Cyclic di-GMP: second messenger extraordinaire

Group B Streptococcus Degrades Cyclic-di-AMP to Modulate STING-Dependent Type I Interferon Production

(2016) Warrison A. Andrade et al.   Cell Host & Microbe

PilZ Domain Protein FlgZ Mediates Cyclic Di-GMP-Dependent Swarming Motility Control in Pseudomonas aeruginosa

(2016) Amy E. Baker et al.   JOURNAL OF BACTERIOLOGY

The Inhibitory Site of a Diguanylate Cyclase Is a Necessary Element for Interaction and Signaling with an Effector Protein

(2016) Kurt M. Dahlstrom et al.   JOURNAL OF BACTERIOLOGY

Biofilms and Cyclic di-GMP (c-di-GMP) Signaling: Lessons fromPseudomonas aeruginosaand Other Bacteria

(2016) Martina Valentini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

C-di-GMP Synthesis: Structural Aspects of Evolution, Catalysis and Regulation

(2016) Tilman Schirmer   JOURNAL OF MOLECULAR BIOLOGY

Cyclic di-AMP targets the cystathionine beta-synthase domain of the osmolyte transporter OpuC

(2016) TuAnh Ngoc Huynh et al.   MOLECULAR MICROBIOLOGY

The RNA Domain Vc1 Regulates Downstream Gene Expression in Response to Cyclic Diguanylate in Vibrio cholerae

(2016) Ankunda T. Kariisa et al.   PLoS One

Structures of the activator ofK. pneumoniabiofilm formation, MrkH, indicates PilZ domains involved in c-di-GMP and DNA binding

(2016) Maria A. Schumacher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The second messenger c-di-AMP inhibits the osmolyte uptake system OpuC inStaphylococcus aureus

(2016) Christopher F. Schuster et al.   Science Signaling

Nucleotide binding by the widespread high-affinity cyclic di-GMP receptor MshEN domain

(2016) Yu-Chuan Wang et al.   Nature Communications

A Minimal Threshold of c-di-GMP Is Essential for Fruiting Body Formation and Sporulation in Myxococcus xanthus

(2016) Dorota Skotnicka et al.   PLoS Genetics

Second Messenger Signaling in Bacillus subtilis: Accumulation of Cyclic di-AMP Inhibits Biofilm Formation

(2016) Jan Gundlach et al.   Frontiers in Microbiology

The second messenger c-di-AMP inhibits the osmolyte uptake system OpuC inStaphylococcus aureus

(2016) Christopher F. Schuster et al.   Science Signaling

Cyclic di-GMP mediates a histidine kinase/phosphatase switch by noncovalent domain cross-linking

(2016) B. N. Dubey et al.   Science Advances

Characterization of a natural triple-tandem c-di-GMP riboswitch and application of the riboswitch-based dual-fluorescence reporter

(2016) Hang Zhou et al.   Scientific Reports

Novel Functions of (p)ppGpp and Cyclic di-GMP in Mycobacterial Physiology Revealed by Phenotype Microarray Analysis of Wild-Type and Isogenic Strains of Mycobacterium smegmatis

(2015) Kuldeepkumar Ramnaresh Gupta et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Structural Insights into the Distinct Binding Mode of Cyclic Di-AMP with SaCpaA_RCK

(2015) Ko-Hsin Chin et al.   BIOCHEMISTRY

The PAMP c-di-AMP Is Essential for Listeria monocytogenes Growth in Rich but Not Minimal Media due to a Toxic Increase in (p)ppGpp

(2015) Aaron T. Whiteley et al.   Cell Host & Microbe

DisA and c-di-AMP act at the intersection between DNA-damage response and stress homeostasis in exponentially growing Bacillus subtilis cells

(2015) Carolina Gándara et al.   DNA REPAIR

Novel genetic tools to tackle c-di-GMP-dependent signalling inPseudomonas aeruginosa

(2015) S. Vishnu Pawar et al.   JOURNAL OF APPLIED MICROBIOLOGY

Expression and Genetic Activation of Cyclic Di-GMP-Specific Phosphodiesterases in Escherichia coli

(2015) Alberto Reinders et al.   JOURNAL OF BACTERIOLOGY

An Extended Cyclic Di-GMP Network in the Predatory Bacterium Bdellovibrio bacteriovorus

(2015) Or Rotem et al.   JOURNAL OF BACTERIOLOGY

Systematic Nomenclature for GGDEF and EAL Domain-Containing Cyclic Di-GMP Turnover Proteins of Escherichia coli: TABLE 1

(2015) Regine Hengge et al.   JOURNAL OF BACTERIOLOGY

Cyclic Di-GMP Regulates Type IV Pilus-Dependent Motility in Myxococcus xanthus

(2015) Dorota Skotnicka et al.   JOURNAL OF BACTERIOLOGY

Regulation of Type IV Pili Contributes to Surface Behaviors of Historical and Epidemic Strains of Clostridium difficile

(2015) Erin B. Purcell et al.   JOURNAL OF BACTERIOLOGY

The Cyclic AMP-Vfr Signaling Pathway in Pseudomonas aeruginosa Is Inhibited by Cyclic Di-GMP

(2015) Henrik Almblad et al.   JOURNAL OF BACTERIOLOGY

Binding of Cyclic Di-AMP to the Staphylococcus aureus Sensor Kinase KdpD Occurs via the Universal Stress Protein Domain and Downregulates the Expression of the Kdp Potassium Transporter

(2015) Joana A. Moscoso et al.   JOURNAL OF BACTERIOLOGY

Diversity of Cyclic Di-GMP-Binding Proteins and Mechanisms

(2015) Shan-Ho Chou et al.   JOURNAL OF BACTERIOLOGY

Bacterial Rotary Export ATPases Are Allosterically Regulated by the Nucleotide Second Messenger Cyclic-di-GMP

(2015) Eleftheria Trampari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and Biochemical Insight into the Mechanism of Rv2837c fromMycobacterium tuberculosisas a c-di-NMP Phosphodiesterase

(2015) Qing He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Studies of Potassium Transport Protein KtrA Regulator of Conductance of K+(RCK) C Domain in Complex with Cyclic Diadenosine Monophosphate (c-di-AMP)

(2015) Henna Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclic diGMP Regulates Production of Sortase Substrates ofClostridium difficileand Their Surface Exposure through ZmpI Protease-mediated Cleavage

(2015) Johann Peltier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Bacterial Virulence by Csr (Rsm) Systems

(2015) Christopher A. Vakulskas et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2′,3′ cGAMP Signaling

(2015) Philip J. Kranzusch et al.   MOLECULAR CELL

Cyclic-di-AMP synthesis by the diadenylate cyclase CdaA is modulated by the peptidoglycan biosynthesis enzyme GlmM in L actococcus lactis

(2015) Yan Zhu et al.   MOLECULAR MICROBIOLOGY

Cyclic di-AMP mediates biofilm formation

(2015) Xian Peng et al.   MOLECULAR MICROBIOLOGY

Cyclic di-GMP acts as a cell cycle oscillator to drive chromosome replication

(2015) C. Lori et al.   NATURE

In vitro and in vivo generation and characterization of Pseudomonas aeruginosa biofilm–dispersed cells via c-di-GMP manipulation

(2015) Song Lin Chua et al.   Nature Protocols

c-di-GMP signalling and the regulation of developmental transitions in streptomycetes

(2015) Matthew J. Bush et al.   NATURE REVIEWS MICROBIOLOGY

Oligoribonuclease is a central feature of cyclic diguanylate signaling inPseudomonas aeruginosa

(2015) Dorit Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oligoribonuclease is the primary degradative enzyme for pGpG inPseudomonas aeruginosathat is required for cyclic-di-GMP turnover

(2015) Mona W. Orr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Three cyanobacteriochromes work together to form a light color-sensitive input system for c-di-GMP signaling of cell aggregation

(2015) Gen Enomoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An HD-domain phosphodiesterase mediates cooperative hydrolysis of c-di-AMP to affect bacterial growth and virulence

(2015) TuAnh Ngoc Huynh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of bacterial exoelectrogenesis by c-AMP-GMP

(2015) James W. Nelson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanistic insights into c-di-GMP–dependent control of the biofilm regulator FleQ fromPseudomonas aeruginosa

(2015) Bruno Y. Matsuyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GEMM-I riboswitches fromGeobactersense the bacterial second messenger cyclic AMP-GMP

(2015) Colleen A. Kellenberger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A direct screen for c-di-GMP modulators reveals aSalmonellaTyphimurium periplasmic ʟ-arginine–sensing pathway

(2015) Erez Mills et al.   Science Signaling

Constitutive production of c-di-GMP is associated with mutations in a variant ofPseudomonas aeruginosawith altered membrane composition

(2015) Andrea Blanka et al.   Science Signaling

Structural Basis for the Catalytic Mechanism of DncV, Bacterial Homolog of Cyclic GMP-AMP Synthase

(2015) Kazuki Kato et al.   STRUCTURE

C-di-GMP Regulates Motile to Sessile Transition by Modulating MshA Pili Biogenesis and Near-Surface Motility Behavior in Vibrio cholerae

(2015) Christopher J. Jones et al.   PLoS Pathogens

The cabABC Operon Essential for Biofilm and Rugose Colony Development in Vibrio vulnificus

(2015) Jin Hwan Park et al.   PLoS Pathogens

Systematic Identification of Cyclic-di-GMP Binding Proteins in Vibrio cholerae Reveals a Novel Class of Cyclic-di-GMP-Binding ATPases Associated with Type II Secretion Systems

(2015) Kevin G. Roelofs et al.   PLoS Pathogens

A direct screen for c-di-GMP modulators reveals aSalmonellaTyphimurium periplasmic ʟ-arginine–sensing pathway

(2015) Erez Mills et al.   Science Signaling

Constitutive production of c-di-GMP is associated with mutations in a variant ofPseudomonas aeruginosawith altered membrane composition

(2015) Andrea Blanka et al.   Science Signaling

Structure-Guided Reprogramming of Human cGAS Dinucleotide Linkage Specificity

(2014) Philip J. Kranzusch et al.   CELL

The Cyclic Dinucleotide c-di-AMP Is an Allosteric Regulator of Metabolic Enzyme Function

(2014) Kamakshi Sureka et al.   CELL

Tetrameric c-di-GMP Mediates Effective Transcription Factor Dimerization to Control Streptomyces Development

(2014) Natalia Tschowri et al.   CELL

Cyclic-di-GMP signalling and biofilm-related properties of the Shiga toxin-producing 2011 German outbreak Escherichia coli O104:H4

(2014) A. M. Richter et al.   EMBO Molecular Medicine

Cyclic Di-GMP Riboswitch-Regulated Type IV Pili Contribute to Aggregation of Clostridium difficile

(2014) Eric Bordeleau et al.   JOURNAL OF BACTERIOLOGY

Control of the Diadenylate Cyclase CdaS inBacillus subtilis

(2014) Felix M. P. Mehne et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inherent Regulation of EAL Domain-catalyzed Hydrolysis of Second Messenger Cyclic di-GMP

(2014) Amit Sundriyal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The cGAS-cGAMP-STING Pathway of Cytosolic DNA Sensing and Signaling

(2014) Xin Cai et al.   MOLECULAR CELL

Activation and polar sequestration of PopA, a c-di-GMP effector protein involved inCaulobacter crescentuscell cycle control

(2014) Shogo Ozaki et al.   MOLECULAR MICROBIOLOGY

Diguanylate cyclase NicD-based signalling mechanism of nutrient-induced dispersion byPseudomonas aeruginosa

(2014) Ankita Basu Roy et al.   MOLECULAR MICROBIOLOGY

Hydrolysis of 2′3′-cGAMP by ENPP1 and design of nonhydrolyzable analogs

(2014) Lingyin Li et al.   Nature Chemical Biology

Mechanism of activation of bacterial cellulose synthase by cyclic di-GMP

(2014) Jacob L W Morgan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Identification of flgZ as a Flagellar Gene Encoding a PilZ Domain Protein That Regulates Swimming Motility and Biofilm Formation in Pseudomonas

(2014) Francisco Martínez-Granero et al.   PLoS One

Cell cycle-dependent adaptor complex for ClpXP-mediated proteolysis directly integrates phosphorylation and second messenger signals

(2014) Stephen C. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel Cyclic di-GMP Effectors of the YajQ Protein Family Control Bacterial Virulence

(2014) Shi-qi An et al.   PLoS Pathogens

Mechanistic insight into the conserved allosteric regulation of periplasmic proteolysis by the signaling molecule cyclic-di-GMP

(2014) Debashree Chatterjee et al.   eLife

High-Throughput Screening Using the Differential Radial Capillary Action of Ligand Assay Identifies Ebselen As an Inhibitor of Diguanylate Cyclases

(2013) Ori J. Lieberman et al.   ACS Chemical Biology

Cyclic Dinucleotides and the Innate Immune Response

(2013) Olga Danilchanka et al.   CELL

A cyclic GMP-dependent signalling pathway regulates bacterial phytopathogenesis

(2013) Shi-Qi An et al.   EMBO JOURNAL

The EAL domain protein YciR acts as a trigger enzyme in a c-di-GMP signalling cascade in E. coli biofilm control

(2013) Sandra Lindenberg et al.   EMBO JOURNAL

De- and repolarization mechanism of flagellar morphogenesis during a bacterial cell cycle

(2013) N. J. Davis et al.   GENES & DEVELOPMENT

Two DHH Subfamily 1 Proteins in Streptococcus pneumoniae Possess Cyclic Di-AMP Phosphodiesterase Activity and Affect Bacterial Growth and Virulence

(2013) Y. Bai et al.   JOURNAL OF BACTERIOLOGY

Listeria monocytogenes Multidrug Resistance Transporters and Cyclic Di-AMP, Which Contribute to Type I Interferon Induction, Play a Role in Cell Wall Stress

(2013) M. Kaplan Zeevi et al.   JOURNAL OF BACTERIOLOGY

The Second Messenger Cyclic Di-GMP Regulates Clostridium difficile Toxin Production by Controlling Expression of sigD

(2013) R. W. McKee et al.   JOURNAL OF BACTERIOLOGY

Radiation-sensitive Gene A (RadA) Targets DisA, DNA Integrity Scanning Protein A, to Negatively Affect Cyclic Di-AMP Synthesis Activity inMycobacterium smegmatis

(2013) Lei Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of Elements Involved in Allosteric Light Regulation of Phosphodiesterase Activity by Comparison of Different Functional BlrP1 States

(2013) Andreas Winkler et al.   JOURNAL OF MOLECULAR BIOLOGY

RNA-Based Fluorescent Biosensors for Live Cell Imaging of Second Messengers Cyclic di-GMP and Cyclic AMP-GMP

(2013) Colleen A. Kellenberger et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cyclic di-GMP: the First 25 Years of a Universal Bacterial Second Messenger

(2013) U. Romling et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Crystal structure of an HD-GYP domain cyclic-di-GMP phosphodiesterase reveals an enzyme with a novel trinuclear catalytic iron centre

(2013) Dom Bellini et al.   MOLECULAR MICROBIOLOGY

Cyclic di-GMP inhibitsVibrio choleraemotility by repressing induction of transcription and inducing extracellular polysaccharide production

(2013) Disha Srivastava et al.   MOLECULAR MICROBIOLOGY

cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING

(2013) Andrea Ablasser et al.   NATURE

Structural mechanism of cytosolic DNA sensing by cGAS

(2013) Filiz Civril et al.   NATURE

Riboswitches in eubacteria sense the second messenger c-di-AMP

(2013) James W Nelson et al.   Nature Chemical Biology

Cyclic di-AMP: another second messenger enters the fray

(2013) Rebecca M. Corrigan et al.   NATURE REVIEWS MICROBIOLOGY

Mutation in the C-Di-AMP Cyclase dacA Affects Fitness and Resistance of Methicillin Resistant Staphylococcus aureus

(2013) Vanina Dengler et al.   PLoS One

Cyclic diguanosine monophosphate represses bacterial flagella synthesis by interacting with the Walker A motif of the enhancer-binding protein FleQ

(2013) C. Baraquet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systematic identification of conserved bacterial c-di-AMP receptor proteins

(2013) R. M. Corrigan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and Signaling Mechanism of a Zinc-Sensory Diguanylate Cyclase

(2013) Franziska Zähringer et al.   STRUCTURE

Integration of the Second Messenger c-di-GMP into the Chemotactic Signaling Pathway

(2013) M. H. Russell et al.   mBio

Cyclic di-AMP Is Critical for Listeria monocytogenes Growth, Cell Wall Homeostasis, and Establishment of Infection

(2013) C. E. Witte et al.   mBio

Microanatomy at Cellular Resolution and Spatial Order of Physiological Differentiation in a Bacterial Biofilm

(2013) D. O. Serra et al.   mBio

The Innate Immune DNA Sensor cGAS Produces a Noncanonical Cyclic Dinucleotide that Activates Human STING

(2013) Elie J. Diner et al.   Cell Reports

Bi-modal Distribution of the Second Messenger c-di-GMP Controls Cell Fate and Asymmetry during the Caulobacter Cell Cycle

(2013) Sören Abel et al.   PLoS Genetics

Genome-Wide Identification of Regulatory RNAs in the Human Pathogen Clostridium difficile

(2013) Olga A. Soutourina et al.   PLoS Genetics

c-di-GMP heterogeneity is generated by the chemotaxis machinery to regulate flagellar motility

(2013) Bridget R Kulasekara et al.   eLife

Fluorescence-Based Reporter for Gauging Cyclic Di-GMP Levels in Pseudomonas aeruginosa

(2012) Morten T. Rybtke et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Coordinated Regulation of Accessory Genetic Elements Produces Cyclic Di-Nucleotides for V. cholerae Virulence

(2012) Bryan W. Davies et al.   CELL

Nucleotide, c-di-GMP, c-di-AMP, cGMP, cAMP, (p)ppGpp signaling in bacteria and implications in pathogenesis

(2012) Dimpy Kalia et al.   CHEMICAL SOCIETY REVIEWS

Allosteric activation of exopolysaccharide synthesis through cyclic di-GMP-stimulated protein–protein interaction

(2012) Samuel Steiner et al.   EMBO JOURNAL

A Tangled Web: Regulatory Connections between Quorum Sensing and Cyclic Di-GMP

(2012) D. Srivastava et al.   JOURNAL OF BACTERIOLOGY

Evidence for Cyclic Di-GMP-Mediated Signaling in Bacillus subtilis

(2012) Yun Chen et al.   JOURNAL OF BACTERIOLOGY

Cyclic Diguanylate Inversely Regulates Motility and Aggregation in Clostridium difficile

(2012) E. B. Purcell et al.   JOURNAL OF BACTERIOLOGY

Cyclic Di-AMP Homeostasis inBacillus subtilis

(2012) Felix M. P. Mehne et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DarR, a TetR-like Transcriptional Factor, Is a Cyclic Di-AMP-responsive Repressor inMycobacterium smegmatis

(2012) Lei Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel capture compound for the identification and analysis of cyclic di-GMP binding proteins

(2012) Jutta Nesper et al.   Journal of Proteomics

Nitric Oxide Modulates Bacterial Biofilm Formation through a Multicomponent Cyclic-di-GMP Signaling Network

(2012) Lars Plate et al.   MOLECULAR CELL

The orphan histidine protein kinase SgmT is a c-di-GMP receptor and regulates composition of the extracellular matrix together with the orphan DNA binding response regulator DigR in Myxococcus xanthus

(2012) Tobias Petters et al.   MOLECULAR MICROBIOLOGY

Surface sensing and lateral subcellular localization of WspA, the receptor in a chemosensory-like system leading to c-di-GMP production

(2012) Jennifer R. O'Connor et al.   MOLECULAR MICROBIOLOGY

The response threshold ofSalmonellaPilZ domain proteins is determined by their binding affinities for c-di-GMP

(2012) Ingrid Swanson Pultz et al.   MOLECULAR MICROBIOLOGY

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

Discrete Cyclic di-GMP-Dependent Control of Bacterial Predation versus Axenic Growth in Bdellovibrio bacteriovorus

(2012) Laura Hobley et al.   PLoS Pathogens

A Dynamic Complex of Signaling Proteins Uses Polar Localization to Regulate Cell-Fate Asymmetry in Caulobacter crescentus

(2011) Christos G. Tsokos et al.   DEVELOPMENTAL CELL

c-di-AMP reports DNA integrity during sporulation in Bacillus subtilis

(2011) Yaara Oppenheimer-Shaanan et al.   EMBO REPORTS

The Pseudomonas aeruginosa sensor RetS switches Type III and Type VI secretion via c-di-GMP signalling

(2011) Joana A. Moscoso et al.   ENVIRONMENTAL MICROBIOLOGY

Solution Structure of the PilZ Domain Protein PA4608 Complex with Cyclic di-GMP Identifies Charge Clustering as Molecular Readout

(2011) Judith Habazettl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A chemical proteomics approach to identify c-di-GMP binding proteins in Pseudomonas aeruginosa

(2011) Juliane Düvel et al.   JOURNAL OF MICROBIOLOGICAL METHODS

Oligomer Formation of the Bacterial Second Messenger c-di-GMP: Reaction Rates and Equilibrium Constants Indicate a Monomeric State at Physiological Concentrations

(2011) Martin Gentner et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Regulatory Cohesion of Cell Cycle and Cell Differentiation through Interlinked Phosphorylation and Second Messenger Networks

(2011) Sören Abel et al.   MOLECULAR CELL

The CRP/FNR family protein Bcam1349 is a c-di-GMP effector that regulates biofilm formation in the respiratory pathogen Burkholderia cenocepacia

(2011) Mustafa Fazli et al.   MOLECULAR MICROBIOLOGY

Analysis of the role of Bacillus subtilis σM in β-lactam resistance reveals an essential role for c-di-AMP in peptidoglycan homeostasis

(2011) Yun Luo et al.   MOLECULAR MICROBIOLOGY

German Outbreak ofEscherichia coliO104:H4 Associated with Sprouts

(2011) Udo Buchholz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Differential radial capillary action of ligand assay for high-throughput detection of protein-metabolite interactions

(2011) K. G. Roelofs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis for c-di-GMP-Mediated Inside-Out Signaling Controlling Periplasmic Proteolysis

(2011) Marcos V. A. S. Navarro et al.   PLOS BIOLOGY

c-di-GMP Turn-Over in Clostridium difficile Is Controlled by a Plethora of Diguanylate Cyclases and Phosphodiesterases

(2011) Eric Bordeleau et al.   PLoS Genetics

c-di-AMP Is a New Second Messenger in Staphylococcus aureus with a Role in Controlling Cell Size and Envelope Stress

(2011) Rebecca M. Corrigan et al.   PLoS Pathogens

Second Messenger-Mediated Adjustment of Bacterial Swimming Velocity

(2010) Alex Boehm et al.   CELL

A liquid chromatography-coupled tandem mass spectrometry method for quantitation of cyclic di-guanosine monophosphate

(2010) Christian Spangler et al.   JOURNAL OF MICROBIOLOGICAL METHODS

The c-di-GMP Binding Protein YcgR Controls Flagellar Motor Direction and Speed to Affect Chemotaxis by a “Backstop Brake” Mechanism

(2010) Koushik Paul et al.   MOLECULAR CELL

A post-translational, c-di-GMP-dependent mechanism regulating flagellar motility

(2010) Xin Fang et al.   MOLECULAR MICROBIOLOGY

Spatial gradient of protein phosphorylation underlies replicative asymmetry in a bacterium

(2010) Y. E. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Allosteric Self-Splicing Ribozyme Triggered by a Bacterial Second Messenger

(2010) E. R. Lee et al.   SCIENCE

Asymmetrical Distribution of the Second Messenger c-di-GMP upon Bacterial Cell Division

(2010) M. Christen et al.   SCIENCE

c-di-AMP Secreted by Intracellular Listeria monocytogenes Activates a Host Type I Interferon Response

(2010) J. J. Woodward et al.   SCIENCE

Vibrio cholerae VpsT Regulates Matrix Production and Motility by Directly Sensing Cyclic di-GMP

(2010) P. V. Krasteva et al.   SCIENCE

Cyclic-di-GMP Reaches Out into the Bacterial RNA World

(2010) R. Hengge   Science Signaling

YfiBNR Mediates Cyclic di-GMP Dependent Small Colony Variant Formation and Persistence in Pseudomonas aeruginosa

(2010) Jacob G. Malone et al.   PLoS Pathogens

An Oxygen-Sensing Diguanylate Cyclase and Phosphodiesterase Couple for c-di-GMP Control

(2009) Jason R. Tuckerman et al.   BIOCHEMISTRY

Second messenger-mediated spatiotemporal control of protein degradation regulates bacterial cell cycle progression

(2009) A. Duerig et al.   GENES & DEVELOPMENT

The Functional Role of a Conserved Loop in EAL Domain-Based Cyclic di-GMP-Specific Phosphodiesterase

(2009) F. Rao et al.   JOURNAL OF BACTERIOLOGY

A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP

(2009) Sarah M. McWhirter et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Structure and mechanism of a bacterial light-regulated cyclic nucleotide phosphodiesterase

(2009) Thomas R. M. Barends et al.   NATURE

Principles of c-di-GMP signalling in bacteria

(2009) Regine Hengge   NATURE REVIEWS MICROBIOLOGY

Allosteric Regulation of Histidine Kinases by Their Cognate Response Regulator Determines Cell Fate

(2008) Ralf Paul et al.   CELL

Inverse regulatory coordination of motility and curli-mediated adhesion in Escherichia coli

(2008) C. Pesavento et al.   GENES & DEVELOPMENT

Structural Biochemistry of a Bacterial Checkpoint Protein Reveals Diadenylate Cyclase Activity Regulated by DNA Recombination Intermediates

(2008) Gregor Witte et al.   MOLECULAR CELL

Phosphorylation-Independent Regulation of the Diguanylate Cyclase WspR

(2008) Nabanita De et al.   PLOS BIOLOGY