Trafficking of ciliary membrane proteins by the intraflagellar transport/BBSome machinery

The molecular machines that traffic signaling receptors into and out of cilia

(2018) Maxence V Nachury   CURRENT OPINION IN CELL BIOLOGY

Interaction of heterotrimeric kinesin-II with IFT-B–connecting tetramer is crucial for ciliogenesis

(2018) Teruki Funabashi et al.   JOURNAL OF CELL BIOLOGY

BBSome trains remove activated GPCRs from cilia by enabling passage through the transition zone

(2018) Fan Ye et al.   JOURNAL OF CELL BIOLOGY

Subcellular localization of MC4R with ADCY3 at neuronal primary cilia underlies a common pathway for genetic predisposition to obesity

(2018) Jacqueline E. Siljee et al.   NATURE GENETICS

Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes

(2018) Niels Grarup et al.   NATURE GENETICS

Loss-of-function mutations in ADCY3 cause monogenic severe obesity

(2018) Sadia Saeed et al.   NATURE GENETICS

The Bardet–Biedl syndrome protein complex is an adapter expanding the cargo range of intraflagellar transport trains for ciliary export

(2018) Peiwei Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CEP128 Localizes to the Subdistal Appendages of the Mother Centriole and Regulates TGF-β/BMP Signaling at the Primary Cilium

(2018) Maren Mönnich et al.   Cell Reports

Reconstitution reveals motor activation for intraflagellar transport

(2018) Mohamed A. A. Mohamed et al.   NATURE

Intraflagellar transport: mechanisms of motor action, cooperation, and cargo delivery

(2017) Bram Prevo et al.   FEBS Journal

BLOC-1 is required for selective membrane protein trafficking from endosomes to primary cilia

(2017) William J. Monis et al.   JOURNAL OF CELL BIOLOGY

BBSome function is required for both the morphogenesis and maintenance of the photoreceptor outer segment

(2017) Ying Hsu et al.   PLoS Genetics

A recombinant BBSome core complex and how it interacts with ciliary cargo

(2017) Björn Udo Klink et al.   eLife

The intraflagellar transport machinery in ciliary signaling

(2016) André Mourão et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Smoothened determines β-arrestin–mediated removal of the G protein–coupled receptor Gpr161 from the primary cilium

(2016) Kasturi Pal et al.   JOURNAL OF CELL BIOLOGY

Cilium transition zone proteome reveals compartmentalization and differential dynamics of ciliopathy complexes

(2016) Samuel Dean et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Intraflagellar Transport Machinery

(2016) Michael Taschner et al.   Cold Spring Harbor Perspectives in Biology

Primary Cilia and Coordination of Receptor Tyrosine Kinase (RTK) and Transforming Growth Factor β (TGF-β) Signaling

(2016) Søren T. Christensen et al.   Cold Spring Harbor Perspectives in Biology

The BBSome Controls Energy Homeostasis by Mediating the Transport of the Leptin Receptor to the Plasma Membrane

(2016) Deng-Fu Guo et al.   PLoS Genetics

Structural Characterization of Bardet-Biedl Syndrome 9 Protein (BBS9)

(2015) Kevin E. Knockenhauer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Architectures of multisubunit complexes revealed by a visible immunoprecipitation assay using fluorescent fusion proteins

(2015) Y. Katoh et al.   JOURNAL OF CELL SCIENCE

Loss of the BBSome perturbs endocytic trafficking and disrupts virulence ofTrypanosoma brucei

(2015) Gerasimos Langousis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Accumulation of non-outer segment proteins in the outer segment underlies photoreceptor degeneration in Bardet–Biedl syndrome

(2015) Poppy Datta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BBS4 and BBS5 show functional redundancy in the BBSome to regulate the degradative sorting of ciliary sensory receptors

(2015) Qingwen Xu et al.   Scientific Reports

Regulation of Insulin Receptor Trafficking by Bardet Biedl Syndrome Proteins

(2015) Rachel D. Starks et al.   PLoS Genetics

Cilia and Diseases

(2014) Jason M. Brown et al.   BIOSCIENCE

BBS4 directly affects proliferation and differentiation of adipocytes

(2014) Olga Aksanov et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Intraflagellar Transport Protein IFT27 Promotes BBSome Exit from Cilia through the GTPase ARL6/BBS3

(2014) Gerald M. Liew et al.   DEVELOPMENTAL CELL

IFT27 Links the BBSome to IFT for Maintenance of the Ciliary Signaling Compartment

(2014) Thibaut Eguether et al.   DEVELOPMENTAL CELL

Bardet–Biedl syndrome proteins 1 and 3 regulate the ciliary trafficking of polycystic kidney disease 1 protein

(2014) Xuefeng Su et al.   HUMAN MOLECULAR GENETICS

Basal body proteins regulate Notch signaling through endosomal trafficking

(2014) C. C. Leitch et al.   JOURNAL OF CELL SCIENCE

Structural basis for membrane targeting of the BBSome by ARL6

(2014) André Mourão et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The MST1/2-SAV1 complex of the Hippo pathway promotes ciliogenesis

(2014) Miju Kim et al.   Nature Communications

Direct evidence for BBSome-associated intraflagellar transport reveals distinct properties of native mammalian cilia

(2014) Corey L. Williams et al.   Nature Communications

Ciliary dysfunction impairs beta-cell insulin secretion and promotes development of type 2 diabetes in rodents

(2014) Jantje M. Gerdes et al.   Nature Communications

Cycling of the signaling protein phospholipase D through cilia requires the BBSome only for the export phase

(2013) Karl F. Lechtreck et al.   JOURNAL OF CELL BIOLOGY

Exome sequencing of Bardet–Biedl syndrome patient identifies a null mutation in the BBSome subunitBBIP1(BBS18)

(2013) Sophie Scheidecker et al.   JOURNAL OF MEDICAL GENETICS

TheLeishmania major BBSome subunit BBS1 is essential for parasite virulence in the mammalian host

(2013) Helen P. Price et al.   MOLECULAR MICROBIOLOGY

Evolution of modular intraflagellar transport from a coatomer-like progenitor

(2013) T. J. P. van Dam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TGF-β Signaling Is Associated with Endocytosis at the Pocket Region of the Primary Cilium

(2013) Christian Alexandro Clement et al.   Cell Reports

Single molecule imaging reveals a major role for diffusion in the exploration of ciliary space by signaling receptors

(2013) Fan Ye et al.   eLife

Endocytosis Genes Facilitate Protein and Membrane Transport in C. elegans Sensory Cilia

(2012) Oktay I. Kaplan et al.   CURRENT BIOLOGY

IFT25 Links the Signal-Dependent Movement of Hedgehog Components to Intraflagellar Transport

(2012) Brian T. Keady et al.   DEVELOPMENTAL CELL

The base of the cilium: roles for transition fibres and the transition zone in ciliary formation, maintenance and compartmentalization

(2012) Jeremy F Reiter et al.   EMBO REPORTS

BBS proteins interact genetically with the IFT pathway to influence SHH-related phenotypes

(2012) Qihong Zhang et al.   HUMAN MOLECULAR GENETICS

Structural Studies of Ciliary Components

(2012) Naoko Mizuno et al.   JOURNAL OF MOLECULAR BIOLOGY

The BBSome controls IFT assembly and turnaround in cilia

(2012) Qing Wei et al.   NATURE CELL BIOLOGY

A size-exclusion permeability barrier and nucleoporins characterize a ciliary pore complex that regulates transport into cilia

(2012) Hooi Lynn Kee et al.   NATURE CELL BIOLOGY

Phenotypic expression of Bardet–Biedl syndrome in patients homozygous for the common M390R mutation in the BBS1 gene

(2012) Kyle F. Cox et al.   VISION RESEARCH

Strange as it may seem: the many links between Wnt signaling, planar cell polarity, and cilia

(2011) J. B. Wallingford et al.   GENES & DEVELOPMENT

Functional analysis of BBS3 A89V that results in non-syndromic retinal degeneration

(2011) P. R. Pretorius et al.   HUMAN MOLECULAR GENETICS

NPHP4, a cilia-associated protein, negatively regulates the Hippo pathway

(2011) Sandra Habbig et al.   JOURNAL OF CELL BIOLOGY

Primary cilia and coordination of receptor tyrosine kinase (RTK) signalling

(2011) Søren T Christensen et al.   JOURNAL OF PATHOLOGY

Hyperactive Neuroendocrine Secretion Causes Size, Feeding, and Metabolic Defects of C. elegans Bardet-Biedl Syndrome Mutants

(2011) Brian H. Lee et al.   PLOS BIOLOGY

The Conserved Bardet-Biedl Syndrome Proteins Assemble a Coat that Traffics Membrane Proteins to Cilia

(2010) Hua Jin et al.   CELL

Dopamine receptor 1 localizes to neuronal cilia in a dynamic process that requires the Bardet-Biedl syndrome proteins

(2010) Jacqueline S. Domire et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The ciliary membrane

(2010) Rajat Rohatgi et al.   CURRENT OPINION IN CELL BIOLOGY

BBS6, BBS10, and BBS12 form a complex with CCT/TRiC family chaperonins and mediate BBSome assembly

(2010) S. Seo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification and Functional Analysis of the Vision-Specific BBS3 (ARL6) Long Isoform

(2010) Pamela R. Pretorius et al.   PLoS Genetics

The BBSome

(2009) Hua Jin et al.   CURRENT BIOLOGY

Requirement of Bardet-Biedl syndrome proteins for leptin receptor signaling

(2009) Seongjin Seo et al.   HUMAN MOLECULAR GENETICS

TheChlamydomonas reinhardtiiBBSome is an IFT cargo required for export of specific signaling proteins from flagella

(2009) Karl-Ferdinand Lechtreck et al.   JOURNAL OF CELL BIOLOGY

Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium

(2009) Ljiljana Milenkovic et al.   JOURNAL OF CELL BIOLOGY

Transient ciliogenesis involving Bardet-Biedl syndrome proteins is a fundamental characteristic of adipogenic differentiation

(2009) Vincent Marion et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A BBSome Subunit Links Ciliogenesis, Microtubule Stability, and Acetylation

(2008) Alexander V. Loktev et al.   DEVELOPMENTAL CELL

Sensory Signaling-Dependent Remodeling of Olfactory Cilia Architecture in C. elegans

(2008) Saikat Mukhopadhyay et al.   DEVELOPMENTAL CELL

Bardet-Biedl syndrome proteins are required for the localization of G protein-coupled receptors to primary cilia

(2008) N. F. Berbari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA