012) Iain A Drummond   CURRENT OPINION IN CELL BIOLOGY

MKS and NPHP modules cooperate to establish basal body/transition zone membrane associations and ciliary gate function during ciliogenesis

(2011) Corey L. Williams et al.   JOURNAL OF CELL BIOLOGY

Ciliary Abnormalities Due to Defects in the Retrograde Transport Protein DYNC2H1 in Short-Rib Polydactyly Syndrome

(2009) Amy E. Merrill et al.   AMERICAN JOURNAL OF HUMAN GENETICS

DYNC2H1 Mutations Cause Asphyxiating Thoracic Dystrophy and Short Rib-Polydactyly Syndrome, Type III

(2009) Nathalie Dagoneau et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Sensory roles of neuronal cilia: Cilia development, morphogenesis, and function in C. elegans

(2008) Young-Kyung Bae   Frontiers in Bioscience-Landmark

TheCaenorhabditis elegansnephrocystins act as global modifiers of cilium structure

(2008) Andrew R. Jauregui et al.   JOURNAL OF CELL BIOLOGY